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Uganda: 2024-2025 Mpox

WEEKLY BULLETIN ON OUTBREAKS
AND OTHER EMERGENCIES

Week 10: 3 - 9 March 2025
Data as reported by: 17:00; 9 March 2025
...
Uganda
Mpox

3 833 Cases
31 Deaths
0.8% CFR


EVENT DESCRIPTION

The mpox outbreak in Uganda continues to unfold, with
new cases being reported across the country. Between
11 February and 4 March 2025, a total of 937 new
confirmed cases with 12 deaths were reported from 63
districts across the country. The majority of these new
cases emerged from high-density urban and peri-urban
areas, with Kampala accounting for 368 cases, followed
by Wakiso (n=107), Mbarara (n=64), and Mukono
(n=50). These four districts together accounted for
62.9% of the new cases. Of the 12 new deaths, Kampala
reported the highest number (n=4), followed by Masaka
City (n=3), and other affected districts such as Kalungu,
Nakasongola, Mbarara, Wakiso, and Mukono, each
contributing one death.

As of 4 March 2025, a cumulative total of 3 833 confirmed
mpox cases with 31 deaths (CFR 0.8%) have been
reported from 95 out of 146 districts in Uganda since
the outbreak began on 24 July 2024. Males are more
affected, accounting for 56.6% (n=2,169) of the total
cases. Most cases are among people in the age group
18 to 39 years, accoounting for close to 70% of all cases
reported across the country. The majority of deaths have
been reported from Kampala (n=15), followed by Wakiso
(n=5), Masaka City (n=3), and Mukono (n=2). Additional
deaths have occurred in Kikuube, Pallisa, Mbarara,
Kalungu, Nakasongola, and Masindi, with one death
reported from each of these districts.

The outbreak remains largely concentrated in and
around the capital, Kampala. So far, clade 1b MPXV,
linked to the outbreak in eastern Democratic Republic
of the Congo, has been detected in the country, and
current evidence indicates that transmission of the virus
is occurring exclusively through close, physical human
to-human contact. Uganda currently reports the second
highest number of confirmed mpox cases in the African
Region following the Democratic Republic of the Congo.

PUBLIC HEALTH ACTIONS

An Incident Management Team, led by the Ministry of
Health with technical support from WHO and health
partners, continues to coordinate the national response to
the outbreak. Weekly meetings are held, including partner
engagements, to inform outbreak response strategies
and activities.

Task forces setup in the affected districts are supporting
national response efforts by coordinating field-level
operations.

Surveillance for mpox is ongoing across all districts in
Uganda. Mpox remains one of the country’s priority
diseases for immediate notification through the Integrated
Disease Surveillance and Response (IDSR) strategy.
In affected districts, surveillance efforts are being
enhanced through the dissemination of case definitions
to surveillance officers and clinicians to facilitate early
detection and reporting of cases. Active case searches
in communities, schools, and other communal places
are ongoing, along with contact tracing activities in the
affected districts.

Laboratory capacity is in place for diagnostics and
genomic sequencing. All suspected cases are routinely
tested to confirm or rule out mpox virus infection. Training
on mpox sample management has been conducted to
ensure proper collection, handling, and transportation of
samples. A sample referral system is in place.

Isolation units have been set up in affected districts for
the management of cases. Bi-weekly case management
webinars are being held to refresh clinicians on
management of mpox cases.

The risk communication and community engagement
(RCCE) pillar continues to analyze and leverage
community feedback insights to develop messaging that
raises awareness, promotes preventive practices, and
encourages early reporting and care-seeking behaviour.

SITUATION INTERPRETATION

The ongoing mpox outbreak in Uganda is occurring
concurrently with outbreaks of Sudan virus disease
and cholera, straining the country’s resources to
manage these simultaneous public health events. The
concentration of mpox cases in urban and peri-urban
areas suggests that close physical contact in crowded,
densely-populated environments may be driving
sustained transmission of the virus. Uganda’s robust
surveillance and reporting system likely accounts for the
high number of confirmed cases reported. The presence
of clade 1b, which is associated with higher virulence,
in the Ugandan outbreak emphasizes the urgency of
controlling its spread to prevent further hospitalizations,
complications, and deaths. Health authorities must
prioritize understanding the transmission dynamics of
the virus and implement tailored public health response
strategies to halt ongoing transmission and mitigate the
impact of the outbreak.​

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​

https://www.afro.who.int/health-topics/disease-outbreaks/outbreaks-and-other-emergencies-updates
 
Uganda's mpox cases reach 4,342, death toll rises to 31

Source: Xinhua| 2025-03-18 21:31:30|Editor: huaxia

KAMPALA, March 18 (Xinhua) -- The cumulative number of laboratory-confirmed mpox cases in Uganda has reached 4,342, with 31 deaths reported since the outbreak was declared in the East African country eight months ago, the Ugandan Ministry of Health said Tuesday.

