Giuseppe
Emeritus
From Emerging Infectious Diseases Review:
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Mutations in Influenza A Virus (H5N1) and Possible Limited Spread, Turkey,
2006
Ender Altiok,*† Fulya Taylan,* Osman Ş. Yenen,‡ Gülşah Demirkeser,* Mürvet Bozaci,‡ Derya Önel,‡ Birsen Akcadag,§ A. Selma Iyisan,§ Meral Ciblak,‡ Emel Bozkaya,‡ Sirin Yuksel,* and Selim Badur‡
*Acibadem Genetic Diagnosis Center, Istanbul, Turkey; †Boğaziçi University, Istanbul, Turkey; ‡Istanbul University School of Medicine, Istanbul, Turkey; and §Pendik Veterinary Control and Research Institute, Istanbul, Turkey
(...)
Conclusions
The Q447L and E627K mutations in FK and MAK virus isolates indicate a common origin of viruses in the 2 siblings. Unique mutations (D158N and S227N in HA and N556K and R46K in PB2) in only the MAK isolate suggest virus evolution in 1 patient. Human-to-human transmission and adaptation of the virus to infect humans have been suggested (3). Incomplete knowledge of the history of infections in humans and lack of sample availability limited our study. Unique mutations in PB2, particularly in these human isolates, emphasize the need for clinical, epidemiologic, and molecular studies for further understanding of the global pattern of evolution of influenza A virus (H5N1).
The close location of mutation T42 to viral regions associated with host specificity and resistance to adamantanes and isolation of virus with this mutation from humans should be studied. Although isolates from the FK and MAK group have not been available for comparison, the unique changes should be studied with respect to their ability to confer survival advantage to virus in humans.
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http://www.cdc.gov/eid/content/14/3/pdfs/06-1237.pdf
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Mutations in Influenza A Virus (H5N1) and Possible Limited Spread, Turkey,
2006
Ender Altiok,*† Fulya Taylan,* Osman Ş. Yenen,‡ Gülşah Demirkeser,* Mürvet Bozaci,‡ Derya Önel,‡ Birsen Akcadag,§ A. Selma Iyisan,§ Meral Ciblak,‡ Emel Bozkaya,‡ Sirin Yuksel,* and Selim Badur‡
*Acibadem Genetic Diagnosis Center, Istanbul, Turkey; †Boğaziçi University, Istanbul, Turkey; ‡Istanbul University School of Medicine, Istanbul, Turkey; and §Pendik Veterinary Control and Research Institute, Istanbul, Turkey
We report mutations in influenza A virus (H5N1) strains associated with 2 outbreaks in Turkey.
Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died.
Four novel amino acid changes (Q447L, N556K, and R46K in RNA polymerase and S133A in hemagglutinin) were detected in virus isolates from 2 siblings who died.
(...)
Conclusions
The Q447L and E627K mutations in FK and MAK virus isolates indicate a common origin of viruses in the 2 siblings. Unique mutations (D158N and S227N in HA and N556K and R46K in PB2) in only the MAK isolate suggest virus evolution in 1 patient. Human-to-human transmission and adaptation of the virus to infect humans have been suggested (3). Incomplete knowledge of the history of infections in humans and lack of sample availability limited our study. Unique mutations in PB2, particularly in these human isolates, emphasize the need for clinical, epidemiologic, and molecular studies for further understanding of the global pattern of evolution of influenza A virus (H5N1).
The close location of mutation T42 to viral regions associated with host specificity and resistance to adamantanes and isolation of virus with this mutation from humans should be studied. Although isolates from the FK and MAK group have not been available for comparison, the unique changes should be studied with respect to their ability to confer survival advantage to virus in humans.
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http://www.cdc.gov/eid/content/14/3/pdfs/06-1237.pdf
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