tetano
Editor, Senior Moderator
Euro Surveill. 2018 Jun;23(25). doi: 10.2807/1560-7917.ES.2018.23.25.1700496.
[h=1]Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16.[/h] Pebody RG[SUP]1[/SUP], Sinnathamby MA[SUP]1[/SUP], Warburton F[SUP]1[/SUP], Andrews N[SUP]1[/SUP], Boddington NL[SUP]1[/SUP], Zhao H[SUP]1[/SUP], Yonova I[SUP]2,[/SUP][SUP]3[/SUP], Ellis J[SUP]1[/SUP], Tessier E[SUP]1[/SUP], Donati M[SUP]4[/SUP], Elliot AJ[SUP]5[/SUP], Hughes HE[SUP]5[/SUP], Pathirannehelage S[SUP]2,[/SUP][SUP]3[/SUP], Byford R[SUP]2,[/SUP][SUP]3[/SUP], Smith GE[SUP]5[/SUP], de Lusignan S[SUP]2,[/SUP][SUP]3[/SUP], Zambon M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The 2015/16 influenza season was the third season of the introduction of an intra-nasally administered live attenuated influenza vaccine (LAIV) for children in England. All children aged 2‒6 years were offered LAIV, and in addition, a series of geographically discrete areas piloted vaccinating school-age children 7‒11 years old. Influenza A(H1N1)pdm09 was the dominant circulating strain during 2015/16 followed by influenza B. We measured influenza vaccine uptake and the overall and indirect effect of vaccinating children of primary school -age, by comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot and non-pilot areas in England. Uptake of 57.9% (range: 43.6-72.0) was achieved in the five pilot areas for children aged 5‒11 years. In pilot areas, cumulative emergency department respiratory attendances, influenza-confirmed hospitalisations and intensive care unit admissions were consistently lower, albeit mostly non-significantly, in targeted and non-targeted age groups compared with non-pilot areas. Effect sizes were less for adults and more severe endpoints. Vaccination of healthy primary school-age children with LAIV at moderately high levels continues to be associated with population-level reductions in influenza-related respiratory illness. Further work to evaluate the population-level impact of the programme is required.
[h=4]KEYWORDS:[/h] Live attenuated influenza vaccine; children; influenza; programme impact; vaccination
PMID: 29945698 DOI: 10.2807/1560-7917.ES.2018.23.25.1700496
[h=1]Uptake and impact of vaccinating primary school-age children against influenza: experiences of a live attenuated influenza vaccine programme, England, 2015/16.[/h] Pebody RG[SUP]1[/SUP], Sinnathamby MA[SUP]1[/SUP], Warburton F[SUP]1[/SUP], Andrews N[SUP]1[/SUP], Boddington NL[SUP]1[/SUP], Zhao H[SUP]1[/SUP], Yonova I[SUP]2,[/SUP][SUP]3[/SUP], Ellis J[SUP]1[/SUP], Tessier E[SUP]1[/SUP], Donati M[SUP]4[/SUP], Elliot AJ[SUP]5[/SUP], Hughes HE[SUP]5[/SUP], Pathirannehelage S[SUP]2,[/SUP][SUP]3[/SUP], Byford R[SUP]2,[/SUP][SUP]3[/SUP], Smith GE[SUP]5[/SUP], de Lusignan S[SUP]2,[/SUP][SUP]3[/SUP], Zambon M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The 2015/16 influenza season was the third season of the introduction of an intra-nasally administered live attenuated influenza vaccine (LAIV) for children in England. All children aged 2‒6 years were offered LAIV, and in addition, a series of geographically discrete areas piloted vaccinating school-age children 7‒11 years old. Influenza A(H1N1)pdm09 was the dominant circulating strain during 2015/16 followed by influenza B. We measured influenza vaccine uptake and the overall and indirect effect of vaccinating children of primary school -age, by comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot and non-pilot areas in England. Uptake of 57.9% (range: 43.6-72.0) was achieved in the five pilot areas for children aged 5‒11 years. In pilot areas, cumulative emergency department respiratory attendances, influenza-confirmed hospitalisations and intensive care unit admissions were consistently lower, albeit mostly non-significantly, in targeted and non-targeted age groups compared with non-pilot areas. Effect sizes were less for adults and more severe endpoints. Vaccination of healthy primary school-age children with LAIV at moderately high levels continues to be associated with population-level reductions in influenza-related respiratory illness. Further work to evaluate the population-level impact of the programme is required.
[h=4]KEYWORDS:[/h] Live attenuated influenza vaccine; children; influenza; programme impact; vaccination
PMID: 29945698 DOI: 10.2807/1560-7917.ES.2018.23.25.1700496