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US FluView: 2017-2018 season

sharon sanders

Editor-in-Chief & President
Please note: Due to data collection procedures these FluView reports are about 4 weeks behind actual current conditions. Some states report timely to the CDC. Some do not. Please see our state threads for more current information.
 
[h=3]2017-2018 Influenza Season Week 40 ending October 7, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Background:[/h] [FONT=&quot]The Centers for Disease Control and Prevention’s (CDC) Influenza Division collects, compiles, and analyzes information on influenza activity year-round in the United States and produces FluView, a weekly influenza surveillance report, and FluView Interactive , an application to customize the presentation of influenza surveillance data. The U.S. influenza surveillance system provides information in five categories collected from eight data sources. This is the first report of the 2017-2018 influenza season.[/FONT]
[FONT=&quot]The five categories and eight data components of CDC influenza surveillance are:[/FONT]
  • Viral Surveillance: U.S. World Health Organization (WHO) collaborating laboratories, the National Respiratory and Enteric Virus Surveillance System (NREVSS), and human infection with novel influenza A virus case reporting;
  • Mortality: National Center for Health Statistics (NCHS) Mortality Surveillance System and influenza-associated pediatric deaths;
  • Hospitalizations: Influenza Hospitalization Network (FluSurv-NET) including the Emerging Infections Program (EIP) and three additional states;
  • Outpatient Illness Surveillance: U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet);
  • Geographic Spread of Influenza: State and territorial epidemiologists’ reports.
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 40 (October 1-7, 2017), influenza activity was low in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 40 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories is low.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: No influenza-associated pediatric deaths were reported.
  • Outpatient Illness Surveillance: The proportion of outpatient visits for influenza-like illness (ILI) was 1.4%, which is below the national baseline of 2.2%. All 10 regions reported ILI below region-specific baseline levels. New York City, the District of Columbia, and 50 states experienced minimal ILI activity and Puerto Rico had insufficient data.
  • Geographic Spread of Influenza: The geographic spread of influenza in Guam was reported as widespread; two states reported local activity; the District of Columbia and 38 states reported sporadic activity; 10 states reported no activity; and Puerto Rico and the U.S. Virgin Islands did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Normal[/TD]
[TD]1 of 54[/TD]
[TD]2.7%[/TD]
[TD]6[/TD]
[TD]49[/TD]
[TD]7[/TD]
[TD]0[/TD]
[TD]5[/TD]
[TD]5[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 1 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.7%[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]1.1%[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.2%[/TD]
[TD]0[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Normal[/TD]
[TD]0 of 8[/TD]
[TD]4.5%[/TD]
[TD]5[/TD]
[TD]9[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 5 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.1%[/TD]
[TD]0[/TD]
[TD]5[/TD]
[TD]4[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 6 [TD]Normal[/TD]
[TD]0 of 5[/TD]
[TD]2.1%[/TD]
[TD]0[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 7 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]0.8%[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.0%[/TD]
[TD]1[/TD]
[TD]8[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Normal[/TD]
[TD]1 of 5[/TD]
[TD]1.4%[/TD]
[TD]0[/TD]
[TD]17[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]4[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]1.7%[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 40 [/TR]
[TR]
No. of specimens tested [TD]10,152[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]270 (2.7%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[/TR]
[TR]
Influenza A [TD]182 (67.4%)[/TD]
[/TR]
[TR]
Influenza B [TD]88 (32.6%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 40 [/TR]
[TR]
No. of specimens tested [TD]407[/TD]
[/TR]
[TR]
No. of positive specimens [TD]72[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[/TR]
[TR]
Influenza A [TD]62 (86.1%)[/TD]
[/TR]
[TR]
A(H1N1)pdm09 [TD]6 (9.7%)[/TD]
[/TR]
[TR]
H3 [TD]49 (79.0%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]7 (11.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]10 (13.9%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]5 (50.0%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]0 (0%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]5 (50.0%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation


View Interactive Application | View Full Screen

[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]CDC characterizes influenza viruses through one or more tests including genomic sequencing, hemagglutination inhibition (HI) and/or neutralization assays. These data are used to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines, and to monitor for changes in circulating influenza viruses. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses. Viruses can be classified into genetic groups/clades based on analysis of their HA gene segments using phylogenetics and key amino acid changes (Klimov Vaccine 2012).A representative subset of influenza-positive surveillance samples are antigenically characterized. However, a proportion of influenza A(H3N2) viruses lack sufficient hemagglutination titers for antigenic characterization using hemagglutination inhibition assays. Therefore, CDC selects a representative subset of influenza A(H3N2) viruses for antigenic characterization using the virus neutralization focus reduction assay to assess the ability of various antisera to neutralize infectivity of the test viruses.[/FONT]
[FONT=&quot]It is important to monitor circulating influenza viruses for evidence of genetic changes. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in the circulating virus populations, with no evidence of substantial antigenic drift. Close monitoring of influenza viruses is required to better assess the potential impact on public health.[/FONT]
[h=2]Genetic Characterization[/h] [FONT=&quot]During May 21 – October 7, 2017, 1,692 influenza positive specimens were collected and reported by public health laboratories in the United States (Figure, left). CDC genetically characterized 382 influenza viruses [51 influenza A(H1N1)pdm09, 230 influenza A(H3N2), and 101 influenza B viruses] collected by U.S. laboratories.[/FONT]
[FONT=&quot]Influenza A Viruses[/FONT]
  • A (H1N1)pdm09 [51]: The HA gene segment of all influenza A(H1N1)pdm09 viruses analyzed showed that one virus belonged to clade 6B, with the remainder belonging to 6B.1, the same genetic clade as the vaccine reference virus, A/Michigan/45/2015.
  • A (H3N2) [230]: Phylogenetic analysis of the HA genes indicate that multiple clades/subclades are circulating. The HA genes show extensive diversity and belong to clades 3C.2a, subclade 3C.2a1 or 3C.3a, with 3C.2a predominating. The vaccine reference virus, A/Hong Kong/4801/2014, belongs to the genetic clade 3C.2a.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria [31]: The HA of influenza B/Victoria-lineage viruses all belonged to genetic group V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008.
  • Two subgroups of viruses within V1A have been detected with a double or triple deletion of amino acids in the HA. The majority of the double deletion viruses were identified in the United States, while no triple deletion viruses have been identified in the United States
  • B/Yamagata [70]: The HA of influenza B/Yamagata-lineage viruses analyzed all belonged to genetic group Y3, the same genetic clade as the vaccine reference virus, B/Phuket/3073/2013.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance issued to the laboratories request that, if available, 2 influenza A (H1N1), 2 A influenza (H3N2), and 2 influenza B viruses be submitted every other week. Because of this, the number of each virus type/subtype characterized should be approximately equal. In the figure below, the results of tests performed by public health labs are presented on the left and sequence results by genetic group of specimens submitted to CDC are presented on the right.[/FONT]
Genetic40_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation
[h=2]Antigenic Characterization[/h] [FONT=&quot]During May 21 – October 7, 2017, CDC antigenically characterized 227 influenza viruses [43 influenza A(H1N1)pdm09, 116 influenza A(H3N2), and 68 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-18 vaccine.[/FONT]
[FONT=&quot]Influenza A Virus [159][/FONT]
  • A (H1N1)pdm09 [43]: All 43 influenza A(H1N1)pdm09 viruses were antigenically characterized using ferret post-infection antisera as A/Michigan/45/2015 (H1N1)pdm09-like.
  • A (H3N2) [116]: 112 of 116 (96.6%) influenza A(H3N2) viruses were antigenically characterized as A/Hong Kong/4801/2014-like by HI testing or neutralization testing. Among the viruses that reacted poorly with ferret antisera raised against A/Hong Kong/4801/2014-like viruses, all belong to genetic group 3C.3a.
[FONT=&quot]Influenza B Virus [68][/FONT]
  • Victoria Lineage [28]: 18 of 28 (64.3%) B/Victoria-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Brisbane/60/2008-like. Among the viruses that reacted poorly with ferret antisera raised against B/Brisbane/60/2008-like viruses, all were double deletion viruses.
  • Yamagata Lineage [40]: All 40 (100%) B/Yamagata-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Phuket/3073/2013-like.
[FONT=&quot]
[/FONT]

[h=2]Antiviral Resistance:[/h] [FONT=&quot]No antiviral resistance data are available for specimens collected after October 1, 2017.[/FONT]
[FONT=&quot]During May 21-Septemer 30, 2017, 364 specimens (49 influenza A(H1N1)pdm09, 218 influenza A(H3N2), and 364 influenza B viruses) collected in the United States were tested for susceptibility to the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir). All tested viruses were sensitive to all three recommended antiviral medications.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A (H1N1)pdm09 viruses and oseltamivir-resistant influenza A (H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available athttp://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on October 12, 2017, 5.4% of the deaths occurring during the week ending September 23, 2017 (week 38) were due to P&I. This percentage is below the epidemic threshold of 6.0% for week 38.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS40_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]No influenza-associated pediatric deaths were reported to CDC during week 40.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in the Emerging Infections Program (EIP) states and Influenza Hospitalization Surveillance Project (IHSP) states. FluSurv-NET estimated hospitalization rates will be updated weekly starting later this season.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 40, 1.4% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 0.4% to 2.1% during week 40. All 10 regions reported a proportion of outpatient visits for ILI below their region-specific baseline levels.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 40, the following ILI activity levels were experienced:[/FONT]
  • New York City, the District of Columbia, and all 50 states experienced minimal ILI activity.
  • Data were insufficient to calculate an ILI activity level from Puerto Rico.
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]During week 40, the following influenza activity was reported::[/FONT]
  • Widespread influenza activity was reported by Guam.
  • Local influenza activity was reported by two states (Colorado and South Carolina).
  • Sporadic influenza activity was reported by the District of Columbia and 38 states (Alaska, Alabama, Arizona, Arkansas, California, Connecticut, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Dakota, Texas, Utah, Virginia, Washington, Wisconsin, and Wyoming).
  • No activity was reported by 10 states (Delaware, Kansas, Maryland, Nebraska, Nevada, New Hampshire, Rhode Island, Tennessee, Vermont, and West Virginia,).
  • Puerto Rico and the U.S. Virgin Islands did not report
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visit http://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
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[TD="width: 139"] Alaska
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[TD="width: 139"] Arizona
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[TD="width: 139"] Arkansas
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[TD="width: 139"] California
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[TD="width: 139"] Colorado
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[TD="width: 139"] Connecticut
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[TD="width: 139"] Delaware
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[TD="width: 139"] District of Columbia
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[TD="width: 139"] Florida
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[TD="width: 139"] Georgia
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[TD="width: 139"] Hawaii
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[TD="width: 139"] Idaho
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[TD="width: 139"] Illinois
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[TD="width: 139"] Indiana
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[TD="width: 139"] Iowa
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[TD="width: 139"] Kansas
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[TD="width: 139"] Kentucky
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[TD="width: 139"] Louisiana
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[TD="width: 139"] Maine
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[TD="width: 139"] Maryland
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[TD="width: 139"] Massachusetts
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[TD="width: 139"] Michigan
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[TD="width: 139"] Minnesota
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[TD="width: 139"] Mississippi
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[TD="width: 139"] Missouri
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[TD="width: 139"] Montana
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[TD="width: 139"] Nebraska
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[TD="width: 139"] Nevada
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[TD="width: 139"] New Hampshire
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[TD="width: 139"] New Jersey
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[TD="width: 139"] New Mexico
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[TD="width: 139"] New York
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[TD="width: 139"] North Carolina
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[TD="width: 139"] North Dakota
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[TD="width: 139"] Ohio
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[TD="width: 139"] Oklahoma
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[TD="width: 139"] Oregon
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[TD="width: 139"] Pennsylvania
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[TD="width: 139"] Rhode Island
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[TD="width: 139"] South Carolina
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[TD="width: 139"] South Dakota
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[TD="width: 139"] Tennessee
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[TD="width: 139"] Texas
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[TD="width: 139"] Utah
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[TD="width: 139"] Vermont
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[TD="width: 139"] Virginia
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[TD="width: 139"] Washington
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[TD="width: 139"] West Virginia
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[TD="width: 139"] Wisconsin
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[TD="width: 139"] Wyoming
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[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control athttp://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.[/FONT]
https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week40.htm
 
[h=3]2017-2018 Influenza Season Week 41 ending October 14, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 41 (October 8-14, 2017), influenza activity was low in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 41 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories is low.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: One influenza-associated pediatric death was reported that occurred during the 2016-2017 season.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 1.3%, which is below the national baseline of 2.2%. All 10 regions reported ILI below region-specific baseline levels. New York City, the District of Columbia, Puerto Rico and all 50 states experienced minimal ILI activity.
  • Geographic Spread of Influenza: The geographic spread of influenza in Guam was reported as regional; five states reported local activity; the U.S. Virgin Islands and 38 states reported sporadic activity; the District of Columbia and seven states reported no activity; and Puerto Rico did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Normal[/TD]
[TD]1 of 54[/TD]
[TD]2.2%[/TD]
[TD]14[/TD]
[TD]158[/TD]
[TD]13[/TD]
[TD]1[/TD]
[TD]14[/TD]
[TD]13[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 1 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.7%[/TD]
[TD]1[/TD]
[TD]4[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]1.3%[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.5%[/TD]
[TD]0[/TD]
[TD]12[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Normal[/TD]
[TD]0 of 8[/TD]
[TD]5.0%[/TD]
[TD]7[/TD]
[TD]17[/TD]
[TD]7[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]2[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 5 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.9%[/TD]
[TD]1[/TD]
[TD]24[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]6[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 6 [TD]Normal[/TD]
[TD]0 of 5[/TD]
[TD]2.8%[/TD]
[TD]0[/TD]
[TD]14[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 7 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]0.6%[/TD]
[TD]1[/TD]
[TD]4[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.8%[/TD]
[TD]2[/TD]
[TD]26[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]4[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Normal[/TD]
[TD]1 of 5[/TD]
[TD]1.5%[/TD]
[TD]1[/TD]
[TD]49[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]7[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]1.9%[/TD]
[TD]1[/TD]
[TD]7[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 41 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]12,290[/TD]
[TD]25,777[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]270 (2.2%)[/TD]
[TD]596 (2.3%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]185 (68.5%)[/TD]
[TD]404 (67.8%)[/TD]
[/TR]
[TR]
Influenza B [TD]85 (31.5%)[/TD]
[TD]192 (32.2%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 41 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]504[/TD]
[TD]1,142[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]96[/TD]
[TD]213[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]82 (85.4%)[/TD]
[TD]185 (86.9%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]3 (3.7%)[/TD]
[TD]14 (7.6%)[/TD]
[/TR]
[TR]
H3 [TD]67 (81.7%)[/TD]
[TD]158 (85.4%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]12 (14.6%)[/TD]
[TD]13 (7.0%)[/TD]
[/TR]
[TR]
Influenza B [TD]10 (14.6%)[/TD]
[TD]28 (13.1%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]6 (42.9%)[/TD]
[TD]14 (50.0%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]1 (7.1%)[/TD]
[TD]1 (3.6%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]7 (50.0%)[/TD]
[TD]13 (46.4%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


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[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]CDC characterizes influenza viruses through one or more tests including genomic sequencing, hemagglutination inhibition (HI) and/or neutralization assays. These data are used to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines, and to monitor for changes in circulating influenza viruses. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses. Viruses can be classified into genetic groups/clades based on analysis of their HA gene segments using phylogenetics and key amino acid changes (Klimov Vaccine 2012).A representative subset of influenza-positive surveillance samples are antigenically characterized. However, a proportion of influenza A(H3N2) viruses lack sufficient hemagglutination titers for antigenic characterization using hemagglutination inhibition assays. Therefore, CDC selects a representative subset of influenza A(H3N2) viruses for antigenic characterization using the virus neutralization focus reduction assay to assess the ability of various antisera to neutralize infectivity of the test viruses.[/FONT]
[FONT=&quot]It is important to monitor circulating influenza viruses for evidence of genetic changes. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in the circulating virus populations, with no evidence of substantial antigenic drift. Close monitoring of influenza viruses is required to better assess the potential impact on public health.[/FONT]
[h=2]Genetic Characterization[/h] [FONT=&quot]During May 21 – October 14, 2017, 1,898 influenza positive specimens were collected and reported by public health laboratories in the United States (Figure, left). CDC genetically characterized 390 influenza viruses [52 influenza A(H1N1)pdm09, 232 influenza A(H3N2), and 106 influenza B viruses] collected by U.S. laboratories..[/FONT]
[FONT=&quot]Influenza A Viruses[/FONT]
  • A (H1N1)pdm09 [52]: The HA gene segment of all influenza A(H1N1)pdm09 viruses analyzed showed that one virus belonged to clade 6B, with the remainder belonging to 6B.1, the same genetic clade as the vaccine reference virus, A/Michigan/45/2015.
  • A (H3N2) [232]: Phylogenetic analysis of the HA genes indicate that multiple clades/subclades are circulating. The HA genes show extensive diversity and belong to clades 3C.2a, subclade 3C.2a1 or 3C.3a, with 3C.2a predominating. The vaccine reference virus, A/Hong Kong/4801/2014, belongs to the genetic clade 3C.2a.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria [31]: The HA of influenza B/Victoria-lineage viruses all belonged to genetic group V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008.
  • Two subgroups of viruses within V1A have been detected with a double or triple deletion of amino acids in the HA. The majority of the double deletion viruses were identified in the United States, while no triple deletion viruses have been identified in the United States
  • B/Yamagata [75]: The HA of influenza B/Yamagata-lineage viruses analyzed all belonged to genetic group Y3, the same genetic clade as the vaccine reference virus, B/Phuket/3073/2013.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance issued to the laboratories request that, if available, 2 influenza A (H1N1), 2 A influenza (H3N2), and 2 influenza B viruses be submitted every other week. Because of this, the number of each virus type/subtype characterized should be approximately equal. In the figure below, the results of tests performed by public health labs are presented on the left and sequence results by genetic group of specimens submitted to CDC are presented on the right.[/FONT]
Genetic41_small.gif

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[h=2]Antigenic Characterization[/h] [FONT=&quot]During May 21 – October 14, 2017, CDC antigenically characterized 228 influenza viruses [43 influenza A(H1N1)pdm09, 117 influenza A(H3N2), and 68 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-2018 vaccine.[/FONT]
[FONT=&quot]Influenza A Virus [160][/FONT]
  • A (H1N1)pdm09 [43]: All 43 influenza A(H1N1)pdm09 viruses were antigenically characterized using ferret post-infection antisera as A/Michigan/45/2015 (H1N1)pdm09-like.
  • A (H3N2) [117]: 113 of 117 (96.6%) influenza A(H3N2) viruses were antigenically characterized as A/Hong Kong/4801/2014-like by HI testing or neutralization testing. Among the viruses that reacted poorly with ferret antisera raised against A/Hong Kong/4801/2014-like viruses, all belong to genetic group 3C.3a.
[FONT=&quot]Influenza B Virus [68][/FONT]
  • Victoria Lineage [28]: 18 of 28 (64.3%) B/Victoria-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Brisbane/60/2008-like. Among the viruses that reacted poorly with ferret antisera raised against B/Brisbane/60/2008-like viruses, all were double deletion viruses.
  • Yamagata Lineage [40]: All 40 (100%) B/Yamagata-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Phuket/3073/2013-like.
[FONT=&quot]
[/FONT]

[h=2]Antiviral Resistance:[/h] [FONT=&quot]During May 21 – October 14, 2017, CDC antigenically characterized 228 influenza viruses [43 influenza A(H1N1)pdm09, 117 influenza A(H3N2), and 68 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-2018 vaccine.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A (H1N1)pdm09 viruses and oseltamivir-resistant influenza A (H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available athttp://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on October 19, 2017, 5.3% of the deaths occurring during the week ending September 30, 2017 (week 39) were due to P&I. This percentage is below the epidemic threshold of 6.0% for week 39.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS41_small.gif

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[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]One influenza-associated pediatric death that occurred during the 2016-2017 season was reported to CDC during week 41. This death was associated with an influenza B virus and occurred during week 14 (the week ending April 8, 2017). This death brings the total number of reported influenza-associated pediatric deaths occurring during that season to 108.[/FONT]
[FONT=&quot]No influenza-associated pediatric deaths for the 2017-2018 season have been reported to CDC[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

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[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in the Emerging Infections Program (EIP) states and Influenza Hospitalization Surveillance Project (IHSP) states. FluSurv-NET estimated hospitalization rates will be updated weekly starting later this season.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 41, 1.3% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 0.5% to 2.2% during week 41. All 10 regions reported a proportion of outpatient visits for ILI below their region-specific baseline levels.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 41, the following ILI activity levels were experienced:[/FONT]
  • New York City, the District of Columbia, Puerto Rico and all 50 states experienced minimal ILI activity.
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]During week 41, the following influenza activity was reported::[/FONT]
  • Regional influenza activity was reported by Guam.
  • Local influenza activity was reported by five states (California, Colorado, Massachusetts, Oklahoma and South Carolina).
  • Sporadic influenza activity was reported by the U.S. Virgin Islands and 38 states (Alaska, Arizona, Arkansas, Connecticut, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oregon, Pennsylvania, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, Wisconsin, and Wyoming).
  • No activity was reported by the District of Columbia and seven states (Alabama, Delaware, Kansas, Nebraska, Nevada, Rhode Island and West Virginia).
  • Puerto Rico did not report.
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visit http://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]

[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]

[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]

[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
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[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]

[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]

[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]

[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]

[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
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[TD="width: 139"] Utah
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[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
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[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]

[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control athttp://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.


https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week41.htm
[/FONT]
 
[h=3]2017-2018 Influenza Season Week 42 ending October 21, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 42 (October 15-21, 2017), influenza activity was low in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 42 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories is low.
  • Novel Influenza A Virus: One human infection with a novel influenza A virus was reported.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: One influenza-associated pediatric death was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 1.3%, which is below the national baseline of 2.2%. All 10 regions reported ILI below region-specific baseline levels. Three states experienced low ILI activity and New York City, the District of Columbia, Puerto Rico and 47 states experienced minimal ILI activity.
  • Geographic Spread of Influenza: The geographic spread of influenza in Guam was reported as regional; Puerto Rico and 12 states reported local activity; the District of Columbia and 33 states reported sporadic activity; five states reported no activity; and the U.S. Virgin Islands did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Normal[/TD]
[TD]1 of 54[/TD]
[TD]2.5%[/TD]
[TD]27[/TD]
[TD]279[/TD]
[TD]12[/TD]
[TD]1[/TD]
[TD]24[/TD]
[TD]15[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 1 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.7%[/TD]
[TD]1[/TD]
[TD]6[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]1.2%[/TD]
[TD]1[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.8%[/TD]
[TD]0[/TD]
[TD]14[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Normal[/TD]
[TD]0 of 8[/TD]
[TD]5.8%[/TD]
[TD]12[/TD]
[TD]45[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]3[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 5 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.9%[/TD]
[TD]3[/TD]
[TD]39[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]7[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 6 [TD]Normal[/TD]
[TD]0 of 5[/TD]
[TD]2.8%[/TD]
[TD]2[/TD]
[TD]27[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]4[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 7 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]0.6%[/TD]
[TD]1[/TD]
[TD]10[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.9%[/TD]
[TD]3[/TD]
[TD]33[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]4[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Normal[/TD]
[TD]1 of 5[/TD]
[TD]1.4%[/TD]
[TD]2[/TD]
[TD]92[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]4[/TD]
[TD]9[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]2.1%[/TD]
[TD]2[/TD]
[TD]11[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 42 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]11,136[/TD]
[TD]39,647[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]274 (2.5%)[/TD]
[TD]898 (2.3%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]188 (68.6%)[/TD]
[TD]616 (68.6%)[/TD]
[/TR]
[TR]
Influenza B [TD]86 (31.4%)[/TD]
[TD]282 (31.4%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 42 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]571[/TD]
[TD]1,989[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]81[/TD]
[TD]358[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]78 (96.3%)[/TD]
[TD]318 (88.8%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]3 (3.8%)[/TD]
[TD]27 (8.5%)[/TD]
[/TR]
[TR]
H3 [TD]69 (88.5%)[/TD]
[TD]279 (87.7%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]6 (7.7%)[/TD]
[TD]12 (3.8%)[/TD]
[/TR]
[TR]
Influenza B [TD]3 (3.7%)[/TD]
[TD]40 (11.2%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]2 (66.7%)[/TD]
[TD]24 (60.0%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]0 (0%)[/TD]
[TD]1 (2.5%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]1 (33.3%)[/TD]
[TD]15 (37.5%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


