tetano
Editor, Senior Moderator
Trends Immunol
. 2021 Sep 15;S1471-4906(21)00177-0.
doi: 10.1016/j.it.2021.09.001. Online ahead of print.
Immune imprinting and SARS-CoV-2 vaccine design
Adam K Wheatley[SUP] 1 [/SUP], Annette Fox[SUP] 2 [/SUP], Hyon-Xhi Tan[SUP] 1 [/SUP], Jennifer A Juno[SUP] 1 [/SUP], Miles P Davenport[SUP] 3 [/SUP], Kanta Subbarao[SUP] 4 [/SUP], Stephen J Kent[SUP] 5 [/SUP]
Affiliations
Abstract
Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain. New strategies may be needed to improve efficacy of SARS-CoV-2 variant vaccines.
. 2021 Sep 15;S1471-4906(21)00177-0.
doi: 10.1016/j.it.2021.09.001. Online ahead of print.
Immune imprinting and SARS-CoV-2 vaccine design
Adam K Wheatley[SUP] 1 [/SUP], Annette Fox[SUP] 2 [/SUP], Hyon-Xhi Tan[SUP] 1 [/SUP], Jennifer A Juno[SUP] 1 [/SUP], Miles P Davenport[SUP] 3 [/SUP], Kanta Subbarao[SUP] 4 [/SUP], Stephen J Kent[SUP] 5 [/SUP]
Affiliations
- PMID: 34580004
- DOI: 10.1016/j.it.2021.09.001
Abstract
Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections. We hypothesize that this may be suboptimal due to immune imprinting from earlier vaccination or infection with the original SARS-CoV-2 strain. New strategies may be needed to improve efficacy of SARS-CoV-2 variant vaccines.