Vaccination: the Likely Failure of a Top-down Response to a Pandemic

[St Michael]

The following is a text-only version of the notes from Dr. David Fedson's presentation at last week's First International Conference on Avian Influenza in Humans

Please see WHO CONSULATION FOR THE DEVELOPMENT OF A GLOBAL ACTION PLAN TO INCREASE THE SUPPLY OF PANDEMIC INFLUENZA VACCINES for an in-depth discussion of the problems of developing and distributing any effective H5N1 vaccination.


Asian European Conference on Avian Influenza 2006

Paris, 29-30 June 2006

Pandemic Influenza: A Potential Role for Statins in Treatment and Prophylaxis

David S. Fedson, MD

Prospects for Global Pandemic Vaccination: a WHO Assessment

?WHO is using international meetings to urge the international community to find ways to increase manufacturing capacity and ensure that developing countries have access to an effective vaccine at an affordable price. On current trends, however, most developing countries will have no access to a vaccine during the first wave of a pandemic and perhaps throughout its duration.?
--WHO, Global Programme on Influenza
Vaccine research and development, current status
November 2005

Six Interrelated Components of a Global Strategy for Pandemic Vaccination
Vaccine research and development

*Regulatory convergence
*Vaccine production capacity (GMP)
*IP issues and liability
*Vaccine purchasing, financing and distribution
*National vaccination programs

No institution or process exists or is planned that can do this at a global level!

Current Status of H5N1 Pandemic Vaccine Development

*Each company is developing its own H5N1 vaccine
*Government funding for clinical trials is limited, except for the US
*H5N1 vaccine viruses replicate poorly and are poorly immunogenic, even if adjuvanted
*In the event of an H5N1 pandemic, the global demand for vaccine will be >> 3-4 billion doses

Today, the world?s vaccine companies could produce enough doses of adjuvanted 30 mg HA vaccine in six months to vaccinate < 100 million people
Production capacity is unlikely to increase substantially within the next 3-5 years

Vaccination: the Likely Failure of a Top-down Response to a Pandemic

- Current efforts involve only a limited number of institutions, companies and governments, and only scientific, business and political elites are involved

- Management of the material and political logistics for global vaccination would require an elaborate international organization and be such a nightmare, it is not even being contemplated

*Pandemic vaccination will not be a realistic possibility for 85% of the world?s people who don?t live in countries with vaccine companies, and it will be difficult even for those who do
-
A Bottom-up Response to an Imminent Pandemic

*Elites have little or no control
*Uses large numbers of ordinary people in all countries
*Uses existing systems for delivering health care services to individuals as well as populations
*Uses existing resources that are affordable and already available worldwide
*Can be implemented on the first day of a pandemic

Statins: a Bottom-up Response to an Imminent Pandemic?

*Influenza increases AMIs, CHF and stroke
*Pro-inflammatory markers (CRP, TNF-a, IL-6) increase risk of CVD
*Influenza viruses up-regulate pro-inflammatory cytokines
*Influenza vaccination decreases AMIs, CHF and stroke

*Statins decrease CRP, TNF-a, and IL-6 and decrease risk of CVD
*Statins down-regulate pro-inflammatory cytokines

Statin-associated Protection in Syndromes with Cytokine Dysregulation

Author Study Statin Prev./Cont. Outcome Statin-assoc. reduction
Liappis (CID 2001) 388 cases continued bact-attr. mortality 87%
Almog (Circ 2004) 361 cases previous severe sepsis 87%
Kruger (ICM 2006) 438 cases continued bact-attr. mortality 92%
Hackam (Lancet 2006) 34,584/34,584 previous sepsis mortality 25%
Mancini (AJCC 2006) 4907/98,917 previous Hosp - COPD 26%

Protective Effect of Statins: Mortality from Bacteremia

*Retrospective study of 438 patients hospitalized with bacterial sepsis
*Conditional regression analysis to adjust for confounding variables

Bacteremia-attributable mortality
statin treated (6.1%) vs. not treated (18.3%)
OR = 0.29 (0.10 to 0.82)
continued Rx (1.8%) vs. no Rx (18.3%)
OR = 0.08 (0.01 to 0.60)

Kruger P et al. Intensive Care Med 2006; 32: 75-9.