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[h=2]Novel Influenza A Virus:[/h] [FONT=&quot]One human infection with a novel influenza A virus was reported from Ohio during week 42. This report is an infection with an influenza A (H1N2) variant (H1N2v) virus in a child (younger than 18 years) that occurred in August 2017. Exposure to swine in a fair setting during the week preceding illness onset was reported. This patient became ill with respiratory symptoms, was not hospitalized, and has fully recovered. No human-to-human transmission was identified.[/FONT]
[FONT=&quot]A total of 62 variant virus infections have been reported to CDC during 2017. Fifty-nine of these were influenza A (H3N2) variant (H3N2v) viruses (Delaware [1], Maryland [39], Michigan [1], North Dakota [1], Ohio [15], Pennsylvania [1], and Texas [1]) and three were influenza A (H1N2) variant (H1N2v) viruses (Ohio [3]).[/FONT]
[FONT=&quot]Early identification and investigation of human infections with novel influenza A viruses are critical so that the risk of infection can be more fully understood and appropriate public health measures can be taken. Additional information on influenza in swine, variant influenza infection in humans, and strategies to interact safely with swine can be found athttp://www.cdc.gov/flu/swineflu/index.htm. .[/FONT]
[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]CDC characterizes influenza viruses through one or more tests including genomic sequencing, hemagglutination inhibition (HI) and/or neutralization assays. These data are used to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines, and to monitor for changes in circulating influenza viruses. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses. Viruses can be classified into genetic groups/clades based on analysis of their HA gene segments using phylogenetics and key amino acid changes (Klimov Vaccine 2012).A representative subset of influenza-positive surveillance samples are antigenically characterized. However, a proportion of influenza A(H3N2) viruses lack sufficient hemagglutination titers for antigenic characterization using hemagglutination inhibition assays. Therefore, CDC selects a representative subset of influenza A(H3N2) viruses for antigenic characterization using the virus neutralization focus reduction assay to assess the ability of various antisera to neutralize infectivity of the test viruses.[/FONT]
[FONT=&quot]It is important to monitor circulating influenza viruses for evidence of genetic changes. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in the circulating virus populations, with no evidence of substantial antigenic drift. Close monitoring of influenza viruses is required to better assess the potential impact on public health.[/FONT]
[h=2]Genetic Characterization[/h] [FONT=&quot]During May 21 – October 21, 2017, 2,068 influenza positive specimens were collected and reported by public health laboratories in the United States (Figure, left). CDC genetically characterized 456 influenza viruses [60 influenza A(H1N1)pdm09, 271 influenza A(H3N2), and 125 influenza B viruses] collected by U.S. laboratories.[/FONT]
[FONT=&quot]Influenza A Viruses[/FONT]
  • A (H1N1)pdm09 [60]: The HA gene segment of all influenza A(H1N1)pdm09 viruses analyzed showed that one virus belonged to clade 6B, with the remainder belonging to 6B.1, the same genetic clade as the vaccine reference virus, A/Michigan/45/2015.
  • A (H3N2) [271]: Phylogenetic analysis of the HA genes indicate that multiple clades/subclades are circulating. The HA genes show extensive diversity and belong to clades 3C.2a, subclade 3C.2a1 or 3C.3a, with 3C.2a predominating. The vaccine reference virus, A/Hong Kong/4801/2014, belongs to the genetic clade 3C.2a.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria [32]: The HA of influenza B/Victoria-lineage viruses all belonged to genetic group V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008.
  • Two subgroups of viruses within V1A have been detected with a double or triple deletion of amino acids in the HA. The majority of the double deletion viruses were identified in the United States, while no triple deletion viruses have been identified in the United States
  • B/Yamagata [93]: The HA of influenza B/Yamagata-lineage viruses analyzed all belonged to genetic group Y3, the same genetic clade as the vaccine reference virus, B/Phuket/3073/2013.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance issued to the laboratories request that, if available, 2 influenza A (H1N1), 2 A influenza (H3N2), and 2 influenza B viruses be submitted every other week. Because of this, the number of each virus type/subtype characterized should be approximately equal. In the figure below, the results of tests performed by public health labs are presented on the left and sequence results by genetic group of specimens submitted to CDC are presented on the right.[/FONT]
Genetic42_small.gif

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[h=2]Antigenic Characterization[/h] [FONT=&quot]During May 21 – October 21, 2017, CDC antigenically characterized 256 influenza viruses [43 influenza A(H1N1)pdm09, 126 influenza A(H3N2), and 87 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-18 vaccine.[/FONT]
[FONT=&quot]Influenza A Virus [169][/FONT]
  • A (H1N1)pdm09 [43]: All 43 influenza A(H1N1)pdm09 viruses were antigenically characterized using ferret post-infection antisera as A/Michigan/45/2015 (H1N1)pdm09-like.
  • A (H3N2) [126]: 122 of 126 (96.8%) influenza A(H3N2) viruses were antigenically characterized as A/Hong Kong/4801/2014-like by HI testing or neutralization testing. Among the viruses that reacted poorly with ferret antisera raised against A/Hong Kong/4801/2014-like viruses, all belong to genetic group 3C.3a.
[FONT=&quot]Influenza B Virus [87][/FONT]
  • Victoria Lineage [28]: 18 of 28 (64.3%) B/Victoria-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Brisbane/60/2008-like. Among the viruses that reacted poorly with ferret antisera raised against B/Brisbane/60/2008-like viruses, all were double deletion viruses.
  • Yamagata Lineage [59]: All 59 (100%) B/Yamagata-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Phuket/3073/2013-like.
[FONT=&quot]
[/FONT]

[h=2]Antiviral Resistance:[/h] [FONT=&quot]During May 21-October 14, 2017, 421 specimens (57 influenza A(H1N1)pdm09, 243 influenza A(H3N2), and 121 influenza B viruses) collected in the United States were tested for susceptibility to the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir). All tested viruses were sensitive to all three recommended antiviral medications.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A (H1N1)pdm09 viruses and oseltamivir-resistant influenza A (H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available athttp://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on October 26, 2017, 5.4% of the deaths occurring during the week ending October 7, 2017 (week 40) were due to P&I. This percentage is below the epidemic threshold of 6.1% for week 40.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS42_small.gif

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[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]The first influenza-associated pediatric death of the 2017-2018 season occurred and was reported to CDC during week 42 (the week ending October 21, 2017). This death was associated with an influenza A (H1N1)pdm09 virus.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in the Emerging Infections Program (EIP) states and Influenza Hospitalization Surveillance Project (IHSP) states. FluSurv-NET estimated hospitalization rates will be updated weekly starting later this season.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 42, 1.3% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 0.5% to 2.1% during week 42. All 10 regions reported a proportion of outpatient visits for ILI below their region-specific baseline levels.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 42, the following ILI activity levels were experienced:[/FONT]
  • Three states experienced low ILI activity (Alaska, Louisiana, and South Carolina).
  • New York City, the District of Columbia, Puerto Rico and 47 states experienced minimal ILI activity (Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]During week 42, the following influenza activity was reported::[/FONT]
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
  • Regional influenza activity was reported by Guam.
  • Local influenza activity was reported by Puerto Rico and 12 states (Arizona, Colorado, Georgia, Hawaii, Kentucky, Louisiana, Maine, Massachusetts, New Mexico, Oklahoma, South Carolina, and Texas).
  • Sporadic influenza activity was reported by the District of Columbia and 33 states (Alabama, Alaska, Arkansas, California, Connecticut, Delaware, Florida, Idaho, Indiana, Iowa, Maryland, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Jersey, New York, North Carolina, North Dakota, Ohio, Oregon, Pennsylvania, South Dakota, Tennessee, Utah, Vermont, Virginia, Washington, Wisconsin, and Wyoming).
  • No activity was reported by and five states (Illinois, Kansas, New Hampshire, Rhode Island, and West Virginia).
  • The U.S. Virgin Islands did not report.
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visit http://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]

[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]

[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]

[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]

[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]

[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]

[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]

[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]

[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]

[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]

[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control athttp://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.


https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week42.htm
[/FONT]
 
[h=3]2017-2018 Influenza Season Week 43 ending October 28, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 43 (October 22-28, 2017), influenza activity was low in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 43 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories is low.
  • Novel Influenza A Virus: Three human infections with novel influenza A viruses were reported.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: One influenza-associated pediatric death was reported that occurred during the 2016-2017 season.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 1.5%, which is below the national baseline of 2.2%. All 10 regions reported ILI below region-specific baseline levels. One state experienced moderate ILI activity, four states experienced low ILI activity, New York City and 45 states experienced minimal ILI activity, and the District of Columbia and Puerto Rico had insufficient data.
  • Geographic Spread of Influenza: The geographic spread of influenza in Guam and four states was reported as regional; Puerto Rico and 12 states reported local activity; the District of Columbia and 31 states reported sporadic activity; one state reported no activity; and the U.S. Virgin Islands and two states did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Normal[/TD]
[TD]5 of 54[/TD]
[TD]2.9%[/TD]
[TD]53[/TD]
[TD]455[/TD]
[TD]12[/TD]
[TD]1[/TD]
[TD]34[/TD]
[TD]27[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 1 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.7%[/TD]
[TD]1[/TD]
[TD]8[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]1.5%[/TD]
[TD]2[/TD]
[TD]14[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.0%[/TD]
[TD]2[/TD]
[TD]18[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Normal[/TD]
[TD]1 of 8[/TD]
[TD]5.7%[/TD]
[TD]23[/TD]
[TD]72[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]6[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 5 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.9%[/TD]
[TD]3[/TD]
[TD]69[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]11[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 6 [TD]Normal[/TD]
[TD]3 of 5[/TD]
[TD]2.3%[/TD]
[TD]7[/TD]
[TD]44[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]4[/TD]
[TD]2[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 7 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]0.4%[/TD]
[TD]2[/TD]
[TD]17[/TD]
[TD]4[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.9%[/TD]
[TD]4[/TD]
[TD]40[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]6[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Normal[/TD]
[TD]1 of 5[/TD]
[TD]2.4%[/TD]
[TD]3[/TD]
[TD]147[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]5[/TD]
[TD]14[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]2.3%[/TD]
[TD]6[/TD]
[TD]26[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]3[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 43 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]11,775[/TD]
[TD]55,515[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]336 (2.9%)[/TD]
[TD]1,313 (2.4%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]228 (67.9%)[/TD]
[TD]905 (68.9%)[/TD]
[/TR]
[TR]
Influenza B [TD]108 (32.1%)[/TD]
[TD]408 (31.1%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 43 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]694[/TD]
[TD]3,265[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]119[/TD]
[TD]583[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]109 (91.6%)[/TD]
[TD]520 (89.3%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]14 (12.8%)[/TD]
[TD]53 (10.2%)[/TD]
[/TR]
[TR]
H3 [TD]88 (80.7%)[/TD]
[TD]455 (87.5%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]7 (6.4%)[/TD]
[TD]12 (2.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]10 (8.4%)[/TD]
[TD]62 (10.7%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]5 (50.0%)[/TD]
[TD]34 (54.8%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]0 (0%)[/TD]
[TD]1 (1.6%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]5 (50.0%)[/TD]
[TD]27 (43.5%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


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[h=2]Novel Influenza A Virus:[/h] [FONT=&quot]Three human infections with novel influenza A viruses were reported by three states (Colorado [1], Nebraska [1], and Michigan [1]) during week 43. Two infections were with influenza A(H3N2) variant (H3N2v) viruses and one infection was with an influenza A(H1N2) variant (H1N2v) virus. The patient in Colorado reported exposure to swine at an agricultural event during the week preceding illness onset. The patient in Nebraska reported no contact with swine during the week preceding illness onset, however a member of same household did report exposure to swine. The patient in Michigan is a close contact of a laboratory-confirmed H3N2v infection that was reported earlier this year. While exposure to swine was reported for the patient, that exposure occurred more than a week preceding illness onset, which is outside of the typical incubation period. It is possible that limited human-to-human transmission occurred. No ongoing human-to-human transmission has been identified.[/FONT]
[FONT=&quot]A total of 65 variant virus infections have been reported to CDC so far during 2017. Sixty-one of these were influenza A (H3N2) variant (H3N2v) viruses (Delaware [1], Maryland [39], Michigan [2], Nebraska [1], North Dakota [1], Ohio [15], Pennsylvania [1], and Texas [1]) and four were influenza A (H1N2) variant (H1N2v) viruses (Colorado [1] and Ohio [3]). Six of the 65 infections resulted in hospitalization; but all patients recovered.[/FONT]
[FONT=&quot]Early identification and investigation of human infections with novel influenza A viruses are critical so that the risk of infection can be more fully understood and appropriate public health measures can be taken. Additional information on influenza in swine, variant influenza infection in humans, and strategies to interact safely with swine can be found athttp://www.cdc.gov/flu/swineflu/index.htm. .[/FONT]
[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]CDC characterizes influenza viruses through one or more tests including genomic sequencing, hemagglutination inhibition (HI) and/or neutralization assays. These data are used to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines, and to monitor for changes in circulating influenza viruses. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses. Viruses can be classified into genetic groups/clades based on analysis of their HA gene segments using phylogenetics and key amino acid changes (Klimov Vaccine 2012).A representative subset of influenza-positive surveillance samples are antigenically characterized. However, a proportion of influenza A(H3N2) viruses lack sufficient hemagglutination titers for antigenic characterization using hemagglutination inhibition assays. Therefore, CDC selects a representative subset of influenza A(H3N2) viruses for antigenic characterization using the virus neutralization focus reduction assay to assess the ability of various antisera to neutralize infectivity of the test viruses.[/FONT]
[FONT=&quot]It is important to monitor circulating influenza viruses for evidence of genetic changes. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Close monitoring of influenza viruses is required to better assess the potential impact on public health.[/FONT]
[h=2]Genetic Characterization[/h] [FONT=&quot]During May 21 – October 28, 2017, 2,318 influenza positive specimens were collected and reported by public health laboratories in the United States (Figure, left). CDC genetically characterized 476 influenza viruses [64 influenza A(H1N1)pdm09, 283 influenza A(H3N2), and 129 influenza B viruses] collected by U.S. laboratories.[/FONT]
[FONT=&quot]Influenza A Viruses[/FONT]
  • A (H1N1)pdm09 [64]: The HA gene segment of all influenza A(H1N1)pdm09 viruses analyzed showed that one virus belonged to clade 6B, with the remainder belonging to 6B.1, the same genetic clade as the vaccine reference virus, A/Michigan/45/2015.
  • A (H3N2) [283]: Phylogenetic analysis of the HA genes indicate that multiple clades/subclades are circulating. The HA genes show extensive diversity and belong to clades 3C.2a, subclade 3C.2a1 or 3C.3a, with 3C.2a predominating. The vaccine reference virus, A/Hong Kong/4801/2014, belongs to the genetic clade 3C.2a.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria [32]: The HA of influenza B/Victoria-lineage viruses all belonged to genetic group V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008.
  • Two subgroups of viruses within V1A have been detected with a double or triple deletion of amino acids in the HA. The majority of the double deletion viruses were identified in the United States, while no triple deletion viruses have been identified in the United States
  • B/Yamagata [97]: The HA of influenza B/Yamagata-lineage viruses analyzed all belonged to genetic group Y3, the same genetic clade as the vaccine reference virus, B/Phuket/3073/2013.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance issued to the laboratories request that, if available, 2 influenza A (H1N1), 2 A influenza (H3N2), and 2 influenza B viruses be submitted every other week. Because of this, the number of each virus type/subtype characterized should be approximately equal. In the figure below, the results of tests performed by public health labs are presented on the left and sequence results by genetic group of specimens submitted to CDC are presented on the right.[/FONT]
Genetic43_small.gif

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[h=2]Antigenic Characterization[/h] [FONT=&quot]During May 21 – October 28, 2017, CDC antigenically characterized 274 influenza viruses [56 influenza A(H1N1)pdm09, 127 influenza A(H3N2), and 91 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-18 vaccine.[/FONT]
[FONT=&quot]Influenza A Virus [183][/FONT]
  • A (H1N1)pdm09 [56]: All 56 influenza A(H1N1)pdm09 viruses were antigenically characterized using ferret post-infection antisera as A/Michigan/45/2015 (H1N1)pdm09-like.
  • A (H3N2) [127]: 123 of 127 (96.8%) influenza A(H3N2) viruses were antigenically characterized as A/Hong Kong/4801/2014-like by HI testing or neutralization testing. Among the viruses that reacted poorly with ferret antisera raised against A/Hong Kong/4801/2014-like viruses, all belong to genetic group 3C.3a.
[FONT=&quot]Influenza B Virus [91][/FONT]
  • Victoria Lineage [32]: 21 of 32 (65.6%) B/Victoria-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Brisbane/60/2008-like. Among the viruses that reacted poorly with ferret antisera raised against B/Brisbane/60/2008-like viruses, all were double deletion viruses.
  • Yamagata Lineage [59]: All 59 (100%) B/Yamagata-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Phuket/3073/2013-like.
[FONT=&quot]
[/FONT]

[h=2]Antiviral Resistance:[/h] [FONT=&quot]During May 21-October 28, 2017, 436 specimens (61 influenza A(H1N1)pdm09, 250 influenza A(H3N2), and 125 influenza B viruses) collected in the United States were tested for susceptibility to the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir). All tested viruses were sensitive to all three recommended antiviral medications.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A (H1N1)pdm09 viruses and oseltamivir-resistant influenza A (H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available athttp://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on November 2, 2017, 5.6% of the deaths occurring during the week ending October 14, 2017 (week 41) were due to P&I. This percentage is below the epidemic threshold of 6.2% for week 41.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS43_small.gif

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[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]One influenza-associated pediatric death that occurred during the 2016-2017 season was reported to CDC during week 43. This death was associated with an influenza A (H3) virus and occurred during week 7 (the week ending February 18, 2017). This death brings the total number of reported influenza-associated pediatric deaths occurring during that season to 109.[/FONT]
[FONT=&quot]One influenza-associated pediatric death for the 2017-2018 season has been reported to CDC.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

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[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in the Emerging Infections Program (EIP) states and Influenza Hospitalization Surveillance Project (IHSP) states. FluSurv-NET estimated hospitalization rates will be updated weekly starting later this season.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 43, 1.5% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 0.7% to 2.3% during week 43. All 10 regions reported a proportion of outpatient visits for ILI below their region-specific baseline levels.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 43, the following ILI activity levels were experienced:[/FONT]
  • One state experienced moderate ILI activity (Wyoming)
  • Four states experienced low ILI activity (Georgia, Louisiana, South Carolina, and South Dakota).
  • New York City and 45 states experienced minimal ILI activity (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin).
  • Data were insufficient to calculate an ILI activity level from the District of Columbia and Puerto Rico.
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]During week 43, the following influenza activity was reported::[/FONT]
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
  • Regional influenza activity was reported by Guam and four states (Georgia, Louisiana, Oklahoma, and Texas).
  • Local influenza activity was reported by Puerto Rico and 12 states (Alaska, Arizona, California, Connecticut, Kentucky, Maine, Massachusetts, Mississippi, New Mexico, Ohio, South Carolina, and Tennessee).
  • Sporadic influenza activity was reported by the District of Columbia and 31 states (Alabama, Arkansas, Colorado, Delaware, Florida, Hawaii, Idaho, Indiana, Illinois, Iowa, Kansas, Maryland, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, New Jersey, New York, North Carolina, North Dakota, Oregon, Pennsylvania, South Dakota, Utah, Vermont, Virginia, Washington, Wisconsin, and Wyoming).
  • No activity was reported by one state (Rhode Island).
  • The U.S. Virgin Islands and two states (New Hampshire and West Virginia) did not report.
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visit http://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]

[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]

[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]

[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]

[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]

[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]

[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]

[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]

[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]

[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]

[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control athttp://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.


https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week43.htm
[/FONT]
 
[h=3]2017-2018 Influenza Season Week 44 ending November 4, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 44 (October 29-November 4, 2017), influenza activity remained low in the United States, but is increasing.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 44 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories is low.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: No influenza-associated pediatric deaths were reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 1.8%, which is below the national baseline of 2.2%. All 10 regions reported ILI below region-specific baseline levels. Two states experienced moderate ILI activity; six states experienced low ILI activity; New York City, the District of Columbia, and 42 states experienced minimal ILI activity; and Puerto Rico had insufficient data.
  • Geographic Spread of Influenza: The geographic spread of influenza in Guam and six states was reported as regional; 13 states reported local activity; the District of Columbia and 31 states reported sporadic activity; and Puerto Rico and the U.S. Virgin Islands did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Normal[/TD]
[TD]7 of 54[/TD]
[TD]3.4%[/TD]
[TD]74[/TD]
[TD]644[/TD]
[TD]16[/TD]
[TD]1[/TD]
[TD]55[/TD]
[TD]45[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 1 [TD]Normal[/TD]
[TD]1 of 6[/TD]
[TD]1.0%[/TD]
[TD]1[/TD]
[TD]13[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]1.2%[/TD]
[TD]2[/TD]
[TD]15[/TD]
[TD]6[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.5%[/TD]
[TD]3[/TD]
[TD]20[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Normal[/TD]
[TD]2 of 8[/TD]
[TD]6.1%[/TD]
[TD]29[/TD]
[TD]97[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]4[/TD]
[TD]12[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 5 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.0%[/TD]
[TD]3[/TD]
[TD]87[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]12[/TD]
[TD]4[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 6 [TD]Normal[/TD]
[TD]3 of 5[/TD]
[TD]3.1%[/TD]
[TD]14[/TD]
[TD]75[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]5[/TD]
[TD]5[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 7 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]2.1%[/TD]
[TD]4[/TD]
[TD]25[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]5[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]2.1%[/TD]
[TD]4[/TD]
[TD]63[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]9[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Normal[/TD]
[TD]1 of 5[/TD]
[TD]2.6%[/TD]
[TD]6[/TD]
[TD]181[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]7[/TD]
[TD]19[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]2.7%[/TD]
[TD]8[/TD]
[TD]68[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]8[/TD]
[TD]4[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 44 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]15,451[/TD]
[TD]78,439[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]529 (3.4%)[/TD]
[TD]1,974 (2.5%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]381 (72.0%)[/TD]
[TD]1,396 (70.7%)[/TD]
[/TR]
[TR]
Influenza B [TD]148 (28.0%)[/TD]
[TD]578 (29.3%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 44 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]719[/TD]
[TD]4,637[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]134[/TD]
[TD]836[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]108 (80.6%)[/TD]
[TD]734 (87.8%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]10 (9.3%)[/TD]
[TD]74 (10.1%)[/TD]
[/TR]
[TR]
H3 [TD]91 (84.3%)[/TD]
[TD]644 (87.7%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]7 (6.5%)[/TD]
[TD]16 (2.2%)[/TD]
[/TR]
[TR]
Influenza B [TD]26 (19.4%)[/TD]
[TD]101 (12.1%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]12 (46.2%)[/TD]
[TD]55 (54.8%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]0 (0%)[/TD]
[TD]1 (1.0%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]14 (53.8%)[/TD]
[TD]45 (44.6%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation


View Interactive Application | View Full Screen

[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]CDC characterizes influenza viruses through one or more tests including genomic sequencing, hemagglutination inhibition (HI) and/or neutralization assays. These data are used to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines, and to monitor for changes in circulating influenza viruses. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses. Viruses can be classified into genetic groups/clades based on analysis of their HA gene segments using phylogenetics and key amino acid changes (Klimov Vaccine 2012).A representative subset of influenza-positive surveillance samples are antigenically characterized. However, a proportion of influenza A(H3N2) viruses lack sufficient hemagglutination titers for antigenic characterization using hemagglutination inhibition assays. Therefore, CDC selects a representative subset of influenza A(H3N2) viruses for antigenic characterization using the virus neutralization focus reduction assay to assess the ability of various antisera to neutralize infectivity of the test viruses.[/FONT]
[FONT=&quot]It is important to monitor circulating influenza viruses for evidence of genetic changes. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Close monitoring of influenza viruses is required to better assess the potential impact on public health.[/FONT]
[h=2]Genetic Characterization[/h] [FONT=&quot]During May 21 – November 4, 2017, 2,577 influenza positive specimens were collected and reported by public health laboratories in the United States (Figure, left). CDC genetically characterized 514 influenza viruses [70 influenza A(H1N1)pdm09, 309 influenza A(H3N2), and 135 influenza B viruses] collected by U.S. laboratories.[/FONT]
[FONT=&quot]Influenza A Viruses[/FONT]
  • A (H1N1)pdm09 [70]: The HA gene segment of all influenza A(H1N1)pdm09 viruses analyzed showed that one virus belonged to clade 6B, with the remainder belonging to 6B.1, the same genetic clade as the vaccine reference virus, A/Michigan/45/2015.
  • A (H3N2) [309]: Phylogenetic analysis of the HA genes indicate that multiple clades/subclades are circulating. The HA genes show extensive diversity and belong to clades 3C.2a, subclade 3C.2a1 or 3C.3a, with 3C.2a predominating. The vaccine reference virus, A/Hong Kong/4801/2014, belongs to the genetic clade 3C.2a.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria [33]: The HA of influenza B/Victoria-lineage viruses all belonged to genetic group V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008.
  • Two subgroups of viruses within V1A have been detected with a double or triple deletion of amino acids in the HA. The majority of the double deletion viruses were identified in the United States, while no triple deletion viruses have been identified in the United States
  • B/Yamagata [102]: The HA of influenza B/Yamagata-lineage viruses analyzed all belonged to genetic group Y3, the same genetic clade as the vaccine reference virus, B/Phuket/3073/2013.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance issued to the laboratories request that, if available, 2 influenza A (H1N1), 2 A influenza (H3N2), and 2 influenza B viruses be submitted every other week. Because of this, the number of each virus type/subtype characterized should be approximately equal. In the figure below, the results of tests performed by public health labs are presented on the left and sequence results by genetic group of specimens submitted to CDC are presented on the right.[/FONT]
Genetic44_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation
[h=2]Antigenic Characterization[/h] [FONT=&quot]During May 21 – November 4, 2017, CDC antigenically characterized 281 influenza viruses [56 influenza A(H1N1)pdm09, 134 influenza A(H3N2), and 91 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-18 vaccine.[/FONT]
[FONT=&quot]Influenza A Virus [190][/FONT]
  • A (H1N1)pdm09 [56]: All 56 influenza A(H1N1)pdm09 viruses were antigenically characterized using ferret post-infection antisera as A/Michigan/45/2015 (H1N1)pdm09-like.
  • A (H3N2) [134]: 130 of 134 (97.0%) influenza A(H3N2) viruses were antigenically characterized as A/Hong Kong/4801/2014-like by HI testing or neutralization testing. Among the viruses that reacted poorly with ferret antisera raised against A/Hong Kong/4801/2014-like viruses, all belong to genetic group 3C.3a.
[FONT=&quot]Influenza B Virus [91][/FONT]
  • Victoria Lineage [32]: 21 of 32 (65.6%) B/Victoria-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Brisbane/60/2008-like. Among the viruses that reacted poorly with ferret antisera raised against B/Brisbane/60/2008-like viruses, all were double deletion viruses.
  • Yamagata Lineage [59]: All 59 (100%) B/Yamagata-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Phuket/3073/2013-like.
[FONT=&quot]
[/FONT]

