tetano
Editor, Senior Moderator
Turk Arch Pediatr
. 2025 Dec 30;61(3):214-222.
doi: 10.5152/TurkArchPediatr.2025.25307.
Burden, Risk Factors, and Clinical Outcomes of Pediatric Influenza in a Population with Extremely Low Vaccine Coverage
Kubra Aykac[SUP] 1 [/SUP], Hacer Yakin[SUP] 1 [/SUP], Eylul Dogan Ickin[SUP] 2 [/SUP], Gozde Uluisik[SUP] 2 [/SUP], Osman Oguz Demir[SUP] 2 [/SUP], Mustafa Genceli[SUP] 3 [/SUP], Ozge Metin Akcan[SUP] 3 [/SUP], Neslihan Mete Atasever[SUP] 4 [/SUP], Ayper Somer[SUP] 4 [/SUP], Eda Sahin Izci[SUP] 5 [/SUP], Nazan Dalgic[SUP] 5 [/SUP], Esra Cakmak Taskin[SUP] 6 [/SUP], Fatma Dilsad Aksoy[SUP] 7 [/SUP], Esra Ciftci[SUP] 7 [/SUP], Solmaz Celebi[SUP] 7 [/SUP], Mustafa Hacimustafaoglu[SUP] 7 [/SUP], Saliha Kanik-Yuksek[SUP] 8 [/SUP], Aslinur Ozkaya-Parlakay[SUP] 8 [/SUP], Seval Ozen[SUP] 8 [/SUP], Hatice Kubra Konca[SUP] 8 [/SUP], Pinar Bayraktar[SUP] 8 [/SUP], Nihan Coskun[SUP] 8 [/SUP], Sevgi Kus[SUP] 9 [/SUP], Ahu Kara Aksay[SUP] 9 [/SUP], Didem Büyüktas Aytac[SUP] 10 [/SUP], Gulsen Akkoc[SUP] 10 [/SUP], Sevliya Ocal Demir[SUP] 10 [/SUP], Canan Ozlu[SUP] 11 [/SUP], Serap Kilic Kaya[SUP] 12 [/SUP], Esra Disci[SUP] 12 [/SUP], Sare Ilbay[SUP] 13 [/SUP], Latife Guder[SUP] 13 [/SUP], Gulsum Alkan[SUP] 14 [/SUP], Busra Ozyalvac[SUP] 14 [/SUP], Melike Emiroglu[SUP] 14 [/SUP], Dicle Sener Okur[SUP] 15 [/SUP], Aysenur Bostan[SUP] 16 [/SUP], Gizem Mardinoglu[SUP] 16 [/SUP], Omer Kilic[SUP] 16 [/SUP], Ayse Hitay Telefon[SUP] 17 [/SUP], Merve Kilic Cil[SUP] 17 [/SUP], Perihan Essizoglu[SUP] 17 [/SUP], Umit Celik[SUP] 17 [/SUP], Gulben Ozgul Postuk[SUP] 18 [/SUP], Zeynep Gokce Gayretli Aydin[SUP] 18 [/SUP], Gulizar Toy Usta[SUP] 19 [/SUP], Kıvanc Celikkalkan[SUP] 19 [/SUP], Hatice Karaoglu Asrak[SUP] 20 [/SUP], Murat Bicen[SUP] 21 [/SUP], Muhammet Asena[SUP] 21 [/SUP], Gulhadiye Avcu[SUP] 22 [/SUP], Coskun Ekemen[SUP] 22 [/SUP], Ayse Cakil Guzin[SUP] 23 [/SUP], Eda Karadag Oncel[SUP] 23 [/SUP], Semra Bayturan Sen[SUP] 24 [/SUP], Hatice Sinav Utku[SUP] 25 [/SUP], Selim Oncel[SUP] 25 [/SUP], Merve Iseri Nepesov[SUP] 26 [/SUP], Ozlem Erdede[SUP] 27 [/SUP], Pelin Kacar[SUP] 28 [/SUP], Mustafa Gulderen[SUP] 28 [/SUP], Arife Ozer[SUP] 28 [/SUP], Onder Kilicaslan[SUP] 29 [/SUP], Adem Karbuz[SUP] 29 [/SUP], Ozlem Cakici[SUP] 30 [/SUP], Ezgi Avci[SUP] 31 [/SUP], Belma Yasar[SUP] 32 [/SUP], Zuhal Umit[SUP] 32 [/SUP], Nurettin Erdem[SUP] 33 [/SUP], Sahika Sahinkaya[SUP] 33 [/SUP], Elif Gudeloglu Cetiz[SUP] 34 [/SUP], Muhammed Selcuk Sinanoglu[SUP] 35 [/SUP], Derya İlhan[SUP] 36 [/SUP], Soner Sertan Kara[SUP] 36 [/SUP], Yildiz Ekemen Keles[SUP] 37 [/SUP], Elif Kiymet[SUP] 37 [/SUP], Nahida Gokay[SUP] 38 [/SUP], Edanur Yesil[SUP] 38 [/SUP], Necdet Kuyucu[SUP] 38 [/SUP], Burcu Ceylan Cura Yayla[SUP] 39 [/SUP], Hanife Avcı[SUP] 40 [/SUP], Ali Bulent Cengiz[SUP] 1 [/SUP], Yasemin Ozsurekci[SUP] 1 [/SUP]
Affiliations
Objective: Influenza is a contagious viral respiratory tract infection that causes severe illness, particularly in high-risk populations such as young children and individuals with pre-existing health conditions. The study aims to identify clinical characteristics and key risk factors associated with respiratory support and mortality in children with influenza infection.
