tetano
Editor, Senior Moderator
Transbound Emerg Dis
. 2022 Sep 27.
doi: 10.1111/tbed.14714. Online ahead of print.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Infection and Humoral Responses Against Different Variants of Concern in Domestic Pet Animals and Stray Cats from North-Eastern Spain
Leira Fernández-Bastit[SUP] 1 2 [/SUP], Silvia Marfil[SUP] 3 [/SUP], Edwards Pradenas[SUP] 3 [/SUP], Rosa Valle[SUP] 1 2 [/SUP], Núria Roca[SUP] 1 2 [/SUP], Jordi Rodon[SUP] 1 2 [/SUP], Lola Pailler-García[SUP] 1 2 [/SUP], Benjamin Trinité[SUP] 3 [/SUP], Mariona Parera[SUP] 3 4 [/SUP], Marc Noguera-Julian[SUP] 3 4 5 [/SUP], Jaume Martorell[SUP] 6 [/SUP], Nuria Izquierdo-Useros[SUP] 3 5 7 [/SUP], Jorge Carrillo[SUP] 3 5 7 [/SUP], Bonaventura Clotet[SUP] 3 4 8 [/SUP], Julià Blanco[SUP] 3 4 5 7 [/SUP], Júlia Vergara-Alert[SUP] 1 2 [/SUP], Joaquim Segalés[SUP] 1 9 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious disease 2019 (COVID-19) pandemic in humans, is able to infect several domestic, captive and wildlife animal species. Since reverse zoonotic transmission to pets has been demonstrated, it is crucial to determine their role in the epidemiology of the disease to prevent further spillover events and major spreads of SARS-CoV-2. In the present study, we determined the presence of virus and the seroprevalence to SARS-CoV-2, as well as the levels of neutralizing antibodies (nAbs) against several variants of concern (VOCs) in pets (cats, dogs and ferrets) and stray cats from North-Eastern of Spain. We confirmed that cats and dogs can be infected by different VOCs of SARS-CoV-2 and, together with ferrets, are able to develop nAbs against the ancestral (B.1), Alpha (B.1.1.7), Beta (B.1.315), Delta (B.1.617.2) and Omicron (BA.1) variants, with lower titres against the latest in dogs and cats, but not in ferrets. Although the prevalence of active SARS-CoV-2 infection measured as direct viral RNA detection was low (0.3%), presence of nAbs in pets living in COVID-19 positive households was relatively high (close to 25% in cats, 10% in dogs and 40% in ferrets). It is essential to continue monitoring SARS-CoV-2 infections in these animals due to their frequent contact with human populations, and we cannot discard the probability of a higher animal susceptibility to new potential SARS-CoV-2 VOCs. This article is protected by copyright. All rights reserved.
Keywords: coronavirus disease 2019 (COVID-19); pets; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); stray cats; variants of concern (VOCs); zoonotic transmission.
. 2022 Sep 27.
doi: 10.1111/tbed.14714. Online ahead of print.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Infection and Humoral Responses Against Different Variants of Concern in Domestic Pet Animals and Stray Cats from North-Eastern Spain
Leira Fernández-Bastit[SUP] 1 2 [/SUP], Silvia Marfil[SUP] 3 [/SUP], Edwards Pradenas[SUP] 3 [/SUP], Rosa Valle[SUP] 1 2 [/SUP], Núria Roca[SUP] 1 2 [/SUP], Jordi Rodon[SUP] 1 2 [/SUP], Lola Pailler-García[SUP] 1 2 [/SUP], Benjamin Trinité[SUP] 3 [/SUP], Mariona Parera[SUP] 3 4 [/SUP], Marc Noguera-Julian[SUP] 3 4 5 [/SUP], Jaume Martorell[SUP] 6 [/SUP], Nuria Izquierdo-Useros[SUP] 3 5 7 [/SUP], Jorge Carrillo[SUP] 3 5 7 [/SUP], Bonaventura Clotet[SUP] 3 4 8 [/SUP], Julià Blanco[SUP] 3 4 5 7 [/SUP], Júlia Vergara-Alert[SUP] 1 2 [/SUP], Joaquim Segalés[SUP] 1 9 [/SUP]
Affiliations
- PMID: 36167932
- DOI: 10.1111/tbed.14714
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus infectious disease 2019 (COVID-19) pandemic in humans, is able to infect several domestic, captive and wildlife animal species. Since reverse zoonotic transmission to pets has been demonstrated, it is crucial to determine their role in the epidemiology of the disease to prevent further spillover events and major spreads of SARS-CoV-2. In the present study, we determined the presence of virus and the seroprevalence to SARS-CoV-2, as well as the levels of neutralizing antibodies (nAbs) against several variants of concern (VOCs) in pets (cats, dogs and ferrets) and stray cats from North-Eastern of Spain. We confirmed that cats and dogs can be infected by different VOCs of SARS-CoV-2 and, together with ferrets, are able to develop nAbs against the ancestral (B.1), Alpha (B.1.1.7), Beta (B.1.315), Delta (B.1.617.2) and Omicron (BA.1) variants, with lower titres against the latest in dogs and cats, but not in ferrets. Although the prevalence of active SARS-CoV-2 infection measured as direct viral RNA detection was low (0.3%), presence of nAbs in pets living in COVID-19 positive households was relatively high (close to 25% in cats, 10% in dogs and 40% in ferrets). It is essential to continue monitoring SARS-CoV-2 infections in these animals due to their frequent contact with human populations, and we cannot discard the probability of a higher animal susceptibility to new potential SARS-CoV-2 VOCs. This article is protected by copyright. All rights reserved.
Keywords: coronavirus disease 2019 (COVID-19); pets; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); stray cats; variants of concern (VOCs); zoonotic transmission.