tetano
Editor, Senior Moderator
Transpl Infect Dis
. 2020 Jul 20;e13421.
doi: 10.1111/tid.13421. Online ahead of print.
COVID-19 in solid organ transplant recipients: No difference in survival compared to general population
Matteo Rinaldi[SUP] 1 [/SUP], Michele Bartoletti[SUP] 1 [/SUP], Linda Bussini[SUP] 1 [/SUP], Livia Pancaldi[SUP] 1 [/SUP], Renato Pascale[SUP] 1 [/SUP], Giorgia Comai[SUP] 2 [/SUP], Mariacristina Morelli[SUP] 3 [/SUP], Matteo Ravaioli[SUP] 4 [/SUP], Matteo Cescon[SUP] 4 [/SUP], Francesco Cristini[SUP] 5 [/SUP], Pierluigi Viale[SUP] 1 [/SUP], Maddalena Giannella[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) may be associated with worse outcome in solid organ transplant (SOT) recipients. We performed a prospective cohort study of hospitalized patients with confirmed diagnosis of COVID-19, from March 15 to April 30, 2020, at two tertiary hospitals in Emilia-Romagna Region. SOT recipients were compared with non-SOT patients. Primary endpoint was all-cause 30-day mortality. Relationship between SOT status and mortality was investigated by univariable and multivariable Cox regression analysis. Patients were assessed from COVID-19 diagnosis to death or 30-day whichever occurred first. Study cohort consisted of 885 patients, of them 24 SOT recipients (n = 22, kidney, n = 2 liver). SOT recipients were younger, had lower BMI, but higher Charlson Index. At admission they presented less frequently with fever and respiratory failure. No difference in 30-day mortality between the two groups (19% vs 22.1%) was found; however, there was a trend toward higher rate of respiratory failure (50% vs 33.1%, P = .07) in SOT recipients. Superinfections were more represented in SOT recipients, (50% vs 15.5%, P < .001). At multivariate analysis adjusted for main covariates, there was no association between SOT and 30-day mortality HR 1.15 (95% CI 0.39-3.35) P = .79. Our data suggest that mortality among COVID-19 SOT recipients is similar to general population.
Keywords: COVID‐19; SARS‐CoV‐2; solid organ transplantation.
. 2020 Jul 20;e13421.
doi: 10.1111/tid.13421. Online ahead of print.
COVID-19 in solid organ transplant recipients: No difference in survival compared to general population
Matteo Rinaldi[SUP] 1 [/SUP], Michele Bartoletti[SUP] 1 [/SUP], Linda Bussini[SUP] 1 [/SUP], Livia Pancaldi[SUP] 1 [/SUP], Renato Pascale[SUP] 1 [/SUP], Giorgia Comai[SUP] 2 [/SUP], Mariacristina Morelli[SUP] 3 [/SUP], Matteo Ravaioli[SUP] 4 [/SUP], Matteo Cescon[SUP] 4 [/SUP], Francesco Cristini[SUP] 5 [/SUP], Pierluigi Viale[SUP] 1 [/SUP], Maddalena Giannella[SUP] 1 [/SUP]
Affiliations
- PMID: 32779808
- PMCID: PMC7404509
- DOI: 10.1111/tid.13421
Abstract
Coronavirus disease 2019 (COVID-19) may be associated with worse outcome in solid organ transplant (SOT) recipients. We performed a prospective cohort study of hospitalized patients with confirmed diagnosis of COVID-19, from March 15 to April 30, 2020, at two tertiary hospitals in Emilia-Romagna Region. SOT recipients were compared with non-SOT patients. Primary endpoint was all-cause 30-day mortality. Relationship between SOT status and mortality was investigated by univariable and multivariable Cox regression analysis. Patients were assessed from COVID-19 diagnosis to death or 30-day whichever occurred first. Study cohort consisted of 885 patients, of them 24 SOT recipients (n = 22, kidney, n = 2 liver). SOT recipients were younger, had lower BMI, but higher Charlson Index. At admission they presented less frequently with fever and respiratory failure. No difference in 30-day mortality between the two groups (19% vs 22.1%) was found; however, there was a trend toward higher rate of respiratory failure (50% vs 33.1%, P = .07) in SOT recipients. Superinfections were more represented in SOT recipients, (50% vs 15.5%, P < .001). At multivariate analysis adjusted for main covariates, there was no association between SOT and 30-day mortality HR 1.15 (95% CI 0.39-3.35) P = .79. Our data suggest that mortality among COVID-19 SOT recipients is similar to general population.
Keywords: COVID‐19; SARS‐CoV‐2; solid organ transplantation.