tetano
Editor, Senior Moderator
Virus Res. 2013 Aug 13. pii: S0168-1702(13)00239-6. doi: 10.1016/j.virusres.2013.07.017. [Epub ahead of print]
Transmission of influenza A/H5N1 viruses in mammals.
Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Fouchier RA, Kawaoka Y.
Source
Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan.
Abstract
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
Airborne transmission, Avian H5N1 influenza A virus, Mammalian model
PMID:
23954580
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23954580
Transmission of influenza A/H5N1 viruses in mammals.
Imai M, Herfst S, Sorrell EM, Schrauwen EJ, Linster M, De Graaf M, Fouchier RA, Kawaoka Y.
Source
Influenza Virus Research Center, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan.
Abstract
Highly pathogenic avian H5N1 influenza A viruses occasionally infect humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred. Nevertheless, further adaptation of avian H5N1 influenza A viruses to humans and/or reassortment with human influenza A viruses may result in aerosol transmissible viruses with pandemic potential. Although the full range of factors that modulate the transmission and replication of influenza A viruses in humans are not yet known, we are beginning to understand some of the molecular changes that may allow H5N1 influenza A viruses to transmit via aerosols or respiratory droplets among mammals. A better understanding of the biological basis and genetic determinants that confer transmissibility to H5N1 influenza A viruses in mammals is important to enhance our pandemic preparedness.
Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:
Airborne transmission, Avian H5N1 influenza A virus, Mammalian model
PMID:
23954580
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23954580