Protective Effect of Statins: Population-based Study of Sepsis

*Ontario administrative database of patients discharged after hospitalization for acute cardiovascular disease
*Nested case-control study - 34,584 treated with statins and 34,584 propensity-matched untreated controls

Adjusted hazard ratios for statins (95% CIs)
All sepsis 0.81 (0.72 to 0.90)
Severe sepsis 0.83 (0.70 to 0.97)
Fatal sepsis 0.75 (0.61 to 0.93)

Hackam DG et al. Lancet 2006; 367: 413-8.

Protective Effect of Statins: Hospitalization for COPD in Quebec

Adjusted odds ratio
High-risk Low-risk
Treatment Myocard. revasc. NSAID Rx
cases/controls 946/18,774 4907/98,087

ACE inhibitors .87 .96
ARBs 1.04 .86
Statins .72 .74
Statins + ACEIs/ARBs .66 .77

Mancini GBJ et al. J Am Coll Card 2006; 47: 2554-60.

Statins and Pneumonia: An Epidemiological ?Signal of Protection?

*Population-based, nested case-control study of 1227 cases of pneumonia
*Three controls for each person on statins < 30 days

Adjusted OR (95% CI)
pneumonia hospitalization 0.63 (0.46 to 0.88)
30-day pneumonia mortality 0.47 (0.25 to 0.88)

Schlienger RG et al. Submitted for publication

Statins and Influenza-related Pneumonia: Reduction in 30-day Mortality

*8652 pneumonia patients ≥ 65 y.o. hospitalized October 1, 1998 - September 30, 1999
*Generalized linear mixed-effect model

Adjusted OR (95% CI)
Treatment (< 90d) Full year Flu season

Statins 0.62 (.48 - .80) 0.56 (.40 - .79)
ACE inhib 0.87 (.72 - 1.03) 0.95 (.75 - 1.19)
ARBs 0.83 (.44 - 1.56) 0.44 (.15 - 1.23)

Mortensen EM et al. Unpublished observations

Possible Mechanisms of Action for Statin Protection Against influenza

Statins interfere with mevalonate pathway decrease cholesterol synthesis and  decrease activation of small GTPases
- Virus assembly and release
alter lipid raft microdomains decrease virus assembly and budding
- Anti-inflammatory / immunomodulatory effects
decrease NF-B and decrease AP-1 decrease cytokines, chemokines, cellular adhesions molecules; modify caspase activation and apoptosis
- Endothelial and epithelial cell function
increase eNOS  increaseNO, vasodilatation, decrease oxidative stress;
alter actin cytoskeleton and intracellular tight junctions increase  lung barrier function,  decrease vascular leak

Other Agents to Consider for Pandemic Treatment and Prophylaxis
Other agents
- ACE inhibitors
- angiotensin-II receptor blockers(ARBs)
- phosphodiesterase inhibitors
- spironolactone
- chloroquine

These agents have anti-inflammatory and immunomodulatory activities
They could be used alone or in combination with
statins or each other

A Research Agenda for Statins and Influenza
*Epidemiological and clinical
- P&I in and out of influenza seasons
- hospitalization and mortality
- previous use only vs. continued use in hospital
*Animal models
- mice and ferrets
- H5N1 and 1918 reassortants
- treatment and prophylaxis
- cytokine profiles
- pathophysiological effects
*Cell-based infection
- basic molecular mechanisms of action

Could Statins and Other Agents Be Useful for Pandemic Influenza?

*The clinical and public health need for an effective agent is profound
*Experimental, clinical and epidemiological evidence suggests statins might be protective
*Generic statins are inexpensive and widely available worldwide
*The statins/influenza research agenda must be undertaken with a great sense of urgency

Preparing for an Imminent Pandemic

*Everyone should ask this question

If the pandemic is imminent, will my country be able to obtain adequate supplies of
- antivirals?
- vaccines?
- statins and other agents?
Preparing a Response to an Imminent Pandemic

?It is not enough to say, ?We are doing our best.? You have got to succeed in doing what is necessary.?