[h=2]Antiviral Resistance:[/h] [FONT=&quot]During May 21-November 4, 2017, 470 specimens (65 influenza A(H1N1)pdm09, 277 influenza A(H3N2), and 128 influenza B viruses) collected in the United States were tested for susceptibility to the neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir). All tested viruses were sensitive to all three recommended antiviral medications.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A (H1N1)pdm09 viruses and oseltamivir-resistant influenza A (H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available athttp://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on November 9, 2017, 5.8% of the deaths occurring during the week ending October 21, 2017 (week 42) were due to P&I. This percentage is below the epidemic threshold of 6.3% for week 42.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS44_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]No influenza-associated pediatric deaths were reported to CDC during week 44.[/FONT]
[FONT=&quot]One influenza-associated pediatric death for the 2017-2018 season has been reported to CDC.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in the Emerging Infections Program (EIP) states and Influenza Hospitalization Surveillance Project (IHSP) states. FluSurv-NET estimated hospitalization rates will be updated weekly starting later this season.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 44, 1.8% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 0.8% to 3.0% during week 44. All 10 regions reported a proportion of outpatient visits for ILI below their region-specific baseline levels.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 44, the following ILI activity levels were experienced:[/FONT]
  • Two states experienced moderate ILI activity (Louisiana and South Carolina)
  • Six states experienced low ILI activity (Alabama, Arizona, Georgia, Mississippi, South Dakota, and Wyoming).
  • New York City, the District of Columbia, and 42 states experienced minimal ILI activity (Alaska, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin).
  • Data were insufficient to calculate an ILI activity level from Puerto Rico.
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.[/FONT]
[FONT=&quot]During week 44, the following influenza activity was reported::[/FONT]
  • Regional influenza activity was reported by Guam and six states (Georgia, Louisiana, Massachusetts, Oklahoma, South Carolina, and Texas).
  • Local influenza activity was reported by 13 states (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Hawaii, Maine, Mississippi, New Mexico, Ohio, and Oregon).
  • Sporadic influenza activity was reported by the District of Columbia and 31 states (Delaware, Florida, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Maryland, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Pennsylvania, Rhode Island, South Dakota, Tennessee, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Puerto Rico and the U.S. Virgin Islands did not report
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visit http://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]

[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]

[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]

[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]

[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]

[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]

[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]

[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]

[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]

[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]

[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control athttp://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.


https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week44.htm
[/FONT]
 
[h=3]2017-2018 Influenza Season Week 45 ending November 11, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 45 (November 5-11, 2017), influenza activity is increasing in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 45 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories is increasing.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: No influenza-associated pediatric deaths were reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 1.9%, which is below the national baseline of 2.2%. One region reported ILI at or above their region-specific baseline level. One state experienced high ILI activity; two states experienced moderate ILI activity; six states experienced low ILI activity; New York City, and the District of Columbia, Puerto Rico, and 41 states experienced minimal ILI activity.
  • Geographic Spread of Influenza: The geographic spread of influenza in Guam, Puerto Rico and nine states was reported as regional; 13 states reported local activity; the U.S. Virgin Islands and 26 states reported sporadic activity; and the District of Columbia and two states reported no activity.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Normal[/TD]
[TD]11 of 54[/TD]
[TD]4.4%[/TD]
[TD]94[/TD]
[TD]878[/TD]
[TD]21[/TD]
[TD]3[/TD]
[TD]75[/TD]
[TD]57[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 1 [TD]Normal[/TD]
[TD]1 of 6[/TD]
[TD]1.2%[/TD]
[TD]1[/TD]
[TD]14[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Normal[/TD]
[TD]1 of 4[/TD]
[TD]1.4%[/TD]
[TD]2[/TD]
[TD]17[/TD]
[TD]7[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]2[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]0.6%[/TD]
[TD]4[/TD]
[TD]24[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]3 of 8[/TD]
[TD]6.9%[/TD]
[TD]33[/TD]
[TD]107[/TD]
[TD]5[/TD]
[TD]0[/TD]
[TD]4[/TD]
[TD]17[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 5 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.2%[/TD]
[TD]3[/TD]
[TD]121[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]17[/TD]
[TD]2[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 6 [TD]Normal[/TD]
[TD]3 of 5[/TD]
[TD]4.8%[/TD]
[TD]20[/TD]
[TD]114[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]6[/TD]
[TD]7[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 7 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]2.5%[/TD]
[TD]4[/TD]
[TD]52[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]6[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]2.8%[/TD]
[TD]4[/TD]
[TD]85[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]15[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Normal[/TD]
[TD]2 of 5[/TD]
[TD]4.5%[/TD]
[TD]12[/TD]
[TD]266[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]10[/TD]
[TD]27[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]1 of 4[/TD]
[TD]3.3%[/TD]
[TD]11[/TD]
[TD]78[/TD]
[TD]1[/TD]
[TD]1[/TD]
[TD]11[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 45 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]15,254[/TD]
[TD]96,628[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]677 (4.4%)[/TD]
[TD]2,811 (2.9%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]507 (74.9%)[/TD]
[TD]2,004 (71.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]170 (25.1%)[/TD]
[TD]807 (28.7%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 45 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]714[/TD]
[TD]5,854[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]173[/TD]
[TD]1,129[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]154 (89.0%)[/TD]
[TD]993 (88.0%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]12 (7.8%)[/TD]
[TD]94 (9.5%)[/TD]
[/TR]
[TR]
H3 [TD]135 (87.7%)[/TD]
[TD]878 (88.4%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]7 (4.5%)[/TD]
[TD]21 (2.1%)[/TD]
[/TR]
[TR]
Influenza B [TD]19 (11.0%)[/TD]
[TD]136 (12.0%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]8 (42.1%)[/TD]
[TD]75 (55.6%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]2 (10.5%)[/TD]
[TD]3 (2.2%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]9 (47.4%)[/TD]
[TD]57 (42.2%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation


View Interactive Application | View Full Screen

[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]CDC characterizes influenza viruses through one or more tests including genomic sequencing, hemagglutination inhibition (HI) and/or neutralization assays. These data are used to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines, and to monitor for changes in circulating influenza viruses. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses. Viruses can be classified into genetic groups/clades based on analysis of their HA gene segments using phylogenetics and key amino acid changes (Klimov Vaccine 2012).A representative subset of influenza-positive surveillance samples are antigenically characterized. However, a proportion of influenza A(H3N2) viruses lack sufficient hemagglutination titers for antigenic characterization using hemagglutination inhibition assays. Therefore, CDC selects a representative subset of influenza A(H3N2) viruses for antigenic characterization using the virus neutralization focus reduction assay to assess the ability of various antisera to neutralize infectivity of the test viruses.[/FONT]
[FONT=&quot]It is important to monitor circulating influenza viruses for evidence of genetic changes. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Close monitoring of influenza viruses is required to better assess the potential impact on public health.[/FONT]
[h=2]Genetic Characterization[/h] [FONT=&quot]During May 21 – November 11, 2017, 2,872 influenza positive specimens were collected and reported by public health laboratories in the United States (Figure, left). CDC genetically characterized 596 influenza viruses [78 influenza A(H1N1)pdm09, 373 influenza A(H3N2), and 145 influenza B viruses] collected by U.S. laboratories.[/FONT]
[FONT=&quot]Influenza A Viruses[/FONT]
  • A (H1N1)pdm09 [78]: The HA gene segment of all influenza A(H1N1)pdm09 viruses analyzed showed that one virus belonged to clade 6B, with the remainder belonging to 6B.1, the same genetic clade as the vaccine reference virus, A/Michigan/45/2015.
  • A (H3N2) [373]: Phylogenetic analysis of the HA genes indicate that multiple clades/subclades are circulating. The HA genes show extensive diversity and belong to clades 3C.2a, subclade 3C.2a1 or 3C.3a, with 3C.2a predominating. The vaccine reference virus, A/Hong Kong/4801/2014, belongs to the genetic clade 3C.2a.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria [34]: The HA of influenza B/Victoria-lineage viruses all belonged to genetic group V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008.
  • o Two subgroups of viruses within V1A have been detected with a double or triple deletion of amino acids in the HA. The majority of the double deletion viruses were identified in the United States, while no triple deletion viruses have been identified in the United States.
  • B/Yamagata [111]: The HA of influenza B/Yamagata-lineage viruses analyzed all belonged to genetic group Y3, the same genetic clade as the vaccine reference virus, B/Phuket/3073/2013.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance issued to the laboratories request that, if available, 2 influenza A (H1N1), 2 A influenza (H3N2), and 2 influenza B viruses be submitted every other week. Because of this, the number of each virus type/subtype characterized should be approximately equal. In the figure below, the results of tests performed by public health labs are presented on the left and sequence results by genetic group of specimens submitted to CDC are presented on the right.[/FONT]
Genetic45_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation
[h=2]Antigenic Characterization[/h] [FONT=&quot]During May 21 – November 11, 2017, CDC antigenically characterized 282 influenza viruses [56 influenza A(H1N1)pdm09, 134 influenza A(H3N2), and 92 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-18 vaccine.[/FONT]
[FONT=&quot]Influenza A Virus [190][/FONT]
  • A (H1N1)pdm09 [56]: All 56 influenza A(H1N1)pdm09 viruses were antigenically characterized using ferret post-infection antisera as A/Michigan/45/2015 (H1N1)pdm09-like.
  • A (H3N2) [134]: 130 of 134 (97.0%) influenza A(H3N2) viruses were antigenically characterized as A/Hong Kong/4801/2014-like by HI testing or neutralization testing. Among the viruses that reacted poorly with ferret antisera raised against A/Hong Kong/4801/2014-like viruses, all belong to genetic group 3C.3a.
[FONT=&quot]Influenza B Virus [92][/FONT]
  • Victoria Lineage [33]: 22 of 33 (66.7%) B/Victoria-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Brisbane/60/2008-like. Among the viruses that reacted poorly with ferret antisera raised against B/Brisbane/60/2008-like viruses, all were double deletion viruses.
  • Yamagata Lineage [59]: All 59 (100%) B/Yamagata-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Phuket/3073/2013-like.
[FONT=&quot]
[/FONT]

[h=2]Antiviral Resistance:[/h] [FONT=&quot]A total of 517 specimens collected during May 21-November 11, 2017, were tested for resistance to the influenza neuraminidase inhibitor antiviral medications currently approved for use against seasonal influenza: oseltamivir, zanamivir, and peramivir. A total of 73 influenza A(H1N1)pdm09, 306 influenza A(H3N2), and 137 influenza B viruses were found to be sensitive to all three antiviral medications. An additional one influenza A(H1N1)pmd09 virus was tested for resistance to oseltamivir and peramivir and 14 influenza A(H3N2) viruses were tested for resistance to oseltamivir and zanamivir. All were found to be sensitive to both antiviral medications.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A (H1N1)pdm09 viruses and oseltamivir-resistant influenza A (H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on November 16, 2017, 5.9% of the deaths occurring during the week ending October 28, 2017 (week 43) were due to P&I. This percentage is below the epidemic threshold of 6.3% for week 43.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS45_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]No influenza-associated pediatric deaths were reported to CDC during week 45.[/FONT]
[FONT=&quot]One influenza-associated pediatric death for the 2017-2018 season has been reported to CDC.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in select counties in the Emerging Infections Program (EIP) states and Influenza Hospitalization Surveillance Project (IHSP) states. FluSurv-NET estimated hospitalization rates will be updated weekly starting later this season.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 45, 1.9% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 0.9% to 3.3% during week 45. One region (Region 4) reported a proportion of outpatient visits for ILI at or above their region-specific baseline level.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 45, the following ILI activity levels were experienced:[/FONT]
  • One state experienced high ILI activity (Louisiana)
  • Two states experienced moderate ILI activity (Georgia and Mississippi)
  • Six states experienced low ILI activity (Alabama, Hawaii, Nebraska, South Carolina, South Dakota and Wyoming).
  • New York City, the District of Columbia, Puerto Rico, and 41 states experienced minimal ILI activity (Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, and Wisconsin).
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.[/FONT]
[FONT=&quot]During week 45, the following influenza activity was reported::[/FONT]
  • Regional influenza activity was reported by Guam, Puerto Rico, and nine states (Arkansas, California, Georgia, Louisiana, Massachusetts, Mississippi, Oklahoma, South Carolina, and Washington).
  • Local influenza activity was reported by 13 states (Alaska, Arizona, Colorado, Connecticut, Kentucky, Maine, Maryland, New Mexico, Ohio, Oregon, Pennsylvania, Texas, and Wisconsin).
  • Sporadic influenza activity was reported by the U.S. Virgin Islands and 26 states (Delaware, Florida, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New York, North Carolina, North Dakota, Rhode Island, South Dakota, Tennessee, Utah, Vermont, Virginia, and Wyoming).
  • No activity was reported by the District of Columbia and two states (Alabama and West Virginia).
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visit http://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]

[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]

[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]

[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]

[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]

[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]

[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]

[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]

[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]

[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]

[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control athttp://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.[/FONT]
 
[h=3]2017-2018 Influenza Season Week 46 ending November 18, 2017[/h] All data are preliminary and may change as more reports are received.
[h=3]Synopsis:[/h] During week 46 (November 12-18, 2017), influenza activity increased in the United States.
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 46 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories is increasing.
  • Novel Influenza A Virus: One human infection with a novel influenza A virus was reported.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: Five influenza-associated pediatric deaths were reported, one of which occurred during the 2016-17 season.
  • Influenza-associated Hospitalizations: A cumulative rate of 1.4 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 2.0%, which is below the national baseline of 2.2%. Regions 1, 2, 4 and 6 reported ILI at or above region-specific baseline levels. Two states experienced high ILI activity, one state experienced moderate ILI activity, New York City and 4 states experienced low ILI activity, the District of Columbia and 43 states experienced minimal ILI activity, and Puerto Rico had insufficient data.
  • Geographic Spread of Influenza:The geographic spread of influenza in two states was reported as widespread; Guam and six states reported regional activity; 20 states reported local activity; the District of Columbia, the U.S. Virgin Islands and 21 states reported sporadic activity; one state reported no activity; and Puerto Rico did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI? Number of jurisdictions reporting regional or widespread activity? % respiratory specimens positive for flu in clinical laboratories? A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Normal[/TD]
[TD]9 of 54[/TD]
[TD]5.3%[/TD]
[TD]136[/TD]
[TD]1,193[/TD]
[TD]28[/TD]
[TD]6[/TD]
[TD]105[/TD]
[TD]85[/TD]
[TD]5[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]1 of 6[/TD]
[TD]1.7%[/TD]
[TD]2[/TD]
[TD]21[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]1[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]0 of 4[/TD]
[TD]1.8%[/TD]
[TD]2[/TD]
[TD]23[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]4[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.1%[/TD]
[TD]6[/TD]
[TD]40[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]4 of 8[/TD]
[TD]7.3%[/TD]
[TD]49[/TD]
[TD]133[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]7[/TD]
[TD]26[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 5 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]1.9%[/TD]
[TD]3[/TD]
[TD]167[/TD]
[TD]6[/TD]
[TD]0[/TD]
[TD]19[/TD]
[TD]5[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]3 of 5[/TD]
[TD]6.0%[/TD]
[TD]34[/TD]
[TD]143[/TD]
[TD]1[/TD]
[TD]1[/TD]
[TD]7[/TD]
[TD]11[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 7 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]4.3%[/TD]
[TD]6[/TD]
[TD]68[/TD]
[TD]12[/TD]
[TD]0[/TD]
[TD]13[/TD]
[TD]5[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]0 of 6[/TD]
[TD]3.4%[/TD]
[TD]4[/TD]
[TD]138[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]16[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Normal[/TD]
[TD]1 of 5[/TD]
[TD]5.8%[/TD]
[TD]21[/TD]
[TD]340[/TD]
[TD]3[/TD]
[TD]2[/TD]
[TD]18[/TD]
[TD]35[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]0 of 4[/TD]
[TD]4.6%[/TD]
[TD]12[/TD]
[TD]120[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]17[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
? Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks


[h=2]U.S. Virologic Surveillance:[/h] WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.
Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.
The results of tests performed by clinical laboratories are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD="width: 200"] [/TD]
Week 46 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]15,584[/TD]
[TD]114,844[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]832 (5.3%)[/TD]
[TD]3,764 (3.3%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]616 (74.0%)[/TD]
[TD]2,722 (72.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]216 (26.0%)[/TD]
[TD]1,042 (27.7%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD] [/TD]
Week 46 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]937[/TD]
[TD]7,642[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]241[/TD]
[TD]1,554[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]201 (83.4%)[/TD]
[TD]1,358 (87.4%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]27 (13.4%)[/TD]
[TD]136 (10.0%)[/TD]
[/TR]
[TR]
H3 [TD]157 (78.1%)[/TD]
[TD]1,193 (87.8%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]17 (8.5%)[/TD]
[TD]28 (2.1%)[/TD]
[/TR]
[TR]
Influenza B [TD]40 (16.6%)[/TD]
[TD]196 (12.6%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]16 (40.0%)[/TD]
[TD]105 (53.6%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]1 (2.5%)[/TD]
[TD]6 (3.1%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]23 (57.5%)[/TD]
[TD]85 (43.4%)[/TD]
[/TR]
[/TABLE]
*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation


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[h=2]Novel Influenza A Virus:[/h] One human infection with a novel influenza A virus was reported from Iowa during week 46. This person was infected with an influenza A(H1N1) variant (H1N1v) virus and reported direct contact to swine during the week preceding illness onset. This patient was an adult < 50 years of age, was not hospitalized, and has fully recovered from their illness. No human-to-human transmission has been identified. This is the first H1N1v virus infection detected in the United States in 2017. This brings the total number of reported H1N1v infections in the United States since 2005 to 21.
A total of 66 variant virus infections have been reported to CDC during 2017. Sixty-one of these were influenza A(H3N2) variant (H3N2v) viruses (Delaware [1], Maryland [39], Michigan [2], Nebraska [1], North Dakota [1], Ohio [15], Pennsylvania [1], and Texas [1]), one was influenza A(H1N1) variant (H1N1v) (Iowa [1]), and four were influenza A(H1N2) variant (H1N2v) viruses (Colorado [1] and Ohio [3]). Six of these 66 infections have resulted in hospitalization; all have recovered.
Early identification and investigation of human infections with novel influenza A viruses are critical so that the risk of infection can be more fully understood and appropriate public health measures can be taken. Additional information on influenza in swine, variant influenza infection in humans, and strategies to interact safely with swine can be found at http://www.cdc.gov/flu/swineflu/index.htm. .
[h=2]Influenza Virus Characterization:[/h] CDC characterizes influenza viruses through one or more tests including genomic sequencing, hemagglutination inhibition (HI) and/or neutralization assays. These data are used to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines, and to monitor for changes in circulating influenza viruses. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.
For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses. Viruses can be classified into genetic groups/clades based on analysis of their HA gene segments using phylogenetics and key amino acid changes (Klimov Vaccine 2012).A representative subset of influenza-positive surveillance samples are antigenically characterized. However, a proportion of influenza A(H3N2) viruses lack sufficient hemagglutination titers for antigenic characterization using hemagglutination inhibition assays. Therefore, CDC selects a representative subset of influenza A(H3N2) viruses for antigenic characterization using the virus neutralization focus reduction assay to assess the ability of various antisera to neutralize infectivity of the test viruses.
It is important to monitor circulating influenza viruses for evidence of genetic changes. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Close monitoring of influenza viruses is required to better assess the potential impact on public health.
[h=2]Genetic Characterization[/h] During May 21 ? November 18, 2017, 3,298 influenza positive specimens were collected and reported by public health laboratories in the United States (Figure, left). CDC genetically characterized 665 influenza viruses [91 influenza A(H1N1)pdm09, 415 influenza A(H3N2), and 159 influenza B viruses] collected by U.S. laboratories.
Influenza A Viruses
  • A (H1N1)pdm09 [91]: The HA gene segment of all influenza A(H1N1)pdm09 viruses analyzed showed that one virus belonged to clade 6B, with the remainder belonging to 6B.1, the same genetic clade as the vaccine reference virus, A/Michigan/45/2015.
  • A (H3N2) [415]: Phylogenetic analysis of the HA genes indicate that multiple clades/subclades are circulating. The HA genes show extensive diversity and belong to clades 3C.2a, subclade 3C.2a1 or 3C.3a, with 3C.2a predominating. The vaccine reference virus, A/Hong Kong/4801/2014, belongs to the genetic clade 3C.2a.
Influenza B Viruses
  • B/Victoria [35]: The HA of influenza B/Victoria-lineage viruses all belonged to genetic group V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008.
  • Two subgroups of viruses within V1A have been detected with a double or triple deletion of amino acids in the HA. The majority of the double deletion viruses were identified in the United States, while no triple deletion viruses have been identified in the United States.
  • B/Yamagata [124]: The HA of influenza B/Yamagata-lineage viruses analyzed all belonged to genetic group Y3, the same genetic clade as the vaccine reference virus, B/Phuket/3073/2013.

The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmapconsiderations, specimen submission guidance issued to the laboratories request that, if available, 2 influenza A (H1N1), 2 A influenza (H3N2), and 2 influenza B viruses be submitted every other week. Because of this, the number of each virus type/subtype characterized should be approximately equal. In the figure below, the results of tests performed by public health labs are presented on the left and sequence results by genetic group of specimens submitted to CDC are presented on the right.
Genetic46_small.gif

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[h=2]Antigenic Characterization[/h] During May 21 ? November 18, 2017, CDC antigenically characterized 351 influenza viruses [73 influenza A(H1N1)pdm09, 145 influenza A(H3N2), and 133 influenza B viruses] collected by U.S. laboratories. Antigenic similarity is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing the recommended vaccine components of the Northern Hemisphere 2017-18 vaccine.
Influenza A Virus [218]
  • A (H1N1)pdm09 [73]: 72 of 73 (98.6%) influenza A(H1N1)pdm09 viruses were antigenically characterized using ferret post-infection antisera as A/Michigan/45/2015 (H1N1)pdm09-like.
  • A (H3N2) [145]: 141 of 145 (97.2%) influenza A(H3N2) viruses were antigenically characterized as A/Hong Kong/4801/2014-like by HI testing or neutralization testing. Among the viruses that reacted poorly with ferret antisera raised against A/Hong Kong/4801/2014-like viruses, all belong to genetic group 3C.3a.
Influenza B Virus [133]
  • Victoria Lineage [33]: 22 of 33 (66.7%) B/Victoria-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Brisbane/60/2008-like. Among the viruses that reacted poorly with ferret antisera raised against B/Brisbane/60/2008-like viruses, all were double deletion viruses.
  • Yamagata Lineage [100]: All 100 (100%) B/Yamagata-lineage viruses were antigenically characterized using ferret post-infection antisera as B/Phuket/3073/2013-like.


[h=2]Antiviral Resistance:[/h] A total of 625 specimens collected during May 21-November 18, 2017, were tested for resistance to the influenza neuraminidase inhibitor antiviral medications currently approved for use against seasonal influenza: oseltamivir, zanamivir, and peramivir. A total of 92 influenza A(H1N1)pdm09, 383 influenza A(H3N2), and 150 influenza B viruses were found to be sensitive to all three antiviral medications. An additional one influenza A(H1N1)pmd09 virus was tested for resistance to oseltamivir and peramivir and 14 influenza A(H3N2) viruses were tested for resistance to oseltamivir and zanamivir. All were found to be sensitive to both antiviral medications.
The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A (H1N1)pdm09 viruses and oseltamivir-resistant influenza A (H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] Based on National Center for Health Statistics (NCHS) mortality surveillance data available on November 22, 2017, 5.6% of the deaths occurring during the week ending November 4, 2017 (week 44) were due to P&I. This percentage is below the epidemic threshold of 6.4% for week 44.
Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.
Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.
NCHS46_small.gif

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[h=2]Influenza-Associated Pediatric Mortality:[/h] Five influenza-associated pediatric deaths were reported to CDC during week 46.
Two deaths were associated with an influenza A (H3) virus and occurred during weeks 45 and 46 (the weeks ending November 11 and November 18, 2017, respectively). One death was associated with an influenza A (H1N1)pdm09 virus and occurred during week 44 (the week ending November 4, 2017). One death was associated with an influenza A virus for which no subtyping was performed and occurred during week 44.
A total of five influenza-associated pediatric deaths have been reported for the 2017-2018 season.
One death that occurred during the 2016-2017 season was associated with an influenza A (H3) virus and occurred during week 15 (the week ending April 15, 2017). This death brings the total number of reported influenza-associated pediatric deaths occurring during that season to 110.
Additional data can be found at: http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html.

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[h=2]Influenza-Associated Hospitalizations:[/h] The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).
The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.
Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.
A total of 400 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and November 18, 2017. The overall hospitalization rate was 1.4 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (5.1 per 100,000 population), followed by adults aged 50-64 (1.7 per 100,000 population) and children aged 0-4 years (1.0 per 100,000 population). Among 400 hospitalizations, 330 (82.5%) were associated with influenza A virus, 65 (16.3%) with influenza B virus, 2 (0.5%) with influenza A virus and influenza B virus co-infection, and 3 (0.8%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 87 (91.6%) were A(H3N2) and 8 (8.4%) were A(H1N1)pdm09 virus.
Additional FluSurv-NET data can be found at: http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html and http://gis.cdc.gov/grasp/fluview/FluHospChars.html.
[SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics? (NCHS) population estimates for the counties included in the surveillance catchment area.[/SIZE]
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[h=2]Outpatient Illness Surveillance:[/h] Nationwide during week 46, 2.0% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is below the national baseline of 2.2%. (ILI is defined as fever (temperature of 100?F [37.8?C] or greater) and cough and/or sore throat.)

Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.

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On a regional level, the percentage of outpatient visits for ILI ranged from 0.7% to 4.5% during week 46. Regions 1, 2, 4 and 6 reported percentages of outpatient visits for ILI at or above their region specific baselines.



[h=2]ILINet State Activity Indicator Map:[/h] Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.
During week 46, the following ILI activity levels were experienced:
  • Two states experienced high activity (Louisiana and Mississippi)
  • One state experienced moderate ILI activity (Georgia)
  • New York City and four states experienced low ILI activity (Alabama, Nebraska, South Carolina, and Texas).
  • The District of Columbia and 43 states experienced minimal ILI activity (Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Hawaii, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Dakota, Tennessee, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin and Wyoming).
  • Data were insufficient to calculate an ILI activity level from Puerto Rico.