A total of 25 new cases were recorded in the past 24 hours, with the capital, Kampala, the epicenter of the virus, registering 12 cases, the ministry said in a national situation report issued here.
...

https://english.news.cn/africa/20250318/f4486b4eb1354f6e9fdd43f5a092f246/c.html
 
Source: https://www.independent.co.ug/mpox-kitgum-reports-12-suspected-cases-in-children/

MPOX: Kitgum reports 12 suspected cases in children
The Independent March 23, 2025

KITGUM, UGANDA | THE INDEPENDENT | 12 suspected cases of MPOX have been reported in children in Namokora Town Council, Kitgum District.

According to Titus Komakech, the Surveillance focal person, the children, ranging from 3-9 years, are from two schools, St Kizito and St Paul Nursery and Primary schools in Namokora Town Council.

Komakech revealed that the 12 suspected cases were identified after exhibiting symptoms of Mpox, a viral disease characterized by fever, headache, and a characteristic rash and were rushed to Namokora Health Centre IV for treatment.

“We have identified 12 suspected cases of Mpox in children from St Kizito and St Paul schools,” Komakech said. “We are taking this situation seriously and are working to contain the outbreak.”

Komakech added that 28 contacts of the suspected cases have been traced, and three adults are showing signs of the disease.​..
 
Source: https://www.independent.co.ug/mpox-outbreak-reported-in-moroto/

Mpox outbreak reported in Moroto
The Independent April 5, 2025 NEWS

Moroto, Uganda | THE INDEPENDENT | Moroto district is on high alert following the outbreak of mpox disease.

This was revealed on Friday by the Moroto district health department after a 28-year-old businesswoman from Singila Trading Center in Katikekile sub-county presented symptoms of Mpox, whose tests turned positive.

The patient is believed to have a history of travel and had many contacts, of which one had already presented similar symptoms. Other contacts are said to be in Moroto Prison barracks.

Dr Charles Onyang Omudu, the district health educator, said that both the confirmed case and the contact are isolated in Moroto Regional Referral Hospital. Omudu added that a disease surveillance team has embarked on tracing other contacts for testing and isolation.​..
 
Mpox death toll rises to 40 in Uganda as cases surpass 5,400

Source: Xinhua| 2025-04-21 20:23:45|Editor: huaxia

KAMPALA, April 21 (Xinhua) -- The cumulative number of confirmed mpox cases in Uganda has hit 5,431, with 40 deaths reported since the outbreak was declared in the East African country nine months ago, the Ministry of Health said Monday.

A total of 44 new infections were recorded in the previous 24 hours, the ministry said in a situation report, noting an increased severity among patients admitted to hospital with mpox.

"The cities and fishing communities exhibit the highest attack rates especially," it said, citing Mbarara City and Kampala, and fishing districts in Buvuma, Kalangala and Nakasongola.
...
https://english.news.cn/africa/20250421/d8c204b07e99403b8b6a69102402e489/c.html
​
 
Source: https://reliefweb.int/report/uganda/uganda-national-mpox-situation-report-june-4-2025

Uganda: National Mpox Situation Report | June 4, 2025

Format Situation Report
Sources Govt. UgandaWHO
Posted 5 Jun 2025
Originally published 5 Jun 2025


Key Points:

1. Epidemic remains active. The epidemic remains active and evolving, with varying transmission dynamics across the country. While there is a notable decline in weekly incident cases, sustained transmission is ongoing in identified hotspots. Todate 79% (115/146) of districts resported atleast one case since the beginning of the outbreak and 38%(55/146) reporting new cases in the past 21 days.

2. High-risk mortality observed. A total of 44 deaths have occurred among confirmed cases, over half (52.3%) of whom were co-infected with HIV, underscoring vulnerabilities in this population. Persons co-infected with HIV had four times higher odds of severe Mpox disease

3. Young adults are disproportionately affected. Attack rates are highest among females aged 25–29 (2.8/100,000). In the last 3 weeks, there has been a shift in the most affected among males from 35-39 tomales aged 44–49 (4.2/100,000). This may be indicative of a shift in the transmission dynamics among males.

​
 
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