tetano
Editor, Senior Moderator
Transfus Apher Sci
. 2020 Jul 15;102875.
doi: 10.1016/j.transci.2020.102875. Online ahead of print.
Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study
Hassan Abolghasemi[SUP] 1 [/SUP], Peyman Eshghi[SUP] 2 [/SUP], Abdol Majid Cheraghali[SUP] 3 [/SUP], Abbas Ali Imani Fooladi[SUP] 1 [/SUP], Farzaneh Bolouki Moghaddam[SUP] 4 [/SUP], Sina Imanizadeh[SUP] 4 [/SUP], Matin Moeini Maleki[SUP] 4 [/SUP], Mohammad Ranjkesh[SUP] 4 [/SUP], Mohammad Rezapour[SUP] 4 [/SUP], Ali Bahramifar[SUP] 5 [/SUP], Behzad Einollahi[SUP] 6 [/SUP], Mohammad Javad Hosseini[SUP] 7 [/SUP], Nematollah Joneidi Jafari[SUP] 8 [/SUP], Mohamad Nikpouraghdam[SUP] 6 [/SUP], Nariman Sadri[SUP] 9 [/SUP], Mokhtar Tazik[SUP] 9 [/SUP], Shanaz Sali[SUP] 10 [/SUP], Shamsi Okati[SUP] 11 [/SUP], Elham Askari[SUP] 12 [/SUP], Payam Tabarsi[SUP] 12 [/SUP], Jafar Aslani[SUP] 13 [/SUP], Ehsan Sharifipour[SUP] 14 [/SUP], Mohammad Hossein Jarahzadeh[SUP] 15 [/SUP], Nastaran Khodakarim[SUP] 16 [/SUP], Mahmood Salesi[SUP] 13 [/SUP], Ramezan Jafari[SUP] 13 [/SUP], Samira Shahverdi[SUP] 17 [/SUP]
Affiliations
Abstract
Since Dec. 2019 the new coronavirus (SARS-CoV-2) has infected millions and claimed life of several hundred thousand worldwide. However, so far no approved vaccine or drug therapy is available for treatment of virus infection. Convalescent plasma has been considered a potential modality for COVID-19 infection. One hundred eighty-nine COVID-19 positive patients including 115 patients in plasma therapy group and 74 patients in control group, registered in the hospitals with confirmed COVID-19 infection, entered this multi-center clinical study. Comparison of outcomes including all-cause mortality, total hospitalization days and patients' need for intubation between the two patient groups shows that total of 98 (98.2 %) of patients who received convalescent plasma were discharged from hospital which is substantially higher compared to 56 (78.7 %) patients in control group. Length of hospitalization days was significantly lower (9.54 days) in convalescent plasma group compared with that of control group (12.88 days). Only 8 patients (7%) in convalescent plasma group required intubation while that was 20 % in control group. This clinical study provides strong evidence to support the efficacy of convalescent plasma therapy in COVID-19 patients and recommends this treatment for management of these patients. Clinical efficacy, immediate availability and potential cost effectiveness could be considered as main advantages of convalescent plasma therapy.
Keywords: COVID-19; Clinical trial; Convalescent plasma; Hospital stay; Mortality rate.
. 2020 Jul 15;102875.
doi: 10.1016/j.transci.2020.102875. Online ahead of print.
Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study
Hassan Abolghasemi[SUP] 1 [/SUP], Peyman Eshghi[SUP] 2 [/SUP], Abdol Majid Cheraghali[SUP] 3 [/SUP], Abbas Ali Imani Fooladi[SUP] 1 [/SUP], Farzaneh Bolouki Moghaddam[SUP] 4 [/SUP], Sina Imanizadeh[SUP] 4 [/SUP], Matin Moeini Maleki[SUP] 4 [/SUP], Mohammad Ranjkesh[SUP] 4 [/SUP], Mohammad Rezapour[SUP] 4 [/SUP], Ali Bahramifar[SUP] 5 [/SUP], Behzad Einollahi[SUP] 6 [/SUP], Mohammad Javad Hosseini[SUP] 7 [/SUP], Nematollah Joneidi Jafari[SUP] 8 [/SUP], Mohamad Nikpouraghdam[SUP] 6 [/SUP], Nariman Sadri[SUP] 9 [/SUP], Mokhtar Tazik[SUP] 9 [/SUP], Shanaz Sali[SUP] 10 [/SUP], Shamsi Okati[SUP] 11 [/SUP], Elham Askari[SUP] 12 [/SUP], Payam Tabarsi[SUP] 12 [/SUP], Jafar Aslani[SUP] 13 [/SUP], Ehsan Sharifipour[SUP] 14 [/SUP], Mohammad Hossein Jarahzadeh[SUP] 15 [/SUP], Nastaran Khodakarim[SUP] 16 [/SUP], Mahmood Salesi[SUP] 13 [/SUP], Ramezan Jafari[SUP] 13 [/SUP], Samira Shahverdi[SUP] 17 [/SUP]
Affiliations
- PMID: 32694043
- DOI: 10.1016/j.transci.2020.102875
Abstract
Since Dec. 2019 the new coronavirus (SARS-CoV-2) has infected millions and claimed life of several hundred thousand worldwide. However, so far no approved vaccine or drug therapy is available for treatment of virus infection. Convalescent plasma has been considered a potential modality for COVID-19 infection. One hundred eighty-nine COVID-19 positive patients including 115 patients in plasma therapy group and 74 patients in control group, registered in the hospitals with confirmed COVID-19 infection, entered this multi-center clinical study. Comparison of outcomes including all-cause mortality, total hospitalization days and patients' need for intubation between the two patient groups shows that total of 98 (98.2 %) of patients who received convalescent plasma were discharged from hospital which is substantially higher compared to 56 (78.7 %) patients in control group. Length of hospitalization days was significantly lower (9.54 days) in convalescent plasma group compared with that of control group (12.88 days). Only 8 patients (7%) in convalescent plasma group required intubation while that was 20 % in control group. This clinical study provides strong evidence to support the efficacy of convalescent plasma therapy in COVID-19 patients and recommends this treatment for management of these patients. Clinical efficacy, immediate availability and potential cost effectiveness could be considered as main advantages of convalescent plasma therapy.
Keywords: COVID-19; Clinical trial; Convalescent plasma; Hospital stay; Mortality rate.