Winston Churchill

Will We Succeed in Doing What Is Necessary?
?Try again, fail again, fail better.?
Samuel Beckett
Worstward Ho
1983

Suggested Readings: Statins and Influenza

*Fedson DS. Pandemic influenza: a potential role for statins in treatment and prevention. Clin Infect Dis 2006, to be published (July 15th)
*Leser GP, Lamb RA. Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins. Virology 2005; 342; 215-27.
*Ludwig S, et al. Ringing the alarm bells: signaling and apopotosis in influenza virus infected cells. Cell Microbiol 2006; 8: 375-86.
*Jain MK, Ridker PM. Anti-inflammatory effects of statins: clinical evidence and basic mechanisms. Nat Rev Drug Discov 2005; 4: 977-87.
*Beckman JA, Creager MA. The nonlipid effects of statins on endothelial function. Trends Cardiovasc Med 2006; 16: 156-62.
*Jacobson JR, et al. Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol 2005; 288: L1026-32.

 

[St Michael]

Re: Vaccination: the Likely Failure of a Top-down Response to a Pandemic

Human Vaccines 2006; Vol. 2 Issue 1


Received 01/29/06; Accepted 01/29/06

Previously published as a Human Vaccines E-publication:

http://www.landesbioscience.com/journals/vaccines/abstract.php?id=2554

KEY WORDS
pandemic, influenza, vaccine, vaccination, H5N1,
reverse genetics, antigen sparing, adjuvant, alum, WHO

Commentary
Vaccine Development for an Imminent Pandemic
Why We Should Worry, What Must We Do

ABSTRACT

The avian H5N1 virus continues to evolve and poses an imminent pandemic threat.
Pandemic vaccine development, however, has progressed slowly. For it to succeed, it
must be based on a public health perspective that reflects the arithmetic of pandemic
vaccine demand, especially by countries without vaccine companies. Clinical trials of
H5N1 vaccines have been discouraging, and we must understand why the H5N1 virus
is so poorly immunogenic. Antigen-sparing pandemic vaccines will be required, and
future trials must identify the most effective adjuvant and determine whether whole virus
vaccines will be needed. Problems related to intellectual property and concerns about several
regulatory issues must be resolved. Public funding for clinical trials must be provided and
firm leadership and coordination exercised by national and international (WHO) public
health officials. Vaccination for an imminent pandemic requires a global perspective not
only for vaccine development but also for vaccine production and distribution.
Avian A/H5N1 influenza first appeared in poultry markets in Hong Kong in 1997 and
infected 18 people, six of whom died. The virus returned to Hong Kong in 1999 and
2003, reemerged in several countries in Southeast Asia in 2004 and recently spread to
Europe.1 Among diagnosed patients in Southeast Asia, approximately 50% have died.
Health officials everywhere are deeply concerned that events such as these will inevitably
lead to a new influenza pandemic, and many have said it is imminent. When a new pandemic
virus emerges, vaccination will be central to pandemic response. For this reason, we must
be concerned about developing an effective pandemic vaccine.2

WHY WE SHOULD WORRY ABOUT AN IMMINENT PANDEMIC

This year, 3 million people will die of AIDS, but the death toll from the next influenza
pandemic could be much higher. Historians now estimate that 50?100 million people
died in the 1918?1920 pandemic?2 1/2 to 5% of the world?s population.2 Given the
more than 3-fold increase in population since then, a 1918-like pandemic today could kill
175?350 million people. This is 1000 times more people than were swept away by the
2004 tsunamis. It is more than the number of people killed in all wars and by the most
murderous governments throughout the 20th Century. These people would die not in
100 years, but in 1 or 2. A pandemic caused by an H5N1 virus with undiminished virulence
would be far worse.

Since 1997, many influenza scientists have felt that sooner or later the H5N1 virus will
eventually develop the capacity to not only infect humans and cause disease, but also
acquire the ability to be transmitted efficiently from one person to the next. Almost nine
years have passed and this has not happened, but no one should think the pandemic threat
is receding. The H5N1 viruses isolated in recent years are more virulent for birds than they
were in 1997, and they have spread to several mammalian species in addition to man.3

