Mary Wilson
Well-known member
Marshleen Yadav[SUP]1 [/SUP],Sagar Bhayana[SUP]1[/SUP], Joseph Liu[SUP]1[/SUP], Lanchun Lu[SUP]1[/SUP], Jason Huang[SUP]1[/SUP], Ya Ma[SUP]1[/SUP], Zahida Qamri[SUP]1[/SUP], Xiaokui Mo[SUP]3[/SUP],
Diviya S. Jacob[SUP]1[/SUP], Shashaank T. Parasa[SUP]1[/SUP], Noureen Bhuiya[SUP]1[/SUP], Paolo Fadda[SUP]1[/SUP], Meng Xu-Welliver[SUP]1[/SUP],
Arnab Chakravarti[SUP]1[/SUP],and Naduparambil K. Jacob[SUP]1[/SUP],
See all authors and affiliations
Science Translational Medicine 15 Jul 2020:
Vol. 12, Issue 552, eaaw5831
DOI: 10.1126/scitranslmed.aaw5831
Detecting radiation in a single drop
Practical, scalable approaches for measuring therapeutic or accidental ionizing radiation exposure are needed. Yadav et al. show that the expression of two miRNAs in a drop of blood allowed inference of recent gamma or neutron radiation exposure in a variety of mouse models subjected to fractionated or single acute radiation and patients with leukemia undergoing fractionated radiotherapy within a few hours after blood collection. Although validation in nonhuman primates and testing of mixed-field exposure is needed, this simple two-miRNA assay shows preclinical promise for estimating radiation exposure at a range of doses relevant to clinical and catastrophic radiation exposure in humans.
https://stm.sciencemag.org/content/12/552/eaaw5831
Diviya S. Jacob[SUP]1[/SUP], Shashaank T. Parasa[SUP]1[/SUP], Noureen Bhuiya[SUP]1[/SUP], Paolo Fadda[SUP]1[/SUP], Meng Xu-Welliver[SUP]1[/SUP],
Arnab Chakravarti[SUP]1[/SUP],and Naduparambil K. Jacob[SUP]1[/SUP],
See all authors and affiliations
Science Translational Medicine 15 Jul 2020:
Vol. 12, Issue 552, eaaw5831
DOI: 10.1126/scitranslmed.aaw5831
Detecting radiation in a single drop
Practical, scalable approaches for measuring therapeutic or accidental ionizing radiation exposure are needed. Yadav et al. show that the expression of two miRNAs in a drop of blood allowed inference of recent gamma or neutron radiation exposure in a variety of mouse models subjected to fractionated or single acute radiation and patients with leukemia undergoing fractionated radiotherapy within a few hours after blood collection. Although validation in nonhuman primates and testing of mixed-field exposure is needed, this simple two-miRNA assay shows preclinical promise for estimating radiation exposure at a range of doses relevant to clinical and catastrophic radiation exposure in humans.
https://stm.sciencemag.org/content/12/552/eaaw5831