tetano
Editor, Senior Moderator
Trends Mol Med
. 2021 Dec 7;S1471-4914(21)00316-6.
doi: 10.1016/j.molmed.2021.12.001. Online ahead of print.
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates
Marieke A Stammes[SUP] 1 [/SUP], Ji Hyun Lee[SUP] 2 [/SUP], Lisette Meijer[SUP] 3 [/SUP], Thibaut Naninck[SUP] 4 [/SUP], Lara A Doyle-Meyers[SUP] 5 [/SUP], Alexander G White[SUP] 6 [/SUP], H Jacob Borish[SUP] 6 [/SUP], Amy L Hartman[SUP] 7 [/SUP], Xavier Alvarez[SUP] 8 [/SUP], Shashank Ganatra[SUP] 8 [/SUP], Deepak Kaushal[SUP] 8 [/SUP], Rudolf P Bohm[SUP] 5 [/SUP], Roger le Grand[SUP] 4 [/SUP], Charles A Scanga[SUP] 9 [/SUP], Jan A M Langermans[SUP] 10 [/SUP], Ronald E Bontrop[SUP] 11 [/SUP], Courtney L Finch[SUP] 2 [/SUP], JoAnne L Flynn[SUP] 9 [/SUP], Claudia Calcagno[SUP] 2 [/SUP], Ian Crozier[SUP] 12 [/SUP], Jens H Kuhn[SUP] 2 [/SUP]
Affiliations
Abstract
Chest X-ray (CXR), computed tomography (CT), and positron emission tomography-computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.
Keywords: COVID-19; SARS-CoV-2; imaging; lung; non-human primate.
. 2021 Dec 7;S1471-4914(21)00316-6.
doi: 10.1016/j.molmed.2021.12.001. Online ahead of print.
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates
Marieke A Stammes[SUP] 1 [/SUP], Ji Hyun Lee[SUP] 2 [/SUP], Lisette Meijer[SUP] 3 [/SUP], Thibaut Naninck[SUP] 4 [/SUP], Lara A Doyle-Meyers[SUP] 5 [/SUP], Alexander G White[SUP] 6 [/SUP], H Jacob Borish[SUP] 6 [/SUP], Amy L Hartman[SUP] 7 [/SUP], Xavier Alvarez[SUP] 8 [/SUP], Shashank Ganatra[SUP] 8 [/SUP], Deepak Kaushal[SUP] 8 [/SUP], Rudolf P Bohm[SUP] 5 [/SUP], Roger le Grand[SUP] 4 [/SUP], Charles A Scanga[SUP] 9 [/SUP], Jan A M Langermans[SUP] 10 [/SUP], Ronald E Bontrop[SUP] 11 [/SUP], Courtney L Finch[SUP] 2 [/SUP], JoAnne L Flynn[SUP] 9 [/SUP], Claudia Calcagno[SUP] 2 [/SUP], Ian Crozier[SUP] 12 [/SUP], Jens H Kuhn[SUP] 2 [/SUP]
Affiliations
- PMID: 34955425
- DOI: 10.1016/j.molmed.2021.12.001
Abstract
Chest X-ray (CXR), computed tomography (CT), and positron emission tomography-computed tomography (PET-CT) are noninvasive imaging techniques widely used in human and veterinary pulmonary research and medicine. These techniques have recently been applied in studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-exposed non-human primates (NHPs) to complement virological assessments with meaningful translational readouts of lung disease. Our review of the literature indicates that medical imaging of SARS-CoV-2-exposed NHPs enables high-resolution qualitative and quantitative characterization of disease otherwise clinically invisible and potentially provides user-independent and unbiased evaluation of medical countermeasures (MCMs). However, we also found high variability in image acquisition and analysis protocols among studies. These findings uncover an urgent need to improve standardization and ensure direct comparability across studies.
Keywords: COVID-19; SARS-CoV-2; imaging; lung; non-human primate.