Mary Wilson
Well-known member
News release Geneva
12 July 2022
The World Health Organization today released the first-ever report on the pipeline of the vaccines currently in development to prevent infections caused by antimicrobial-resistant (AMR) bacterial pathogens. WHO’s analysis points to the need to accelerate trials for AMR related vaccines in late-stage development and maximise the use of existing vaccines.
The silent pandemic of antimicrobial resistance is of major growing public health concern. Resistant bacterial infections alone are associated with nearly 4.95 million deaths per year, with 1.27 million deaths directly attributed to AMR. But AMR is about more than bacterial infections. AMR occurs when bacteria, viruses, fungi, and parasites change over time and no longer respond to medicines. When an individual becomes infected with these microbes, the infection is said to be resistant to antimicrobial medicines. These infections are often difficult to treat.
Vaccines are powerful tools to prevent infections in the first place, and therefore have the potential to curb the spread of AMR infections. The AMR vaccine pipeline report aims to guide investments and research into feasible vaccines to mitigate AMR.
The analysis identifies sixty-one vaccine candidates in various stages of clinical development, including several in late stages of development to address diseases listed on the bacterial priority pathogens list, which WHO has prioritized for R&D. While the report describes these late-stage vaccine candidates as having a high development feasibility, the report cautions that most will not be available anytime soon.
“Preventing infections using vaccination reduces the use of antibiotics, which is one of the main drivers of AMR. Yet of the top six bacterial pathogens responsible for deaths due to AMR, only one, Pneumococcal disease (Streptococcus pneumoniae) has a vaccine” said Dr Hanan Balkhy, WHO Assistant Director-General, Antimicrobial Resistance. “Affordable and equitable access to life-saving vaccines such as those against pneumococcus, are urgently needed to save lives, and mitigate the rise of AMR” she added. ...
https://www.who.int/news/item/12-07...and-development-of-new-vaccines-to-tackle-amr
____________________________________________________
The full report can be read here.
Bacterial vaccines in clinical and preclinical development 2021
An overview and analysis
12 July 2022 | Technical document
https://www.who.int/publications/i/item/9789240052451
12 July 2022
The World Health Organization today released the first-ever report on the pipeline of the vaccines currently in development to prevent infections caused by antimicrobial-resistant (AMR) bacterial pathogens. WHO’s analysis points to the need to accelerate trials for AMR related vaccines in late-stage development and maximise the use of existing vaccines.
The silent pandemic of antimicrobial resistance is of major growing public health concern. Resistant bacterial infections alone are associated with nearly 4.95 million deaths per year, with 1.27 million deaths directly attributed to AMR. But AMR is about more than bacterial infections. AMR occurs when bacteria, viruses, fungi, and parasites change over time and no longer respond to medicines. When an individual becomes infected with these microbes, the infection is said to be resistant to antimicrobial medicines. These infections are often difficult to treat.
Vaccines are powerful tools to prevent infections in the first place, and therefore have the potential to curb the spread of AMR infections. The AMR vaccine pipeline report aims to guide investments and research into feasible vaccines to mitigate AMR.
The analysis identifies sixty-one vaccine candidates in various stages of clinical development, including several in late stages of development to address diseases listed on the bacterial priority pathogens list, which WHO has prioritized for R&D. While the report describes these late-stage vaccine candidates as having a high development feasibility, the report cautions that most will not be available anytime soon.
“Preventing infections using vaccination reduces the use of antibiotics, which is one of the main drivers of AMR. Yet of the top six bacterial pathogens responsible for deaths due to AMR, only one, Pneumococcal disease (Streptococcus pneumoniae) has a vaccine” said Dr Hanan Balkhy, WHO Assistant Director-General, Antimicrobial Resistance. “Affordable and equitable access to life-saving vaccines such as those against pneumococcus, are urgently needed to save lives, and mitigate the rise of AMR” she added. ...
https://www.who.int/news/item/12-07...and-development-of-new-vaccines-to-tackle-amr
____________________________________________________
The full report can be read here.
Bacterial vaccines in clinical and preclinical development 2021
An overview and analysis
12 July 2022 | Technical document
https://www.who.int/publications/i/item/9789240052451