Virologists have convincingly shown that the virus of the 1918 pandemic was of avian
origin,4 a finding that emphasizes the threat posed by evolutionary changes in the genome
of the H5N1 virus.
The precise molecular requirements for efficient human-to human transmission of the
H5N1 virus have yet to be defined, but changes in only a few amino acids in a few key
gene products might be sufficient.4 For example, a strain-specific difference in hemagglutinin
(HA) receptor binding specificity between two different 1918 viruses has been shown
to be due to a single amino acid substitution at position 190.5 Similarly, in a mouse model
of A/Hong Kong/97 (H5N1) infection, substitution of glutamine for lysine at position
627 of the PB2 protein converted a nonlethal to a lethal infection.6 Recent gene sequencing studies of two H5N1 isolates obtained from fatal human cases in Turkey have shown that their PB2 proteins also have this amino acid
substitution at position 627. In addition, their HAs have a substitution
at position 223 that is associated with increased affinity for sialic acid
receptors on human cells.7,8 These two human isolates are the first
to show both of these mutations. Although the mutations have not
been associated with efficient human-to-human transmission, they
provide a sobering reminder of the continuing H5N1 pandemic threat.

Several years ago, a respected influenza expert cautioned against
what he called influenza ?extrapolitis?; that is, the assumption that
the next pandemic will be as severe as the one in 1918.9 No one can
know how severe the next pandemic will be, nor which influenza
virus will be its cause?it could be an H2, H7, H9 or another subtype.
However, given the alarming experience with human H5N1 influenza,
it would be prudent to prepare for the ?worst-case? scenario.

WHY WE SHOULD WORRY ABOUT DEVELOPING
A PANDEMIC VACCINE

No influenza vaccine was available for the 1918 pandemic and
very little was used for the last pandemic in 1968. Things are vastly
different now. In virtually all countries where influenza vaccines are
used, the level of use is increasing; currently, almost 300 million people
are being vaccinated worldwide each year.10 Nonetheless, the global
vaccine supply is fragile. In 2004, contamination of vaccine produced
in the U.K. led to the loss of half the normal U.S. supply. Because
the U.S. has only one domestic influenza vaccine producer, intense
efforts were undertaken to obtain supplies from other countries.
Only a few million doses could be found.

We have not paid attention to the arithmetic of pandemic vaccine
supply. In 2003, more than 95% of the world?s influenza vaccines
were produced in only nine countries, and more than 65% of all
doses came from five Western European countries.10 Overall, the
nine-vaccine producing countries used 62% of world?s vaccines, yet
they accounted for only 12% of the world?s population. The remaining
38% of all doses were used in countries that have little or no capacity
to produce influenza vaccines on their own. These ?have not? countries
had to rely on Western European companies for 99% of their
vaccines. Because influenza vaccination is increasing rapidly in these
countries, they soon will account for half of the global use of seasonal
vaccines. If the ?have not? countries are to have adequate supplies of
vaccines for the next pandemic, we must ensure that effective vaccines
are developed and that they can be quickly produced and equitably
distributed to all countries that want to use them.

Anticipating the number of doses of pandemic vaccine the world
will demand involves some common sense and a bit of arithmetic.
Because few people will have had previous exposure to the pandemic
virus, most will require two doses to ensure adequate protection.
Given the world?s current vaccine production capacity (300 million
doses of trivalent vaccine in ~6 months),2 if a monovalent pandemic
vaccine were produced according to the formulation of seasonal
influenza vaccines (15 μg hemagglutinin [HA] per dose), only
450 million people could be vaccinated (300 x 3/2 = 450). This will
not begin to meet the needs of even the vaccine-producing countries.
Consequently, their governments, having decided to vaccinate most
if not all of their populations, will probably not allow the export of
pandemic vaccines to ?have not? countries until their own needs have
been met.2 This is the arithmetic of pandemic vaccine supply, and it
is unforgiving.

