Re: Two Tamiflu-resistant swine flu cases reported in WA
Re: Two Tamiflu-resistant swine flu cases reported in WA
Re: Two Tamiflu-resistant swine flu cases reported in WA
It "could" do a lot of things. However, swine H1N1 that acquires human N almost always also acquires human H. In Sasketchewan, 2 or 3 farm workers were infected with a triple reassortant that was Tamiflu resistance because the virus had acquired the N1 from Bisbane/59, which had H274Y. However, it also acquired H1 from Brisbane/59, so the resulting virus had a human H1N1 serotype, but a pandemic strain is defined by a new serotype. Brisbane/59 H1N1 is not new (and most humans have immunity by virtue of earlier H1N1 seasonal flu infections and earlier vaccination with Brisbane/59 H1N1).it can acquire NA (and others...) and not HA.
any such reassortment is dangerous since it could change virulence.
e.g. it could acquire PB1 with a functional PB1-F2
reassortment means prolonged evolution. Once it goes loose
the virus may get other ideas how to change