Click on map to launch interactive tool
*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
During week 46, the following influenza activity was reported::
  • Widespread influenza activity was reported by two states (Louisiana and Oklahoma).
  • Regional influenza activity was reported by Guam and six states (Arkansas, Georgia, Kentucky, Massachusetts, Mississippi, and South Carolina).
  • Local influenza activity was reported by 20 states (Alabama, Alaska, Arizona, California, Colorado, Connecticut, Florida, Kansas, Maine, Maryland, Nebraska, New Hampshire, New Mexico, North Dakota, Ohio, Pennsylvania, Texas, Utah, Washington, and Wisconsin).
  • Sporadic influenza activity was reported by the District of Columbia, the U.S. Virgin Islands and 21 states (Delaware, Hawaii, Idaho, Illinois, Indiana, Iowa, Michigan, Minnesota, Missouri, Montana, Nevada, New Jersey, New York, North Carolina, Oregon, Rhode Island, South Dakota, Tennessee, Vermont, Virginia, and Wyoming).
  • No influenza activity was reported by one state (West Virginia).
  • Puerto Rico did not report.



[h=2]Additional National and International Influenza Surveillance Information[/h] FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.
U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.

[TABLE="width: 100%"]
[TR]
[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]
[/TR]
[TR]
[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]
[/TR]
[TR]
[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]
[/TR]
[TR]
[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]
[/TR]
[TR]
[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]
[/TR]
[TR]
[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]
[/TR]
[TR]
[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]
[/TR]
[TR]
[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]
[/TR]
[TR]
[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]
[/TR]
[TR]
[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]
[/TR]
[TR]
[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]
[/TR]
[/TABLE]

World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.
WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).
Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.
Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/
Public Health England: The most up-to-date influenza information from the United Kingdom is available athttps://www.gov.uk/government/statistics/weekly-national-flu-reports



Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links.
An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.
 
[h=3]2017-2018 Influenza Season Week 49 ending December 9, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 49 (December 3-9, 2017), influenza activity increased in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus type reported by public health laboratories during week 49 was influenza A. The percentage of respiratory specimens testing positive for influenza in clinical laboratories increased.
  • Novel Influenza A Virus: One human infection with a novel influenza A virus was reported.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: One influenza-associated pediatric death was reported.
  • Influenza-associated Hospitalizations: A cumulative rate of 4.3 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 2.7%, which is above the national baseline of 2.2%. Seven of the 10 regions reported ILI at or above region-specific baseline levels. Four states experienced high ILI activity; five states experienced moderate ILI activity; New York City, Puerto Rico, and 16 states experienced low ILI activity; 25 states experienced minimal ILI activity; and the District of Columbia had insufficient data.
  • Geographic Spread of Influenza:The geographic spread of influenza in 12 states was reported as widespread; Puerto Rico and 26 states reported regional activity; 10 states reported local activity; the District of Columbia, the U.S. Virgin Islands and two states reported sporadic activity; and Guam did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]39 of 54[/TD]
[TD]8.4%[/TD]
[TD]276[/TD]
[TD]2,916[/TD]
[TD]36[/TD]
[TD]22[/TD]
[TD]318[/TD]
[TD]143[/TD]
[TD]8[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]2.7%[/TD]
[TD]4[/TD]
[TD]76[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]6[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]4.3%[/TD]
[TD]3[/TD]
[TD]76[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]10[/TD]
[TD]3[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]2 of 6[/TD]
[TD]3.7%[/TD]
[TD]21[/TD]
[TD]168[/TD]
[TD]4[/TD]
[TD]0[/TD]
[TD]21[/TD]
[TD]7[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]7 of 8[/TD]
[TD]7.9%[/TD]
[TD]71[/TD]
[TD]243[/TD]
[TD]5[/TD]
[TD]0[/TD]
[TD]21[/TD]
[TD]51[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]4 of 6[/TD]
[TD]5.6%[/TD]
[TD]18[/TD]
[TD]529[/TD]
[TD]7[/TD]
[TD]2[/TD]
[TD]63[/TD]
[TD]11[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]11.0%[/TD]
[TD]78[/TD]
[TD]256[/TD]
[TD]1[/TD]
[TD]2[/TD]
[TD]20[/TD]
[TD]24[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]6.8%[/TD]
[TD]8[/TD]
[TD]203[/TD]
[TD]2[/TD]
[TD]0[/TD]
[TD]47[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Normal[/TD]
[TD]4 of 6[/TD]
[TD]9.4%[/TD]
[TD]11[/TD]
[TD]347[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]33[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]2 of 5[/TD]
[TD]11.8%[/TD]
[TD]47[/TD]
[TD]758[/TD]
[TD]14[/TD]
[TD]15[/TD]
[TD]56[/TD]
[TD]38[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 10 [TD]Normal[/TD]
[TD]4 of 4[/TD]
[TD]10.0%[/TD]
[TD]15[/TD]
[TD]260[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]41[/TD]
[TD]8[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 49 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]19,326[/TD]
[TD]195,339[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]1,633 (8.4%)[/TD]
[TD]9,446 (4.8%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]1,343 (82.2%)[/TD]
[TD]7,218 (76.4%)[/TD]
[/TR]
[TR]
Influenza B [TD]290 (17.8%)[/TD]
[TD]2,228 (23.6%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 49 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]1,411[/TD]
[TD]13,393[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]562[/TD]
[TD]3,711[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]500 (89.0%)[/TD]
[TD]3,228 (87.0%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]26 (5.2%)[/TD]
[TD]276 (8.6%)[/TD]
[/TR]
[TR]
H3N2 [TD]464 (92.8%)[/TD]
[TD]2,916 (90.3%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]10 (2.0%)[/TD]
[TD]36 (1.1%)[/TD]
[/TR]
[TR]
Influenza B [TD]62 (11.0%)[/TD]
[TD]483 (13.0%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]34 (54.8%)[/TD]
[TD]318 (65.8%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]1 (1.6%)[/TD]
[TD]22 (4.6%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]27 (43.5%)[/TD]
[TD]143 (29.6%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
View Interactive Application | View Full Screen [h=2]Novel Influenza A Virus:[/h] [FONT=&quot]One human infection with a novel influenza A virus was reported by Iowa during week 49. This person was infected with an influenza A(H3N2) variant [A(H3N2)v] virus and reported direct contact with swine during the week preceding illness onset. The patient was an adult < 50 years of age, was not hospitalized, and has fully recovered from their illness. No human-to-human transmission has been identified.[/FONT]
[FONT=&quot]A total of 67 variant virus infections have been reported to CDC during 2017. Sixty-two of these have been A(H3N2)v viruses (Delaware [1], Iowa [1], Maryland [39], Michigan [2], Nebraska [1], North Dakota [1], Ohio [15], Pennsylvania [1], and Texas [1]), one was an influenza A(H1N1) variant [A(H1N1)v] (Iowa [1]) virus, and four were influenza A(H1N2) variant [A(H1N2)v] viruses (Colorado [1] and Ohio [3]). Six of these 67 infections resulted in hospitalization; all patients have recovered.[/FONT]
[FONT=&quot]Early identification and investigation of human infections with novel influenza A viruses are critical so that the risk of infection can be more fully understood and appropriate public health measures can be taken. Additional information on influenza in swine, variant influenza infection in humans, and strategies to interact safely with swine can be found at http://www.cdc.gov/flu/swineflu/index.htm. .[/FONT]
[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI) (i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.[/FONT]
[FONT=&quot]CDC has antigenically or genetically characterized 400 influenza viruses collected during October 1 – December 9, 2017, and submitted by U.S. laboratories, including 58 influenza A(H1N1)pdm09 viruses, 256 influenza A(H3N2) viruses, and 86 influenza B viruses.[/FONT]
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 58 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. 41 A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017–18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 256 A(H3N2) viruses revealed extensive genetic diversity with? multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=198), subclade 3C.2a1 (n=56) or clade 3C.3a (n=2). 68 influenza A(H3N2) viruses were antigenically characterized, and 67 (98.5%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of? 2017–18 Northern Hemisphere influenza vaccines.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria: Phylogenetic analysis of five B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a small number of viruses identified in 2017 had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). One (50%) of two B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017–18 Northern Hemisphere influenza vaccines.? One B/Victoria lineage virus reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and this virus had the two amino acid deletion in the HA of the V1A-2Del viruses.
  • B/Yamagata: Phylogenetic analysis of 81 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 57 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017–18 Northern Hemisphere quadrivalent vaccines.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.[/FONT]
Genetic49_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation
[h=2]Antiviral Resistance:[/h] [FONT=&quot]Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.[/FONT]
[FONT=&quot]High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.[/FONT]
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in"]
[TR]
[TD] [/TD]
Oseltamivir
Zanamivir
Peramivir
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD] 58
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 50
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 58
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD] 314
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 314
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 236
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[TR]
Influenza B
[TD] 61
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 61
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 61
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[/TABLE]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on December 14, 2017, 5.5% of the deaths occurring during the week ending November 25, 2017 (week 47) were due to P&I. This percentage is below the epidemic threshold of 6.6% for week 47.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS49_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]One influenza-associated pediatric death was reported to CDC during week 49. This death was associated with an influenza A virus for which no subtyping was performed and occurred during week 44 (the week ending November 4, 2017).[/FONT]
[FONT=&quot]A total of eight influenza-associated pediatric deaths have been reported for the 2017-2018 season.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).[/FONT]
[FONT=&quot]The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.[/FONT]
[FONT=&quot]Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.[/FONT]
[FONT=&quot]A total of 1,232 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and December 9, 2017. The overall hospitalization rate was 4.3 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (17.3 per 100,000 population), followed by adults aged 50-64 (4.5 per 100,000 population) and children aged 0-4 years (3.5 per 100,000 population). Among 1,232 hospitalizations, 1,077 (87.4%) were associated with influenza A virus, 150 (12.2%) with influenza B virus, 4 (0.3%) with influenza A virus and influenza B virus co-infection, and 1 (0.1%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 282 (87.0%) were A(H3N2) and 42 (13.0%) were A(H1N1)pdm09 virus.[/FONT]
[FONT=&quot]Among 237 hospitalized adults with information on underlying medical conditions, 218 (92.0%) had at least one reported underlying medical condition; the most commonly reported were cardiovascular disease, metabolic disorder, and obesity. Among 19 hospitalized children with information on underlying medical conditions, 14 (73.7%) had at least one underlying medical condition; the most commonly reported were asthma and immune suppression conditions. Among 20 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 5 (25.0%) were pregnant.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]
[FONT=&quot][/FONT]
[FONT=&quot][SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics’ (NCHS) population estimates for the counties included in the surveillance catchment area.[/SIZE][/FONT]
View Interactive Application | View Full Screen | View PowerPoint Presentation
[FONT=&quot][/FONT]
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseasesinclude conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications; Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
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[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 49, 2.7% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 1.2% to 5.3% during week 49. Seven of 10 regions (regions 1, 2, 4, 5, 6, 7 and 9) reported percentages of outpatient visits for ILI at or above their region specific baselines.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 49, the following ILI activity levels were experienced:[/FONT]
  • Four states experienced high activity (Louisiana, Mississippi, South Carolina, and Texas).
  • Five states experienced moderate ILI activity (Alabama, Alaska, Arizona, Georgia, and Kentucky).
  • New York City, Puerto Rico, and 16 states experienced low ILI activity (Arkansas, California, Colorado, Hawaii, Indiana, Kansas, Massachusetts, Minnesota, Missouri, Nebraska, Nevada, Oklahoma, Oregon, South Dakota, Virginia, and Wyoming).
  • 25 states experienced minimal ILI activity (Connecticut, Delaware, Florida, Idaho, Illinois, Iowa, Maine, Maryland, Michigan, Montana, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Pennsylvania, Rhode Island, Tennessee, Utah, Vermont, Washington, West Virginia, and Wisconsin).
  • Data were insufficient to calculate an ILI activity from the District of Columbia.
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.[/FONT]
[FONT=&quot]During week 49, the following influenza activity was reported::[/FONT]
  • Widespread influenza activity was reported by 12 states (Arkansas, California, Connecticut, Louisiana, Massachusetts, Mississippi, Missouri, New York, Ohio, Oklahoma, Virginia, and Wisconsin).
  • Regional influenza activity was reported by Puerto Rico and 26 states (Alabama, Alaska, Arizona, Colorado, Florida, Georgia, Idaho, Illinois, Kansas, Kentucky, Maine, Maryland, Minnesota, Montana, Nebraska, New Hampshire, New Jersey, New Mexico, North Dakota, Oregon, Rhode Island, South Carolina, Tennessee, Texas, Washington, and Wyoming).
  • Local influenza activity was reported by 10 states (Delaware, Hawaii, Indiana, Iowa, Michigan, North Carolina, Pennsylvania, South Dakota, Vermont, and West Virginia).
  • Sporadic influenza activity was reported by the District of Columbia, the U.S. Virgin Islands and two states (Nevada and Utah).
  • Guam did not report.
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
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[TD="width: 139"] Alaska
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[TD="width: 139"] Arizona
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[TD="width: 139"] Arkansas
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[TD="width: 139"] California
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[TD="width: 139"] Colorado
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[TD="width: 139"] Connecticut
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[TD="width: 139"] Delaware
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[TD="width: 139"] District of Columbia
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[TD="width: 139"] Florida
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[TD="width: 139"] Georgia
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[TD="width: 139"] Hawaii
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[TD="width: 139"] Idaho
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[TD="width: 139"] Illinois
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[TD="width: 139"] Indiana
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[TD="width: 139"] Iowa
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[TD="width: 139"] Kansas
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[TD="width: 139"] Kentucky
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[TD="width: 139"] Louisiana
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[TD="width: 139"] Maine
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[TD="width: 139"] Maryland
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[TD="width: 139"] Massachusetts
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[TD="width: 139"] Michigan
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[TD="width: 139"] Minnesota
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[TD="width: 139"] Mississippi
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[TD="width: 139"] Missouri
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[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
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[TD="width: 139"] Nevada
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[TD="width: 139"] New Hampshire
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[TD="width: 139"] New Jersey
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[TD="width: 139"] New Mexico
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[TD="width: 139"] New York
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[TD="width: 139"] North Carolina
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[TD="width: 139"] North Dakota
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[TD="width: 139"] Ohio
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[TD="width: 139"] Oklahoma
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[TD="width: 139"] Oregon
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[TD="width: 139"] Pennsylvania
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[TD="width: 139"] Rhode Island
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[TD="width: 139"] South Carolina
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[TD="width: 139"] South Dakota
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[TD="width: 139"] Tennessee
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[TD="width: 139"] Texas
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[TD="width: 139"] Utah
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[TD="width: 139"] Vermont
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[TD="width: 139"] Virginia
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[TD="width: 139"] Washington
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[TD="width: 139"] West Virginia
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[TD="width: 139"] Wisconsin
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[TD="width: 139"] Wyoming
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[TD="width: 139"] New York City
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[TD="width: 139"] Puerto Rico
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[TD="width: 139"] Virgin Islands
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[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.[/FONT]

https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week49.htm
 
[h=3]2017-2018 Influenza Season Week 50 ending December 16, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 50 (December 10-16, 2017), influenza activity sharply increased in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 50 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories increased.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: One influenza-associated pediatric death was reported.
  • Influenza-associated Hospitalizations: A cumulative rate of 6.2 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 3.5%, which is above the national baseline of 2.2%. Nine of the 10 regions reported ILI at or above region-specific baseline levels. Ten states experienced high ILI activity; Puerto Rico and eight states experienced moderate ILI activity; New York City, the District of Columbia, and 11 states experienced low ILI activity; and 21 states experienced minimal ILI activity.
  • Geographic Spread of Influenza:The geographic spread of influenza in 23 states was reported as widespread; Puerto Rico and 23 states reported regional activity; the District of Columbia and four states reported local activity; the U.S. Virgin Islands reported sporadic activity; and Guam did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]47 of 54[/TD]
[TD]14.0%[/TD]
[TD]366[/TD]
[TD]3,965[/TD]
[TD]56[/TD]
[TD]39[/TD]
[TD]438[/TD]
[TD]182[/TD]
[TD]9[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]4.1%[/TD]
[TD]6[/TD]
[TD]96[/TD]
[TD]0[/TD]
[TD]1[/TD]
[TD]6[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]6.0%[/TD]
[TD]4[/TD]
[TD]172[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]23[/TD]
[TD]4[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 3 [TD]Normal[/TD]
[TD]3 of 6[/TD]
[TD]4.9%[/TD]
[TD]36[/TD]
[TD]252[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]41[/TD]
[TD]7[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]9.5%[/TD]
[TD]90[/TD]
[TD]298[/TD]
[TD]6[/TD]
[TD]2[/TD]
[TD]30[/TD]
[TD]57[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]9.2%[/TD]
[TD]32[/TD]
[TD]763[/TD]
[TD]8[/TD]
[TD]5[/TD]
[TD]72[/TD]
[TD]19[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]15.2%[/TD]
[TD]97[/TD]
[TD]290[/TD]
[TD]5[/TD]
[TD]2[/TD]
[TD]25[/TD]
[TD]27[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]8.4%[/TD]
[TD]9[/TD]
[TD]272[/TD]
[TD]13[/TD]
[TD]0[/TD]
[TD]69[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]10.9%[/TD]
[TD]12[/TD]
[TD]444[/TD]
[TD]3[/TD]
[TD]2[/TD]
[TD]42[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]3 of 5[/TD]
[TD]12.2%[/TD]
[TD]62[/TD]
[TD]1,048[/TD]
[TD]17[/TD]
[TD]25[/TD]
[TD]79[/TD]
[TD]52[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]17.6%[/TD]
[TD]18[/TD]
[TD]330[/TD]
[TD]1[/TD]
[TD]2[/TD]
[TD]51[/TD]
[TD]15[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 50 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]23,607[/TD]
[TD]225,889[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]3,308 (14.0%)[/TD]
[TD]13,475 (6.0%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]2,812 (85.0%)[/TD]
[TD]10,567 (78.4%)[/TD]
[/TR]
[TR]
Influenza B [TD]496 (15.0%)[/TD]
[TD]2,908 (21.6%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 50 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]1,623[/TD]
[TD]15,994[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]795[/TD]
[TD]5,046[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]689 (86.7%)[/TD]
[TD]4,387 (86.9%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]58 (8.4%)[/TD]
[TD]366 (8.3%)[/TD]
[/TR]
[TR]
H3N2 [TD]611 (88.7%)[/TD]
[TD]3,965 (90.4%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]20 (2.9%)[/TD]
[TD]56 (1.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]106 (13.3%)[/TD]
[TD]659 (13.1%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]75 (70.8%)[/TD]
[TD]438 (66.5%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]10 (9.4%)[/TD]
[TD]39 (5.9%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]21 (19.8%)[/TD]
[TD]182 (27.6%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
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[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI) (i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.[/FONT]
[FONT=&quot]CDC has antigenically or genetically characterized 526 influenza viruses collected during October 1 – December 16, 2017, and submitted by U.S. laboratories, including 63 influenza A(H1N1)pdm09 viruses, 336 influenza A(H3N2) viruses, and 127 influenza B viruses.[/FONT]
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 63 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. 41 A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017–18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 336 A(H3N2) viruses revealed extensive genetic diversity with multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=265), subclade 3C.2a1 (n=68) or clade 3C.3a (n=3). 88 influenza A(H3N2) viruses were antigenically characterized, and 87 (98.9%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of 2017–18 Northern Hemisphere influenza vaccines.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria: Phylogenetic analysis of 12 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a small number of viruses identified in 2017 had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). One (50%) of two B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017–18 Northern Hemisphere influenza vaccines. One B/Victoria lineage virus reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and this virus had the two amino acid deletion in the HA of the V1A-2Del viruses.
  • B/Yamagata: Phylogenetic analysis of 115 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 70 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017–18 Northern Hemisphere quadrivalent vaccines.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.[/FONT]
Genetic50_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation
[h=2]Antiviral Resistance:[/h] [FONT=&quot]Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.[/FONT]
[FONT=&quot]High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.[/FONT]
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in"]
[TR]
[TD] [/TD]
Oseltamivir
Zanamivir
Peramivir
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD] 79
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 67
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 79
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD] 391
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 391
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 304
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[TR]
Influenza B
[TD] 85
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 85
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 85
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[/TABLE]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on December 21, 2017, 6.2% of the deaths occurring during the week ending December 2, 2017 (week 48) were due to P&I. This percentage is below the epidemic threshold of 7.4% for week 48.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS50_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]One influenza-associated pediatric death was reported to CDC during week 50. This death was associated with an influenza A(H1N1)pdm09 virus and occurred during week 50 (the week ending December 16, 2017).[/FONT]
[FONT=&quot]A total of nine influenza-associated pediatric deaths have been reported for the 2017-2018 season.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).[/FONT]
[FONT=&quot]The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.[/FONT]
[FONT=&quot]Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.[/FONT]
[FONT=&quot]A total of 1,772 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and December 16, 2017. The overall hospitalization rate was 6.2 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (25.3 per 100,000 population), followed by adults aged 50-64 (6.5 per 100,000 population), and children aged 0-4 years (4.7 per 100,000 population). Among 1,772 hospitalizations, 1,567 (88.4%) were associated with influenza A virus, 192 (10.8%) with influenza B virus, 5 (0.3%) with influenza A virus and influenza B virus co-infection, and 8 (0.5%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 396 (87.0%) were A(H3N2) and 59 (13.0%) were A(H1N1)pdm09 virus.[/FONT]
[FONT=&quot]Among 352 hospitalized adults with information on underlying medical conditions, 317 (90.0%) had at least one reported underlying medical condition; the most commonly reported were metabolic disorder, cardiovascular disorder, obesity, and chronic lung disease. Among 33 hospitalized children with information on underlying medical conditions, 20 (60.6%) had at least one underlying medical condition; the most commonly reported were asthma and obesity. Among 34 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 11 (32.4%) were pregnant.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]
[FONT=&quot][/FONT]
[FONT=&quot][SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics’ (NCHS) population estimates for the counties included in the surveillance catchment area.[/SIZE][/FONT]
View Interactive Application | View Full Screen | View PowerPoint Presentation
[FONT=&quot][/FONT]
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseasesinclude conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications; Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 50, 3.5% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 1.4% to 8.3% during week 50. Nine of 10 regions (regions 1, 2, 4, 5, 6, 7, 8, 9 and 10) reported percentages of outpatient visits for ILI at or above their region specific baselines.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 50, the following ILI activity levels were experienced:[/FONT]
  • Ten states experienced high activity (Alabama, Arizona, Arkansas, Kentucky, Louisiana, Mississippi, Nevada, Oklahoma, South Carolina, and Texas)
  • Puerto Rico and eight states experienced moderate ILI activity (California, Georgia, Illinois, Kansas, Missouri, Nebraska, Oregon, and West Virginia).
  • New York City, the District of Columbia, and 11 states experienced low ILI activity (Alaska, Colorado, Connecticut, Massachusetts, Michigan, Minnesota, New Jersey, New Mexico, South Dakota, Virginia, and Wyoming).
  • 21 states experienced minimal ILI activity (Delaware, Florida, Hawaii, Idaho, Indiana, Iowa, Maine, Maryland, Montana, New Hampshire, New York, North Carolina, North Dakota, Ohio, Pennsylvania, Rhode Island, Tennessee, Utah, Vermont, Washington, and Wisconsin).
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.[/FONT]
[FONT=&quot]During week 50, the following influenza activity was reported::[/FONT]
  • Widespread influenza activity was reported by 23 states (Alabama, Arizona, Arkansas, California, Connecticut, Idaho, Illinois, Indiana, Kentucky, Louisiana, Maryland, Massachusetts, Mississippi, Missouri, New York, North Dakota, Ohio, Oklahoma, Oregon, South Carolina, Texas, Virginia, and Wisconsin).
  • Regional influenza activity was reported by Puerto Rico and 23 states (Alaska, Colorado, Florida, Georgia, Iowa, Kansas, Maine, Michigan, Minnesota, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, North Carolina, Pennsylvania, Rhode Island, South Dakota, Tennessee, Vermont, Washington, and Wyoming).
  • Local influenza activity was reported by the District of Columbia and four states (Delaware, Hawaii, Utah, and West Virginia).
  • Sporadic influenza activity was reported by the U.S. Virgin Islands.
  • Guam did not report.
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
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[TD="width: 139"] Alaska
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[TD="width: 139"] Arizona
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[TD="width: 139"] Arkansas
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[TD="width: 139"] California
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[TD="width: 139"] Colorado
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[TD="width: 139"] Connecticut
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[TD="width: 139"] Delaware
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[TD="width: 139"] District of Columbia
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[TD="width: 139"] Florida
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[TD="width: 139"] Georgia
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[TD="width: 139"] Hawaii
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[TD="width: 139"] Idaho
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[TD="width: 139"] Illinois
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[TD="width: 139"] Indiana
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[TD="width: 139"] Iowa
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[TD="width: 139"] Kansas
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[TD="width: 139"] Kentucky
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[TD="width: 139"] Louisiana
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[TD="width: 139"] Maine
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[TD="width: 139"] Maryland
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[TD="width: 139"] Massachusetts
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[TD="width: 139"] Michigan
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[TD="width: 139"] Minnesota
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[TD="width: 139"] Mississippi
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[TD="width: 139"] Missouri
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[TD="width: 139"] Montana
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[TD="width: 139"] Nebraska
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[TD="width: 139"] Nevada
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[TD="width: 139"] New Hampshire
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[TD="width: 139"] New Jersey
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[TD="width: 139"] New Mexico
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[TD="width: 139"] New York
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[TD="width: 139"] North Carolina
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[TD="width: 139"] North Dakota
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[TD="width: 139"] Ohio
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[TD="width: 139"] Oklahoma
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[TD="width: 139"] Oregon
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[TD="width: 139"] Pennsylvania
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[TD="width: 139"] Rhode Island
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[TD="width: 139"] South Carolina
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[TD="width: 139"] South Dakota
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[TD="width: 139"] Tennessee
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[TD="width: 139"] Texas
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[TD="width: 139"] Utah
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[TD="width: 139"] Vermont
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[TD="width: 139"] Virginia
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[TD="width: 139"] Washington
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[TD="width: 139"] West Virginia
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[TD="width: 139"] Wisconsin
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[TD="width: 139"] Wyoming
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[TD="width: 139"] New York City
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[TD="width: 139"] Puerto Rico
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[TD="width: 139"] Virgin Islands
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[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.