We have been slow to recognize that an antigen-sparing pandemic
vaccine will be essential. If the global supply of pandemic vaccines
is to be sufficient to meet world demand, its formulation must be
?antigen-sparing?; in other words, each dose must contain a much
smaller amount of HA antigen.2,11 Intradermal (ID) vaccination using
a very low (e.g., 1/10th) dose of antigen has been proposed, but there
has been very little experience with ID vaccination of immunologically
na?ve individuals, and ID vaccine administration would be
difficult to implement in large-scale vaccination programs. Most
efforts to date have focused on developing traditional inactivated
vaccines that can be administered intramuscularly. Many studies
have shown that in unprimed individuals, whole-virus vaccines are
more immunogenic than split-virus or subunit vaccines. But
whole-virus vaccines alone will not be sufficiently antigen sparing;
an adjuvant will have to be used.2,11,12

The arithmetic of global pandemic vaccine supply will be less
unforgiving if the next pandemic is caused by an H2 or H9 virus.
Seed strains for formulating pilot lots of H2 or H9 vaccines have been
produced using conventional genetic reassortment techniques.2,11-13
Preliminary clinical trials have shown that two doses of alumadjuvanted,
whole virus H2 and H9 vaccines are adequately
immunogenic when formulated with 3.75 and even 1.875 μg HA
per dose. If globally produced, such vaccines could theoretically
immunize (with two doses) as many as 1.8 billion (3.75 μg HA) or
3.6 (1.875 μg HA) billion people.2

Clinical trials of H5N1 vaccines have been disappointing.
Developing pandemic vaccines against H5 (or H7) viruses will be
much more difficult. Until recently, no commercially viable human
vaccine against an H5N1 virus could be produced because these
highly pathogenic viruses are lethal for embryonated eggs. However,
virologists can use reverse genetics (RG) to remove the polybasic
amino acid sequence at the HA cleavage site that is responsible for
H5N1 virulence.2,12,13 Within 10?20 days, a high-growth, 6:2
reassortant virus can be prepared that can be safely used for
egg-based vaccine production. The first RG-engineered H5N1 virus
was prepared in early 2003, and a similar virus prepared in early
2004 is being used by most vaccine companies to produce pilot lots
of H5N1 vaccines for clinical trials.

Clinical trials to assess the immunogenicity and safety of several
candidate H5N1 vaccines are underway, and preliminary (but as yet
unpublished) results of two studies have been announced. In the
U.S., the NIH tested a nonadjuvanted, split virus H5N1 vaccine
produced by Sanofi Pasteur (U.S.). In healthy adults, two doses of
this vaccine induced acceptable levels of antibody only at 90 μg HA
per dose.14 In France, two doses of an alum adjuvanted, split virus
H5N1 vaccine produced by Sanofi Pasteur (France) have been shown
to be acceptably immunogenic at 30 μg HA per dose.15
The implications of the H5N1 vaccine trial results for pandemic
vaccine supply are extremely discouraging, even for vaccine-producing
countries. Take the U.S., for example. Given the usual 6-month
vaccine production cycle and current U.S. production capacity (60
million doses of trivalent vaccine), the supply of a nonadjuvanted
H5N1 vaccine formulated at 90 μg HA per dose would be sufficient
to vaccinate (with two doses) only 15 million Americans. An alumadjuvanted
H5N1 vaccine formulated at 30 μg HA per dose would
vaccinate only 45 million people. These numbers are far short of the
public health needs of a country that is moving steadily toward
routine universal influenza vaccination every year. For the world as
a whole, supplies of these two vaccines would be sufficient to vaccinate,
with six months? production, only 75 or 225 million people,
respectively. Although several companies are planning to conduct
additional trials of adjuvanted H5N1 vaccines, the results of these
trials might not be much better.

We have not managed to coordinate the development of pandemic
vaccines by all companies. If we are worried about the H5N1
vaccine trial results, we should be equally concerned about the
process by which the vaccines are being developed. It is worth remembering
that in 1976, the last time a pandemic threat was perceived,
the U.S. conducted publicly funded clinical trials of four different
swine flu vaccines produced by four companies in more than 6000
healthy adults, children and older adults.16,17 The trials provided
information on the swine flu vaccine formulation and vaccination
schedule. They were completed in 4?5 months. In contrast, an
RG-engineered H5N1 virus was prepared in early 2003 and a vaccine
could have been quickly produced and introduced into clinical trials.
This was not done. Three years later, the most important thing we
have learned is that we will be totally unable to produce supplies of
effective H5N1 vaccines that will be large enough to meet global
needs for an imminent pandemic.

