tetano
Editor, Senior Moderator
Trends Pharmacol Sci
. 2021 Mar 26;S0165-6147(21)00053-5.
doi: 10.1016/j.tips.2021.03.006. Online ahead of print.
Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
Tahsin F Kellici[SUP] 1 [/SUP], Ewa S Pilka[SUP] 2 [/SUP], Michael J Bodkin[SUP] 2 [/SUP]
Affiliations
Abstract
Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target.
. 2021 Mar 26;S0165-6147(21)00053-5.
doi: 10.1016/j.tips.2021.03.006. Online ahead of print.
Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19
Tahsin F Kellici[SUP] 1 [/SUP], Ewa S Pilka[SUP] 2 [/SUP], Michael J Bodkin[SUP] 2 [/SUP]
Affiliations
- PMID: 33867130
- DOI: 10.1016/j.tips.2021.03.006
Abstract
Latest research shows that SERPINE1 overexpression has an important role in Coronavirus 2019 (COVID-19)-associated coagulopathy leading to acute respiratory distress syndrome (ARDS). However, ways to target this protein remain elusive. In this forum, we discuss recent evidence linking SERPINE1 with COVID-19-related ARDS and summarize the available data on inhibitors of this target.