tetano
Editor, Senior Moderator
Case Rep Infect Dis. 2015;2015:504975. doi: 10.1155/2015/504975. Epub 2015 Aug 9.
[h=1]Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir.[/h] Meijer WJ[SUP]1[/SUP], Kromdijk W[SUP]2[/SUP], van den Broek MP[SUP]3[/SUP], Haas PJ[SUP]4[/SUP], Minnema MC[SUP]5[/SUP], Boucher CA[SUP]6[/SUP], de Lange DW[SUP]7[/SUP], Wensing AM[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Immunocompromised patients are at increased risk of complications of influenza virus infection. We report on two critically ill patients on immunosuppressive medication with influenza pneumonia. In both patients, oseltamivir monotherapy did not result in clearance of the virus after 18 and five days, respectively. After adding zanamivir and amantadine to the treatment, PCRs on pharyngeal and/or plasma specimens turned negative in both patients after four and three days, respectively. We suggest, that in critically ill patients with influenza A H1N1 infection, treatment efficacy should be monitored closely and treatment with a combination of antiviral drugs should be considered.
PMID: 26346659 [PubMed] PMCID: PMC4546743 Free PMC Article
[h=1]Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir.[/h] Meijer WJ[SUP]1[/SUP], Kromdijk W[SUP]2[/SUP], van den Broek MP[SUP]3[/SUP], Haas PJ[SUP]4[/SUP], Minnema MC[SUP]5[/SUP], Boucher CA[SUP]6[/SUP], de Lange DW[SUP]7[/SUP], Wensing AM[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Immunocompromised patients are at increased risk of complications of influenza virus infection. We report on two critically ill patients on immunosuppressive medication with influenza pneumonia. In both patients, oseltamivir monotherapy did not result in clearance of the virus after 18 and five days, respectively. After adding zanamivir and amantadine to the treatment, PCRs on pharyngeal and/or plasma specimens turned negative in both patients after four and three days, respectively. We suggest, that in critically ill patients with influenza A H1N1 infection, treatment efficacy should be monitored closely and treatment with a combination of antiviral drugs should be considered.
PMID: 26346659 [PubMed] PMCID: PMC4546743 Free PMC Article