https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week50.htm
[/FONT]
 
[h=3]2017-2018 Influenza Season Week 51 ending December 23, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 51 (December 17-23, 2017), influenza activity increased sharply in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 51 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories increased.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: Three influenza-associated pediatric deaths were reported.
  • Influenza-associated Hospitalizations: A cumulative rate of 8.7 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 5.0%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above region-specific baseline levels. Twenty-one states experienced high ILI activity; New York City and five states experienced moderate ILI activity; eight states experienced low ILI activity; 14 states experienced minimal ILI activity; and the District of Columbia, Puerto Rico and two states had insufficient data.
  • Geographic Spread of Influenza:The geographic spread of influenza in 36 states was reported as widespread; Puerto Rico and 13 states reported regional activity; one state reported local activity; and the District of Columbia, the U.S. Virgin Islands, and Guam did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]50 of 54[/TD]
[TD]22.4%[/TD]
[TD]482[/TD]
[TD]5,169[/TD]
[TD]80[/TD]
[TD]50[/TD]
[TD]546[/TD]
[TD]235[/TD]
[TD]12[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]6.5%[/TD]
[TD]7[/TD]
[TD]129[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]6[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]8.7%[/TD]
[TD]4[/TD]
[TD]176[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]23[/TD]
[TD]5[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 3 [TD]Elevated[/TD]
[TD]4 of 6[/TD]
[TD]9.7%[/TD]
[TD]53[/TD]
[TD]313[/TD]
[TD]0[/TD]
[TD]0[/TD]
[TD]48[/TD]
[TD]12[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]13.7%[/TD]
[TD]121[/TD]
[TD]382[/TD]
[TD]9[/TD]
[TD]2[/TD]
[TD]41[/TD]
[TD]63[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]14.5%[/TD]
[TD]54[/TD]
[TD]1,074[/TD]
[TD]12[/TD]
[TD]6[/TD]
[TD]86[/TD]
[TD]19[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]22.8%[/TD]
[TD]105[/TD]
[TD]388[/TD]
[TD]8[/TD]
[TD]2[/TD]
[TD]34[/TD]
[TD]34[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]14.4%[/TD]
[TD]11[/TD]
[TD]341[/TD]
[TD]26[/TD]
[TD]0[/TD]
[TD]80[/TD]
[TD]4[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]14.4%[/TD]
[TD]15[/TD]
[TD]531[/TD]
[TD]3[/TD]
[TD]2[/TD]
[TD]58[/TD]
[TD]3[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]4 of 5[/TD]
[TD]23.7%[/TD]
[TD]83[/TD]
[TD]1,421[/TD]
[TD]18[/TD]
[TD]34[/TD]
[TD]105[/TD]
[TD]72[/TD]
[TD]4[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]24.9%[/TD]
[TD]29[/TD]
[TD]414[/TD]
[TD]1[/TD]
[TD]2[/TD]
[TD]65[/TD]
[TD]22[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 51 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]28,394[/TD]
[TD]261,076[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]6,373 (22.4%)[/TD]
[TD]21,123 (8.1%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]5,527 (86.7%)[/TD]
[TD]17,224 (81.5%)[/TD]
[/TR]
[TR]
Influenza B [TD]846 (13.3%)[/TD]
[TD]3,899 (18.5%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 51 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]1,684[/TD]
[TD]18,948[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]831[/TD]
[TD]6,562[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]740 (89.0%)[/TD]
[TD]5,731 (87.3%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]55 (7.4%)[/TD]
[TD]482 (8.4%)[/TD]
[/TR]
[TR]
H3N2 [TD]652 (88.1%)[/TD]
[TD]5,169 (90.2%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]33 (4.5%)[/TD]
[TD]80 (1.4%)[/TD]
[/TR]
[TR]
Influenza B [TD]91 (11.0%)[/TD]
[TD]831 (12.7%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]52 (57.1%)[/TD]
[TD]546 (65.7%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]3 (3.3%)[/TD]
[TD]50 (6.0%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]36 (39.6%)[/TD]
[TD]235 (28.3%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
View Interactive Application | View Full Screen
[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI)(i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.[/FONT]
[FONT=&quot]CDC has antigenically or genetically characterized 648 influenza viruses collected during October 1 – December 23, 2017, and submitted by U.S. laboratories, including 73 influenza A(H1N1)pdm09 viruses, 405 influenza A(H3N2) viruses, and 170 influenza B viruses.[/FONT]
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 73 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. Forty-one A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017–18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 405 A(H3N2) viruses revealed extensive genetic diversity with? multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=322), subclade 3C.2a1 (n=79) or clade 3C.3a (n=4). One hundred twenty seven influenza A(H3N2) viruses were antigenically characterized, and 126 (99.2%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of? 2017–18 Northern Hemisphere influenza vaccines.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria: Phylogenetic analysis of 17 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a small number of viruses identified in 2017 had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). Four (57.1%) B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017–18 Northern Hemisphere influenza vaccines.? Three (42.9%) B/Victoria lineage virus reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and these viruses had the V1A-2Del HA.
  • B/Yamagata: Phylogenetic analysis of 153 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 71 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017–18 Northern Hemisphere quadrivalent vaccines.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.[/FONT]
Genetic51_small.gif

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[h=2]Antiviral Resistance:[/h] [FONT=&quot]Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.[/FONT]
[FONT=&quot]High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.[/FONT]
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in"]
[TR]
[TD] [/TD]
Oseltamivir
Zanamivir
Peramivir
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD] 97
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 85
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 97
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD] 437
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 437
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 350
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[TR]
Influenza B
[TD] 118
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 118
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 118
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[/TABLE]
[FONT=&quot]On December 27, 2017, a Health Advisory was released by CDC providing: 1) a notice about increased influenza A(H3N2) activity and its clinical implications; 2) a summary of influenza antiviral drug treatment recommendations; 3) an update about approved treatment drugs and supply this season; and 4) background information for patients about influenza treatment. More information is available at https://emergency.cdc.gov/han/han00409.asp.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on December 28, 2017, 6.2% of the deaths occurring during the week ending December 9, 2017 (week 49) were due to P&I. This percentage is below the epidemic threshold of 6.8% for week 49.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS51_small.gif

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[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]Three influenza-associated pediatric deaths were reported to CDC during week 51. One death was associated with an influenza A virus for which no subtyping was performed and occurred during week 50 (the week ending December 16, 2017).? Two deaths were associated with an influenza B virus and occurred during week 51 (the week ending December 23, 2017).[/FONT]
[FONT=&quot]A total of 12 influenza-associated pediatric deaths have been reported for the 2017-2018 season.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

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[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).[/FONT]
[FONT=&quot]The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.[/FONT]
[FONT=&quot]Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.[/FONT]
[FONT=&quot]A total of 2,485 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and December 23, 2017. The overall hospitalization rate was 8.7 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (35.8 per 100,000 population), followed by adults aged 50-64 (9.4 per 100,000 population) and children aged 0-4 years (6.5 per 100,000 population). Among 2,485 hospitalizations, 2,224 (89.5%) were associated with influenza A virus, 244 (9.8%) with influenza B virus, 8 (0.3%) with influenza A virus and influenza B virus co-infection, and 9 (0.4%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 563 (87.4%) were A(H3N2) and 81 (12.6%) were A(H1N1)pdm09 virus./p>[/FONT]
[FONT=&quot]Among 475 hospitalized adults with information on underlying medical conditions, 425 (89.5%) had at least one reported underlying medical condition; the most commonly reported were metabolic disorder, cardiovascular disorder, obesity, and chronic lung disease. Among 63 hospitalized children with information on underlying medical conditions, 41 (65.1%) had at least one underlying medical condition; the most commonly reported were asthma, obesity, neurologic disorder, and cardiovascular disease. Among 46 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 14 (30.4%) were pregnant.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]
[FONT=&quot][/FONT]
[FONT=&quot][SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics’ (NCHS) population estimates for the counties included in the surveillance catchment area.[/SIZE][/FONT]
View Interactive Application | View Full Screen | View PowerPoint Presentation
[FONT=&quot][/FONT]
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseases include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications; Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation



[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 51, 5.0% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 1.4% to 11.9% during week 51. All 10 regions reported percentages of outpatient visits for ILI at or above their region specific baselines.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 51, the following ILI activity levels were experienced:[/FONT]
  • 21 states experienced high activity (Alabama, Arizona, Arkansas, California, Georgia, Illinois, Indiana, Kansas, Kentucky, Louisiana, Mississippi, Missouri, Nebraska, Nevada, New Mexico, Oklahoma, Oregon, South Carolina, Tennessee, Texas, and West Virginia).
  • New York City and five states experienced moderate ILI activity (Colorado, Hawaii, New York, North Dakota, and Virginia).
  • Eight states experienced low ILI activity (Alaska, Florida, Massachusetts, Minnesota, New Jersey, Pennsylvania, South Dakota, and Wyoming).
  • 14 states experienced minimal ILI activity (Delaware, Idaho, Iowa, Maine, Maryland, Michigan, Montana, New Hampshire, Ohio, Rhode Island, Utah, Vermont, Washington, and Wisconsin).
  • Data was insufficient to calculate an ILI activity level from the District of Columbia, Puerto Rico and two states (Connecticut and North Carolina).
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.[/FONT]
[FONT=&quot]During week 51, the following influenza activity was reported::[/FONT]
  • Widespread influenza activity was reported by 36 states (Alabama, Arizona, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Idaho, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Minnesota, Mississippi, Missouri, Montana, Nebraska, New Mexico, New York, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, South Dakota, Texas, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Regional influenza activity was reported by Puerto Rico and 13 states (Alaska, Hawaii, Iowa, Maine, Michigan, Nevada, New Hampshire, New Jersey, North Carolina, Rhode Island, Tennessee, Utah, and Vermont).
  • Local influenza activity was reported by one state (Delaware).
  • The District of Columbia, the U.S. Virgin Islands, and Guam did not report.
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]

[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]

[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]

[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]

[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]

[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]

[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]

[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]

[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]

[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]

[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.[/FONT]

https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week51.htm
 
[h=3]2017-2018 Influenza Season Week 52 ending December 30, 2017[/h] [FONT=&quot]All data are preliminary and may change as more reports are received.[/FONT]
[h=3]Synopsis:[/h] [FONT=&quot]During week 52 (December 24-30, 2017), influenza activity increased sharply in the United States.[/FONT]
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 52 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories increased.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was below the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: One influenza-associated pediatric death was reported.
  • Influenza-associated Hospitalizations: A cumulative rate of 13.7 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 5.8%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above region-specific baseline levels. New York City and 26 states experienced high ILI activity; Puerto Rico and nine states experienced moderate ILI activity; the District of Columbia and six states experienced low ILI activity; and nine states experienced minimal ILI activity.
  • Geographic Spread of Influenza:The geographic spread of influenza in 46 states was reported as widespread; four states reported regional activity; the District of Columbia reported local activity; and Guam, Puerto Rico, and the U.S. Virgin Islands did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[FONT=&quot] [TABLE="class: table table-bordered opt-in"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI[SUP]?[/SUP] Number of jurisdictions reporting regional or widespread activity[SUP]?[/SUP] % respiratory specimens positive for flu in clinical laboratories[SUP]?[/SUP] A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]50 of 54[/TD]
[TD]25.5%[/TD]
[TD]644[/TD]
[TD]7,012[/TD]
[TD]98[/TD]
[TD]76[/TD]
[TD]748[/TD]
[TD]315[/TD]
[TD]13[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]10.2%[/TD]
[TD]9[/TD]
[TD]189[/TD]
[TD]0[/TD]
[TD]2[/TD]
[TD]12[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]2 of 4[/TD]
[TD]11.9%[/TD]
[TD]5[/TD]
[TD]279[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]36[/TD]
[TD]5[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 3 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]16.4%[/TD]
[TD]91[/TD]
[TD]469[/TD]
[TD]0[/TD]
[TD]6[/TD]
[TD]85[/TD]
[TD]12[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]17.1%[/TD]
[TD]140[/TD]
[TD]511[/TD]
[TD]17[/TD]
[TD]2[/TD]
[TD]50[/TD]
[TD]74[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]20.7%[/TD]
[TD]93[/TD]
[TD]1,464[/TD]
[TD]14[/TD]
[TD]8[/TD]
[TD]113[/TD]
[TD]30[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]29.2%[/TD]
[TD]117[/TD]
[TD]466[/TD]
[TD]6[/TD]
[TD]2[/TD]
[TD]55[/TD]
[TD]42[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]18.3%[/TD]
[TD]16[/TD]
[TD]456[/TD]
[TD]24[/TD]
[TD]0[/TD]
[TD]100[/TD]
[TD]0[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]18.1%[/TD]
[TD]24[/TD]
[TD]677[/TD]
[TD]3[/TD]
[TD]2[/TD]
[TD]76[/TD]
[TD]3[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]4 of 5[/TD]
[TD]28.8%[/TD]
[TD]102[/TD]
[TD]2,059[/TD]
[TD]28[/TD]
[TD]52[/TD]
[TD]153[/TD]
[TD]117[/TD]
[TD]4[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]30.7%[/TD]
[TD]47[/TD]
[TD]442[/TD]
[TD]3[/TD]
[TD]2[/TD]
[TD]68[/TD]
[TD]31[/TD]
[TD]0[/TD]
[/TR]
[/TABLE]
[/FONT]
[FONT=&quot]*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
§ Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks

[/FONT]

[h=2]U.S. Virologic Surveillance:[/h] [FONT=&quot]WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.[/FONT]
[FONT=&quot]Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.[/FONT]
[FONT=&quot]The results of tests performed by clinical laboratories are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD="width: 200"] [/TD]
Week 52 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]36,226[/TD]
[TD]311,593[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]9,228 (25.5%)[/TD]
[TD]32,826 (10.5%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]7,818 (84.6%)[/TD]
[TD]27,241 (83.0%)[/TD]
[/TR]
[TR]
Influenza B [TD]1,410 (13.3%)[/TD]
[TD]5,585 (17.0%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.[/FONT]
[TABLE="class: table table-bordered table-condensed opt-in"]
[TR]
[TD] [/TD]
Week 52 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]1,801[/TD]
[TD]22,827[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]923[/TD]
[TD]8,893[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]784 (84.9%)[/TD]
[TD]7,754 (87.2%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]60 (7.7%)[/TD]
[TD]644 (8.3%)[/TD]
[/TR]
[TR]
H3N2 [TD]682 (87.0%)[/TD]
[TD]7,012 (90.4%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]42 (5.4%)[/TD]
[TD]98 (1.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]139 (15.1%)[/TD]
[TD]1,139 (12.8%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]81 (58.3%)[/TD]
[TD]748 (65.7%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]9 (6.5%)[/TD]
[TD]76 (6.7%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]49 (35.3%)[/TD]
[TD]315 (27.7%)[/TD]
[/TR]
[/TABLE]
[FONT=&quot]*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.
[/FONT]


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[h=2]Influenza Virus Characterization:[/h] [FONT=&quot]Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI)(i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.[/FONT]
[FONT=&quot]For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.[/FONT]
[FONT=&quot]CDC has antigenically or genetically characterized 686 influenza viruses collected during October 1 – December 30, 2017, and submitted by U.S. laboratories, including 100 influenza A(H1N1)pdm09 viruses, 410 influenza A(H3N2) viruses, and 176 influenza B viruses.[/FONT]
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 100 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. Sixty-seven A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017–18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 410 A(H3N2) viruses revealed extensive genetic diversity with multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=326), subclade 3C.2a1 (n=80) or clade 3C.3a (n=4). One hundred sixty one influenza A(H3N2) viruses were antigenically characterized, and 159 (99.2%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of 2017–18 Northern Hemisphere influenza vaccines.
[FONT=&quot]Influenza B Viruses[/FONT]
  • B/Victoria: Phylogenetic analysis of 20 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a small number of viruses identified in 2017 had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). Four (57.1%) B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017–18 Northern Hemisphere influenza vaccines. Three (42.9%) B/Victoria lineage viruses reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and these viruses had the V1A-2Del HA.
  • B/Yamagata: Phylogenetic analysis of 156 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 71 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017–18 Northern Hemisphere quadrivalent vaccines.
[FONT=&quot] [/FONT]
[FONT=&quot]The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmap considerations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.[/FONT]
Genetic52_small.gif

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[h=2]Antiviral Resistance:[/h] [FONT=&quot]Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.[/FONT]
[FONT=&quot]High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.[/FONT]
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in"]
[TR]
[TD] [/TD]
Oseltamivir
Zanamivir
Peramivir
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
Virus Samples tested (n)
Resistant Viruses, Number (%)
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD] 111
[/TD]
[TD] 1 (0.9)
[/TD]
[TD] 99
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 111
[/TD]
[TD] 1 (0.9)
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD] 462
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 462
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 375
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[TR]
Influenza B
[TD] 127
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 127
[/TD]
[TD] 0 (0.0)
[/TD]
[TD] 127
[/TD]
[TD] 0 (0.0)
[/TD]
[/TR]
[/TABLE]
[FONT=&quot]On December 27, 2017, a Health Advisory was released by CDC providing: 1) a notice about increased influenza A(H3N2) activity and its clinical implications; 2) a summary of influenza antiviral drug treatment recommendations; 3) an update about approved treatment drugs and supply this season; and 4) background information for patients about influenza treatment. More information is available at https://emergency.cdc.gov/han/han00409.asp.[/FONT]
[FONT=&quot]The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.[/FONT]


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] [FONT=&quot]Based on National Center for Health Statistics (NCHS) mortality surveillance data available on January 4, 2018, 6.7% of the deaths occurring during the week ending December 16, 2017 (week 50) were due to P&I. This percentage is below the epidemic threshold of 6.9% for week 50.[/FONT]
[FONT=&quot]Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.[/FONT]
[FONT=&quot]Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.[/FONT]
NCHS52_small.gif

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[h=2]Influenza-Associated Pediatric Mortality:[/h] [FONT=&quot]One influenza-associated pediatric death was reported to CDC during week 52. This death was associated with an influenza A virus for which no subtyping was performed and occurred during week 52 (the week ending December 30, 2017).[/FONT]
[FONT=&quot]A total of 13 influenza-associated pediatric deaths have been reported for the 2017-2018 season.[/FONT]
[FONT=&quot]Additional data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]

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[h=2]Influenza-Associated Hospitalizations:[/h] [FONT=&quot]The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).[/FONT]
[FONT=&quot]The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.[/FONT]
[FONT=&quot]Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.[/FONT]
[FONT=&quot]A total of 3,927 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and December 30, 2017. The overall hospitalization rate was 13.7 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (56.6 per 100,000 population), followed by adults aged 50-64 (15.4 per 100,000 population) and children aged 0-4 years (9.9 per 100,000 population). Among 3,927 hospitalizations, 3,538 (90.1%) were associated with influenza A virus, 363 (9.2%) with influenza B virus, 12 (0.3%) with influenza A virus and influenza B virus co-infection, and 14 (0.4%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 829 (85.9%) were A(H3N2) and 136 (14.1%) were A(H1N1)pdm09 virus.[/FONT]
[FONT=&quot]Among 631 hospitalized adults with information on underlying medical conditions, 547 (86.7%) had at least one reported underlying medical condition; the most commonly reported were cardiovascular disease, metabolic disorder, obesity, and chronic lung disease. Among 71 hospitalized children with information on underlying medical conditions, 44 (62.0%) had at least one underlying medical condition; the most commonly reported were asthma, obesity, neurologic disorder, and cardiovascular disease. Among 56 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 22 (39.3%) were pregnant.[/FONT]
[FONT=&quot]Additional FluSurv-NET data can be found at: [/FONT]http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html[FONT=&quot] and [/FONT]http://gis.cdc.gov/grasp/fluview/FluHospChars.html[FONT=&quot].[/FONT] [FONT=&quot] [/FONT]
[FONT=&quot][/FONT]
[FONT=&quot][SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics’ (NCHS) population estimates for the counties included in the surveillance catchment area.[/SIZE][/FONT]
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[FONT=&quot][/FONT]
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseases include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications; Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
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[h=2]Outpatient Illness Surveillance:[/h] [FONT=&quot]Nationwide during week 52, 5.8% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%. (ILI is defined as fever (temperature of 100°F [37.8°C] or greater) and cough and/or sore throat.)[/FONT]
[FONT=&quot] [/FONT]
[FONT=&quot]Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.[/FONT]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
[FONT=&quot]On a regional level, the percentage of outpatient visits for ILI ranged from 2.4% to 11.3% during week 52. All 10 regions reported percentages of outpatient visits for ILI at or above their region specific baselines.[/FONT]
[FONT=&quot]

[/FONT]

[h=2]ILINet State Activity Indicator Map:[/h] [FONT=&quot]Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.[/FONT]
[FONT=&quot]During week 52, the following ILI activity levels were experienced:[/FONT]
  • New York City and 26 states experienced high activity (Alabama, Arizona, Arkansas, California, Georgia, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maryland, Michigan, Mississippi, Missouri, Nebraska, Nevada, New Jersey, New Mexico, Ohio, Oklahoma, Oregon, South Carolina, Texas, Virginia, Washington, and West Virginia).
  • Puerto Rico and nine states experienced moderate ILI activity (Alaska, Colorado, Hawaii, Iowa, Massachusetts, North Carolina, Pennsylvania, Tennessee, and Wyoming).
  • The District of Columbia and six states experienced low ILI activity (Florida, Minnesota, New York, South Dakota, Utah, and Wisconsin).
  • Nine states experienced minimal ILI activity (Connecticut, Delaware, Idaho, Maine, Montana, New Hampshire, North Dakota, Rhode Island, and Vermont).
[FONT=&quot][/FONT]
[FONT=&quot]Click on map to launch interactive tool[/FONT]
[FONT=&quot]*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.[/FONT]



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] [FONT=&quot]The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.[/FONT]
[FONT=&quot]Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.[/FONT]
[FONT=&quot]During week 52, the following influenza activity was reported::[/FONT]
  • Widespread influenza activity was reported by 46 states (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Regional influenza activity was reported by four states (Hawaii, Maine, New Hampshire, and New Jersey).
  • Local influenza activity was reported by the District of Columbia.
  • Guam, Puerto Rico, and the U.S. Virgin Islands did not report.
[FONT=&quot][/FONT]

[FONT=&quot] [/FONT]
[h=2]Additional National and International Influenza Surveillance Information[/h] [FONT=&quot]FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.[/FONT]
[FONT=&quot]U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.[/FONT]
[FONT=&quot] [/FONT]

[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]

[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]

[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]

[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]

[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]

[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]

[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]

[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]

[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]

[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]

[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]

[FONT=&quot]World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.[/FONT]
[FONT=&quot]WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).[/FONT]
[FONT=&quot]Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.[/FONT]
[FONT=&quot]Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/[/FONT]
[FONT=&quot]Public Health England: The most up-to-date influenza information from the United Kingdom is available at https://www.gov.uk/government/statistics/weekly-national-flu-reports[/FONT]
[FONT=&quot] [/FONT]

[FONT=&quot] [/FONT]
Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links. [FONT=&quot] [/FONT]
[FONT=&quot]An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.[/FONT]

https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week52.htm
 
[h=3]2017-2018 Influenza Season Week 1 ending January 6, 2018[/h] All data are preliminary and may change as more reports are received.
[h=3]Synopsis:[/h] During week 1 (December 31, 2017-January 6, 2018), influenza activity increased in the United States.
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 1 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories remained elevated.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was at the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: Seven influenza-associated pediatric deaths were reported.
  • Influenza-associated Hospitalizations: A cumulative rate of 22.7 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 5.8%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above region-specific baseline levels. New York City and 26 states experienced high ILI activity; Puerto Rico and 10 states experienced moderate ILI activity; the District of Columbia and six states experienced low ILI activity; and eight states experienced minimal ILI activity.
  • Geographic Spread of Influenza:The geographic spread of influenza in 49 states was reported as widespread; Guam and one state reported regional activity; the District of Columbia reported local activity; the U.S. Virgin Islands reported sporadic activity; and Puerto Rico did not report.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI? Number of jurisdictions reporting regional or widespread activity? % respiratory specimens positive for flu in clinical laboratories? A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]51 of 54[/TD]
[TD]24.7%[/TD]
[TD]957[/TD]
[TD]9,773[/TD]
[TD]142[/TD]
[TD]102[/TD]
[TD]1,036[/TD]
[TD]462[/TD]
[TD]20[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]13.3%[/TD]
[TD]19[/TD]
[TD]295[/TD]
[TD]1[/TD]
[TD]2[/TD]
[TD]25[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]2 of 4[/TD]
[TD]15.9%[/TD]
[TD]23[/TD]
[TD]336[/TD]
[TD]3[/TD]
[TD]0[/TD]
[TD]38[/TD]
[TD]8[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 3 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]19.5%[/TD]
[TD]179[/TD]
[TD]777[/TD]
[TD]8[/TD]
[TD]10[/TD]
[TD]115[/TD]
[TD]21[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]20.2%[/TD]
[TD]176[/TD]
[TD]637[/TD]
[TD]20[/TD]
[TD]2[/TD]
[TD]66[/TD]
[TD]83[/TD]
[TD]6[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]24.7%[/TD]
[TD]140[/TD]
[TD]2,241[/TD]
[TD]24[/TD]
[TD]15[/TD]
[TD]160[/TD]
[TD]39[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]29.5%[/TD]
[TD]132[/TD]
[TD]563[/TD]
[TD]14[/TD]
[TD]2[/TD]
[TD]76[/TD]
[TD]49[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]22.4%[/TD]
[TD]17[/TD]
[TD]540[/TD]
[TD]29[/TD]
[TD]0[/TD]
[TD]104[/TD]
[TD]18[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]21.7%[/TD]
[TD]36[/TD]
[TD]925[/TD]
[TD]5[/TD]
[TD]6[/TD]
[TD]117[/TD]
[TD]4[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]32.1%[/TD]
[TD]144[/TD]
[TD]2,855[/TD]
[TD]35[/TD]
[TD]63[/TD]
[TD]193[/TD]
[TD]174[/TD]
[TD]5[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]30.4%[/TD]
[TD]91[/TD]
[TD]604[/TD]
[TD]3[/TD]
[TD]2[/TD]
[TD]142[/TD]
[TD]65[/TD]
[TD]1[/TD]
[/TR]
[/TABLE]
*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
? Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks


[h=2]U.S. Virologic Surveillance:[/h] WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.
Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.
The results of tests performed by clinical laboratories are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD="width: 200"] [/TD]
Week 1 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]41,712[/TD]
[TD]371,863[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]10,320 (24.7%)[/TD]
[TD]47,689 (12.8%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]8,628 (83.6%)[/TD]
[TD]39,529 (82.9%)[/TD]
[/TR]
[TR]
Influenza B [TD]1,692 (16.4%)[/TD]
[TD]8,160 (17.1%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD] [/TD]
Week 1 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]2,401[/TD]
[TD]28,264[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]1,398[/TD]
[TD]12,472[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]1,202 (86.0%)[/TD]
[TD]10,872 (87.2%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]132 (11.0%)[/TD]
[TD]6957 (8.8%)[/TD]
[/TR]
[TR]
H3N2 [TD]1,021 (84.9%)[/TD]
[TD]9,773 (89.9%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]49 (4.1%)[/TD]
[TD]142 (1.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]196 (14.0%)[/TD]
[TD]1,600 (12.8%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]95 (48.5%)[/TD]
[TD]1,036 (64.8%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]8 (4.1%)[/TD]
[TD]102 (6.4%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]93 (47.4%)[/TD]
[TD]462 (28.9%)[/TD]
[/TR]
[/TABLE]
*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
View Interactive Application | View Full Screen [h=2]Influenza Virus Characterization:[/h] Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI) (i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.
For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.
CDC has antigenically or genetically characterized 836 influenza viruses collected during October 1, 2017 ? January 6, 2018, and submitted by U.S. laboratories, including 138 influenza A(H1N1)pdm09 viruses, 474 influenza A(H3N2) viruses, and 224 influenza B viruses.
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 138 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. Eighty-five A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017?18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 474 A(H3N2) viruses revealed extensive genetic diversity with multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=384), subclade 3C.2a1 (n=85) or clade 3C.3a (n=5). One hundred sixty two influenza A(H3N2) viruses were antigenically characterized, and 160 (98.8%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of 2017?18 Northern Hemisphere influenza vaccines.
Influenza B Viruses
  • B/Victoria: Phylogenetic analysis of 26 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a small number of viruses identified in 2017 had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). Fifteen (71.4%) B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017?18 Northern Hemisphere influenza vaccines. Six (28.6%) B/Victoria lineage viruses reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and these viruses had the V1A-2Del HA.
  • B/Yamagata: Phylogenetic analysis of 198 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 71 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017?18 Northern Hemisphere quadrivalent vaccines.
The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmapconsiderations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.
Genetic01_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation [h=2]Antiviral Resistance:[/h] Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.
High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0, width: 100%"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[TD] [/TD]
Oseltamivir​
Zanamivir​
Peramivir​
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD]
164​
[/TD]
[TD]
2 (1.2)​
[/TD]
[TD]
142​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
164​
[/TD]
[TD]
2 (1.2)​
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD]
555​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
555​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
555​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[TR]
Influenza B
[TD]
201​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
201​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
201​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[/TABLE]
On December 27, 2017, a Health Advisory was released by CDC providing: 1) a notice about increased influenza A(H3N2) activity and its clinical implications; 2) a summary of influenza antiviral drug treatment recommendations; 3) an update about approved treatment drugs and supply this season; and 4) background information for patients about influenza treatment. More information is available at https://emergency.cdc.gov/han/han00409.asp.
The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] Based on National Center for Health Statistics (NCHS) mortality surveillance data available on January 11, 2018, 7.0% of the deaths occurring during the week ending December 23, 2017 (week 51) were due to P&I. This percentage is at the epidemic threshold of 7.0% for week 51.
Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. There is a backlog of data requiring manual coding within NCHS mortality surveillance data. The percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records and may result in initially reported P&I percentages that are lower than percentages calculated from final data. Efforts continue to reduce and monitor the number of records awaiting manual coding.
Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.
NCHS01_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] Seven influenza-associated pediatric deaths were reported to CDC during week 1. One death was associated with an influenza A(H3) virus and occurred during week 1 (the week ending January 6, 2018). One death was associated with an influenza A(H1N1)pdm09 virus and occurred during week 1. Two deaths were associated with an influenza A virus for which no subtyping was performed and occurred during week 1. Three deaths were associated with an influenza B virus and occurred during weeks 50 and 51 (the weeks ending December 16 and December 23, 2017, respectively).
A total of 20 influenza-associated pediatric deaths have been reported for the 2017-2018 season.
Additional data can be found at: http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html.

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).
The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.
Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.
A total of 6,486 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and January 6, 2018. The overall hospitalization rate was 22.7 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (98.0 per 100,000 population), followed by adults aged 50-64 (24.0 per 100,000 population) and children aged 0-4 years (16.0 per 100,000 population). Among 6,486 hospitalizations, 5,836 (90.0%) were associated with influenza A virus, 610 (9.4%) with influenza B virus, 21 (0.3%) with influenza A virus and influenza B virus co-infection, and 19 (0.3%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 1,346 (85.5%) were A(H3N2) and 228 (14.5%) were A(H1N1)pdm09 virus.
Among 897 hospitalized adults with information on underlying medical conditions, 704 (78.5%) had at least one reported underlying medical condition; the most commonly reported were cardiovascular disease, metabolic disorder, obesity, and chronic lung disease. Among 101 hospitalized children with information on underlying medical conditions, 58 (57.4%) had at least one underlying medical condition; the most commonly reported were asthma, neurologic disorder, and obesity. Among 80 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 24 (30.0%) were pregnant.
Additional FluSurv-NET data can be found at: http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html and http://gis.cdc.gov/grasp/fluview/FluHospChars.html.
[SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics? (NCHS) population estimates for the counties included in the surveillance catchment area.

View Interactive Application | View Full Screen | View PowerPoint Presentation
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseases include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications;Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation



[h=2]Outpatient Illness Surveillance:[/h] Nationwide during week 1, 5.8% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%. (ILI is defined as fever (temperature of 100?F [37.8?C] or greater) and cough and/or sore throat.)

Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation On a regional level, the percentage of outpatient visits for ILI ranged from 2.7% to 11.2% during week 1. All 10 regions reported percentages of outpatient visits for ILI at or above their region specific baselines.



[h=2]ILINet State Activity Indicator Map:[/h] Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.
During week 1, the following ILI activity levels were experienced:
  • New York City and 26 states experienced high activity (Alabama, Arizona, Arkansas, California, Colorado, Georgia, Illinois, Indiana, Kansas, Kentucky, Louisiana, Mississippi, Missouri, Nebraska, Nevada, New Jersey, New Mexico, Ohio, Oklahoma, Oregon, South Carolina, Texas, Virginia, Washington, West Virginia, and Wyoming).
  • Puerto Rico and 10 states experienced moderate ILI activity (Idaho, Massachusetts, Michigan, New York, North Carolina, Pennsylvania, Rhode Island, South Dakota, Tennessee, and Wisconsin).
  • The District of Columbia and six states experienced low ILI activity (Alaska, Hawaii, Iowa, Maryland, Minnesota, and Vermont).
  • Eight states experienced minimal ILI activity (Connecticut, Delaware, Florida, Maine, Montana, New Hampshire, North Dakota, and Utah).
Click on map to launch interactive tool
*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.


[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
During week 1, the following influenza activity was reported::
  • Widespread influenza activity was reported by 49 states (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Regional influenza activity was reported by Guam and one state (Hawaii).
  • Local influenza activity was reported by the District of Columbia.
  • Sporadic activity was reported by the U.S. Virgin Islands.
  • Puerto Rico did not report.

[h=2]Additional National and International Influenza Surveillance Information[/h] FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.
U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.

[TABLE="width: 100%"]
[TR]
[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]
[/TR]
[TR]
[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]
[/TR]
[TR]
[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]
[/TR]
[TR]
[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]
[/TR]
[TR]
[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]
[/TR]
[TR]
[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]
[/TR]
[TR]
[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]
[/TR]
[TR]
[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]
[/TR]
[TR]
[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]
[/TR]
[TR]
[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]
[/TR]
[TR]
[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]
[/TR]
[/TABLE]
World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.
WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).
Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.
Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/
Public Health England: The most up-to-date influenza information from the United Kingdom is available athttps://www.gov.uk/government/statistics/weekly-national-flu-reports


Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links.
An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.
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[h=5]File Formats Help:[/h] How do I view different file formats (PDF, DOC, PPT, MPEG) on this site?

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https://www.cdc.gov/flu/weekly/index.htm
 
[h=3]2017-2018 Influenza Season Week 2 ending January 13, 2018[/h] All data are preliminary and may change as more reports are received.
[h=3]Synopsis:[/h] During week 2 (January 7-13, 2018), influenza activity increased in the United States.
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 2 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories increased.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was above the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: Ten influenza-associated pediatric deaths were reported
  • Influenza-associated Hospitalizations: A cumulative rate of 31.5 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 6.3%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above region-specific baseline levels. New York City, Puerto Rico, and 32 states experienced high ILI activity; 9 states experienced moderate ILI activity; the District of Columbia and six states experienced low ILI activity; and three states experienced minimal ILI activity.
  • Geographic Spread of Influenza:The geographic spread of influenza in Puerto Rico and 49 states was reported as widespread; Guam reported regional activity; the District of Columbia and one state reported local activity; and the U.S. Virgin Islands reported sporadic activity.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI? Number of jurisdictions reporting regional or widespread activity? % respiratory specimens positive for flu in clinical laboratories? A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]51 of 54[/TD]
[TD]25.6%[/TD]
[TD]1,219[/TD]
[TD]12,489[/TD]
[TD]219[/TD]
[TD]123[/TD]
[TD]1,366[/TD]
[TD]620[/TD]
[TD]30[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]16.9%[/TD]
[TD]32[/TD]
[TD]475[/TD]
[TD]1[/TD]
[TD]3[/TD]
[TD]49[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]19.3%[/TD]
[TD]42[/TD]
[TD]528[/TD]
[TD]4[/TD]
[TD]0[/TD]
[TD]47[/TD]
[TD]43[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 3 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]23.1%[/TD]
[TD]216[/TD]
[TD]959[/TD]
[TD]1[/TD]
[TD]11[/TD]
[TD]175[/TD]
[TD]31[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]22.4%[/TD]
[TD]213[/TD]
[TD]798[/TD]
[TD]45[/TD]
[TD]3[/TD]
[TD]86[/TD]
[TD]94[/TD]
[TD]6[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]26.5%[/TD]
[TD]176[/TD]
[TD]2,805[/TD]
[TD]25[/TD]
[TD]17[/TD]
[TD]204[/TD]
[TD]47[/TD]
[TD]5[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]28.7%[/TD]
[TD]181[/TD]
[TD]679[/TD]
[TD]16[/TD]
[TD]2[/TD]
[TD]106[/TD]
[TD]73[/TD]
[TD]6[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]25.0%[/TD]
[TD]17[/TD]
[TD]621[/TD]
[TD]26[/TD]
[TD]0[/TD]
[TD]134[/TD]
[TD]2[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]23.5%[/TD]
[TD]52[/TD]
[TD]1,117[/TD]
[TD]13[/TD]
[TD]7[/TD]
[TD]165[/TD]
[TD]7[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]4 of 5[/TD]
[TD]30.3%[/TD]
[TD]178[/TD]
[TD]3,787[/TD]
[TD]79[/TD]
[TD]75[/TD]
[TD]240[/TD]
[TD]227[/TD]
[TD]8[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]29.7%[/TD]
[TD]112[/TD]
[TD]720[/TD]
[TD]9[/TD]
[TD]5[/TD]
[TD]160[/TD]
[TD]95[/TD]
[TD]2[/TD]
[/TR]
[/TABLE]
*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
? Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks


[h=2]U.S. Virologic Surveillance:[/h] WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.
Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.
The results of tests performed by clinical laboratories are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD="width: 200"] [/TD]
Week 2 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]50,435[/TD]
[TD]446,698[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]12,894 (25.6%)[/TD]
[TD]65,735 (14.7%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]10,622 (82.4%)[/TD]
[TD]54,430 (82.8%)[/TD]
[/TR]
[TR]
Influenza B [TD]2,272 (17.6%)[/TD]
[TD]11,305 (17.2%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD] [/TD]
Week 1 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]2,242[/TD]
[TD]33,651[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]1,507[/TD]
[TD]16,036[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]1,319 (87.5%)[/TD]
[TD]13,927 (86.8%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]118 (8.9%)[/TD]
[TD]1,219 (8.8%)[/TD]
[/TR]
[TR]
H3N2 [TD]1,111 (84.2%)[/TD]
[TD]12,489 (89.7%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]90 (6.8%)[/TD]
[TD]219 (1.6%)[/TD]
[/TR]
[TR]
Influenza B [TD]188 (12.5%)[/TD]
[TD]2,109 (13.2%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]112 (59.6%)[/TD]
[TD]1,366 (64.8%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]11 (5.9%)[/TD]
[TD]123 (5.8%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]65 (34.6%)[/TD]
[TD]620 (29.4%)[/TD]
[/TR]
[/TABLE]
*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
View Interactive Application | View Full Screen [h=2]Influenza Virus Characterization:[/h] Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI) (i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.
For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.
CDC has antigenically or genetically characterized 893 influenza viruses collected during October 1, 2017 ? January 13, 2018, and submitted by U.S. laboratories, including 146 influenza A(H1N1)pdm09 viruses, 498 influenza A(H3N2) viruses, and 249 influenza B viruses.
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 146 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. Eighty-five A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017?18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 498 A(H3N2) viruses revealed extensive genetic diversity with multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=406), subclade 3C.2a1 (n=87) or clade 3C.3a (n=5). One hundred ninety two influenza A(H3N2) viruses were antigenically characterized, and 189 (98.4%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of 2017?18 Northern Hemisphere influenza vaccines.
Influenza B Viruses
  • B/Victoria: Phylogenetic analysis of 35 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a small number of viruses had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). Fifteen (71.4%) B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017?18 Northern Hemisphere influenza vaccines. Six (28.6%) B/Victoria lineage viruses reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and these viruses had the V1A-2Del HA.
  • B/Yamagata: Phylogenetic analysis of 214 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 152 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017?18 Northern Hemisphere quadrivalent vaccines.
The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmapconsiderations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.
Genetic02_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation [h=2]Antiviral Resistance:[/h] Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.
High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0, width: 100%"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[TD] [/TD]
Oseltamivir​
Zanamivir​
Peramivir​
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD]
168​
[/TD]
[TD]
2 (1.2)​
[/TD]
[TD]
146​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
168​
[/TD]
[TD]
2 (1.2)​
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD]
587​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
587​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
456​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[TR]
Influenza B
[TD]
209​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
209​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
209​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[/TABLE]
On December 27, 2017, a Health Advisory was released by CDC providing: 1) a notice about increased influenza A(H3N2) activity and its clinical implications; 2) a summary of influenza antiviral drug treatment recommendations; 3) an update about approved treatment drugs and supply this season; and 4) background information for patients about influenza treatment. More information is available at https://emergency.cdc.gov/han/han00409.asp.
The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] Based on National Center for Health Statistics (NCHS) mortality surveillance data available on January 18, 2018, 8.2% of the deaths occurring during the week ending December 30, 2017 (week 52) were due to P&I. This percentage is above the epidemic threshold of 7.1% for week 52.
Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. Percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records. Due to the additional time needed for manual coding, the initially reported P&I percentages may be lower than percentages calculated from final data. Previous longer backlogs in manual coding have been resolved and death records are now coded within 10 days from receipt of a death record by NCHS.
Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.
NCHS02_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] Ten influenza-associated pediatric deaths were reported to CDC during week 2. Four deaths were associated with an influenza A(H1N1)pdm09 virus and occurred during weeks 51, 1 and 2 (the weeks ending December 23, 2017, January 6, 2018, and January 13, 2018, respectively). Three deaths were associated with an influenza A virus for which no subtyping was performed and occurred during weeks 44, 46, and 52 (the weeks ending November 4, 2017, November 18, 2017, and December 30, 2017, respectively). Three deaths were associated with an influenza B virus and occurred during weeks 52, 1, and 2 (the weeks ending December 30, 2017, January 6, 2018, and January 13, 2018, respectively).
A total of 30 influenza-associated pediatric deaths have been reported for the 2017-2018 season.
Additional data can be found at: http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html.

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).
The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.
Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.
A total of 8,990 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and January 13, 2018. The overall hospitalization rate was 31.5 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (136.5 per 100,000 population), followed by adults aged 50-64 (33.2 per 100,000 population) and children aged 0-4 years (22.8 per 100,000 population). Among 8,990 hospitalizations, 8,037 (89.4%) were associated with influenza A virus, 908 (10.1%) with influenza B virus, 25 (0.3%) with influenza A virus and influenza B virus co-infection, and 20 (0.2%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 1,866 (85.8%) were A(H3N2) and 310 (14.2%) were A(H1N1)pdm09 virus.
Among 1,154 hospitalized adults with information on underlying medical conditions, 861 (74.6%) had at least one reported underlying medical condition; the most commonly reported were cardiovascular disease, metabolic disorder, obesity, and chronic lung disease. Among 129 hospitalized children with information on underlying medical conditions, 75 (58.1%) had at least one underlying medical condition; the most commonly reported were asthma, neurologic disorder, obesity, and cardiovascular disease. Among 92 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 25 (27.2%) were pregnant.
Additional FluSurv-NET data can be found at: http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html and http://gis.cdc.gov/grasp/fluview/FluHospChars.html.
[SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics? (NCHS) population estimates for the counties included in the surveillance catchment area.

View Interactive Application | View Full Screen | View PowerPoint Presentation
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseases include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications;Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation



[h=2]Outpatient Illness Surveillance:[/h] Nationwide during week 2, 6.3% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%. (ILI is defined as fever (temperature of 100?F [37.8?C] or greater) and cough and/or sore throat.)

Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation On a regional level, the percentage of outpatient visits for ILI ranged from 2.7% to 12.6% during week 2. All 10 regions reported percentages of outpatient visits for ILI at or above their region specific baselines.



[h=2]ILINet State Activity Indicator Map:[/h] Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.
During week 2, the following ILI activity levels were experienced:
  • New York City, Puerto Rico, and 32 states experienced high activity (Alabama, Arizona, Arkansas, California, Florida, Georgia, Hawaii, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maryland, Mississippi, Missouri, Nebraska, Nevada, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, South Carolina, South Dakota, Tennessee, Texas, Virginia, West Virginia, Wisconsin, and Wyoming).
  • Nine states experienced moderate ILI activity (Alaska, Colorado, Idaho, Iowa, Massachusetts, Minnesota, North Dakota, Pennsylvania, and Rhode Island).
  • The District of Columbia and six states experienced low ILI activity (Connecticut, Michigan, New Hampshire, Utah, Vermont, and Washington).
  • Three states experienced minimal ILI activity (Delaware, Maine, and Montana).
Click on map to launch interactive tool
*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.


[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
During week 2, the following influenza activity was reported::
  • Widespread influenza activity was reported by Puerto Rico and 49 states (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Regional influenza activity was reported by Guam.
  • Local influenza activity was reported by the District of Columbia and one state (Hawaii).
  • Sporadic activity was reported by the U.S. Virgin Islands.

[h=2]Additional National and International Influenza Surveillance Information[/h] FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.
U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.

[TABLE="width: 100%"]
[TR]
[TD="width: 139"] Alabama
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[TD="width: 139"] Alaska
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[TD="width: 139"] Arizona
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[TD="width: 139"] Arkansas
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[TD="width: 139"] California
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[TR]
[TD="width: 139"] Colorado
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[TD="width: 139"] Connecticut
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[TD="width: 139"] Delaware
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[TD="width: 139"] District of Columbia
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[TD="width: 139"] Florida
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[TD="width: 139"] Georgia
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[TD="width: 139"] Hawaii
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[TD="width: 139"] Idaho
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[TD="width: 139"] Illinois
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[TD="width: 139"] Indiana
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[TR]
[TD="width: 139"] Iowa
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[TD="width: 139"] Kansas
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[TD="width: 139"] Kentucky
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[TD="width: 139"] Louisiana
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[TD="width: 139"] Maine
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[/TR]
[TR]
[TD="width: 139"] Maryland
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[TD="width: 139"] Massachusetts
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[TD="width: 139"] Michigan
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[TD="width: 139"] Minnesota
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[TD="width: 139"] Mississippi
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[/TR]
[TR]
[TD="width: 139"] Missouri
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[TD="width: 139"] Montana
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[TD="width: 139"] Nebraska
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[TD="width: 139"] Nevada
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[TD="width: 139"] New Hampshire
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[TR]
[TD="width: 139"] New Jersey
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[TD="width: 139"] New Mexico
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[TD="width: 139"] New York
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[TD="width: 139"] North Carolina
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[TD="width: 139"] North Dakota
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[TD="width: 139"] Ohio
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[TD="width: 139"] Oklahoma
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[TD="width: 139"] Oregon
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[TD="width: 139"] Pennsylvania
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[TD="width: 139"] Rhode Island
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[TD="width: 139"] South Carolina
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[TD="width: 139"] South Dakota
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[TD="width: 139"] Tennessee
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[TD="width: 139"] Texas
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[TD="width: 139"] Utah
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[TD="width: 139"] Vermont
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[TD="width: 139"] Virginia
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[TD="width: 139"] Washington
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[TD="width: 139"] West Virginia
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[TD="width: 139"] Wisconsin
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[TD="width: 139"] Wyoming
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[TD="width: 139"] New York City
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[TD="width: 139"] Puerto Rico
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[TD="width: 139"] Virgin Islands
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[TD="width: 139"] [/TD]
[/TR]
[/TABLE]
World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.
WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).
Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.
Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/
Public Health England: The most up-to-date influenza information from the United Kingdom is available athttps://www.gov.uk/government/statistics/weekly-national-flu-reports


Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links.
An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.
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[h=5]File Formats Help:[/h] How do I view different file formats (PDF, DOC, PPT, MPEG) on this site?

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https://www.cdc.gov/flu/weekly/index.htm
 
Since Week 1, the MMWRs do not contain the table of notifiable diseases, which lists the number of pediatric influenza deaths in each state. I cannot find this information elsewhere. If anyone can locate the tables for Weeks 1 and 2, please post a link here.
 
[h=3]2017-2018 Influenza Season Week 3 ending January 20, 2018[/h] All data are preliminary and may change as more reports are received.
[h=3]Synopsis:[/h] During week 3 (January 14-20, 2018), influenza activity increased in the United States.
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 3 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories slightly increased.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was above the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: Seven influenza-associated pediatric deaths were reported.
  • Influenza-associated Hospitalizations: A cumulative rate of 41.9 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 6.6%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above region-specific baseline levels. New York City, Puerto Rico, and 39 states experienced high ILI activity; the District of Columbia and five states experienced moderate ILI activity; three states experienced low ILI activity; and three states experienced minimal ILI activity.
  • Geographic Spread of Influenza:The geographic spread of influenza in Puerto Rico and 49 states was reported as widespread; Guam reported regional activity; the District of Columbia and one state reported local activity; and the U.S. Virgin Islands reported sporadic activity.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI? Number of jurisdictions reporting regional or widespread activity? % respiratory specimens positive for flu in clinical laboratories? A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]51 of 54[/TD]
[TD]26.7%[/TD]
[TD]1,530[/TD]
[TD]15,376[/TD]
[TD]299[/TD]
[TD]184[/TD]
[TD]1,750[/TD]
[TD]730[/TD]
[TD]37[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]20.2%[/TD]
[TD]54[/TD]
[TD]657[/TD]
[TD]2[/TD]
[TD]4[/TD]
[TD]85[/TD]
[TD]1[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]20.7%[/TD]
[TD]58[/TD]
[TD]625[/TD]
[TD]5[/TD]
[TD]1[/TD]
[TD]68[/TD]
[TD]46[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 3 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]23.2%[/TD]
[TD]297[/TD]
[TD]1,351[/TD]
[TD]2[/TD]
[TD]20[/TD]
[TD]244[/TD]
[TD]15[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]25.2%[/TD]
[TD]259[/TD]
[TD]1,076[/TD]
[TD]63[/TD]
[TD]4[/TD]
[TD]95[/TD]
[TD]124[/TD]
[TD]7[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]27.5%[/TD]
[TD]217[/TD]
[TD]3,354[/TD]
[TD]34[/TD]
[TD]21[/TD]
[TD]245[/TD]
[TD]47[/TD]
[TD]5[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]30.5%[/TD]
[TD]190[/TD]
[TD]755[/TD]
[TD]16[/TD]
[TD]2[/TD]
[TD]117[/TD]
[TD]78[/TD]
[TD]7[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]24.8%[/TD]
[TD]27[/TD]
[TD]763[/TD]
[TD]19[/TD]
[TD]0[/TD]
[TD]169[/TD]
[TD]5[/TD]
[TD]0[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]22.3%[/TD]
[TD]74[/TD]
[TD]1,405[/TD]
[TD]14[/TD]
[TD]10[/TD]
[TD]211[/TD]
[TD]8[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]4 of 5[/TD]
[TD]23.9%[/TD]
[TD]228[/TD]
[TD]4,550[/TD]
[TD]130[/TD]
[TD]117[/TD]
[TD]322[/TD]
[TD]296[/TD]
[TD]12[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]27.5%[/TD]
[TD]126[/TD]
[TD]840[/TD]
[TD]14[/TD]
[TD]5[/TD]
[TD]194[/TD]
[TD]110[/TD]
[TD]2[/TD]
[/TR]
[/TABLE]
*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
? Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks


[h=2]U.S. Virologic Surveillance:[/h] WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.
Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.
The results of tests performed by clinical laboratories are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD="width: 200"] [/TD]
Week 3 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]50,276[/TD]
[TD]513,252[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]13,421 (26.7%)[/TD]
[TD]83,450 (16.3%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]10,536 (78.5%)[/TD]
[TD]68,517 (82.1%)[/TD]
[/TR]
[TR]
Influenza B [TD]2,885 (21.5%)[/TD]
[TD]14,933 (17.9%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD] [/TD]
Week 3 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]2,209[/TD]
[TD]39,400[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]1,349[/TD]
[TD]19,869[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]1,136 (84.2%)[/TD]
[TD]17,205 (86.6%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]144 (12.7%)[/TD]
[TD]1,530 (8.9%)[/TD]
[/TR]
[TR]
H3N2 [TD]914 (80.5%)[/TD]
[TD]15,376 (89.4%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]78 (6.9%)[/TD]
[TD]299 (1.7%)[/TD]
[/TR]
[TR]
Influenza B [TD]213 (15.8%)[/TD]
[TD]2,664 (13.2%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]127 (59.6%)[/TD]
[TD]1,750 (65.7%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]8 (3.8%)[/TD]
[TD]184 (6.9%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]78 (36.6%)[/TD]
[TD]730 (27.4%)[/TD]
[/TR]
[/TABLE]
*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
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[h=2]Influenza Virus Characterization:[/h] Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI) (i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.
For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.
CDC has antigenically or genetically characterized 1,041 influenza viruses collected during October 1, 2017 ? January 20, 2018, and submitted by U.S. laboratories, including 181 influenza A(H1N1)pdm09 viruses, 561 influenza A(H3N2) viruses, and 299 influenza B viruses.
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 181 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. Eighty-five A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017?18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 561 A(H3N2) viruses revealed extensive genetic diversity with multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=461), subclade 3C.2a1 (n=93) or clade 3C.3a (n=7). One hundred ninety four influenza A(H3N2) viruses were antigenically characterized, and 191 (98.5%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of 2017?18 Northern Hemisphere influenza vaccines.
Influenza B Viruses
  • B/Victoria: Phylogenetic analysis of 43 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a small number of viruses had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). Sixteen (59.3%) B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017?18 Northern Hemisphere influenza vaccines. Eleven (40.7%) B/Victoria lineage viruses reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and these viruses had the V1A-2Del HA.
  • B/Yamagata: Phylogenetic analysis of 256 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 152 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017?18 Northern Hemisphere quadrivalent vaccines.

