tetano
Editor, Senior Moderator
Bioorg Med Chem. 2013 Oct 30. pii: S0968-0896(13)00891-2. doi: 10.1016/j.bmc.2013.10.026. [Epub ahead of print]
Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.
Bozzini T, Botta G, Delfino M, Onofri S, Saladino R, Amatore D, Sgarbanti R, Nencioni L, Palamara AT.
Source
Department of Ecology and Biology, University of Tuscia, Via S. Camillo de Lellis, 01100 Viterbo, Italy.
Abstract
Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
Antiviral, Biocatalysis, Catechols, Immobilized tyrosinase, Influenza A virus
PMID:
24216089
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24216089
Tyrosinase and Layer-by-Layer supported tyrosinases in the synthesis of lipophilic catechols with antiinfluenza activity.
Bozzini T, Botta G, Delfino M, Onofri S, Saladino R, Amatore D, Sgarbanti R, Nencioni L, Palamara AT.
Source
Department of Ecology and Biology, University of Tuscia, Via S. Camillo de Lellis, 01100 Viterbo, Italy.
Abstract
Catechol derivatives with lipophilic properties have been selectively synthesized by tyrosinase in high yield avoiding long and tedious protection/deprotection steps usually required in traditional procedures. The synthesis was effective also with immobilized tyrosinase able to perform for more runs. The novel catechols were evaluated against influenza A virus, that continue to represent a severe threat worldwide. A significant antiviral activity was observed in derivatives characterized by antioxidant activity and long carbon alkyl side-chains, suggesting the possibility of a new inhibition mechanism based on both redox and lipophilic properties.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
Antiviral, Biocatalysis, Catechols, Immobilized tyrosinase, Influenza A virus
PMID:
24216089
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24216089