tetano
Editor, Senior Moderator
United European Gastroenterol J
. 2020 Jun;8(5):509-519.
doi: 10.1177/2050640620924157.
Liver Injury in COVID-19: The Current Evidence
Saleh A Alqahtani[SUP] 1 2 [/SUP], J?rn M Schattenberg[SUP] 3 [/SUP]
Affiliations
Abstract
Patients with novel coronavirus disease 2019 (COVID-19) experience various degrees of liver function abnormalities. Liver injury requires extensive work-up and continuous surveillance and can be multifactorial and heterogeneous in nature. In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of COVID-19, direct effect of the virus, or a complicated disease course. Recent studies proposed several theories on potential mechanisms of liver injury in these patients. This review summarizes current evidence related to hepatobiliary complications in COVID-19, provides an overview of the available case series and critically elucidates the proposed mechanisms and provides recommendations for clinicians.
Keywords: COVID-19; SARS-CoV2; cholangiocytes; cytokine storm; liver function test; liver injury; lymphopenia.
. 2020 Jun;8(5):509-519.
doi: 10.1177/2050640620924157.
Liver Injury in COVID-19: The Current Evidence
Saleh A Alqahtani[SUP] 1 2 [/SUP], J?rn M Schattenberg[SUP] 3 [/SUP]
Affiliations
- PMID: 32450787
- DOI: 10.1177/2050640620924157
Abstract
Patients with novel coronavirus disease 2019 (COVID-19) experience various degrees of liver function abnormalities. Liver injury requires extensive work-up and continuous surveillance and can be multifactorial and heterogeneous in nature. In the context of COVID-19, clinicians will have to determine whether liver injury is related to an underlying liver disease, drugs used for the treatment of COVID-19, direct effect of the virus, or a complicated disease course. Recent studies proposed several theories on potential mechanisms of liver injury in these patients. This review summarizes current evidence related to hepatobiliary complications in COVID-19, provides an overview of the available case series and critically elucidates the proposed mechanisms and provides recommendations for clinicians.
Keywords: COVID-19; SARS-CoV2; cholangiocytes; cytokine storm; liver function test; liver injury; lymphopenia.