WHAT WE MUST DO TO DEVELOP PANDEMIC VACCINES

The threat of an H5N1 pandemic has been present for nine years,
and nothing suggests it is going to disappear. The need to develop
vaccines to meet this threat is understood by all. If we could be
certain that the pandemic would not arrive for another ten years, we
would then be able to call on several new vaccines; cell cultureproduced
vaccines, well established live-attenuated vaccines, new
adjuvanted vaccines and perhaps universal vaccines containing crossprotective
antigens.13,18 Nonetheless, we cannot count on the
pandemic virus waiting this long to emerge. Common sense tells us
we must take the threat of an imminent pandemic seriously. In many
ways, we have been living on borrowed time because vaccine development
has proceeded so slowly. Several things must be done to
change this.

We must view pandemic vaccine development as a public health
problem, not as a vaccine problem. Thus far, vaccine companies
have been allowed to develop their own H5N1 vaccine formulations,
and there has been no overarching public health strategy for coordinating
their efforts. Yet, development of pandemic vaccines must be
based on the needs of public health, not vaccine companies, and it
must pay special attention to the needs of ?have not? countries. Much
of the delay in developing vaccines for an imminent pandemic can
be traced to a widespread failure to appreciate the implications of
this public health perspective.

We must understand why the H5N1 virus is poorly immunogenic.
Investigators who first studied vaccines directed against the H5N1
virus were forced to use a vaccine that contained a non-pathogenic
surrogate H5N3 virus because reverse genetics was not yet available.
In mice, inactivated whole-virus and alum-adjuvanted subunit
H5N3 vaccines were protective against lethal H5N1 challenge.12 In
a small clinical trial of a surface antigen H5N3 vaccine, an acceptable
neutralizing antibody response was achieved only with two doses of
an MF59 adjuvanted preparation (7.5 to 30 μg HA per dose).12

More recent studies in mice19 and ferrets20 of whole-virus adjuvanted
(incomplete Freund?s adjuvant) H5N1 vaccines prepared with reverse
genetics have shown protection again lethal challenge with homologous
and heterologous H5N1 viruses. Moreover, serologic studies in
man suggest that a current adjuvanted H5N1 vaccine could be used
for priming against a future H5N1 pandemic virus.21

What is worrisome is that clinical trials of the H5N1 vaccines
have shown that higher amounts of HA have been required to elicit
an immune response when compared with responses to the HAs of
other influenza virus subtypes.12 In addition, vaccine companies
have found that the amounts of HA antigen they obtain in their
production processes are 30?40% of what they normally expect.

Little is known about the molecular basis for the poor immunogenicity
and poor yields for the H5 hemagglutinin, and, in particular,
whether crucial epitopes are modified during the preparation of
reverse genetics reassortants, during inactivation or during the process
of preparing split virus vaccines. Successful development of an effective
H5N1 vaccine may depend on the answers to these questions.
We must use an adjuvant if we are to have an antigen-sparing
vaccine. Although the pace of pandemic vaccine development in the
U.S. has recently picked up, the NIH program for H5N1 vaccine
initially began with a trial of a nonadjuvanted formulation. Yet U.S.
policy for pandemic vaccination requires that 600 million doses be
produced within at least 6 months. Given a domestic production
capacity of only 180 million doses of monovalent 15 μg HAcontaining
vaccine (60 x 3), the arithmetic should have informed
government scientists early on that producing a number of doses
sufficient to meet public health needs would require that each dose
contain no more than 4.5 μg HA per dose. Thus, from the outset the
NIH should have focused on developing an antigen-sparing H5N1
vaccine formulation by comparing low-dose adjuvanted and nonadjuvanted
H5N1 vaccines in the same set of clinical trials. Testing
only a non-adjuvanted H5N1 vaccine first wasted at least one year
and probably more.

Vaccine companies in other countries have not made the same
mistake; they understand better the arithmetic of pandemic vaccination,
not only for their own countries but also for the countries they
supply with seasonal vaccines. For this reason, they have compared
or will compare non-adjuvanted with adjuvanted vaccines in their
clinical trials.

