tetano
Editor, Senior Moderator
Trends Immunol
. 2020 Oct 14;S1471-4906(20)30233-7.
doi: 10.1016/j.it.2020.10.004. Online ahead of print.
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis
Andrew G Harrison[SUP] 1 [/SUP], Tao Lin[SUP] 1 [/SUP], Penghua Wang[SUP] 2 [/SUP]
Affiliations
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic. However, important questions remain regarding its transmissibility and pathogenesis. In this review, we summarize current SARS-CoV-2 research, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antagonism. We further present advances in animal models that are important for understanding the pathogenesis of SARS-CoV-2, vaccine development, and therapeutic testing. When necessary, comparisons are made from studies with SARS to provide further perspectives on coronavirus infectious disease 2019 (COVID-19), as well as draw inferences for future investigations.
Keywords: COVID-19; SARS, SARS-CoV-2; coronavirus; severe acute respiratory syndrome.
. 2020 Oct 14;S1471-4906(20)30233-7.
doi: 10.1016/j.it.2020.10.004. Online ahead of print.
Mechanisms of SARS-CoV-2 Transmission and Pathogenesis
Andrew G Harrison[SUP] 1 [/SUP], Tao Lin[SUP] 1 [/SUP], Penghua Wang[SUP] 2 [/SUP]
Affiliations
- PMID: 33132005
- DOI: 10.1016/j.it.2020.10.004
Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic. However, important questions remain regarding its transmissibility and pathogenesis. In this review, we summarize current SARS-CoV-2 research, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antagonism. We further present advances in animal models that are important for understanding the pathogenesis of SARS-CoV-2, vaccine development, and therapeutic testing. When necessary, comparisons are made from studies with SARS to provide further perspectives on coronavirus infectious disease 2019 (COVID-19), as well as draw inferences for future investigations.
Keywords: COVID-19; SARS, SARS-CoV-2; coronavirus; severe acute respiratory syndrome.