tetano
Editor, Senior Moderator
Transbound Emerg Dis
. 2021 Jun 25.
doi: 10.1111/tbed.14202. Online ahead of print.
Inferring within-flock transmission dynamics of highly pathogenic avian influenza H5N8 virus in France, 2020
Timothée Vergne[SUP] 1 [/SUP], Simon Gubbins[SUP] 2 [/SUP], Claire Guinat[SUP] 3 4 [/SUP], Billy Bauzile[SUP] 1 [/SUP], Mattias Delpont[SUP] 1 [/SUP], Debapriyo Chakraborty[SUP] 1 [/SUP], Hugo Gruson[SUP] 5 [/SUP], Benjamin Roche[SUP] 5 6 7 [/SUP], Mathieu Andraud[SUP] 8 [/SUP], Mathilde Paul[SUP] 1 [/SUP], Jean-Luc Guérin[SUP] 1 [/SUP]
Affiliations
Abstract
Following the emergence of highly pathogenic avian influenza (H5N8) in France in early December 2020, we used duck mortality data from the index farm to investigate within-flock transmission dynamics. A stochastic epidemic model was fitted to the daily mortality data and model parameters were estimated using an approximate Bayesian computation sequential Monte Carlo (ABC-SMC) algorithm. The model predicted that the first bird in the flock was infected 5 days (95% credible interval, CI: 3-6) prior to the day of suspicion and that the transmission rate was 4.1 new infections per day (95% CI: 2.8-5.8). On average, ducks became infectious 4.1 hours (95% CI: 0.7-9.1) after infection and remained infectious for 4.3 days (95% CI: 2.8-5.7). The model also predicted that 34% (50% prediction interval: 8%-76%) of birds would already be infectious by the day of suspicion, emphasising the substantial latent threat this virus could pose to other poultry farms and to neighbouring wild birds. This study illustrates how mechanistic models can help provide rapid relevant insights that contribute to the management of infectious disease outbreaks of farmed animals. These methods can be applied to future outbreaks and the resulting parameter estimates made available to veterinary services within a few hours. This article is protected by copyright. All rights reserved.
Keywords: R0; avian flu; beta; duck; inference; mechanistic model; mortality; spread.
. 2021 Jun 25.
doi: 10.1111/tbed.14202. Online ahead of print.
Inferring within-flock transmission dynamics of highly pathogenic avian influenza H5N8 virus in France, 2020
Timothée Vergne[SUP] 1 [/SUP], Simon Gubbins[SUP] 2 [/SUP], Claire Guinat[SUP] 3 4 [/SUP], Billy Bauzile[SUP] 1 [/SUP], Mattias Delpont[SUP] 1 [/SUP], Debapriyo Chakraborty[SUP] 1 [/SUP], Hugo Gruson[SUP] 5 [/SUP], Benjamin Roche[SUP] 5 6 7 [/SUP], Mathieu Andraud[SUP] 8 [/SUP], Mathilde Paul[SUP] 1 [/SUP], Jean-Luc Guérin[SUP] 1 [/SUP]
Affiliations
- PMID: 34170081
- DOI: 10.1111/tbed.14202
Abstract
Following the emergence of highly pathogenic avian influenza (H5N8) in France in early December 2020, we used duck mortality data from the index farm to investigate within-flock transmission dynamics. A stochastic epidemic model was fitted to the daily mortality data and model parameters were estimated using an approximate Bayesian computation sequential Monte Carlo (ABC-SMC) algorithm. The model predicted that the first bird in the flock was infected 5 days (95% credible interval, CI: 3-6) prior to the day of suspicion and that the transmission rate was 4.1 new infections per day (95% CI: 2.8-5.8). On average, ducks became infectious 4.1 hours (95% CI: 0.7-9.1) after infection and remained infectious for 4.3 days (95% CI: 2.8-5.7). The model also predicted that 34% (50% prediction interval: 8%-76%) of birds would already be infectious by the day of suspicion, emphasising the substantial latent threat this virus could pose to other poultry farms and to neighbouring wild birds. This study illustrates how mechanistic models can help provide rapid relevant insights that contribute to the management of infectious disease outbreaks of farmed animals. These methods can be applied to future outbreaks and the resulting parameter estimates made available to veterinary services within a few hours. This article is protected by copyright. All rights reserved.
Keywords: R0; avian flu; beta; duck; inference; mechanistic model; mortality; spread.