tetano
Editor, Senior Moderator
Trop Med Infect Dis
. 2022 Mar 4;7(3):43.
doi: 10.3390/tropicalmed7030043.
Detection of SARS-CoV-2 Antigens in the AV-Node of a Cardiac Conduction System-A Case Report
Hrvoje Jakovac[SUP] 1 [/SUP], Antun Ferenčić[SUP] 2 [/SUP], Christophe Stemberger[SUP] 3 [/SUP], Bojana Mohar Vitezić[SUP] 4 [/SUP], Dražen Cuculić[SUP] 2 [/SUP]
Affiliations
Abstract
Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavirus disease (COVID-19), posing additional mortality risk in older-aged and critically ill patients. However, the underlying mechanisms and cardio pathological substrates of COVID-related arrhythmias have not been clarified yet. Here, we report findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and genes in the atrioventricular node (AV-node) of a cardiac conduction system, pointing to its direct infection as a possible arrhythmogenic factor.
Keywords: AV-node; COVID-19; SARS-CoV-2; cardiac arrhythmia; cardiac conduction system; nucleocapsid protein; spike protein.
. 2022 Mar 4;7(3):43.
doi: 10.3390/tropicalmed7030043.
Detection of SARS-CoV-2 Antigens in the AV-Node of a Cardiac Conduction System-A Case Report
Hrvoje Jakovac[SUP] 1 [/SUP], Antun Ferenčić[SUP] 2 [/SUP], Christophe Stemberger[SUP] 3 [/SUP], Bojana Mohar Vitezić[SUP] 4 [/SUP], Dražen Cuculić[SUP] 2 [/SUP]
Affiliations
- PMID: 35324590
- DOI: 10.3390/tropicalmed7030043
Abstract
Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavirus disease (COVID-19), posing additional mortality risk in older-aged and critically ill patients. However, the underlying mechanisms and cardio pathological substrates of COVID-related arrhythmias have not been clarified yet. Here, we report findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and genes in the atrioventricular node (AV-node) of a cardiac conduction system, pointing to its direct infection as a possible arrhythmogenic factor.
Keywords: AV-node; COVID-19; SARS-CoV-2; cardiac arrhythmia; cardiac conduction system; nucleocapsid protein; spike protein.