tetano
Editor, Senior Moderator
Transl Lung Cancer Res
. 2022 Jan;11(1):53-63.
doi: 10.21037/tlcr-21-504.
Seroprevalence and immunological memory against SARS-CoV-2 in lung cancer patients: the SOLID study
Mariano Provencio[SUP] 1 [/SUP], Delvys Rodríguez-Abreu[SUP] 2 [/SUP], Ana L Ortega[SUP] 3 [/SUP], Gloria Serrano[SUP] 4 [/SUP], Carlos Aguado[SUP] 5 [/SUP], Fernando Franco[SUP] 1 [/SUP], Vanesa Gutierrez[SUP] 6 [/SUP], Guillermo López Vivanco[SUP] 7 [/SUP], María Guirado[SUP] 8 [/SUP], Gretel Benítez[SUP] 2 [/SUP], Anna Estival[SUP] 9 [/SUP], Virginia Calvo[SUP] 1 [/SUP], Beatriz Jiménez[SUP] 10 [/SUP], Hugo Arasanz[SUP] 11 [/SUP], Juan Coves[SUP] 12 [/SUP], Margarita Majem[SUP] 13 [/SUP], Bartomeu Massutí[SUP] 14 [/SUP], Sergio Vázquez[SUP] 15 [/SUP], Oscar Juan-Vidal[SUP] 16 [/SUP], Ana Collazo-Lorduy[SUP] 1 [/SUP], Clara L Gozálvez[SUP] 17 [/SUP], Edel Del Barco[SUP] 18 [/SUP], Adriana Rosero[SUP] 19 [/SUP], Joaquim Bosch-Barrerra[SUP] 20 [/SUP], María A Moreno[SUP] 21 [/SUP], Xabier Mielgo-Rubio[SUP] 22 [/SUP], José C Villa[SUP] 23 [/SUP], Ana López-Martin[SUP] 24 [/SUP], Juan F Córdoba[SUP] 25 [/SUP], Francisco de Asís Aparisi[SUP] 26 [/SUP], Marta Zafra[SUP] 27 [/SUP], Joaquín Mosquera[SUP] 28 [/SUP], Javier Pérez Altozano[SUP] 29 [/SUP], Ernest Nadal[SUP] 30 [/SUP], Silvia Catot[SUP] 31 [/SUP], José Balsalobre[SUP] 32 [/SUP], Teresa de Portugal[SUP] 33 [/SUP], Paloma Martín[SUP] 34 [/SUP], Susanaa Cuesta de Juan[SUP] 35 [/SUP], Manuel Cobo[SUP] 6 [/SUP]
Affiliations
Abstract
Background: At present, we did not find any articles that studied seroprevalence and its persistence several months later in lung cancer patients in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Most patients with coronavirus disease 2019 (COVID-19) go on to develop antibodies (Abs) against viral proteins. However, it is not known how long these Abs last nor whether cancer treatments could affect the duration of immune response.
Methods: This prospective, longitudinal, multicenter serological study in the setting of SARS-CoV-2 infection was carried out in 50 Spanish hospitals. Eligibility criterion was the diagnosis of any lung cancer. The determination of anti-SARS-CoV-2 IgG Abs was performed by qualitative immuno-enzymatic assay using enzyme-linked immunosorbent assay (ELISA) kit from NovaLisa whose Abs target the recombinant antigen N of the nucleocapsid of SARS-CoV-2. The first Ab determination was performed between April 21 and June 3, 2020. The second Ab determination was performed in all previously seropositive patients, between September 10 and November 20, 2020. Study objectives were to prospectively determine seroprevalence in unselected lung cancer patients during the first wave of the pandemic; the persistence of immunity; protection or lack thereof against reinfection; and the influence of treatments on maintenance or loss of immunity.
Results: Of 1,500 patients, 128 were seropositive, overall prevalence of 8.5% seropositivity [95% confidence interval (CI): 7.2-10.1%]. Seventy-five percent were in active cancer treatment. Forty-seven point seven percent of IgG positive participants had experienced a symptomatic illness suspected of being infected with SARS-CoV-2 (95% CI: 38.8-56.6%). A second determination was performed on average 4.5 months later [interquartile range (IQR), 4.0-5.0 months] and obtained for 104 of the initially seropositive patients (81%), it could not be obtained in 24 patients, the majority due to death caused by disease progression (73%). In the second determination, IgG was not detected in 30.8% of patients. The severity of the infection, the need for hospitalization (P=0.032) and the presence of symptoms at diagnosis (P=0.02) were associated with persistence of immunity in the second determination. No variables or treatments received were associated with Abs loss.
Conclusions: Immunity against SARS-CoV-2 does not appear to be compromised by treatment and persists beyond 4 months. Neither do mortality rates appear to be particularly high in this unselected population.
