tetano
Editor, Senior Moderator
Vaccine. 2014 Jul 28. pii: S0264-410X(14)00979-7. doi: 10.1016/j.vaccine.2014.06.093. [Epub ahead of print]
Vaccination against the M protein of Streptococcus pyogenes prevents death after influenza virus:S. pyogenes super-infection.
Klonoski JM1, Hurtig HR1, Juber BA1, Schuneman MJ1, Bickett TE1, Svendsen JM1, Burum B2, Penfound TA3, Sereda G2, Dale JB3, Chaussee MS1, Huber VC4.
Author information
Abstract
Influenza virus infections are associated with a significant number of illnesses and deaths on an annual basis. Many of the deaths are due to complications from secondary bacterial invaders, including Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pyogenes. The β-hemolytic bacteria S. pyogenes colonizes both skin and respiratory surfaces, and frequently presents clinically as strep throat or impetigo. However, when these bacteria gain access to normally sterile sites, they can cause deadly diseases including sepsis, necrotizing fasciitis, and pneumonia. We previously developed a model of influenza virus:S. pyogenes super-infection, which we used to demonstrate that vaccination against influenza virus can limit deaths associated with a secondary bacterial infection, but this protection was not complete. In the current study, we evaluated the efficacy of a vaccine that targets the M protein of S. pyogenes to determine whether immunity toward the bacteria alone would allow the host to survive an influenza virus:S. pyogenes super-infection. Our data demonstrate that vaccination against the M protein induces IgG antibodies, in particular those of the IgG1 and IgG2a isotypes, and that these antibodies can interact with macrophages. Ultimately, this vaccine-induced immunity eliminated death within our influenza virus:S. pyogenes super-infection model, despite the fact that all M protein-vaccinated mice showed signs of illness following influenza virus inoculation. These findings identify immunity against bacteria as an important component of protection against influenza virus:bacteria super-infection.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Bacteria; Influenza; Super-infection
PMID:
25077423
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25077423
Vaccination against the M protein of Streptococcus pyogenes prevents death after influenza virus:S. pyogenes super-infection.
Klonoski JM1, Hurtig HR1, Juber BA1, Schuneman MJ1, Bickett TE1, Svendsen JM1, Burum B2, Penfound TA3, Sereda G2, Dale JB3, Chaussee MS1, Huber VC4.
Author information
Abstract
Influenza virus infections are associated with a significant number of illnesses and deaths on an annual basis. Many of the deaths are due to complications from secondary bacterial invaders, including Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Streptococcus pyogenes. The β-hemolytic bacteria S. pyogenes colonizes both skin and respiratory surfaces, and frequently presents clinically as strep throat or impetigo. However, when these bacteria gain access to normally sterile sites, they can cause deadly diseases including sepsis, necrotizing fasciitis, and pneumonia. We previously developed a model of influenza virus:S. pyogenes super-infection, which we used to demonstrate that vaccination against influenza virus can limit deaths associated with a secondary bacterial infection, but this protection was not complete. In the current study, we evaluated the efficacy of a vaccine that targets the M protein of S. pyogenes to determine whether immunity toward the bacteria alone would allow the host to survive an influenza virus:S. pyogenes super-infection. Our data demonstrate that vaccination against the M protein induces IgG antibodies, in particular those of the IgG1 and IgG2a isotypes, and that these antibodies can interact with macrophages. Ultimately, this vaccine-induced immunity eliminated death within our influenza virus:S. pyogenes super-infection model, despite the fact that all M protein-vaccinated mice showed signs of illness following influenza virus inoculation. These findings identify immunity against bacteria as an important component of protection against influenza virus:bacteria super-infection.
Copyright ? 2014 Elsevier Ltd. All rights reserved.
KEYWORDS:
Bacteria; Influenza; Super-infection
PMID:
25077423
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25077423