We must include whole virus vaccines in clinical trials. Given the
known superiority of whole virus vaccines in unprimed individuals,11,12
clinical trials of H5N1 adjuvanted vaccines should have included
whole virus, not just split virus or subunit preparations. The clinical
trials of adjuvanted H5N1 vaccines planned by GlaxoSmithKline in
Germany and by four companies in Japan will test alum-adjuvanted
whole-virus formulations.22 However, the clinical trial of CSL
currently underway in Australia and other trials planned by Sanofi
Pasteur in the U.S. and by Chiron will only test adjuvanted split
virus or subunit preparations. Remarkably, despite discouraging
results from its alum-adjuvanted split-virus H5N1 vaccine trial,
Sanofi Pasteur in France has said it will ?not look at whole virus vaccines?.
23 From the perspective of a company, this is understandable.
Some companies depend on the splitting process to contribute to
virus inactivation, although influenza viruses can be inactivated
without splitting. Adopting a new inactivation process risks regulatory
uncertainty, something that companies producing split virus or
subunit seasonal vaccines want to avoid. Yet, adjuvanted whole-virus
H5N1 vaccines might be better able to meet the public health need
for antigen-sparing vaccines. Company decisions not to test whole
virus formulations ignore this need.

We must not let intellectual property issues and regulatory
concerns cause further delay. Several nonvirological issues have
delayed clinical trials of candidate pandemic vaccines.2 Initially,
uncertainty over intellectual property (IP) rights for reverse genetics
was a troubling issue for several European vaccine companies. Now
that RG patent rights have been consolidated in the hands of one
company (MedImmune),24 uncertainties over RG-IP have receded.
MedImmune has indicated that it will allow reverse genetics-engineered
viruses to be used for pandemic vaccine development without
payment of royalties.25 It has also stated that it ?will waive royalties
on its intellectual property for any and all pandemic influenza vaccines
that are offered free of charge in the interest of public health.?
However, intellectual property issues could still be important if
clinical trials demonstrate that proprietary adjuvants such as MF59
are better able to meet the need for an antigen sparing pandemic
vaccine.26

European regulatory officials are also concerned about the safety
of RG-engineered viruses, despite reassurance from WHO experts
that this should not be a problem.27 In one European country, regulations
that consider RG-engineered viruses to be ?genetically
modified organisms? have prevented its vaccine company from
undertaking H5N1 vaccine development. Moreover, in the U.S., the
FDA until recently required that a license for an adjuvanted pandemic
vaccine could be obtained only if a company presented evidence of
the clinical efficacy of a similarly adjuvanted seasonal influenza
vaccine. Although this requirement has been lifted, it undoubtedly
influenced the initial decision by the NIH to test only a nonadjuvanted
H5N1 vaccine.

We must obtain public funding for clinical trials of pandemic
vaccines. Several countries have negotiated contracts for supplies of
pandemic vaccines, Canada being the first in 2000, and many more
are attempting to do so. However, with the exception of the U.S.,
Australia and Japan, pandemic vaccine development itself has
received little if any financial support from governments.2 In
Europe, vaccine companies have had to pay for clinical trials of their
?pandemic-like? vaccines, and consequently each of the few trials that
have been conducted has enrolled only a small number of subjects.
No European country has yet provided the public funding needed for
clinical trials of H5N1 vaccines, and neither has the European
Union. In contrast, the U.S. has understood that pandemic vaccine
development requires public funding (although the NIH has had
trouble knowing what should be done), whereas European investigators
have known what to do but have had no public funding to do it.
Why European governments have chosen not to fund the development
of something essential for their national health security is unclear; it
is difficult to imagine they would similarly expect industry to fully
fund the development of weapons systems deemed vital for their
national defence. The U.S. and Europe (and other vaccine-producing
countries and even non vaccine-producing countries) must find a
way to collaborate and publicly fund this urgently needed research.

We must have firm leadership for pandemic vaccine development
at the international level. WHO has done a remarkable job of
calling attention to the global threat of pandemic influenza.
However, its contributions to pandemic vaccine development have
been less impressive. WHO has convened several meetings that have
allowed companies and national health officials to share information,
but WHO has only ?encouraged companies to test vaccine formulations
that include an adjuvant?.28 Like national governments, WHO
has let companies decide what kinds of pandemic vaccines they will
develop. In doing so, and in the face of what could be an imminent
pandemic, the critical needs of ?have not? countries for the timely
development of antigen sparing vaccines have received little attention.

