Gert van der Hoek
In Memoriam - Editor, Senior Moderator
With all the news on the "new" NDM-1, we must not forget other antibiotic resistant genes are circulating, among others: VIM-7.
Antimicrob Agents Chemother. 2004 January; 48(1): 329–332.
blaVIM-7, an Evolutionarily Distinct Metallo-β-Lactamase Gene in a Pseudomonas aeruginosa Isolate from the United States
This is the first report of a mobile metallo-β-lactamase, VIM-7, being found in the bacterial population of the United States. blaVIM-7 has been shown to be highly mobile and can be expressed in Enterobacteriaceae as well as Pseudomonas spp. Given that these enzymes can hydrolyze all known classes of therapeutic β-lactams and that there is no clinically available metallo-β-lactamase inhibitor, mobile metallo-β-lactamases will pose a serious threat to broad-spectrum β-lactam therapies within the United States.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC310168/
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Antimicrobial Agents and Chemotherapy, September 2008, p. 3099-3105, Vol. 52, No. 9
Complete Sequence of p07-406, a 24,179-Base-Pair Plasmid Harboring the blaVIM-7 Metallo-β-Lactamase Gene in a Pseudomonas aeruginosa Isolate from the United States
An outbreak involving a Pseudomonas aeruginosa strain that was resistant to all tested antimicrobials except polymyxin B occurred in a hospital in Houston, TX. Previous studies on this strain showed that it possesses a novel mobile metallo-β-lactamase (MBL) gene, designated blaVIM-7, located on a plasmid (p07-406).
http://aac.asm.org/cgi/content/short/52/9/3099
Maryn McKenna on "plasmids":
- snip -
As the Lancet ID paper reports, NDM-1 resides on a plasmid — a snippet of DNA, not on a chromosome, that reproduces on its own and can move freely between organisms. Intuitively, you would think that bacteria either inherit resistance from their progenitors or develop it on their own when they encounter a drug. Plasmids short-circuit both those processes, allowing resistance to spread rapidly within a single bacterial generation to organisms that have never experienced the drug they are acquiring defenses against.
http://www.superbugtheblog.com/
"Vim-7" is located on a plasmid too.
.
Antimicrob Agents Chemother. 2004 January; 48(1): 329–332.
blaVIM-7, an Evolutionarily Distinct Metallo-β-Lactamase Gene in a Pseudomonas aeruginosa Isolate from the United States
This is the first report of a mobile metallo-β-lactamase, VIM-7, being found in the bacterial population of the United States. blaVIM-7 has been shown to be highly mobile and can be expressed in Enterobacteriaceae as well as Pseudomonas spp. Given that these enzymes can hydrolyze all known classes of therapeutic β-lactams and that there is no clinically available metallo-β-lactamase inhibitor, mobile metallo-β-lactamases will pose a serious threat to broad-spectrum β-lactam therapies within the United States.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC310168/
----------------------------------------------------------
Antimicrobial Agents and Chemotherapy, September 2008, p. 3099-3105, Vol. 52, No. 9
Complete Sequence of p07-406, a 24,179-Base-Pair Plasmid Harboring the blaVIM-7 Metallo-β-Lactamase Gene in a Pseudomonas aeruginosa Isolate from the United States
An outbreak involving a Pseudomonas aeruginosa strain that was resistant to all tested antimicrobials except polymyxin B occurred in a hospital in Houston, TX. Previous studies on this strain showed that it possesses a novel mobile metallo-β-lactamase (MBL) gene, designated blaVIM-7, located on a plasmid (p07-406).
http://aac.asm.org/cgi/content/short/52/9/3099
Maryn McKenna on "plasmids":
- snip -
As the Lancet ID paper reports, NDM-1 resides on a plasmid — a snippet of DNA, not on a chromosome, that reproduces on its own and can move freely between organisms. Intuitively, you would think that bacteria either inherit resistance from their progenitors or develop it on their own when they encounter a drug. Plasmids short-circuit both those processes, allowing resistance to spread rapidly within a single bacterial generation to organisms that have never experienced the drug they are acquiring defenses against.
http://www.superbugtheblog.com/
"Vim-7" is located on a plasmid too.
.