tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2017 Jul 14:0. doi: 10.1080/21645515.2017.1342907. [Epub ahead of print]
[h=1]Trends of influenza B during the 2010-2016 seasons in two regions of north and south Italy: the impact of the vaccine mismatch on influenza immunisation strategy.[/h] Orsi A[SUP]1,[/SUP][SUP]2[/SUP], Colomba GME[SUP]3[/SUP], Pojero F[SUP]3[/SUP], Calamusa G[SUP]3[/SUP], Alicino C[SUP]1[/SUP], Trucchi C[SUP]1[/SUP], Canepa P[SUP]1[/SUP], Ansaldi F[SUP]1,[/SUP][SUP]2[/SUP], Vitale F[SUP]3,[/SUP][SUP]4[/SUP], Tramuto F[SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The two viral types often co-circulate and influenza B plays an important role in the spread of infection. A 6-year retrospective surveillance study was conducted between 2010 and 2016 in two large administrative regions of Italy, located in the north (Liguria) and in the south (Sicily) of the country, in order to describe the burden and epidemiology of both B/Victoria and B/Yamagata lineages in different healthcare settings. Influenza B viruses were detected in five of six seasonal outbreaks, exceeding influenza A during the season 2012-2013. Most of influenza B infections were found in children aged ≤14 years and significant differences were observed in the age-groups infected by the different lineages. B/Victoria strains prevailed in younger population than B/Yamagata, but also were more frequently found in the community setting. Conversely, B/Yamagata viruses were prevalent among hospitalized cases suggesting their potential role in the development of more severe disease. The relative proportions of viral lineages varied from year to year, resulting in different lineage-level mismatch for the B component of trivalent influenza vaccine. Our findings confirmed the need for continuous virological surveillance of seasonal epidemics and bring attention to the adoption of universal influenza immunization programme in the childhood. The use of tetravalent vaccine formulations may be useful to improve the prevention and control of the influenza burden in general population.
[h=4]KEYWORDS:[/h] B/Victoria; B/Yamagata; Influenza type B; community; hospital; lineage; vaccine-mismatch
PMID: 28708953 DOI: 10.1080/21645515.2017.1342907
[h=1]Trends of influenza B during the 2010-2016 seasons in two regions of north and south Italy: the impact of the vaccine mismatch on influenza immunisation strategy.[/h] Orsi A[SUP]1,[/SUP][SUP]2[/SUP], Colomba GME[SUP]3[/SUP], Pojero F[SUP]3[/SUP], Calamusa G[SUP]3[/SUP], Alicino C[SUP]1[/SUP], Trucchi C[SUP]1[/SUP], Canepa P[SUP]1[/SUP], Ansaldi F[SUP]1,[/SUP][SUP]2[/SUP], Vitale F[SUP]3,[/SUP][SUP]4[/SUP], Tramuto F[SUP]3,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The two viral types often co-circulate and influenza B plays an important role in the spread of infection. A 6-year retrospective surveillance study was conducted between 2010 and 2016 in two large administrative regions of Italy, located in the north (Liguria) and in the south (Sicily) of the country, in order to describe the burden and epidemiology of both B/Victoria and B/Yamagata lineages in different healthcare settings. Influenza B viruses were detected in five of six seasonal outbreaks, exceeding influenza A during the season 2012-2013. Most of influenza B infections were found in children aged ≤14 years and significant differences were observed in the age-groups infected by the different lineages. B/Victoria strains prevailed in younger population than B/Yamagata, but also were more frequently found in the community setting. Conversely, B/Yamagata viruses were prevalent among hospitalized cases suggesting their potential role in the development of more severe disease. The relative proportions of viral lineages varied from year to year, resulting in different lineage-level mismatch for the B component of trivalent influenza vaccine. Our findings confirmed the need for continuous virological surveillance of seasonal epidemics and bring attention to the adoption of universal influenza immunization programme in the childhood. The use of tetravalent vaccine formulations may be useful to improve the prevention and control of the influenza burden in general population.
[h=4]KEYWORDS:[/h] B/Victoria; B/Yamagata; Influenza type B; community; hospital; lineage; vaccine-mismatch
PMID: 28708953 DOI: 10.1080/21645515.2017.1342907