tetano
Editor, Senior Moderator
Transl Pediatr
. 2021 Feb;10(2):423-434.
doi: 10.21037/tp-20-144.
Is there possibility of vertical transmission of COVID-19: a systematic review
Jiajun Yuan[SUP] 1 2 [/SUP], Han Qian[SUP] 3 [/SUP], Shiyan Cao[SUP] 4 [/SUP], Bin Dong[SUP] 1 [/SUP], Xiaoyu Yan[SUP] 5 [/SUP], Shuanghong Luo[SUP] 6 [/SUP], Min Zhou[SUP] 1 [/SUP], Sha Zhou[SUP] 7 [/SUP], Botao Ning[SUP] 1 3 [/SUP], Liebin Zhao[SUP] 1 2 8 [/SUP]
Affiliations
Abstract
In order to investigate the clinical features of pregnant women and their neonates with coronavirus disease 2019 (COVID-19) and the evidence of vertical transmission of COVID-19, we retrieved studies included in PubMed, Medline and Chinese databases from January 1, 2000 to October 25, 2020 using relevant terms, such as 'COVID-19', 'vertical transmission' et al. in 'Title/Abstract'. Case reports and case series were included according to the inclusion and exclusion criteria. We conducted literature screening and data extraction, and performed literature bias risk assessment. Total of 13 case series and 16 case reports were collected, including a total of 564 pregnant women with COVID-19 and their 555 neonates, of which 549 neonates received nucleic acid test for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 18 neonates was diagnosed with COVID-19. The positive rate is 3.28%. Amniotic fluid of one woman was tested positive for SARS-CoV-2. The majority of infected neonates were born under strict infection control and received isolation and artificial feeding. Up till now, there is no sufficient evidence to exclude the possibility of vertical transmission for COVID-19 based on the current available data.
Keywords: Coronavirus disease 2019 (COVID-19); neonates; pregnant women; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); vertical transmission.
. 2021 Feb;10(2):423-434.
doi: 10.21037/tp-20-144.
Is there possibility of vertical transmission of COVID-19: a systematic review
Jiajun Yuan[SUP] 1 2 [/SUP], Han Qian[SUP] 3 [/SUP], Shiyan Cao[SUP] 4 [/SUP], Bin Dong[SUP] 1 [/SUP], Xiaoyu Yan[SUP] 5 [/SUP], Shuanghong Luo[SUP] 6 [/SUP], Min Zhou[SUP] 1 [/SUP], Sha Zhou[SUP] 7 [/SUP], Botao Ning[SUP] 1 3 [/SUP], Liebin Zhao[SUP] 1 2 8 [/SUP]
Affiliations
- PMID: 33708529
- PMCID: PMC7944168
- DOI: 10.21037/tp-20-144
Abstract
In order to investigate the clinical features of pregnant women and their neonates with coronavirus disease 2019 (COVID-19) and the evidence of vertical transmission of COVID-19, we retrieved studies included in PubMed, Medline and Chinese databases from January 1, 2000 to October 25, 2020 using relevant terms, such as 'COVID-19', 'vertical transmission' et al. in 'Title/Abstract'. Case reports and case series were included according to the inclusion and exclusion criteria. We conducted literature screening and data extraction, and performed literature bias risk assessment. Total of 13 case series and 16 case reports were collected, including a total of 564 pregnant women with COVID-19 and their 555 neonates, of which 549 neonates received nucleic acid test for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 18 neonates was diagnosed with COVID-19. The positive rate is 3.28%. Amniotic fluid of one woman was tested positive for SARS-CoV-2. The majority of infected neonates were born under strict infection control and received isolation and artificial feeding. Up till now, there is no sufficient evidence to exclude the possibility of vertical transmission for COVID-19 based on the current available data.
Keywords: Coronavirus disease 2019 (COVID-19); neonates; pregnant women; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); vertical transmission.