The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmapconsiderations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.
Genetic03_small.gif

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[h=2]Antiviral Resistance:[/h] Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.
High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0, width: 100%"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[TD] [/TD]
Oseltamivir​
Zanamivir​
Peramivir​
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD]
181​
[/TD]
[TD]
2 (1.1)​
[/TD]
[TD]
147​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
181​
[/TD]
[TD]
2 (1.1)​
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD]
645​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
645​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
474​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[TR]
Influenza B
[TD]
229​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
229​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
229​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[/TABLE]
On December 27, 2017, a Health Advisory was released by CDC providing: 1) a notice about increased influenza A(H3N2) activity and its clinical implications; 2) a summary of influenza antiviral drug treatment recommendations; 3) an update about approved treatment drugs and supply this season; and 4) background information for patients about influenza treatment. More information is available at https://emergency.cdc.gov/han/han00409.asp.
The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] Based on National Center for Health Statistics (NCHS) mortality surveillance data available on January 25, 2018, 9.1% of the deaths occurring during the week ending January 6, 2018 (week 1) were due to P&I. This percentage is above the epidemic threshold of 7.2% for week 1.
Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. Percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records. Due to the additional time needed for manual coding, the initially reported P&I percentages may be lower than percentages calculated from final data. Previous longer backlogs in manual coding have been resolved and death records are now coded within 10 days from receipt of a death record by NCHS.
Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.
NCHS03_small.gif

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[h=2]Influenza-Associated Pediatric Mortality:[/h] Seven influenza-associated pediatric deaths were reported to CDC during week 3. One death was associated with an influenza A(H3) virus and occurred during week 2 (the week ending January 13, 2018). Two deaths were associated with an influenza A(H1N1)pdm09 virus and occurred during weeks 1 and 3 (the weeks ending January 6, 2018, and January 20, 2018, respectively). Three deaths were associated with an influenza A virus for which no subtyping was performed and occurred during weeks 52 and 1 (the weeks ending December 30, 2017, and January 6, 2018, respectively). One death was associated with an influenza B virus and occurred during week 2.
A total of 37 influenza-associated pediatric deaths have been reported for the 2017-2018 season.
Additional data can be found at: http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html.

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).
The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.
Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.
A total of 11,965 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and January 20, 2018. The overall hospitalization rate was 41.9 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (183.1 per 100,000 population), followed by adults aged 50-64 (44.2 per 100,000 population) and children aged 0-4 years (27.0 per 100,000 population). Among 11,965 hospitalizations, 10,612 (88.7%) were associated with influenza A virus, 1,295 (10.8%) with influenza B virus, 28 (0.2%) with influenza A virus and influenza B virus co-infection, and 30 (0.3%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 2,360 (86.4%) were A(H3N2) and 372 (13.6%) were A(H1N1)pdm09 virus.
Among 1,445 hospitalized adults with information on underlying medical conditions, 1,038 (71.8%) had at least one reported underlying medical condition; the most commonly reported were cardiovascular disease, metabolic disorder, obesity, and chronic lung disease. Among 148 hospitalized children with information on underlying medical conditions, 83 (56.1%) had at least one underlying medical condition; the most commonly reported were asthma, neurologic disorder, and obesity. Among 115 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 29 (25.2%) were pregnant.
Additional FluSurv-NET data can be found at: http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html and http://gis.cdc.gov/grasp/fluview/FluHospChars.html.
[SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics? (NCHS) population estimates for the counties included in the surveillance catchment area.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseases include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications;Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation



[h=2]Outpatient Illness Surveillance:[/h] Nationwide during week 3, 6.6% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%.(ILI is defined as fever (temperature of 100?F [37.8?C] or greater) and cough and/or sore throat.)

Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
On a regional level, the percentage of outpatient visits for ILI ranged from 2.9% to 11.7% during week 3. All 10 regions reported percentages of outpatient visits for ILI at or above their region specific baselines.



[h=2]ILINet State Activity Indicator Map:[/h] Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.
During week 3, the following ILI activity levels were experienced:
  • New York City, Puerto Rico, and 39 states experienced high activity (Alabama, Arizona, Arkansas, California, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • The District of Columbia and five states experienced moderate ILI activity (Colorado, Connecticut, Hawaii, Idaho, and Vermont).
  • Three states experienced low ILI activity (Alaska, North Dakota and Utah).
  • Three states experienced minimal ILI activity (Delaware, Maine, and Montana).

Click on map to launch interactive tool
*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.



[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
During week 3, the following influenza activity was reported::
  • Widespread influenza activity was reported by Puerto Rico and 49 states (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Regional influenza activity was reported by Guam.
  • Local influenza activity was reported by the District of Columbia and one state (Hawaii).
  • Sporadic activity was reported by the U.S. Virgin Islands.



[h=2]Additional National and International Influenza Surveillance Information[/h] FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.
U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.

[TABLE="width: 100%"]
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[TD="width: 139"] Alabama
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[TD="width: 139"] Alaska
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[TD="width: 139"] Arizona
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[TD="width: 139"] Arkansas
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[TD="width: 139"] California
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[TD="width: 139"] Colorado
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[TD="width: 139"] Connecticut
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[TD="width: 139"] Delaware
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[TD="width: 139"] District of Columbia
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[TD="width: 139"] Florida
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[TD="width: 139"] Georgia
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[TD="width: 139"] Hawaii
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[TD="width: 139"] Idaho
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[TD="width: 139"] Illinois
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[TD="width: 139"] Indiana
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[TD="width: 139"] Iowa
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[TD="width: 139"] Kansas
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[TD="width: 139"] Kentucky
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[TD="width: 139"] Louisiana
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[TD="width: 139"] Maine
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[TD="width: 139"] Maryland
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[TD="width: 139"] Massachusetts
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[TD="width: 139"] Michigan
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[TD="width: 139"] Minnesota
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[TD="width: 139"] Mississippi
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[TD="width: 139"] Missouri
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[TD="width: 139"] Montana
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[TD="width: 139"] Nebraska
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[TD="width: 139"] Nevada
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[TD="width: 139"] New Hampshire
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[TD="width: 139"] New Jersey
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[TD="width: 139"] New Mexico
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[TD="width: 139"] New York
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[TD="width: 139"] North Carolina
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[TD="width: 139"] North Dakota
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[TD="width: 139"] Ohio
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[TD="width: 139"] Oklahoma
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[TD="width: 139"] Oregon
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[TD="width: 139"] Pennsylvania
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[TD="width: 139"] Rhode Island
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[TD="width: 139"] South Carolina
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[TD="width: 139"] South Dakota
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[TD="width: 139"] Tennessee
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[TD="width: 139"] Texas
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[TD="width: 139"] Utah
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[TD="width: 139"] Vermont
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[TD="width: 139"] Virginia
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[TD="width: 139"] Washington
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[TD="width: 139"] West Virginia
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[TD="width: 139"] Wisconsin
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[TD="width: 139"] Wyoming
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[TD="width: 139"] New York City
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[TD="width: 139"] Puerto Rico
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[TD="width: 139"] Virgin Islands
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[TD="width: 139"] [/TD]
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World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.
WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).
Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.
Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/
Public Health England: The most up-to-date influenza information from the United Kingdom is available athttps://www.gov.uk/government/statistics/weekly-national-flu-reports



Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links.
An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.
 
[h=3]2017-2018 Influenza Season Week 4 ending January 27, 2018[/h] All data are preliminary and may change as more reports are received.
[h=3]Synopsis:[/h] During week 4 (January 21-27, 2018), influenza activity increased in the United States.
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 4 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories remained elevated.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was above the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: Seventeen influenza-associated pediatric deaths were reported, one of which occurred during the 2015-2016 season.
  • Influenza-associated Hospitalizations: A cumulative rate of 51.4 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 7.1%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above region-specific baseline levels. New York City, the District of Columbia, and 42 states experienced high ILI activity; Puerto Rico and two states experienced moderate ILI activity; three states experienced low ILI activity; and three states experienced minimal ILI activity.
  • Geographic Spread of Influenza:The geographic spread of influenza in Puerto Rico and 48 states was reported as widespread; Guam and one state reported regional activity; the District of Columbia and one state reported local activity; and the U.S. Virgin Islands reported sporadic activity.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI? Number of jurisdictions reporting regional or widespread activity? % respiratory specimens positive for flu in clinical laboratories? A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]51 of 54[/TD]
[TD]26.1%[/TD]
[TD]1,896[/TD]
[TD]18,068[/TD]
[TD]348[/TD]
[TD]228[/TD]
[TD]2,292[/TD]
[TD]921[/TD]
[TD]53[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]24.0%[/TD]
[TD]74[/TD]
[TD]939[/TD]
[TD]2[/TD]
[TD]5[/TD]
[TD]135[/TD]
[TD]8[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]23.5%[/TD]
[TD]78[/TD]
[TD]731[/TD]
[TD]5[/TD]
[TD]1[/TD]
[TD]78[/TD]
[TD]56[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 3 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]24.6%[/TD]
[TD]354[/TD]
[TD]1,645[/TD]
[TD]9[/TD]
[TD]28[/TD]
[TD]313[/TD]
[TD]17[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]24.6%[/TD]
[TD]315[/TD]
[TD]1,314[/TD]
[TD]88[/TD]
[TD]7[/TD]
[TD]142[/TD]
[TD]171[/TD]
[TD]14[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]30.3%[/TD]
[TD]281[/TD]
[TD]3,928[/TD]
[TD]44[/TD]
[TD]27[/TD]
[TD]359[/TD]
[TD]17[/TD]
[TD]8[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]32.3%[/TD]
[TD]216[/TD]
[TD]840[/TD]
[TD]16[/TD]
[TD]2[/TD]
[TD]150[/TD]
[TD]110[/TD]
[TD]9[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]23.7%[/TD]
[TD]36[/TD]
[TD]863[/TD]
[TD]10[/TD]
[TD]1[/TD]
[TD]207[/TD]
[TD]7[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]21.0%[/TD]
[TD]106[/TD]
[TD]1,669[/TD]
[TD]14[/TD]
[TD]15[/TD]
[TD]267[/TD]
[TD]8[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]4 of 5[/TD]
[TD]18.3%[/TD]
[TD]268[/TD]
[TD]5,158[/TD]
[TD]150[/TD]
[TD]135[/TD]
[TD]413[/TD]
[TD]344[/TD]
[TD]13[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]24.6%[/TD]
[TD]168[/TD]
[TD]981[/TD]
[TD]10[/TD]
[TD]7[/TD]
[TD]228[/TD]
[TD]183[/TD]
[TD]2[/TD]
[/TR]
[/TABLE]
*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
? Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks


[h=2]U.S. Virologic Surveillance:[/h] WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.
Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.
The results of tests performed by clinical laboratories are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD="width: 200"] [/TD]
Week 4 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]59,200[/TD]
[TD]584,362[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]15,427 (26.1%)[/TD]
[TD]102,364 (17.5%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]11,792 (76.4%)[/TD]
[TD]83,239 (81.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]3,635 (23.6%)[/TD]
[TD]19,125 (18.7%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD] [/TD]
Week 4 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]2,660[/TD]
[TD]44,852[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]1,597[/TD]
[TD]23,753[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]1,280(80.2%)[/TD]
[TD]20,312 (85.5%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]189 (14.8%)[/TD]
[TD]1,896 (9.3%)[/TD]
[/TR]
[TR]
H3N2 [TD]1,017 (79.5%)[/TD]
[TD]18,068 (89.0%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]74 (5.8%)[/TD]
[TD]348 (1.7%)[/TD]
[/TR]
[TR]
Influenza B [TD]317 (19.8%)[/TD]
[TD]3,441 (14.5%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]201 (63.4%)[/TD]
[TD]2,292 (66.6%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]13 (4.1%)[/TD]
[TD]228 (6.6%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]103 (32.5%)[/TD]
[TD]921 (26.8%)[/TD]
[/TR]
[/TABLE]
*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
View Interactive Application | View Full Screen [h=2]Influenza Virus Characterization:[/h] Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI) (i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.
For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.
CDC has antigenically or genetically characterized 1,289 influenza viruses collected during October 1, 2017 ? January 27, 2018, and submitted by U.S. laboratories, including 253 influenza A(H1N1)pdm09 viruses, 668 influenza A(H3N2) viruses, and 368 influenza B viruses.
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 253 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. One hundred thirty six A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017?18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 668 A(H3N2) viruses revealed extensive genetic diversity with multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=554), subclade 3C.2a1 (n=104) or clade 3C.3a (n=10). Two hundred forty five influenza A(H3N2) viruses were antigenically characterized, and 242 (98.8%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of 2017?18 Northern Hemisphere influenza vaccines.
Influenza B Viruses
  • B/Victoria: Phylogenetic analysis of 51 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a number of viruses had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). Seventeen (58.6%) B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017?18 Northern Hemisphere influenza vaccines. Twelve (41.4%) B/Victoria lineage viruses reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and these viruses had the V1A-2Del HA.
  • B/Yamagata: Phylogenetic analysis of 317 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 202 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017?18 Northern Hemisphere quadrivalent vaccines.
The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmapconsiderations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.
Genetic04_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation [h=2]Antiviral Resistance:[/h] Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.
High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0, width: 100%"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[TD] [/TD]
Oseltamivir​
Zanamivir​
Peramivir​
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD]
282​
[/TD]
[TD]
2 (0.7)​
[/TD]
[TD]
235​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
282​
[/TD]
[TD]
2 (0.7)​
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD]
828​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
828​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
610​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[TR]
Influenza B
[TD]
337​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
337​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
337​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[/TABLE]
On December 27, 2017, a Health Advisory was released by CDC providing: 1) a notice about increased influenza A(H3N2) activity and its clinical implications; 2) a summary of influenza antiviral drug treatment recommendations; 3) an update about approved treatment drugs and supply this season; and 4) background information for patients about influenza treatment. More information is available at https://emergency.cdc.gov/han/han00409.asp.
The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] Based on National Center for Health Statistics (NCHS) mortality surveillance data available on February 1, 2018, 9.7% of the deaths occurring during the week ending January 13, 2018 (week 2) were due to P&I. This percentage is above the epidemic threshold of 7.2% for week 2.
Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. Percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records. There is currently a delay in manual coding for deaths occurring in 2018. Because of this delay initially reported P&I percentages will be lower than those calculated from the final data.
Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.
NCHS04_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] Seventeen influenza-associated pediatric deaths were reported to CDC during week 4.
Five deaths were associated with an influenza A(H3) virus and occurred during weeks 1, 2, 3, and 4 (the weeks ending January 6, January 13, January 20, and January 27, 2018). Two deaths were associated with an influenza A(H1N1)pdm09 virus and occurred during weeks 3 and 4 (the weeks ending January 20, 2018, and January 27, 2018, respectively). Four deaths were associated with an influenza A virus for which no subtyping was performed and occurred during weeks 3 and 4. Five deaths were associated with an influenza B virus and occurred during weeks 1, 3, and 4 (the week ending January 6, January 20, and January 27, 2018, respectively).
A total of 53 influenza-associated pediatric deaths have been reported for the 2017-2018 season.
One death that occurred during the 2015-2016 season was associated with an influenza A virus for which no subtyping was performed and occurred during week 28 (the week ending July 16, 2016). This death brings the total number of reported influenza-associated deaths occurring during that season to 93.
Additional data can be found at: http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html.

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).
The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.
Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.
A total of 14,676 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and January 27, 2018. The overall hospitalization rate was 51.4 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (226.8 per 100,000 population), followed by adults aged 50-64 (54.0 per 100,000 population) and children aged 0-4 years (33.3 per 100,000 population). Among 14,676 hospitalizations, 12,849 (87.5%) were associated with influenza A virus, 1,762 (12.0%) with influenza B virus, 35 (0.2%) with influenza A virus and influenza B virus co-infection, and 30 (0.2%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 2,797 (86.5%) were A(H3N2) and 437 (13.5%) were A(H1N1)pdm09 virus.
Among 1,708 hospitalized adults with information on underlying medical conditions, 1,183 (69.3%) had at least one reported underlying medical condition; the most commonly reported were cardiovascular disease, metabolic disorder, obesity, and chronic lung disease. Among 180 hospitalized children with information on underlying medical conditions, 93 (51.7%) had at least one underlying medical condition; the most commonly reported were asthma, neurologic disorder, and obesity. Among 138 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 33 (23.9%) were pregnant.
Additional FluSurv-NET data can be found at: http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html and http://gis.cdc.gov/grasp/fluview/FluHospChars.html.
[SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics? (NCHS) population estimates for the counties included in the surveillance catchment area.

View Interactive Application | View Full Screen | View PowerPoint Presentation
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseases include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications;Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation



[h=2]Outpatient Illness Surveillance:[/h] Nationwide during week 4, 7.1% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%.(ILI is defined as fever (temperature of 100?F [37.8?C] or greater) and cough and/or sore throat.)

Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation On a regional level, the percentage of outpatient visits for ILI ranged from 2.8% to 13.0% during week 4. All 10 regions reported percentages of outpatient visits for ILI at or above their region specific baselines.



[h=2]ILINet State Activity Indicator Map:[/h] Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.
During week 4, the following ILI activity levels were experienced:
  • New York City, the District of Columbia, and 42 states experienced high activity (Alabama, Alaska, Arizona, Arkansas, Colorado, Connecticut, Florida, Georgia, Hawaii, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Vermont, Virginia, West Virginia, Wisconsin, and Wyoming).
  • Puerto Rico and two states experienced moderate ILI activity (California and Idaho).
  • Three states experienced low ILI activity (Delaware, North Dakota and Washington).
  • Three states experienced minimal ILI activity (Maine, Montana, and Utah).
Click on map to launch interactive tool
*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.


[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
During week 4, the following influenza activity was reported::
  • Widespread influenza activity was reported by Puerto Rico and 48 states (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Regional influenza activity was reported by Guam and one state (Oregon).
  • Local influenza activity was reported by the District of Columbia and one state (Hawaii).
  • Sporadic activity was reported by the U.S. Virgin Islands.

[h=2]Additional National and International Influenza Surveillance Information[/h] FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.
U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.

[TABLE="width: 100%"]
[TR]
[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
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[TD="width: 139"] California
[/TD]
[/TR]
[TR]
[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
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[TD="width: 139"] Delaware
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[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
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[TR]
[TD="width: 139"] Georgia
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[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
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[TD="width: 139"] Indiana
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[/TR]
[TR]
[TD="width: 139"] Iowa
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[TD="width: 139"] Kansas
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[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
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[TD="width: 139"] Maine
[/TD]
[/TR]
[TR]
[TD="width: 139"] Maryland
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[TD="width: 139"] Massachusetts
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[TD="width: 139"] Michigan
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[TD="width: 139"] Minnesota
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[TD="width: 139"] Mississippi
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[/TR]
[TR]
[TD="width: 139"] Missouri
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[TD="width: 139"] Montana
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[TD="width: 139"] Nebraska
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[TD="width: 139"] Nevada
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[TD="width: 139"] New Hampshire
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[TR]
[TD="width: 139"] New Jersey
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[TD="width: 139"] New Mexico
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[TD="width: 139"] New York
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[TD="width: 139"] North Carolina
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[TD="width: 139"] North Dakota
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[TR]
[TD="width: 139"] Ohio
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[TD="width: 139"] Oklahoma
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[TD="width: 139"] Oregon
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[TD="width: 139"] Pennsylvania
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[TD="width: 139"] Rhode Island
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[TD="width: 139"] South Carolina
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[TD="width: 139"] South Dakota
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[TD="width: 139"] Tennessee
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[TD="width: 139"] Texas
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[TD="width: 139"] Utah
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[/TR]
[TR]
[TD="width: 139"] Vermont
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[TD="width: 139"] Virginia
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[TD="width: 139"] Washington
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[TD="width: 139"] West Virginia
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[TD="width: 139"] Wisconsin
[/TD]
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[TR]
[TD="width: 139"] Wyoming
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[TD="width: 139"] New York City
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[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]
[/TR]
[/TABLE]
World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.
WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).
Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.
Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/
Public Health England: The most up-to-date influenza information from the United Kingdom is available athttps://www.gov.uk/government/statistics/weekly-national-flu-reports


Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links.
An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.
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[h=5]File Formats Help:[/h] How do I view different file formats (PDF, DOC, PPT, MPEG) on this site?

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  • Page last reviewed: February 2, 2018
 
[h=3]2017-2018 Influenza Season Week 5 ending February 3, 2018[/h] All data are preliminary and may change as more reports are received.
[h=3]Synopsis:[/h] During week 5 (January 28-February 3, 2018), influenza activity increased in the United States.
  • Viral Surveillance: The most frequently identified influenza virus subtype reported by public health laboratories during week 5 was influenza A(H3). The percentage of respiratory specimens testing positive for influenza in clinical laboratories remained elevated.
  • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was above the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.
  • Influenza-associated Pediatric Deaths: Ten influenza-associated pediatric deaths were reported.
  • Influenza-associated Hospitalizations: A cumulative rate of 59.9 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported.
  • Outpatient Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) was 7.7%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above region-specific baseline levels. New York City, the District of Columbia, Puerto Rico and 43 states experienced high ILI activity; three states experienced moderate ILI activity; two states experienced low ILI activity; and two states experienced minimal ILI activity.
  • Geographic Spread of Influenza:The geographic spread of influenza in Puerto Rico and 48 states was reported as widespread; two states reported regional activity; the District of Columbia and Guam reported local activity; and the U.S. Virgin Islands reported sporadic activity.
[h=3]National and Regional Summary of Select Surveillance Components[/h]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[/TR]
[TR]
HHS Surveillance Regions* Data for current week Data cumulative since October 1, 2017 (week 40) [/TR]
[TR]
Out-patient ILI? Number of jurisdictions reporting regional or widespread activity? % respiratory specimens positive for flu in clinical laboratories? A(H1N1)pdm09 A (H3) A (Subtyping not Performed) B Victoria lineage B Yamagata lineage B lineage not performed Pediatric Deaths [/TR]
[TR]
Influenza test results from public health laboratories only [/TR]
[TR]
Nation [TD]Elevated[/TD]
[TD]51 of 54[/TD]
[TD]26.3%[/TD]
[TD]2,298[/TD]
[TD]20,512[/TD]
[TD]445[/TD]
[TD]309[/TD]
[TD]3,010[/TD]
[TD]1,093[/TD]
[TD]63[/TD]
[/TR]
[TR]
Region 1 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]26.6%[/TD]
[TD]118[/TD]
[TD]1,159[/TD]
[TD]2[/TD]
[TD]7[/TD]
[TD]200[/TD]
[TD]10[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 2 [TD]Elevated[/TD]
[TD]3 of 4[/TD]
[TD]28.8%[/TD]
[TD]108[/TD]
[TD]931[/TD]
[TD]5[/TD]
[TD]5[/TD]
[TD]127[/TD]
[TD]79[/TD]
[TD]2[/TD]
[/TR]
[TR]
Region 3 [TD]Elevated[/TD]
[TD]5 of 6[/TD]
[TD]25.4%[/TD]
[TD]418[/TD]
[TD]1,928[/TD]
[TD]10[/TD]
[TD]41[/TD]
[TD]393[/TD]
[TD]14[/TD]
[TD]3[/TD]
[/TR]
[TR]
Region 4 [TD]Elevated[/TD]
[TD]8 of 8[/TD]
[TD]25.8%[/TD]
[TD]395[/TD]
[TD]1,660[/TD]
[TD]133[/TD]
[TD]10[/TD]
[TD]202[/TD]
[TD]215[/TD]
[TD]18[/TD]
[/TR]
[TR]
Region 5 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]30.6%[/TD]
[TD]315[/TD]
[TD]4,379[/TD]
[TD]44[/TD]
[TD]27[/TD]
[TD]442[/TD]
[TD]18[/TD]
[TD]10[/TD]
[/TR]
[TR]
Region 6 [TD]Elevated[/TD]
[TD]5 of 5[/TD]
[TD]29.1%[/TD]
[TD]233[/TD]
[TD]898[/TD]
[TD]16[/TD]
[TD]2[/TD]
[TD]202[/TD]
[TD]127[/TD]
[TD]9[/TD]
[/TR]
[TR]
Region 7 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]21.6%[/TD]
[TD]44[/TD]
[TD]924[/TD]
[TD]14[/TD]
[TD]1[/TD]
[TD]250[/TD]
[TD]5[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 8 [TD]Elevated[/TD]
[TD]6 of 6[/TD]
[TD]20.1%[/TD]
[TD]128[/TD]
[TD]1,864[/TD]
[TD]15[/TD]
[TD]19[/TD]
[TD]330[/TD]
[TD]8[/TD]
[TD]1[/TD]
[/TR]
[TR]
Region 9 [TD]Elevated[/TD]
[TD]4 of 5[/TD]
[TD]15.2%[/TD]
[TD]345[/TD]
[TD]5,699[/TD]
[TD]195[/TD]
[TD]190[/TD]
[TD]589[/TD]
[TD]408[/TD]
[TD]15[/TD]
[/TR]
[TR]
Region 10 [TD]Elevated[/TD]
[TD]4 of 4[/TD]
[TD]21.3%[/TD]
[TD]194[/TD]
[TD]1,070[/TD]
[TD]11[/TD]
[TD]7[/TD]
[TD]275[/TD]
[TD]209[/TD]
[TD]3[/TD]
[/TR]
[/TABLE]
*https://www.hhs.gov/about/agencies/iea/regional-offices/index.html
? Elevated means the % of visits for ILI is at or above the national or region-specific baseline
? Includes all 50 states, the District of Columbia, Guam, Puerto Rico, and U.S. Virgin Islands
? National data are for current week; regional data are for the most recent three weeks


