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Two Cases of Influenza B Virus-Related Fatal Fulminant Pneumonia Complicated With Staphylococcus aureus Infection in China Diagnosed Using Next-Genera

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tetano

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Front Public Health. 2020 Apr 15;8:121. doi: 10.3389/fpubh.2020.00121. eCollection 2020.
Two Cases of Influenza B Virus-Related Fatal Fulminant Pneumonia Complicated With Staphylococcus aureus Infection in China Diagnosed Using Next-Generation Sequencing (2018).

Bai B[SUP]1[/SUP], Wang H[SUP]1[/SUP], Li M[SUP]2[/SUP], Ma X[SUP]1[/SUP], Zheng J[SUP]1[/SUP], Deng Q[SUP]1[/SUP], Yu Z[SUP]1[/SUP].
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Abstract

Two rare cases of Chinese female patients with influenza B virus infection complicated with both fulminant pneumonia and septicemia caused by Panton-Valentine leukocidin(PVL) positive methicillin-sensitive Staphylococcus aureus (MASS) were reported for the first time in China through next-generation sequencing (NGS). An increasing body of evidence indicates that co-infection with influenza B virus and bacterial pneumonia is often fatal. Rapid and precise identification of the co-infection bacteria can guide the selection of treatment for patients with influenza virus infection in the clinical setting. In this study, next-generation sequencing (NGS) was applied for the rapid diagnosis of these two cases. Despite the unfavorable survival outcome of these patients, the application of next-generation sequencing showed promise as a diagnostic tool for the rapid diagnosis of unknown pathogens in patients with bacterial pneumonia and sepsis. This method can guide the administration of medications in such patients.
Copyright ? 2020 Bai, Wang, Li, Ma, Zheng, Deng and Yu.


KEYWORDS:

Staphylococcus aureus; fatal pneumonia; influenza B virus; next-generation sequencing; sepsis

PMID:32351925PMCID:PMC7175880DOI:10.3389/fpubh.2020.00121
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