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Trivalent influenza vaccine only 46% effective in 2010-2011 season - UK mid-season analysis 2010/11 - Eurosurveillance

Giuseppe

Emeritus
Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11 (Euro Surveill., abstract, edited)


[Source: Eurosurveillance, full text: <cite cite="http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19791">Eurosurveillance - View Article</cite>. Abstract, edited.]

Eurosurveillance, Volume 16, Issue 6, 10 February 2011

Rapid communications

Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11

R Pebody 1, P Hardelid 1, D M Fleming 2, J McMenamin 3, N Andrews 1, C Robertson 3,4, D R Thomas 5, P SebastianPillai 6, J Ellis 6, W Carman 7, T Wreghitt 8, M Zambon 6, J M Watson 1

1. Health Protection Agency Health Protection Services ? Colindale, London, United Kingdom
2. Royal College of General Practitioners Research and Surveillance Centre, Birmingham, United Kingdom
3. Health Protection Scotland, Glasgow, United Kingdom
4. University of Strathclyde, Glasgow, United Kingdom
5. Public Health Wales, Cardiff, United Kingdom
6. Health Protection Agency Microbiology Services ? Colindale, London, United Kingdom
7. West of Scotland Specialist Virology Centre, Glasgow, United Kingdom
8. Health Protection Agency Microbiology Services, Cambridge, United Kingdom

Citation style for this article: Pebody R, Hardelid P, Fleming DM, McMenamin J, Andrews N, Robertson C, Thomas DR, SebastianPillai P, Ellis J, Carman W, Wreghitt T, Zambon M, Watson JM. Effectiveness of seasonal 2010/11 and pandemic influenza A(H1N1)2009 vaccines in preventing influenza infection in the United Kingdom: mid-season analysis 2010/11 . Euro Surveill. 2011;16(6):pii=19791. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=19791

Date of submission: 26 January 2011


This study provides mid-season estimates of the effectiveness of 2010/11 trivalent influenza vaccine and previous vaccination with monovalent influenza A(H1N1)2009 vaccine in preventing confirmed influenza A(H1N1)2009 infection in the United Kingdom in the 2010/11 season. The adjusted vaccine effectiveness was 34% (95% CI: -10 - 60%) if vaccinated only with monovalent vaccine in the 2009/10 season; 46% (95% CI: 7 - 69%) if vaccinated only with trivalent influenza vaccine in the 2010/11 season and 63% (95% CI: 37 - 78%) if vaccinated in both seasons.

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