[h=2]U.S. Virologic Surveillance:[/h] WHO and NREVSS collaborating laboratories, which include both public health and clinical laboratories located in all 50 states, Puerto Rico, and the District of Columbia, report to CDC the total number of respiratory specimens tested for influenza and the number positive for influenza by virus type. In addition, public health laboratories also report the influenza A subtype (H1 or H3) and influenza B lineage information of the viruses they test and the age or age group of the persons from whom the specimens were collected.
Additional virologic data, including national, regional and select state-level data, can be found at: http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html. Age group proportions and totals by influenza subtype reported by public health laboratories can be found at: http://gis.cdc.gov/grasp/fluview/flu_by_age_virus.html.
The results of tests performed by clinical laboratories are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD="width: 200"] [/TD]
Week 5 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]63,180[/TD]
[TD]666,493[/TD]
[/TR]
[TR]
No. of positive specimens (%) [TD]16,641 (26.3%)[/TD]
[TD]124,316 (18.7%)[/TD]
[/TR]
[TR]
Positive specimens by type [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]11,517 (69.2%)[/TD]
[TD]98,606 (79.3%)[/TD]
[/TR]
[TR]
Influenza B [TD]5,124 (30.8%)[/TD]
[TD]25,710 (20.7%)[/TD]
[/TR]
[/TABLE]

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation The results of tests performed by public health laboratories, as well as the age group distribution of influenza positive tests, during the current week are summarized below.
[TABLE="class: table table-bordered table-condensed opt-in, width: 100%"]
[TR]
[TD] [/TD]
Week 5 Data Cumulative since
October 1, 2017 (Week 40) [/TR]
[TR]
No. of specimens tested [TD]2,608[/TD]
[TD]51,014[/TD]
[/TR]
[TR]
No. of positive specimens* [TD]1,453[/TD]
[TD]27,667[/TD]
[/TR]
[TR]
Positive specimens by type/subtype [TD] [/TD]
[TD] [/TD]
[/TR]
[TR]
Influenza A [TD]1,065 (73.3%)[/TD]
[TD]23,255 (84.1%)[/TD]
[/TR]
[TR]
A(H1N1)pmd09 [TD]144 (13.5%)[/TD]
[TD]2,298 (9.9%)[/TD]
[/TR]
[TR]
H3N2 [TD]834 (78.3%)[/TD]
[TD]20,512 (88.2%)[/TD]
[/TR]
[TR]
Subtyping not performed [TD]87 (8.2%)[/TD]
[TD]445 (1.9%)[/TD]
[/TR]
[TR]
Influenza B [TD]388 (26.7%)[/TD]
[TD]4,412 (15.9%)[/TD]
[/TR]
[TR]
Yamagata lineage [TD]266 (68.6%)[/TD]
[TD]3,010 (68.2%)[/TD]
[/TR]
[TR]
Victoria lineage [TD]22 (5.7%)[/TD]
[TD]309 (7.0%)[/TD]
[/TR]
[TR]
Lineage not performed [TD]100 (25.8%)[/TD]
[TD]1,093 (24.8%)[/TD]
[/TR]
[/TABLE]
*The percent of specimens testing positive for influenza is not reported because public health laboratories often receive samples that have already tested positive for influenza at a clinical laboratory and therefore percent positive would not be a valid indicator of influenza activity. Additional information is available at http://www.cdc.gov/flu/weekly/overview.htm.


View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation
View Interactive Application | View Full Screen [h=2]Influenza Virus Characterization:[/h] Close monitoring of influenza viruses is required to better assess the potential impact on public health. CDC characterizes influenza viruses through one or more tests including genomic sequencing and hemagglutination inhibition (HI) (i.e., hemagglutination inhibition (HI) and/or neutralization assays). These data are used to monitor for changes in circulating influenza viruses and to compare how similar currently circulating influenza viruses are to the reference viruses used for developing influenza vaccines. Antigenic and genetic characterization of circulating influenza viruses can give an indication of the influenza vaccine's ability to produce an immune response against the wide array of influenza viruses co-circulating, but annual vaccine effectiveness estimates are needed to determine how much protection has been provided to the population by vaccination.
For nearly all influenza-positive surveillance samples received at CDC, next-generation sequencing is performed to determine the genetic identity of circulating influenza viruses and to monitor viruses for evidence of genetic changes. Viruses are classified into genetic clades/subclades based on analysis of the genetic sequences of the HA gene segments. However, genetic changes do not always result in antigenic change. Extensive genetic variation may exist in circulating viruses, with no evidence of substantial antigenic drift. Antigenic drift is evaluated by comparing cell-propagated circulating viruses with cell-propagated reference viruses representing currently recommended vaccine components.
CDC has antigenically or genetically characterized 1,365 influenza viruses collected during October 1, 2017 ? February 3, 2018, and submitted by U.S. laboratories, including 276 influenza A(H1N1)pdm09 viruses, 695 influenza A(H3N2) viruses, and 394 influenza B viruses.
  • A (H1N1)pdm09: Phylogenetic analysis of the HA genes from 276 A(H1N1)pdm09 viruses showed that all belonged to clade 6B.1. Two hundred five A(H1N1)pdm09 viruses were antigenically characterized, and all were antigenically similar (analyzed using HI with ferret antisera) to the reference 6B.1 virus A/Michigan/45/2015, representing the recommended influenza A(H1N1)pdm09 reference virus for the 2017?18 Northern Hemisphere influenza vaccines.
  • A (H3N2): Phylogenetic analysis of the HA genes from 695 A(H3N2) viruses revealed extensive genetic diversity with multiple clades/subclades co-circulating. The HA genes of circulating viruses belonged to clade 3C.2a (n=577), subclade 3C.2a1 (n=108) or clade 3C.3a (n=10). Two hundred sixty-two influenza A(H3N2) viruses were antigenically characterized, and 257 (98.1%) A(H3N2) viruses tested were well-inhibited (reacting at titers that were within fourfold of the homologous virus titer) by ferret antisera raised against A/Michigan/15/2014 (3C.2a), a cell propagated A/Hong Kong/4801/2014-like reference virus representing the A(H3N2) component of 2017?18 Northern Hemisphere influenza vaccines.
Influenza B Viruses
  • B/Victoria: Phylogenetic analysis of 56 B/Victoria-lineage viruses indicate that all HA genes belonged to genetic clade V1A, the same genetic clade as the vaccine reference virus, B/Brisbane/60/2008. However, a number of viruses had a 6-nucleotide deletion (encoding amino acids 162 and 163) in the HA (abbreviated as V1A-2Del). Seventeen (58.6%) B/Victoria lineage viruses were well-inhibited by ferret antisera raised against cell -propagated B/Brisbane/60/2008 reference virus, representing a recommended B virus component of 2017?18 Northern Hemisphere influenza vaccines. Twelve (41.4%) B/Victoria lineage viruses reacted poorly (at titers that were 8-fold or greater reduced compared with the homologous virus titer) with ferret antisera raised against cell-propagated B/Brisbane/60/2008, and these viruses had the V1A-2Del HA.
  • B/Yamagata: Phylogenetic analysis of 338 influenza B/Yamagata-lineage viruses indicate that the HA genes belonged to clade Y3. A total of 202 influenza B/Yamagata-lineage viruses were antigenically characterized, and all were antigenically similar to cell propagated B/Phuket/3073/2013, the reference vaccine virus representing the influenza B/Yamagata-lineage component of the 2017?18 Northern Hemisphere quadrivalent vaccines.
The majority of U.S. viruses submitted for characterization come from state and local public health laboratories. Due to Right Size Roadmapconsiderations, specimen submission guidance to laboratories is that, if available, 2 influenza A(H1N1)pdm09, 2 influenza A(H3N2), and 2 influenza B viruses be submitted every other week.. Therefore, the numbers of each virus type/subtype characterized should be more balanced across subtypes/lineages but will not reflect the actual proportion of circulating viruses. In the figure below, the results of tests performed by public health labs are shown on the left and CDC sequence results (by genetic clade/subclade) are shown on the right.
Genetic05_small.gif

View Chart Data | View Full Screen | View PowerPoint Presentation [h=2]Antiviral Resistance:[/h] Testing of influenza A (H1N1)pdm09, influenza A (H3N2), and influenza B virus isolates for resistance to neuraminidase inhibitors (oseltamivir, zanamivir, and peramivir) is performed at CDC using a functional assay. Additional influenza A (H1N1)pdm09 and influenza A (H3N2) viruses from clinical samples are tested for mutations known to confer oseltamivir resistance. The data summarized below combine the results of both testing methods. These samples are routinely obtained for surveillance purposes rather than for diagnostic testing of patients suspected to be infected with antiviral-resistant virus.
High levels of resistance to the adamantanes (amantadine and rimantadine) persist among influenza A (H1N1)pdm09 and influenza A (H3N2) viruses (the adamantanes are not effective against influenza B viruses). Therefore, data from adamantane resistance testing are not presented below.
[TABLE="class: table, align: center, border: 0, cellpadding: 3, cellspacing: 0, width: 100%"]
[h=3]Neuraminidase Inhibitor Resistance Testing Results on Samples Collected Since October 1, 2017[/h] [/TABLE]
[TABLE="class: table table-bordered opt-in, width: 100%"]
[TR]
[TD] [/TD]
Oseltamivir​
Zanamivir​
Peramivir​
[/TR]
[TR]
[TD] [/TD]
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
Virus Samples tested (n)
Resistant Viruses, Number (%)​
[/TR]
[TR]
Influenza A (H1N1)pdm09
[TD]
376​
[/TD]
[TD]
4 (1.1)​
[/TD]
[TD]
265​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
376​
[/TD]
[TD]
4 (1.1)​
[/TD]
[/TR]
[TR]
Influenza A (H3N2)
[TD]
903​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
903​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
638​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[TR]
Influenza B
[TD]
387​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
387​
[/TD]
[TD]
0 (0.0)​
[/TD]
[TD]
387​
[/TD]
[TD]
0 (0.0)​
[/TD]
[/TR]
[/TABLE]
On December 27, 2017, a Health Advisory was released by CDC providing: 1) a notice about increased influenza A(H3N2) activity and its clinical implications; 2) a summary of influenza antiviral drug treatment recommendations; 3) an update about approved treatment drugs and supply this season; and 4) background information for patients about influenza treatment. More information is available at https://emergency.cdc.gov/han/han00409.asp.
The majority of recently circulating influenza viruses are susceptible to the neuraminidase inhibitor antiviral medications, oseltamivir, zanamivir, and peramivir; however, rare sporadic instances of oseltamivir-resistant and peramivir-resistant influenza A(H1N1)pdm09 viruses and oseltamivir-resistant influenza A(H3N2) viruses have been detected worldwide. Antiviral treatment as early as possible is recommended for patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or who are at high risk for serious influenza-related complications. Additional information on recommendations for treatment and chemoprophylaxis of influenza virus infection with antiviral agents is available at http://www.cdc.gov/flu/antivirals/index.htm.


[h=2]Pneumonia and Influenza (P&I) Mortality Surveillance:[/h] Based on National Center for Health Statistics (NCHS) mortality surveillance data available on February 8, 2018, 10.1% of the deaths occurring during the week ending January 20, 2018 (week 3) were due to P&I. This percentage is above the epidemic threshold of 7.3% for week 3.
Background: Weekly mortality surveillance data include a combination of machine coded and manually coded causes of death collected from death certificates. Percentages of deaths due to P&I are higher among manually coded records than more rapidly available machine coded records. There is currently a delay in manual coding for deaths occurring in 2018. Because of this delay initially reported P&I percentages will be lower than those calculated from the final data.
Region and state-specific data are available at http://gis.cdc.gov/grasp/fluview/mortality.html.
NCHS05_small.gif

View Regional and State Level Data | View Chart Data | View Full Screen | View PowerPoint Presentation

[h=2]Influenza-Associated Pediatric Mortality:[/h] Ten influenza-associated pediatric deaths were reported to CDC during week 5. Four deaths were associated with an influenza A(H3) virus and occurred during weeks 3 and 4 (the weeks ending January 20, and January 27, 2018, respectively). Three deaths were associated with an influenza A virus for which no subtyping was performed and occurred during weeks 52, 4, and 5 (the weeks ending December 30, 2017, January 27, and February 3, 2018, respectively). Three deaths were associated with an influenza B virus and occurred during weeks 2 and 4 (the weeks ending January 13, and January 27, 2018, respectively).
A total of 63 influenza-associated pediatric deaths have been reported for the 2017-2018 season.
Additional data can be found at: http://gis.cdc.gov/GRASP/Fluview/PedFluDeath.html.

View Interactive Application | View Full Screen | View PowerPoint Presentation


[h=2]Influenza-Associated Hospitalizations:[/h] The Influenza Hospitalization Surveillance Network (FluSurv-NET) conducts population-based surveillance for laboratory-confirmed influenza-related hospitalizations in children younger than 18 years of age (since the 2003-2004 influenza season) and adults (since the 2005-2006 influenza season).
The FluSurv-NET covers more than 70 counties in the 10 Emerging Infections Program (EIP) states (CA, CO, CT, GA, MD, MN, NM, NY, OR, and TN) and additional Influenza Hospitalization Surveillance Project (IHSP) states. The IHSP began during the 2009-2010 season to enhance surveillance during the 2009 H1N1 pandemic. IHSP sites included IA, ID, MI, OK and SD during the 2009-2010 season; ID, MI, OH, OK, RI, and UT during the 2010-2011 season; MI, OH, RI, and UT during the 2011-2012 season; IA, MI, OH, RI, and UT during the 2012-2013 season; and MI, OH, and UT during the 2013-2014, 2014-15, 2015-16, 2016-17, and 2017-18 seasons.
Data gathered are used to estimate age-specific hospitalization rates on a weekly basis, and describe characteristics of persons hospitalized with influenza illness. The rates provided are likely to be an underestimate as influenza-related hospitalizations can be missed, either because testing is not performed, or because cases may be attributed to other causes of pneumonia or other common influenza-related complications.
A total of 17,101 laboratory-confirmed influenza-associated hospitalizations were reported between October 1, 2017 and February 3, 2018. The overall hospitalization rate was 59.9 per 100,000 population. The highest rate of hospitalization was among adults aged ≥65 years (263.6 per 100,000 population), followed by adults aged 50-64 (63.1 per 100,000 population) and children aged 0-4 years (40.0 per 100,000 population). Among 17,101 hospitalizations, 14,770 (86.4%) were associated with influenza A virus, 2,251 (13.2%) with influenza B virus, 43 (0.3%) with influenza A virus and influenza B virus co-infection, and 37 (0.2%) with influenza virus for which the type was not determined. Among those with influenza A subtype information, 3,308 (86.1%) were A(H3N2) and 533 (13.9%) were A(H1N1)pdm09 virus.
Among 1,955 hospitalized adults with information on underlying medical conditions, 1,325 (67.8%) had at least one reported underlying medical condition; the most commonly reported were cardiovascular disease, metabolic disorder, obesity, and chronic lung disease. Among 192 hospitalized children with information on underlying medical conditions, 97 (50.5%) had at least one underlying medical condition; the most commonly reported were asthma, neurologic disorder, and obesity. Among 151 hospitalized women of childbearing age (15-44 years) with information on pregnancy status, 36 (23.8%) were pregnant.
Additional FluSurv-NET data can be found at: http://gis.cdc.gov/GRASP/Fluview/FluHospRates.html and http://gis.cdc.gov/grasp/fluview/FluHospChars.html.
[SIZE=1.5]Data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), a population-based surveillance for influenza related hospitalizations in children and adults in 13 U.S. states. Cumulative incidence rates are calculated using the National Center for Health Statistics? (NCHS) population estimates for the counties included in the surveillance catchment area.

View Interactive Application | View Full Screen | View PowerPoint Presentation
[SIZE=1.5]FluSurv-NET data are preliminary and displayed as they become available. Therefore, figures are based on varying denominators as some variables represent information that may require more time to be collected. Data are refreshed and updated weekly. Asthma includes a medical diagnosis of asthma or reactive airway disease; Cardiovascular diseases include conditions such as coronary heart disease, cardiac valve disorders, congestive heart failure, and pulmonary hypertension; does not include isolated hypertension; Chronic lung diseases include conditions such as chronic obstructive pulmonary disease, bronchiolitis obliterans, chronic aspiration pneumonia, and interstitial lung disease; Immune suppression includes conditions such as immunoglobulin deficiency, leukemia, lymphoma, HIV/AIDS, and individuals taking immunosuppressive medications;Metabolic disorders include conditions such as diabetes mellitus; Neurologic diseases include conditions such as seizure disorders, cerebral palsy, and cognitive dysfunction; Neuromuscular diseases include conditions such as multiple sclerosis and muscular dystrophy; Obesity was assigned if indicated in patient's medical chart or if body mass index (BMI) >30 kg/m2; Pregnancy percentage calculated using number of female cases aged between 15 and 44 years of age as the denominator; Renal diseases include conditions such as acute or chronic renal failure, nephrotic syndrome, glomerulonephritis, and impaired creatinine clearance; No known condition indicates that the case did not have any known high risk medical condition indicated in medical chart at the time of hospitalization.[/SIZE]
View Interactive Application | View Full Screen | View PowerPoint Presentation



[h=2]Outpatient Illness Surveillance:[/h] Nationwide during week 5, 7.7% of patient visits reported through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet) were due to influenza-like illness (ILI). This percentage is above the national baseline of 2.2%.(ILI is defined as fever (temperature of 100?F [37.8?C] or greater) and cough and/or sore throat.)

Additional ILINet data, including national, regional and select state-level data, are available at http://gis.cdc.gov/grasp/fluview/fluportaldashboard.html.

View National and Regional Level Graphs and Data | View Chart Data | View Full Screen | View PowerPoint Presentation On a regional level, the percentage of outpatient visits for ILI ranged from 3.4% to 12.5% during week 5. All 10 regions reported percentages of outpatient visits for ILI at or above their region specific baselines.



[h=2]ILINet State Activity Indicator Map:[/h] Data collected in ILINet are used to produce a measure of ILI activity* by state. Activity levels are based on the percent of outpatient visits in a state due to ILI and are compared to the average percent of ILI visits that occur during weeks with little or no influenza virus circulation. Activity levels range from minimal, which would correspond to ILI activity from outpatient clinics being below, or only slightly above, the average, to high, which would correspond to ILI activity from outpatient clinics being much higher than average.
During week 5, the following ILI activity levels were experienced:
  • New York City, the District of Columbia, Puerto Rico and 43 states experienced high activity (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Vermont, Virginia, West Virginia, Wisconsin, and Wyoming).
  • Three states experienced moderate ILI activity (Hawaii, Idaho, and Washington).
  • Two states experienced low ILI activity (North Dakota and Utah).
  • Two states experienced minimal ILI activity (Maine and Montana).
Click on map to launch interactive tool
*This map uses the proportion of outpatient visits to health care providers for ILI to measure the ILI activity level within a state. It does not, however, measure the extent of geographic spread of flu within a state. Therefore, outbreaks occurring in a single city could cause the state to display high activity levels.
Data collected in ILINet may disproportionally represent certain populations within a state, and therefore, may not accurately depict the full picture of influenza activity for the whole state.
Data displayed in this map are based on data collected in ILINet, whereas the State and Territorial flu activity map is based on reports from state and territorial epidemiologists. The data presented in this map are preliminary and may change as more data are received.
Differences in the data presented here by CDC and independently by some state health departments likely represent differing levels of data completeness with data presented by the state likely being the more complete.


[h=2]Geographic Spread of Influenza as Assessed by State and Territorial Epidemiologists[/h] The influenza activity reported by state and territorial epidemiologists indicates geographic spread of influenza viruses, but does not measure the severity of influenza activity.
Additional data can be found at https://gis.cdc.gov/grasp/fluview/FluView8.html.
During week 5, the following influenza activity was reported:
  • Widespread influenza activity was reported by Puerto Rico and 48 states (Alabama, Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Georgia, Idaho, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Carolina, North Dakota, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, South Dakota, Tennessee, Texas, Utah, Vermont, Virginia, Washington, West Virginia, Wisconsin, and Wyoming).
  • Regional influenza activity was reported by two states (Hawaii and Oregon).
  • Local influenza activity was reported by the District of Columbia and Guam.
  • Sporadic activity was reported by the U.S. Virgin Islands.

[h=2]Additional National and International Influenza Surveillance Information[/h] FluView Interactive: FluView includes enhanced web-based interactive applications that can provide dynamic visuals of the influenza data collected and analyzed by CDC. These FluView Interactive applications allow people to create customized, visual interpretations of influenza data, as well as make comparisons across flu seasons, regions, age groups and a variety of other demographics. To access these tools, visithttp://www.cdc.gov/flu/weekly/fluviewinteractive.htm.
U.S. State and local influenza surveillance: Click on a jurisdiction below to access the latest local influenza information.

[TABLE="width: 100%"]
[TR]
[TD="width: 139"] Alabama
[/TD]
[TD="width: 139"] Alaska
[/TD]
[TD="width: 139"] Arizona
[/TD]
[TD="width: 139"] Arkansas
[/TD]
[TD="width: 139"] California
[/TD]
[/TR]
[TR]
[TD="width: 139"] Colorado
[/TD]
[TD="width: 139"] Connecticut
[/TD]
[TD="width: 139"] Delaware
[/TD]
[TD="width: 139"] District of Columbia
[/TD]
[TD="width: 139"] Florida
[/TD]
[/TR]
[TR]
[TD="width: 139"] Georgia
[/TD]
[TD="width: 139"] Hawaii
[/TD]
[TD="width: 139"] Idaho
[/TD]
[TD="width: 139"] Illinois
[/TD]
[TD="width: 139"] Indiana
[/TD]
[/TR]
[TR]
[TD="width: 139"] Iowa
[/TD]
[TD="width: 139"] Kansas
[/TD]
[TD="width: 139"] Kentucky
[/TD]
[TD="width: 139"] Louisiana
[/TD]
[TD="width: 139"] Maine
[/TD]
[/TR]
[TR]
[TD="width: 139"] Maryland
[/TD]
[TD="width: 139"] Massachusetts
[/TD]
[TD="width: 139"] Michigan
[/TD]
[TD="width: 139"] Minnesota
[/TD]
[TD="width: 139"] Mississippi
[/TD]
[/TR]
[TR]
[TD="width: 139"] Missouri
[/TD]
[TD="width: 139"] Montana
[/TD]
[TD="width: 139"] Nebraska
[/TD]
[TD="width: 139"] Nevada
[/TD]
[TD="width: 139"] New Hampshire
[/TD]
[/TR]
[TR]
[TD="width: 139"] New Jersey
[/TD]
[TD="width: 139"] New Mexico
[/TD]
[TD="width: 139"] New York
[/TD]
[TD="width: 139"] North Carolina
[/TD]
[TD="width: 139"] North Dakota
[/TD]
[/TR]
[TR]
[TD="width: 139"] Ohio
[/TD]
[TD="width: 139"] Oklahoma
[/TD]
[TD="width: 139"] Oregon
[/TD]
[TD="width: 139"] Pennsylvania
[/TD]
[TD="width: 139"] Rhode Island
[/TD]
[/TR]
[TR]
[TD="width: 139"] South Carolina
[/TD]
[TD="width: 139"] South Dakota
[/TD]
[TD="width: 139"] Tennessee
[/TD]
[TD="width: 139"] Texas
[/TD]
[TD="width: 139"] Utah
[/TD]
[/TR]
[TR]
[TD="width: 139"] Vermont
[/TD]
[TD="width: 139"] Virginia
[/TD]
[TD="width: 139"] Washington
[/TD]
[TD="width: 139"] West Virginia
[/TD]
[TD="width: 139"] Wisconsin
[/TD]
[/TR]
[TR]
[TD="width: 139"] Wyoming
[/TD]
[TD="width: 139"] New York City
[/TD]
[TD="width: 139"] Puerto Rico
[/TD]
[TD="width: 139"] Virgin Islands
[/TD]
[TD="width: 139"] [/TD]
[/TR]
[/TABLE]
World Health Organization: Additional influenza surveillance information from participating WHO member nations is available through FluNet and the Global Epidemiology Reports.
WHO Collaborating Centers for Influenza located in Australia, China, Japan, the United Kingdom, and the United States (CDC in Atlanta, Georgia).
Europe: For the most recent influenza surveillance information from Europe, please see WHO/Europe and the European Centre for Disease Prevention and Control at http://www.flunewseurope.org/.
Public Health Agency of Canada: The most up-to-date influenza information from Canada is available at http://www.phac-aspc.gc.ca/fluwatch/
Public Health England: The most up-to-date influenza information from the United Kingdom is available athttps://www.gov.uk/government/statistics/weekly-national-flu-reports


Any links provided to non-Federal organizations are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization web pages found at these links.
An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at: http://www.cdc.gov/flu/weekly/overview.htm.
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  • Page last reviewed: February 9, 2018



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