tetano
Editor, Senior Moderator
Transbound Emerg Dis
. 2022 Jun 1.
doi: 10.1111/tbed.14601. Online ahead of print.
SARS-CoV-2 and influenza A virus co-infection alters viral tropism and hematological composition in Syrian hamsters
Hye Kwon Kim[SUP] 1 [/SUP], Jung-Ah Kang[SUP] 2 [/SUP], Kwang-Soo Lyoo[SUP] 3 [/SUP], Tran Bac Le[SUP] 2 4 [/SUP], Yoon Hwan Yeo[SUP] 3 [/SUP], Sook-San Wong[SUP] 5 [/SUP], Woonsung Na[SUP] 6 [/SUP], Daesub Song[SUP] 7 [/SUP], Richard J Webby[SUP] 8 [/SUP], Mark Zanin[SUP] 5 [/SUP], Dae Gwin Jeong[SUP] 2 4 [/SUP], Sun-Woo Yoon[SUP] 2 4 [/SUP]
Affiliations
Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic and its overlap with the influenza season lead to concerns over severe disease caused by influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infections. Using a Syrian hamster co-infection model, with SARS-CoV-2 and the pandemic influenza virus A/California/04/2009 (H1N1), we found (a) more severe disease in co-infected animals compared to those infected with influenza virus alone but not SARS-CoV-2 infection alone; (b) altered hematological changes in only co-infected animals; and (c) altered influenza virus tropism in the respiratory tracts of co-infected animals. Overall, our study revealed that co-infection with SARS-CoV-2 and influenza virus is associated with altered disease severity and tissue tropism, as well as hematological changes, compared to infection with either virus alone. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; co-infection; hematological change; influenza A virus; viral tropism.
. 2022 Jun 1.
doi: 10.1111/tbed.14601. Online ahead of print.
SARS-CoV-2 and influenza A virus co-infection alters viral tropism and hematological composition in Syrian hamsters
Hye Kwon Kim[SUP] 1 [/SUP], Jung-Ah Kang[SUP] 2 [/SUP], Kwang-Soo Lyoo[SUP] 3 [/SUP], Tran Bac Le[SUP] 2 4 [/SUP], Yoon Hwan Yeo[SUP] 3 [/SUP], Sook-San Wong[SUP] 5 [/SUP], Woonsung Na[SUP] 6 [/SUP], Daesub Song[SUP] 7 [/SUP], Richard J Webby[SUP] 8 [/SUP], Mark Zanin[SUP] 5 [/SUP], Dae Gwin Jeong[SUP] 2 4 [/SUP], Sun-Woo Yoon[SUP] 2 4 [/SUP]
Affiliations
- PMID: 35648595
- DOI: 10.1111/tbed.14601
Abstract
The ongoing coronavirus disease 2019 (COVID-19) pandemic and its overlap with the influenza season lead to concerns over severe disease caused by influenza virus and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infections. Using a Syrian hamster co-infection model, with SARS-CoV-2 and the pandemic influenza virus A/California/04/2009 (H1N1), we found (a) more severe disease in co-infected animals compared to those infected with influenza virus alone but not SARS-CoV-2 infection alone; (b) altered hematological changes in only co-infected animals; and (c) altered influenza virus tropism in the respiratory tracts of co-infected animals. Overall, our study revealed that co-infection with SARS-CoV-2 and influenza virus is associated with altered disease severity and tissue tropism, as well as hematological changes, compared to infection with either virus alone. This article is protected by copyright. All rights reserved.
Keywords: SARS-CoV-2; co-infection; hematological change; influenza A virus; viral tropism.