tetano
Editor, Senior Moderator
Transplant Direct
. 2022 Jan 13;8(2):e1286.
doi: 10.1097/TXD.0000000000001286. eCollection 2022 Feb.
Solid Organ Transplantation From SARS-CoV-2-infected Donors to Uninfected Recipients: A Single-center Experience
Channa R Jayasekera[SUP] 1 [/SUP], Holenarasipur R Vikram[SUP] 2 [/SUP], Zeeshan Rifat[SUP] 3 [/SUP], Josiah Wagler[SUP] 3 [/SUP], Keita Okubo[SUP] 3 [/SUP], Brandon R Braaksma[SUP] 3 [/SUP], Jack W Harbell[SUP] 3 [/SUP], Caroline C Jadlowiec[SUP] 3 [/SUP], Nitin N Katariya[SUP] 3 [/SUP], Amit K Mathur[SUP] 3 [/SUP], Adyr Moss[SUP] 3 [/SUP], K Sudhakar Reddy[SUP] 3 [/SUP], Andrew Singer[SUP] 3 [/SUP], Robert Orenstein[SUP] 2 [/SUP], Christopher F Saling[SUP] 2 [/SUP], Maria T Seville[SUP] 2 [/SUP], Girish K Mour[SUP] 4 [/SUP], Hugo E Vargas[SUP] 1 [/SUP], Thomas J Byrne[SUP] 1 [/SUP], Winston R Hewitt Jr[SUP] 3 [/SUP], Bashar A Aqel[SUP] 1 [/SUP]
Affiliations
Abstract
Background: The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission.
Methods: Abdominal solid organs from SARS-CoV-2-infected donors were transplanted into uninfected recipients.
Results: Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2-infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA.
Conclusions: Transplanting nonlung organs from SARS-CoV-2-infected donors into uninfected recipients demonstrated no evidence of virus transmission.
. 2022 Jan 13;8(2):e1286.
doi: 10.1097/TXD.0000000000001286. eCollection 2022 Feb.
Solid Organ Transplantation From SARS-CoV-2-infected Donors to Uninfected Recipients: A Single-center Experience
Channa R Jayasekera[SUP] 1 [/SUP], Holenarasipur R Vikram[SUP] 2 [/SUP], Zeeshan Rifat[SUP] 3 [/SUP], Josiah Wagler[SUP] 3 [/SUP], Keita Okubo[SUP] 3 [/SUP], Brandon R Braaksma[SUP] 3 [/SUP], Jack W Harbell[SUP] 3 [/SUP], Caroline C Jadlowiec[SUP] 3 [/SUP], Nitin N Katariya[SUP] 3 [/SUP], Amit K Mathur[SUP] 3 [/SUP], Adyr Moss[SUP] 3 [/SUP], K Sudhakar Reddy[SUP] 3 [/SUP], Andrew Singer[SUP] 3 [/SUP], Robert Orenstein[SUP] 2 [/SUP], Christopher F Saling[SUP] 2 [/SUP], Maria T Seville[SUP] 2 [/SUP], Girish K Mour[SUP] 4 [/SUP], Hugo E Vargas[SUP] 1 [/SUP], Thomas J Byrne[SUP] 1 [/SUP], Winston R Hewitt Jr[SUP] 3 [/SUP], Bashar A Aqel[SUP] 1 [/SUP]
Affiliations
- PMID: 35047665
- PMCID: PMC8759616
- DOI: 10.1097/TXD.0000000000001286
Abstract
Background: The risk of donor-derived severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in solid organ (heart, lung, liver, kidney, pancreas, and intestine) transplant recipients is poorly understood. Since hematogenous transmission of SARS-CoV-2 has not been documented to date, nonlung solid organs might be suitable for transplantation since they likely portend a low risk of viral transmission.
Methods: Abdominal solid organs from SARS-CoV-2-infected donors were transplanted into uninfected recipients.
Results: Between April 18, 2021, and October 30, 2021, we performed transplants of 2 livers, 1 simultaneous liver and kidney, 1 kidney, and 1 simultaneous kidney and pancreas from SARS-CoV-2-infected donors into 5 uninfected recipients. None of the recipients developed SARS-CoV-2 infection or coronavirus disease 2019, and when tested, allograft biopsies showed no evidence of SARS-CoV-2 RNA.
Conclusions: Transplanting nonlung organs from SARS-CoV-2-infected donors into uninfected recipients demonstrated no evidence of virus transmission.