tetano
Editor, Senior Moderator
Trends Endocrinol Metab
. 2021 Jan 8;S1043-2760(21)00001-1.
doi: 10.1016/j.tem.2021.01.001. Online ahead of print.
Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
Yahya Sohrabi[SUP] 1 [/SUP], Holger Reinecke[SUP] 2 [/SUP], Rinesh Godfrey[SUP] 2 [/SUP]
Affiliations
Abstract
Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
Keywords: COVID-19; cholesterol synthesis; cytokine storm; lipid synthesis; obesity.
. 2021 Jan 8;S1043-2760(21)00001-1.
doi: 10.1016/j.tem.2021.01.001. Online ahead of print.
Altered Cholesterol and Lipid Synthesis Mediates Hyperinflammation in COVID-19
Yahya Sohrabi[SUP] 1 [/SUP], Holger Reinecke[SUP] 2 [/SUP], Rinesh Godfrey[SUP] 2 [/SUP]
Affiliations
- PMID: 33455862
- DOI: 10.1016/j.tem.2021.01.001
Abstract
Recent data have revealed that fructose-rich diet triggers inflammation and lipid synthesis. Furthermore, lipid metabolism, cholesterol synthesis and sterol regulatory element binding protein-2 (SREBP-2) activation correlates with coronavirus disease 2019 (COVID-19)-induced cytokine storm. High fructose consumption result in SREBPs activation, altered cholesterol and lipid synthesis and may establish an innate immune memory in the cells, leading to severe COVID-19 in patients with obesity.
Keywords: COVID-19; cholesterol synthesis; cytokine storm; lipid synthesis; obesity.