tetano
Editor, Senior Moderator
Transplantation
. 2022 Oct 13.
doi: 10.1097/TP.0000000000004359. Online ahead of print.
High Prevalence of Long-COVID Among Kidney Transplant Recipients: A Longitudinal Cohort Study
Carlos Eduardo Neves Amorim[SUP] 1 [/SUP], Vinicius Lafico Teixeira Gomes[SUP] 2 [/SUP], Marina Pontello Cristelli[SUP] 2 [/SUP], Laila Almeida Viana[SUP] 2 [/SUP], Hugo de Luca Correa[SUP] 3 [/SUP], Gierisson Brenno Borges Lima[SUP] 1 [/SUP], Flaviana Santos de Sousa Silva[SUP] 1 [/SUP], Gabriel Santos de Castro Lima[SUP] 1 [/SUP], Thiago Dos Santos Rosa[SUP] 3 [/SUP], Monica Rika Nakamura[SUP] 2 [/SUP], Priscilla Monteiro Quintino[SUP] 2 [/SUP], Helio Tedesco-Silva[SUP] 2 [/SUP], José Medina-Pestana[SUP] 2 [/SUP]
Affiliations
Abstract
Background: Kidney transplant recipients are at a higher risk to develop more severe clinical forms of coronavirus disease 2019 (COVID-19), perhaps increasing the risk of presenting its long-term clinical complications, labeled as Long-COVID.
Methods: This single-center, observational, prospective study included adult kidney transplant recipients with COVID-19 confirmed by reverse transcription polymerase chain reaction between March 20, 2020, and May 31, 2021, who were alive and with functioning graft 3 mo after the onset of symptoms. The prevalence of Long-COVID was investigated by a phone survey using a structured questionnaire of organic symptoms. Adjusted multivariable logistic regression models were used to investigate independent risk factors.
Results: Of 1741 patients who developed COVID-19, 465 died, and 37 returned to dialysis. Of the 1239 eligible patients, 780 (63%) answered the survey during the window period. The mean age was 48 ± 12 y, 41% were women, and the mean time from transplantation was 8 ± 6 y. During acute illness, 45% needed hospitalization. Long-COVID was identified in 214 (27%) of the subjects, with body aches being the most prevalent symptom (44%). Of 233 who provided working status, 17% did not return to work within 3 mo. No baseline characteristics or infection-related variables predicted Long-COVID; actually, the number of symptoms in the acute illness was the only independent risk factor identified (hazard ratio, 1.12; 95% confidence interval, 1.02-1.22).
Conclusion: In this cohort of kidney transplant recipients, Long-COVID was prevalent and associated with a reduced return to work. The burden of acute phase symptoms was the only risk factor associated with Long-COVID.
. 2022 Oct 13.
doi: 10.1097/TP.0000000000004359. Online ahead of print.
High Prevalence of Long-COVID Among Kidney Transplant Recipients: A Longitudinal Cohort Study
Carlos Eduardo Neves Amorim[SUP] 1 [/SUP], Vinicius Lafico Teixeira Gomes[SUP] 2 [/SUP], Marina Pontello Cristelli[SUP] 2 [/SUP], Laila Almeida Viana[SUP] 2 [/SUP], Hugo de Luca Correa[SUP] 3 [/SUP], Gierisson Brenno Borges Lima[SUP] 1 [/SUP], Flaviana Santos de Sousa Silva[SUP] 1 [/SUP], Gabriel Santos de Castro Lima[SUP] 1 [/SUP], Thiago Dos Santos Rosa[SUP] 3 [/SUP], Monica Rika Nakamura[SUP] 2 [/SUP], Priscilla Monteiro Quintino[SUP] 2 [/SUP], Helio Tedesco-Silva[SUP] 2 [/SUP], José Medina-Pestana[SUP] 2 [/SUP]
Affiliations
- PMID: 36228200
- DOI: 10.1097/TP.0000000000004359
Abstract
Background: Kidney transplant recipients are at a higher risk to develop more severe clinical forms of coronavirus disease 2019 (COVID-19), perhaps increasing the risk of presenting its long-term clinical complications, labeled as Long-COVID.
Methods: This single-center, observational, prospective study included adult kidney transplant recipients with COVID-19 confirmed by reverse transcription polymerase chain reaction between March 20, 2020, and May 31, 2021, who were alive and with functioning graft 3 mo after the onset of symptoms. The prevalence of Long-COVID was investigated by a phone survey using a structured questionnaire of organic symptoms. Adjusted multivariable logistic regression models were used to investigate independent risk factors.
Results: Of 1741 patients who developed COVID-19, 465 died, and 37 returned to dialysis. Of the 1239 eligible patients, 780 (63%) answered the survey during the window period. The mean age was 48 ± 12 y, 41% were women, and the mean time from transplantation was 8 ± 6 y. During acute illness, 45% needed hospitalization. Long-COVID was identified in 214 (27%) of the subjects, with body aches being the most prevalent symptom (44%). Of 233 who provided working status, 17% did not return to work within 3 mo. No baseline characteristics or infection-related variables predicted Long-COVID; actually, the number of symptoms in the acute illness was the only independent risk factor identified (hazard ratio, 1.12; 95% confidence interval, 1.02-1.22).
Conclusion: In this cohort of kidney transplant recipients, Long-COVID was prevalent and associated with a reduced return to work. The burden of acute phase symptoms was the only risk factor associated with Long-COVID.