Materials and methods: This retrospective, multicenter study was conducted across 33 hospitals from 19 cities in Türkiye. Data from pediatric inpatients aged <18 years diagnosed with influenza between October 2023 and May 2024 were analyzed.
Results: Among 1032 hospitalized children infected with influenza, 394 (38.2%) required respiratory support. The respiratory support group was significantly younger, with a mean age of 3.40 ± 4.37 years, compared to 4.96 ± 4.36 years in the non-respiratory support group (P < .001). The frequency of any underlying disease was significantly higher in the respiratory support group (P < .001). Notably, conditions such as neurometabolic disorders (20.3% vs. 9.6%) and pulmonary diseases (7.1% vs. 2.8%) were more common in this group. Influenza A infection and viral coinfections, particularly with respiratory syncytial virus, increased the likelihood of mechanical ventilation and mortality. The mortality proportion of all patients with influenza infection was 1.3% and the influenza vaccine coverage was only 1.1%.
Conclusion: These findings highlight the urgent need to incorporate influenza vaccination into the national immunization program, especially for high-risk pediatric populations.
Keywords: Hospitalization respiratory support; Türkiye; influenza; mechanical ventilation; vaccination coverage.
. 2025 Dec 30;61(3):214-222.
doi: 10.5152/TurkArchPediatr.2025.25307.
Burden, Risk Factors, and Clinical Outcomes of Pediatric Influenza in a Population with Extremely Low Vaccine Coverage
Kubra Aykac[SUP] 1 [/SUP], Hacer Yakin[SUP] 1 [/SUP], Eylul Dogan Ickin[SUP] 2 [/SUP], Gozde Uluisik[SUP] 2 [/SUP], Osman Oguz Demir[SUP] 2 [/SUP], Mustafa Genceli[SUP] 3 [/SUP], Ozge Metin Akcan[SUP] 3 [/SUP], Neslihan Mete Atasever[SUP] 4 [/SUP], Ayper Somer[SUP] 4 [/SUP], Eda Sahin Izci[SUP] 5 [/SUP], Nazan Dalgic[SUP] 5 [/SUP], Esra Cakmak Taskin[SUP] 6 [/SUP], Fatma Dilsad Aksoy[SUP] 7 [/SUP], Esra Ciftci[SUP] 7 [/SUP], Solmaz Celebi[SUP] 7 [/SUP], Mustafa Hacimustafaoglu[SUP] 7 [/SUP], Saliha Kanik-Yuksek[SUP] 8 [/SUP], Aslinur Ozkaya-Parlakay[SUP] 8 [/SUP], Seval Ozen[SUP] 8 [/SUP], Hatice Kubra Konca[SUP] 8 [/SUP], Pinar Bayraktar[SUP] 8 [/SUP], Nihan Coskun[SUP] 8 [/SUP], Sevgi Kus[SUP] 9 [/SUP], Ahu Kara Aksay[SUP] 9 [/SUP], Didem Büyüktas Aytac[SUP] 10 [/SUP], Gulsen Akkoc[SUP] 10 [/SUP], Sevliya Ocal Demir[SUP] 10 [/SUP], Canan Ozlu[SUP] 11 [/SUP], Serap Kilic Kaya[SUP] 12 [/SUP], Esra Disci[SUP] 12 [/SUP], Sare Ilbay[SUP] 13 [/SUP], Latife Guder[SUP] 13 [/SUP], Gulsum Alkan[SUP] 14 [/SUP], Busra Ozyalvac[SUP] 14 [/SUP], Melike Emiroglu[SUP] 14 [/SUP], Dicle Sener Okur[SUP] 15 [/SUP], Aysenur Bostan[SUP] 16 [/SUP], Gizem Mardinoglu[SUP] 16 [/SUP], Omer Kilic[SUP] 16 [/SUP], Ayse Hitay Telefon[SUP] 17 [/SUP], Merve Kilic Cil[SUP] 17 [/SUP], Perihan Essizoglu[SUP] 17 [/SUP], Umit Celik[SUP] 17 [/SUP], Gulben Ozgul Postuk[SUP] 18 [/SUP], Zeynep Gokce Gayretli Aydin[SUP] 18 [/SUP], Gulizar Toy Usta[SUP] 