PANDEMIC VACCINATION REQUIRES A GLOBAL PERSPECTIVE

Preparing for pandemic vaccination will require solutions to
many problems that go beyond vaccine development.2 Governments
will have to assume legal liability for vaccine-associated adverse
events. The international community must decide how to forecast
the vaccine demands of all countries and determine how ?have not?
countries will be able to obtain vaccine supplies from countries
whose political leaders have ?nationalized? their own vaccine companies.

No one should under-estimate how difficult it will be to solve these
problems, but everyone should recognize that not solving them
beforehand could lead to an extraordinary humanitarian and political
crisis worldwide. Everyone must also recognize that managing this
crisis will be less difficult if the global supply of pandemic vaccine is
large instead of small.

Vaccine companies are already doing much to develop pandemic
vaccines, but they could certainly do more. However, final responsibility
for pandemic vaccine development rests with public officials.2
The 2004 tsunamis and Hurricane Katrina have reminded us of
the dreadful suffering people experience when public officials fail to
make adequate preparations for future emergencies. Vaccine development
for an imminent pandemic requires similar preparation.29 In
its absence, the political and moral fallout can and will be profound.30,31
Winston Churchill once wrote, ?It is no use saying, ?We are doing
our best.? You have got to succeed in doing what is necessary.? If
public officials fail to do what is necessary to develop effective
antigen-sparing pandemic vaccines and a highly virulent pandemic
virus emerges within the next few years, the consequences of their
failure will be all too evident, and they will haunt us for years to come.

References

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(H5N1) infection in humans. N Engl J Med 2005; 353:1374-85.
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Infect Dis 2006; 12:3-8.
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amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding
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affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses
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vaccine candidate with an adjuvant. Lyon: 2005, (http://www.sanofipasteur.com).
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virus vaccines in adults. J Infect Dis 1977; 136(Suppl):S722-30.
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influenza A/New Jersey/76 virus vaccine in normal children: An overview of age-related
antigenicity and reactogenicity. J Infect Dis 1977; 136(Suppl):S371-41.
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vaccines produced by reverse genetics in a lethal mouse model. J Infect Dis 2005; 191:1216-20.
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[AlaskaDenise]

Re: Vaccination: the Likely Failure of a Top-down Response to a Pandemic

While it is reassuring to see more treatment alternatives, without basic surge capacity and healthy HCW, is this actually realistic for much of the developed countries population?

I'd like to see more information about what ordinary people without access to health care can do for themselves at home. Will people be able to keep a supply of statins at home?

I often wonder about the long-term "bottom up" response to preventable pandemic deaths. The failure of developed countries to allocate sufficient resources to production of vaccines & medications may elicite a response from the citizenry that will have profound historical implications. While using excuses like "liability issues", etc. in their policies, perhaps they should give more thought to long term political implications. I had one of the first polio sugarcubes and we knew it carried risks, but we gladly accepted the opportunity to avoid the alternative.

.

 

[St Michael]

Re: Vaccination: the Likely Failure of a Top-down Response to a Pandemic

While it is reassuring to see more treatment alternatives, without basic surge capacity and healthy HCW, is this actually realistic for much of the developed countries population?

I'd like to see more information about what ordinary people without access to health care can do for themselves at home. Will people be able to keep a supply of statins at home?

It seems to me that statins are now OTC in England.

 

[AlaskaDenise]

Re: Vaccination: the Likely Failure of a Top-down Response to a Pandemic

OTC - WOW!

Here they are very expensive, however a small supply as a pandemic treatment is likely affordable.

.

 

[St Michael]

Re: Vaccination: the Likely Failure of a Top-down Response to a Pandemic

OTC Statins - The UK Experience
Statins in Aisle 7?

 

[St Michael]

Re: Vaccination: the Likely Failure of a Top-down Response to a Pandemic

A half a year later, and still the world medical community is ignoring this?

 

[DRJJ]

Re: Vaccination: the Likely Failure of a Top-down Response to a Pandemic

Is is prudent to ask my physician for a prophylatic set of prescriptions for the drugs you have mentioned above? If so, what doses are appropriate? and what would a course of drug administration treatment? Would or should caretakers take them as preventatives? as well as giving them to H5N1 patients?