tetano
Editor, Senior Moderator
Trop Med Infect Dis
. 2022 Oct 29;7(11):338.
doi: 10.3390/tropicalmed7110338.
Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola
Cruz S Sebastião[SUP] 1 2 3 [/SUP], Adis Cogle[SUP] 1 4 [/SUP], Alice D'Alva Teixeira[SUP] 4 [/SUP], Ana Micolo Cândido[SUP] 2 [/SUP], Chissengo Tchoni[SUP] 1 4 [/SUP], Maria João Amorim[SUP] 5 6 [/SUP], N'gueza Loureiro[SUP] 4 [/SUP], Paolo Parimbelli[SUP] 7 [/SUP], Carlos Penha-Gonçalves[SUP] 5 [/SUP], Jocelyne Demengeot[SUP] 5 [/SUP], Euclides Sacomboio[SUP] 2 3 [/SUP], Manuela Mendes[SUP] 7 [/SUP], Margarete Arrais[SUP] 1 8 [/SUP], Joana Morais[SUP] 2 9 [/SUP], Jocelyne Neto de Vasconcelos[SUP] 1 2 [/SUP], Miguel Brito[SUP] 1 10 [/SUP]
Affiliations
Abstract
Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola.
Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05.
Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05).
Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.
Keywords: Angola; COVID-19; Luanda; SARS-CoV-2; clinical features.
. 2022 Oct 29;7(11):338.
doi: 10.3390/tropicalmed7110338.
Clinical Features Related to Severity and Mortality among COVID-19 Patients in a Pre-Vaccine Period in Luanda, Angola
Cruz S Sebastião[SUP] 1 2 3 [/SUP], Adis Cogle[SUP] 1 4 [/SUP], Alice D'Alva Teixeira[SUP] 4 [/SUP], Ana Micolo Cândido[SUP] 2 [/SUP], Chissengo Tchoni[SUP] 1 4 [/SUP], Maria João Amorim[SUP] 5 6 [/SUP], N'gueza Loureiro[SUP] 4 [/SUP], Paolo Parimbelli[SUP] 7 [/SUP], Carlos Penha-Gonçalves[SUP] 5 [/SUP], Jocelyne Demengeot[SUP] 5 [/SUP], Euclides Sacomboio[SUP] 2 3 [/SUP], Manuela Mendes[SUP] 7 [/SUP], Margarete Arrais[SUP] 1 8 [/SUP], Joana Morais[SUP] 2 9 [/SUP], Jocelyne Neto de Vasconcelos[SUP] 1 2 [/SUP], Miguel Brito[SUP] 1 10 [/SUP]
Affiliations
- PMID: 36355881
- DOI: 10.3390/tropicalmed7110338
Abstract
Background: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola.
Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05.
Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05).
Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.
Keywords: Angola; COVID-19; Luanda; SARS-CoV-2; clinical features.