tetano
Editor, Senior Moderator
J Asian Nat Prod Res. 2019 Aug 1:1-6. doi: 10.1080/10286020.2019.1645132. [Epub ahead of print]
[h=1]Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities.[/h] Yin ZK[SUP]1[/SUP], Feng ZM[SUP]1[/SUP], Jiang JS[SUP]1[/SUP], Zhang X[SUP]1[/SUP], Zhang PC[SUP]1[/SUP], Yang YN[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of Salvia miltiorrhiza. Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1 and 2 were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC[SUB]50[/SUB] = 0.67 μM) and oseltamivir (IC[SUB]50[/SUB] = 2.01 μM) as a positive control. Compound 1 exhibited moderate inhibitory activity against HSV-1 and influenza A (H3N2) with IC[SUB]50[/SUB] values of 11.11 and 8.62 μM, respectively.
[h=4]KEYWORDS:[/h] ; Labiatae; antiviral activity; isolation and purification; structure elucidation; tanshinone diterpene derivatives
PMID: 31368354 DOI: 10.1080/10286020.2019.1645132
[h=1]Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities.[/h] Yin ZK[SUP]1[/SUP], Feng ZM[SUP]1[/SUP], Jiang JS[SUP]1[/SUP], Zhang X[SUP]1[/SUP], Zhang PC[SUP]1[/SUP], Yang YN[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of Salvia miltiorrhiza. Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1 and 2 were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC[SUB]50[/SUB] = 0.67 μM) and oseltamivir (IC[SUB]50[/SUB] = 2.01 μM) as a positive control. Compound 1 exhibited moderate inhibitory activity against HSV-1 and influenza A (H3N2) with IC[SUB]50[/SUB] values of 11.11 and 8.62 μM, respectively.
[h=4]KEYWORDS:[/h] ; Labiatae; antiviral activity; isolation and purification; structure elucidation; tanshinone diterpene derivatives
PMID: 31368354 DOI: 10.1080/10286020.2019.1645132