. 2022 Jan;11(1):53-63.
doi: 10.21037/tlcr-21-504.
Seroprevalence and immunological memory against SARS-CoV-2 in lung cancer patients: the SOLID study
Mariano Provencio[SUP] 1 [/SUP], Delvys Rodríguez-Abreu[SUP] 2 [/SUP], Ana L Ortega[SUP] 3 [/SUP], Gloria Serrano[SUP] 4 [/SUP], Carlos Aguado[SUP] 5 [/SUP], Fernando Franco[SUP] 1 [/SUP], Vanesa Gutierrez[SUP] 6 [/SUP], Guillermo López Vivanco[SUP] 7 [/SUP], María Guirado[SUP] 8 [/SUP], Gretel Benítez[SUP] 2 [/SUP], Anna Estival[SUP] 9 [/SUP], Virginia Calvo[SUP] 1 [/SUP], Beatriz Jiménez[SUP] 10 [/SUP], Hugo Arasanz[SUP] 11 [/SUP], Juan Coves[SUP] 12 [/SUP], Margarita Majem[SUP] 13 [/SUP], Bartomeu Massutí[SUP] 14 [/SUP], Sergio Vázquez[SUP] 15 [/SUP], Oscar Juan-Vidal[SUP] 16 [/SUP], Ana Collazo-Lorduy[SUP] 1 [/SUP], Clara L Gozálvez[SUP] 17 [/SUP], Edel Del Barco[SUP] 18 [/SUP], Adriana Rosero[SUP] 19 [/SUP], Joaquim Bosch-Barrerra[SUP] 20 [/SUP], María A Moreno[SUP] 21 [/SUP], Xabier Mielgo-Rubio[SUP] 22 [/SUP], José C Villa[SUP] 23 [/SUP], Ana López-Martin[SUP] 24 [/SUP], Juan F Córdoba[SUP] 25 [/SUP], Francisco de Asís Aparisi[SUP] 26 [/SUP], Marta Zafra[SUP] 27 [/SUP], Joaquín Mosquera[SUP] 28 [/SUP], Javier Pérez Altozano[SUP] 29 [/SUP], Ernest Nadal[SUP] 30 [/SUP], Silvia Catot[SUP] 31 [/SUP], José Balsalobre[SUP] 32 [/SUP], Teresa de Portugal[SUP] 33 [/SUP], Paloma Martín[SUP] 34 [/SUP], Susanaa Cuesta de Juan[SUP] 35 [/SUP], Manuel Cobo[SUP] 6 [/SUP]
Affiliations
- PMID: 35242627
- PMCID: PMC8825652
- DOI: 10.21037/tlcr-21-504
Abstract
Background: At present, we did not find any articles that studied seroprevalence and its persistence several months later in lung cancer patients in the setting of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Most patients with coronavirus disease 2019 (COVID-19) go on to develop antibodies (Abs) against viral proteins. However, it is not known how long these Abs last nor whether cancer treatments could affect the duration of immune response.
Methods: This prospective, longitudinal, multicenter serological study in the setting of SARS-CoV-2 infection was carried out in 50 Spanish hospitals. Eligibility criterion was the diagnosis of any lung cancer. The determination of anti-SARS-CoV-2 IgG Abs was performed by qualitative immuno-enzymatic assay using enzyme-linked immunosorbent assay (ELISA) kit from NovaLisa whose Abs target the recombinant antigen N of the nucleocapsid of SARS-CoV-2. The first Ab determination was performed between April 21 and June 3, 2020. The second Ab determination was performed in all previously seropositive patients, between September 10 and November 20, 2020. Study objectives were to prospectively determine seroprevalence in unselected lung cancer patients during the first wave of the pandemic; the persistence of immunity; protection or lack thereof against reinfection; and the influence of treatments on maintenance or loss of immunity.
Results: Of 1,500 patients, 128 were seropositive, overall prevalence of 8.5% seropositivity [95% confidence interval (CI): 7.2-10.1%]. Seventy-five percent were in active cancer treatment. Forty-seven point seven percent of IgG positive participants had experienced a symptomatic illness suspected of being infected with SARS-CoV-2 (95% CI: 38.8-56.6%). A second determination was performed on average 4.5 months later [interquartile range (IQR), 4.0-5.0 months] and obtained for 104 of the initially seropositive patients (81%), it could not be obtained in 24 patients, the majority due to death caused by disease progression (73%). In the second determination, IgG was not detected in 30.8% of patients. The severity of the infection, the need for hospitalization (P=0.032) and the presence of symptoms at diagnosis (P=0.02) were associated with persistence of immunity in the second determination. No variables or treatments received were associated with Abs loss.
Conclusions: Immunity against SARS-CoV-2 does not appear to be compromised by treatment and persists beyond 4 months. Neither do mortality rates appear to be particularly high in this unselected population.