tetano
Editor, Senior Moderator
Scand J Infect Dis. 2012 Jul 25. [Epub ahead of print]
Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children.
Kawashima H, Morichi S, Okumara A, Nakagawa S, Morishima T; The Collaborating Study Group On Influenza-Associated Encephalopathy In Japan.
Source
Department of Pediatrics, Tokyo Medical University , Tokyo.
Abstract
Abstract Background: The novel pandemic influenza A (H1N1) 2009 virus (influenza A(H1N1)pdm09) caused an epidemic of critical illness, with some patients developing fatal encephalopathy as well as pneumonia. Methods: To investigate the actual efficacy of treatments, we investigated data from questionnaires regarding 207 cases that occurred between September 2009 and February 2010. Results: The outcomes were recorded in 188 of the 207 cases; 16 of 188 patients died, while 23 had sequelae. Anti-influenza drugs in patients with severe coma (Glasgow coma scale score of ≤ 8) were statistically effective. In 165 out of 199 cases, steroid pulse treatment with methylprednisolone was given at an early stage. Other intensive treatments were mostly administered in serious cases. Conclusions: Controlled studies are needed to investigate the efficacy of other treatments except for anti-influenza drugs.
PMID:
22830454
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22830454
Treatment of pandemic influenza A (H1N1) 2009-associated encephalopathy in children.
Kawashima H, Morichi S, Okumara A, Nakagawa S, Morishima T; The Collaborating Study Group On Influenza-Associated Encephalopathy In Japan.
Source
Department of Pediatrics, Tokyo Medical University , Tokyo.
Abstract
Abstract Background: The novel pandemic influenza A (H1N1) 2009 virus (influenza A(H1N1)pdm09) caused an epidemic of critical illness, with some patients developing fatal encephalopathy as well as pneumonia. Methods: To investigate the actual efficacy of treatments, we investigated data from questionnaires regarding 207 cases that occurred between September 2009 and February 2010. Results: The outcomes were recorded in 188 of the 207 cases; 16 of 188 patients died, while 23 had sequelae. Anti-influenza drugs in patients with severe coma (Glasgow coma scale score of ≤ 8) were statistically effective. In 165 out of 199 cases, steroid pulse treatment with methylprednisolone was given at an early stage. Other intensive treatments were mostly administered in serious cases. Conclusions: Controlled studies are needed to investigate the efficacy of other treatments except for anti-influenza drugs.
PMID:
22830454
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22830454