tetano
Editor, Senior Moderator
Transplant Direct
. 2025 Apr 29;11(5):e1787.
doi: 10.1097/TXD.0000000000001787. eCollection 2025 May. Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults
Tobias Laue[SUP] 1 2 [/SUP], Maria Pilar Ballester[SUP] 3 [/SUP], Lily Meoli[SUP] 4 [/SUP], Carl Grabitz[SUP] 1 [/SUP], Eva Uson[SUP] 5 [/SUP], Lorenzo D Antiga[SUP] 6 [/SUP], Valerie McLin[SUP] 7 [/SUP], Montserrat Pujadas[SUP] 5 [/SUP], Ângela Carvalho-Gomes[SUP] 8 9 [/SUP], Ivan Sahuco[SUP] 8 [/SUP], Ariadna Bono[SUP] 8 [/SUP], Federico D'Amico[SUP] 10 11 [/SUP], Raffaela Viganò[SUP] 12 [/SUP], Elena Diago[SUP] 13 14 15 [/SUP], Beatriz Tormo Lanseros[SUP] 13 15 [/SUP], Elvira Inglese[SUP] 12 [/SUP], Dani Martinez Vazquez[SUP] 16 [/SUP], Annelotte Broekhoven[SUP] 17 [/SUP], Marjolein Kikkert[SUP] 18 [/SUP], Shessy P Torres Morales[SUP] 18 [/SUP], Sebenzile K Myeni[SUP] 18 [/SUP], Mar Riveiro-Barciela[SUP] 15 16 19 [/SUP], Adriana Palom[SUP] 15 16 [/SUP], Nicola Zeni[SUP] 20 [/SUP], Alessandra Brocca[SUP] 20 [/SUP], Annarosa Cussigh[SUP] 21 [/SUP], Sara Cmet[SUP] 21 [/SUP], Maria Desamparados Escudero-García[SUP] 3 22 [/SUP], Matteo Stocco[SUP] 3 [/SUP], Leonardo Antonio Natola[SUP] 23 [/SUP], Donatella Ieluzzi[SUP] 23 [/SUP], Veronica Paon[SUP] 23 [/SUP], Angelo Sangiovanni[SUP] 24 [/SUP], Elisa Farina[SUP] 24 [/SUP], Clara Dibenedetto[SUP] 24 [/SUP], Yolanda Sánchez-Torrijos[SUP] 25 [/SUP], Ana Lucena-Varela[SUP] 25 [/SUP], Eva Román[SUP] 15 26 27 [/SUP], Elisabet Sánchez[SUP] 15 26 [/SUP], Rubén Sánchez-Aldehuelo[SUP] 28 [/SUP], Julia López-Cardona[SUP] 28 [/SUP], Dhaarica Jeyanesan[SUP] 4 [/SUP], Alejandro Esquivel Morocho[SUP] 4 [/SUP], Itzel Canas-Perez[SUP] 29 [/SUP], Christine Eastgate[SUP] 29 [/SUP], Simone Di Cola[SUP] 30 [/SUP], Lucia Lapenna[SUP] 30 [/SUP], Giacomo Zaccherini[SUP] 31 32 [/SUP], Deborah Bongiovanni[SUP] 31 [/SUP], Antonio Riva[SUP] 33 [/SUP], Rajni Sharma[SUP] 33 [/SUP], Hio Lam Phoebe Tsou[SUP] 33 [/SUP], Nicola Harris[SUP] 33 [/SUP], Paola Zanaga[SUP] 34 35 [/SUP], Katia Sayaf[SUP] 34 35 [/SUP], Sabir Hossain[SUP] 36 [/SUP], Javier Crespo[SUP] 37 38 [/SUP], Mercedes Robles-Díaz[SUP] 15 39 [/SUP], Antonio Madejón[SUP] 40 [/SUP], Helena Degroote[SUP] 41 42 [/SUP], Marko Korenjak[SUP] 43 [/SUP], Xavier Verhelst[SUP] 19 41 44 [/SUP], Javier García-Samaniego[SUP] 40 [/SUP], Raúl J Andrade[SUP] 15 39 [/SUP], Paula Iruzubieta[SUP] 37 38 [/SUP], Gavin Wright[SUP] 36 [/SUP], Paolo Caraceni[SUP] 31 32 [/SUP], Manuela Merli[SUP] 30 [/SUP], Vishal C Patel[SUP] 4 33 [/SUP], Amir Gander[SUP] 29 [/SUP], Agustín Albillos[SUP] 28 [/SUP], Germán Soriano[SUP] 15 26 [/SUP], Maria Francesca Donato[SUP] 24 [/SUP], David Sacerdoti[SUP] 23 [/SUP], Pierluigi Toniutto[SUP] 21 [/SUP], Maria Buti[SUP] 14 16 [/SUP], Christophe Duvoux[SUP] 45 [/SUP], Paolo Antonio Grossi[SUP] 46 [/SUP], Thomas Berg[SUP] 47 [/SUP], Wojciech G Polak[SUP] 48 [/SUP], Massimo Puoti[SUP] 49 [/SUP], Anna Bosch-Comas[SUP] 5 [/SUP], Luca S Belli[SUP] 12 [/SUP], Patrizia Burra[SUP] 34 35 [/SUP], Francesco Paolo Russo[SUP] 34 35 [/SUP], Minneke Coenraad[SUP] 17 [/SUP], José Luis Calleja[SUP] 13 15 [/SUP], Giovanni Perricone[SUP] 12 [/SUP], Shilpa Chokshi[SUP] 33 50 [/SUP], Marina Berenguer[SUP] 8 9 [/SUP], Joan Clària[SUP] 5 51 [/SUP], Richard Moreau[SUP] 5 52 53 [/SUP], Javier Fernández[SUP] 5 54 [/SUP], Vicente Arroyo[SUP] 5 [/SUP], Paolo Angeli[SUP] 19 [/SUP], Cristina Sánchez-Garrido[SUP] 5 [/SUP], Javier Ampuero[SUP] 25 [/SUP], Salvatore Piano[SUP] 19 [/SUP], Emanuele Nicastro[SUP] 55 [/SUP], Nathalie Rock[SUP] 7 [/SUP], Debbie Shawcross[SUP] 56 [/SUP], Lindsey Edwards[SUP] 57 [/SUP], Frauke Mutschler[SUP] 1 [/SUP], Anette Melk[SUP] 1 [/SUP], Gautam Mehta[SUP] 29 58 [/SUP], Ulrich Baumann[SUP] 1 59 [/SUP], Rajiv Jalan[SUP] 5 29 58 [/SUP]
Affiliations
Background: Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR.
Methods: A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA.
Results: A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR.
Conclusions: Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.
. 2025 Apr 29;11(5):e1787.
doi: 10.1097/TXD.0000000000001787. eCollection 2025 May. Pediatric Liver and Kidney Transplant Recipients Demonstrate Greater Serological Response to SARS-CoV-2 Vaccination Than Adults
Tobias Laue[SUP] 1 2 [/SUP], Maria Pilar Ballester[SUP] 3 [/SUP], Lily Meoli[SUP] 4 [/SUP], Carl Grabitz[SUP] 1 [/SUP], Eva Uson[SUP] 5 [/SUP], Lorenzo D Antiga[SUP] 6 [/SUP], Valerie McLin[SUP] 7 [/SUP], Montserrat Pujadas[SUP] 5 [/SUP], Ângela Carvalho-Gomes[SUP] 8 9 [/SUP], Ivan Sahuco[SUP] 8 [/SUP], Ariadna Bono[SUP] 8 [/SUP], Federico D'Amico[SUP] 10 11 [/SUP], Raffaela Viganò[SUP] 12 [/SUP], Elena Diago[SUP] 13 14 15 [/SUP], Beatriz Tormo Lanseros[SUP] 13 15 [/SUP], Elvira Inglese[SUP] 12 [/SUP], Dani Martinez Vazquez[SUP] 16 [/SUP], Annelotte Broekhoven[SUP] 17 [/SUP], Marjolein Kikkert[SUP] 18 [/SUP], Shessy P Torres Morales[SUP] 18 [/SUP], Sebenzile K Myeni[SUP] 18 [/SUP], Mar Riveiro-Barciela[SUP] 15 16 19 [/SUP], Adriana Palom[SUP] 15 16 [/SUP], Nicola Zeni[SUP] 20 [/SUP], Alessandra Brocca[SUP] 20 [/SUP], Annarosa Cussigh[SUP] 21 [/SUP], Sara Cmet[SUP] 21 [/SUP], Maria Desamparados Escudero-García[SUP] 3 22 [/SUP], Matteo Stocco[SUP] 3 [/SUP], Leonardo Antonio Natola[SUP] 23 [/SUP], Donatella Ieluzzi[SUP] 23 [/SUP], Veronica Paon[SUP] 23 [/SUP], Angelo Sangiovanni[SUP] 24 [/SUP], Elisa Farina[SUP] 24 [/SUP], Clara Dibenedetto[SUP] 24 [/SUP], Yolanda Sánchez-Torrijos[SUP] 25 [/SUP], Ana Lucena-Varela[SUP] 25 [/SUP], Eva Román[SUP] 15 26 27 [/SUP], Elisabet Sánchez[SUP] 15 26 [/SUP], Rubén Sánchez-Aldehuelo[SUP] 28 [/SUP], Julia López-Cardona[SUP] 28 [/SUP], Dhaarica Jeyanesan[SUP] 4 [/SUP], Alejandro Esquivel Morocho[SUP] 4 [/SUP], Itzel Canas-Perez[SUP] 29 [/SUP], Christine Eastgate[SUP] 29 [/SUP], Simone Di Cola[SUP] 30 [/SUP], Lucia Lapenna[SUP] 30 [/SUP], Giacomo Zaccherini[SUP] 31 32 [/SUP], Deborah Bongiovanni[SUP] 31 [/SUP], Antonio Riva[SUP] 33 [/SUP], Rajni Sharma[SUP] 33 [/SUP], Hio Lam Phoebe Tsou[SUP] 33 [/SUP], Nicola Harris[SUP] 33 [/SUP], Paola Zanaga[SUP] 34 35 [/SUP], Katia Sayaf[SUP] 34 35 [/SUP], Sabir Hossain[SUP] 36 [/SUP], Javier Crespo[SUP] 37 38 [/SUP], Mercedes Robles-Díaz[SUP] 15 39 [/SUP], Antonio Madejón[SUP] 40 [/SUP], Helena Degroote[SUP] 41 42 [/SUP], Marko Korenjak[SUP] 43 [/SUP], Xavier Verhelst[SUP] 19 41 44 [/SUP], Javier García-Samaniego[SUP] 40 [/SUP], Raúl J Andrade[SUP] 15 39 [/SUP], Paula Iruzubieta[SUP] 37 38 [/SUP], Gavin Wright[SUP] 36 [/SUP], Paolo Caraceni[SUP] 31 32 [/SUP], Manuela Merli[SUP] 30 [/SUP], Vishal C Patel[SUP] 4 33 [/SUP], Amir Gander[SUP] 29 [/SUP], Agustín Albillos[SUP] 28 [/SUP], Germán Soriano[SUP] 15 26 [/SUP], Maria Francesca Donato[SUP] 24 [/SUP], David Sacerdoti[SUP] 23 [/SUP], Pierluigi Toniutto[SUP] 21 [/SUP], Maria Buti[SUP] 14 16 [/SUP], Christophe Duvoux[SUP] 45 [/SUP], Paolo Antonio Grossi[SUP] 46 [/SUP], Thomas Berg[SUP] 47 [/SUP], Wojciech G Polak[SUP] 48 [/SUP], Massimo Puoti[SUP] 49 [/SUP], Anna Bosch-Comas[SUP] 5 [/SUP], Luca S Belli[SUP] 12 [/SUP], Patrizia Burra[SUP] 34 35 [/SUP], Francesco Paolo Russo[SUP] 34 35 [/SUP], Minneke Coenraad[SUP] 17 [/SUP], José Luis Calleja[SUP] 13 15 [/SUP], Giovanni Perricone[SUP] 12 [/SUP], Shilpa Chokshi[SUP] 33 50 [/SUP], Marina Berenguer[SUP] 8 9 [/SUP], Joan Clària[SUP] 5 51 [/SUP], Richard Moreau[SUP] 5 52 53 [/SUP], Javier Fernández[SUP] 5 54 [/SUP], Vicente Arroyo[SUP] 5 [/SUP], Paolo Angeli[SUP] 19 [/SUP], Cristina Sánchez-Garrido[SUP] 5 [/SUP], Javier Ampuero[SUP] 25 [/SUP], Salvatore Piano[SUP] 19 [/SUP], Emanuele Nicastro[SUP] 55 [/SUP], Nathalie Rock[SUP] 7 [/SUP], Debbie Shawcross[SUP] 56 [/SUP], Lindsey Edwards[SUP] 57 [/SUP], Frauke Mutschler[SUP] 1 [/SUP], Anette Melk[SUP] 1 [/SUP], Gautam Mehta[SUP] 29 58 [/SUP], Ulrich Baumann[SUP] 1 59 [/SUP], Rajiv Jalan[SUP] 5 29 58 [/SUP]
Affiliations
- PMID: 40309027
- PMCID: PMC12043343
- DOI: 10.1097/TXD.0000000000001787
Background: Adult solid organ transplant recipients (SOTRs) have decreased responsiveness to severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) vaccination and higher incidence of infection, but there are few data on the serological response in pediatric SOTR. The aim of this study was to determine serological response to SARS-CoV-2 vaccination in pediatric liver (LT) and kidney transplant (KT) recipients and compare it with adult SOTR.
Methods: A European, prospective, multicenter study was performed. Samples were taken at 7 and 32 wk following COVID-19 vaccination and serological endpoints were measured by ELISA.
Results: A total of 42 pediatric (16 post-LT and 26 post-KT) and 117 adult (all post-LT) were included. All pediatric participants and 94% adult participants received mRNA vaccines. Paediatric SOTR patients had significantly higher anti-Spike IgG levels than adult participants at week 7 (114 220.7 [59 285.92-220 058.55] versus 8756.7 [5643.69-13 586.71], P < 0.0001) and week 32 (46 113.2 [10 992.91-193 436.14] versus 8207.0 [3561.20-18 913.43], P = 0.0032). No significant difference in week 7 anti-Spike IgG response was found between pediatric LT and KT (129 434.4 [51 888.64-322 869.69] versus 105 304.5 [39 910.20-277 849.50], P = 0.9854). No differences were seen between children and adults in the rate of decline of anti-Spike IgG between weeks 7 and 32 (P = 0.8000). Male sex and hemolytic-uremic syndrome or postischemic kidney disease were associated with lower anti-Spike IgG levels at week 7 in pediatric SOTR.
Conclusions: Paediatric SOTR demonstrate greater SARS-CoV-2 vaccine responses than comparable adult SOTR patients. These data support efficacy and safety of SARS-CoV-2 vaccination in child SOTR and may alleviate vaccine hesitancy in this patient group.