tetano
Editor, Senior Moderator
Trials
. 2022 Aug 15;23(1):660.
doi: 10.1186/s13063-022-06632-y.
Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21
A Morrow[SUP] #[/SUP][SUP] 1 [/SUP], Stuart R Gray[SUP] #[/SUP][SUP] 1 [/SUP], H K Bayes[SUP] 2 [/SUP], R Sykes[SUP] 1 [/SUP], E McGarry[SUP] 2 [/SUP], D Anderson[SUP] 2 [/SUP], D Boiskin[SUP] 3 [/SUP], C Burke[SUP] 3 [/SUP], J G F Cleland[SUP] 4 [/SUP], C Goodyear[SUP] 5 [/SUP], T Ibbotson[SUP] 6 [/SUP], C C Lang[SUP] 7 [/SUP], McConnachie[SUP] 4 [/SUP], F Mair[SUP] 6 [/SUP], K Mangion[SUP] 1 [/SUP], M Patel[SUP] 8 [/SUP], N Sattar[SUP] 1 [/SUP], D Taggart[SUP] 9 [/SUP], R Taylor[SUP] 6 [/SUP], S Dawkes[SUP] 10 [/SUP], C Berry[SUP] 11 [/SUP]
Affiliations
Abstract
Background: Coronavirus disease-19 (COVID-19) infection causes persistent health problems such as breathlessness, chest pain and fatigue, and therapies for the prevention and early treatment of post-COVID-19 syndromes are needed. Accordingly, we are investigating the effect of a resistance exercise intervention on exercise capacity and health status following COVID-19 infection.
Methods: A two-arm randomised, controlled clinical trial including 220 adults with a diagnosis of COVID-19 in the preceding 6 months. Participants will be classified according to clinical presentation: Group A, not hospitalised due to COVID but persisting symptoms for at least 4 weeks leading to medical review; Group B, discharged after an admission for COVID and with persistent symptoms for at least 4 weeks; or Group C, convalescing in hospital after an admission for COVID. Participants will be randomised to usual care or usual care plus a personalised and pragmatic resistance exercise intervention for 12 weeks. The primary outcome is the incremental shuttle walks test (ISWT) 3 months after randomisation with secondary outcomes including spirometry, grip strength, short performance physical battery (SPPB), frailty status, contacts with healthcare professionals, hospitalisation and questionnaires assessing health-related quality of life, physical activity, fatigue and dyspnoea.
Discussion: Ethical approval has been granted by the National Health Service (NHS) West of Scotland Research Ethics Committee (REC) (reference: GN20CA537) and recruitment is ongoing. Trial findings will be disseminated through patient and public forums, scientific conferences and journals.
. 2022 Aug 15;23(1):660.
doi: 10.1186/s13063-022-06632-y.
Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise-CISCO-21
A Morrow[SUP] #[/SUP][SUP] 1 [/SUP], Stuart R Gray[SUP] #[/SUP][SUP] 1 [/SUP], H K Bayes[SUP] 2 [/SUP], R Sykes[SUP] 1 [/SUP], E McGarry[SUP] 2 [/SUP], D Anderson[SUP] 2 [/SUP], D Boiskin[SUP] 3 [/SUP], C Burke[SUP] 3 [/SUP], J G F Cleland[SUP] 4 [/SUP], C Goodyear[SUP] 5 [/SUP], T Ibbotson[SUP] 6 [/SUP], C C Lang[SUP] 7 [/SUP], McConnachie[SUP] 4 [/SUP], F Mair[SUP] 6 [/SUP], K Mangion[SUP] 1 [/SUP], M Patel[SUP] 8 [/SUP], N Sattar[SUP] 1 [/SUP], D Taggart[SUP] 9 [/SUP], R Taylor[SUP] 6 [/SUP], S Dawkes[SUP] 10 [/SUP], C Berry[SUP] 11 [/SUP]
Affiliations
- PMID: 35971155
- DOI: 10.1186/s13063-022-06632-y
Abstract
Background: Coronavirus disease-19 (COVID-19) infection causes persistent health problems such as breathlessness, chest pain and fatigue, and therapies for the prevention and early treatment of post-COVID-19 syndromes are needed. Accordingly, we are investigating the effect of a resistance exercise intervention on exercise capacity and health status following COVID-19 infection.
Methods: A two-arm randomised, controlled clinical trial including 220 adults with a diagnosis of COVID-19 in the preceding 6 months. Participants will be classified according to clinical presentation: Group A, not hospitalised due to COVID but persisting symptoms for at least 4 weeks leading to medical review; Group B, discharged after an admission for COVID and with persistent symptoms for at least 4 weeks; or Group C, convalescing in hospital after an admission for COVID. Participants will be randomised to usual care or usual care plus a personalised and pragmatic resistance exercise intervention for 12 weeks. The primary outcome is the incremental shuttle walks test (ISWT) 3 months after randomisation with secondary outcomes including spirometry, grip strength, short performance physical battery (SPPB), frailty status, contacts with healthcare professionals, hospitalisation and questionnaires assessing health-related quality of life, physical activity, fatigue and dyspnoea.
Discussion: Ethical approval has been granted by the National Health Service (NHS) West of Scotland Research Ethics Committee (REC) (reference: GN20CA537) and recruitment is ongoing. Trial findings will be disseminated through patient and public forums, scientific conferences and journals.