tetano
Editor, Senior Moderator
Transbound Emerg Dis
. 2020 Jul 20.
doi: 10.1111/tbed.13743. Online ahead of print.
Risk factors associated with occurrence of COVID-19 among household persons exposed to patients with confirmed COVID-19 in Qingdao Municipal, China
Hualei Xin[SUP] 1 2 [/SUP], Fachun Jiang[SUP] 1 2 [/SUP], Aili Xue[SUP] 3 [/SUP], Jiwei Liang[SUP] 1 2 [/SUP], Jingfei Zhang[SUP] 1 2 [/SUP], Feng Yang[SUP] 1 2 [/SUP], Yalin Han[SUP] 1 2 [/SUP]
Affiliations
Abstract
Tracing and isolation of close contacts is used to control outbreaks of coronavirus disease 2019 (COVID-19) in China. However, risk factors associated with occurrence of COVID-19 among close contacts have not been well described. 106 household contacts were included in this study, of whom 19 were developed into COVID-19 cases and the secondary attack rate was 17.9%. Multivariable analysis showed increasing risk of occurrence of COVID-19 among household contacts associated with female of index patients (Adjusted Hazard Ratio [aHR] = 3.84, 95%CI = 1.07-13.78), critical disease of index patients ([aHR] = 7.58, 95%CI = 1.66-34.66), effective contact duration with index patients >2 days ([aHR] = 4.21, 95%CI = 1.29-13.73), and effective contact duration >11 days ([aHR] = 17.88, 95%CI = 3.26-98.01).The sex and disease severity of index COVID-19 patients, and longer effective contact duration with COVID-19 confirmed cases could help epidemiologists to identify potential COVID-19 case among household contacts at an early stage.
Keywords: COVID-19; SARS-CoV-2; close contacts; household contacts; risk factor.
. 2020 Jul 20.
doi: 10.1111/tbed.13743. Online ahead of print.
Risk factors associated with occurrence of COVID-19 among household persons exposed to patients with confirmed COVID-19 in Qingdao Municipal, China
Hualei Xin[SUP] 1 2 [/SUP], Fachun Jiang[SUP] 1 2 [/SUP], Aili Xue[SUP] 3 [/SUP], Jiwei Liang[SUP] 1 2 [/SUP], Jingfei Zhang[SUP] 1 2 [/SUP], Feng Yang[SUP] 1 2 [/SUP], Yalin Han[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32688447
- DOI: 10.1111/tbed.13743
Abstract
Tracing and isolation of close contacts is used to control outbreaks of coronavirus disease 2019 (COVID-19) in China. However, risk factors associated with occurrence of COVID-19 among close contacts have not been well described. 106 household contacts were included in this study, of whom 19 were developed into COVID-19 cases and the secondary attack rate was 17.9%. Multivariable analysis showed increasing risk of occurrence of COVID-19 among household contacts associated with female of index patients (Adjusted Hazard Ratio [aHR] = 3.84, 95%CI = 1.07-13.78), critical disease of index patients ([aHR] = 7.58, 95%CI = 1.66-34.66), effective contact duration with index patients >2 days ([aHR] = 4.21, 95%CI = 1.29-13.73), and effective contact duration >11 days ([aHR] = 17.88, 95%CI = 3.26-98.01).The sex and disease severity of index COVID-19 patients, and longer effective contact duration with COVID-19 confirmed cases could help epidemiologists to identify potential COVID-19 case among household contacts at an early stage.
Keywords: COVID-19; SARS-CoV-2; close contacts; household contacts; risk factor.