19 [/SUP], Kıvanc Celikkalkan[SUP] 19 [/SUP], Hatice Karaoglu Asrak[SUP] 20 [/SUP], Murat Bicen[SUP] 21 [/SUP], Muhammet Asena[SUP] 21 [/SUP], Gulhadiye Avcu[SUP] 22 [/SUP], Coskun Ekemen[SUP] 22 [/SUP], Ayse Cakil Guzin[SUP] 23 [/SUP], Eda Karadag Oncel[SUP] 23 [/SUP], Semra Bayturan Sen[SUP] 24 [/SUP], Hatice Sinav Utku[SUP] 25 [/SUP], Selim Oncel[SUP] 25 [/SUP], Merve Iseri Nepesov[SUP] 26 [/SUP], Ozlem Erdede[SUP] 27 [/SUP], Pelin Kacar[SUP] 28 [/SUP], Mustafa Gulderen[SUP] 28 [/SUP], Arife Ozer[SUP] 28 [/SUP], Onder Kilicaslan[SUP] 29 [/SUP], Adem Karbuz[SUP] 29 [/SUP], Ozlem Cakici[SUP] 30 [/SUP], Ezgi Avci[SUP] 31 [/SUP], Belma Yasar[SUP] 32 [/SUP], Zuhal Umit[SUP] 32 [/SUP], Nurettin Erdem[SUP] 33 [/SUP], Sahika Sahinkaya[SUP] 33 [/SUP], Elif Gudeloglu Cetiz[SUP] 34 [/SUP], Muhammed Selcuk Sinanoglu[SUP] 35 [/SUP], Derya İlhan[SUP] 36 [/SUP], Soner Sertan Kara[SUP] 36 [/SUP], Yildiz Ekemen Keles[SUP] 37 [/SUP], Elif Kiymet[SUP] 37 [/SUP], Nahida Gokay[SUP] 38 [/SUP], Edanur Yesil[SUP] 38 [/SUP], Necdet Kuyucu[SUP] 38 [/SUP], Burcu Ceylan Cura Yayla[SUP] 39 [/SUP], Hanife Avcı[SUP] 40 [/SUP], Ali Bulent Cengiz[SUP] 1 [/SUP], Yasemin Ozsurekci[SUP] 1 [/SUP]
Affiliations
- PMID: 42044444
- DOI: 10.5152/TurkArchPediatr.2025.25307
Objective: Influenza is a contagious viral respiratory tract infection that causes severe illness, particularly in high-risk populations such as young children and individuals with pre-existing health conditions. The study aims to identify clinical characteristics and key risk factors associated with respiratory support and mortality in children with influenza infection.
Materials and methods: This retrospective, multicenter study was conducted across 33 hospitals from 19 cities in Türkiye. Data from pediatric inpatients aged <18 years diagnosed with influenza between October 2023 and May 2024 were analyzed.
Results: Among 1032 hospitalized children infected with influenza, 394 (38.2%) required respiratory support. The respiratory support group was significantly younger, with a mean age of 3.40 ± 4.37 years, compared to 4.96 ± 4.36 years in the non-respiratory support group (P < .001). The frequency of any underlying disease was significantly higher in the respiratory support group (P < .001). Notably, conditions such as neurometabolic disorders (20.3% vs. 9.6%) and pulmonary diseases (7.1% vs. 2.8%) were more common in this group. Influenza A infection and viral coinfections, particularly with respiratory syncytial virus, increased the likelihood of mechanical ventilation and mortality. The mortality proportion of all patients with influenza infection was 1.3% and the influenza vaccine coverage was only 1.1%.
Conclusion: These findings highlight the urgent need to incorporate influenza vaccination into the national immunization program, especially for high-risk pediatric populations.
Keywords: Hospitalization respiratory support; Türkiye; influenza; mechanical ventilation; vaccination coverage.