tetano
Editor, Senior Moderator
Clin Transl Immunology. 2018 Jan 31;7(1):e1010. doi: 10.1002/cti2.1010. eCollection 2018.
[h=1]Vaccinating for natural killer cell effector functions.[/h] Wagstaffe HR[SUP]1[/SUP], Mooney JP[SUP]1,[/SUP][SUP]2[/SUP], Riley EM[SUP]1,[/SUP][SUP]2[/SUP], Goodier MR[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination has proved to be highly effective in reducing global mortality and eliminating infectious diseases. Building on this success will depend on the development of new and improved vaccines, new methods to determine efficacy and optimum dosing and new or refined adjuvant systems. NK cells are innate lymphoid cells that respond rapidly during primary infection but also have adaptive characteristics enabling them to integrate innate and acquired immune responses. NK cells are activated after vaccination against pathogens including influenza, yellow fever and tuberculosis, and their subsequent maturation, proliferation and effector function is dependent on myeloid accessory cell-derived cytokines such as IL-12, IL-18 and type I interferons. Activation of antigen-presenting cells by live attenuated or whole inactivated vaccines, or by the use of adjuvants, leads to enhanced and sustained NK cell activity, which in turn contributes to T cell recruitment and memory cell formation. This review explores the role of cytokine-activated NK cells as vaccine-induced effector cells and in recall responses and their potential contribution to vaccine and adjuvant development.
[h=4]KEYWORDS:[/h] NK cell; accessory cell; cytokines; vaccination
PMID: 29484187 PMCID: PMC5822400 DOI: 10.1002/cti2.1010
Free PMC Article
[h=1]Vaccinating for natural killer cell effector functions.[/h] Wagstaffe HR[SUP]1[/SUP], Mooney JP[SUP]1,[/SUP][SUP]2[/SUP], Riley EM[SUP]1,[/SUP][SUP]2[/SUP], Goodier MR[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination has proved to be highly effective in reducing global mortality and eliminating infectious diseases. Building on this success will depend on the development of new and improved vaccines, new methods to determine efficacy and optimum dosing and new or refined adjuvant systems. NK cells are innate lymphoid cells that respond rapidly during primary infection but also have adaptive characteristics enabling them to integrate innate and acquired immune responses. NK cells are activated after vaccination against pathogens including influenza, yellow fever and tuberculosis, and their subsequent maturation, proliferation and effector function is dependent on myeloid accessory cell-derived cytokines such as IL-12, IL-18 and type I interferons. Activation of antigen-presenting cells by live attenuated or whole inactivated vaccines, or by the use of adjuvants, leads to enhanced and sustained NK cell activity, which in turn contributes to T cell recruitment and memory cell formation. This review explores the role of cytokine-activated NK cells as vaccine-induced effector cells and in recall responses and their potential contribution to vaccine and adjuvant development.
[h=4]KEYWORDS:[/h] NK cell; accessory cell; cytokines; vaccination
PMID: 29484187 PMCID: PMC5822400 DOI: 10.1002/cti2.1010
Free PMC Article