tetano
Editor, Senior Moderator
J Virol. 2012 Dec 26. [Epub ahead of print]
Unravel a Neutralization Mechanism by Two Human Antibodies against Conserved Epitopes in the Globular Head of H5 Hemagglutinin.
Qian M, Hu H, Zuo T, Wang G, Zhang L, Zhou P.
Source
The Unit of Anti-viral Immunity and Genetic Therapy, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 200025.
Abstract
Rapid spread of highly pathogenic avian influenza (HPAI) H5N1 virus underscores the importance of effective antiviral treatment. Previously, we developed human monoclonal antibodies 65C6 and 100F4 that neutralize almost all (sub)clades of HPAI H5N1. The conserved 65C6 epitope was mapped to the globular head of HA. However, neither 100F4 epitope nor neutralization mechanism by these antibodies was known. In this study we determined 100F4 epitope and unraveled a neutralization mechanism by antibodies 65C6 and 100F4.
PMID:
23269809
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23269809
Unravel a Neutralization Mechanism by Two Human Antibodies against Conserved Epitopes in the Globular Head of H5 Hemagglutinin.
Qian M, Hu H, Zuo T, Wang G, Zhang L, Zhou P.
Source
The Unit of Anti-viral Immunity and Genetic Therapy, Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China 200025.
Abstract
Rapid spread of highly pathogenic avian influenza (HPAI) H5N1 virus underscores the importance of effective antiviral treatment. Previously, we developed human monoclonal antibodies 65C6 and 100F4 that neutralize almost all (sub)clades of HPAI H5N1. The conserved 65C6 epitope was mapped to the globular head of HA. However, neither 100F4 epitope nor neutralization mechanism by these antibodies was known. In this study we determined 100F4 epitope and unraveled a neutralization mechanism by antibodies 65C6 and 100F4.
PMID:
23269809
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23269809