tetano
Editor, Senior Moderator
Transbound Emerg Dis
. 2025 Aug 13:2025:8009335.
doi: 10.1155/tbed/8009335. eCollection 2025. Evolution and Spread of Y280-Lineage H9N2 Low Pathogenicity Avian Influenza Viruses in Korea, 2020-2023
Andrew Y Cho[SUP] 1 [/SUP], Tae-Hyeon Kim[SUP] 1 [/SUP], Heesu Lee[SUP] 1 [/SUP], Sun-Hak Lee[SUP] 1 [/SUP], Yeram Seo[SUP] 1 [/SUP], Bitgoeul Kim[SUP] 2 [/SUP], Chung-Young Lee[SUP] 2 [/SUP], Sungsu Youk[SUP] 3 [/SUP], Jung-Hoon Kwon[SUP] 4 [/SUP], Chang-Seon Song[SUP] 1 [/SUP], Dong-Hun Lee[SUP] 5 [/SUP]
Affiliations
In 2020, Y280-lineage H9N2 low pathogenic avian influenza was detected in South Korea for the first time. Active surveillance from live bird markets (LBMs) and farms revealed the continuous circulation of Y280-lineage H9N2 viruses, replacing the previously indigenous Y439-lineage and becoming dominant in South Korea. Antigenic mapping showed a substantial antigenic difference between the Y280 and Y439-lineage viruses. Bayesian phylodynamic approach suggests the introduction of Y280-lineage viruses from China and revealed the frequent exchange of viruses between LBM and farms. The presence of mammalian adaptation markers and high binding affinity to human-type sialic acid receptor raise a concern on interspecies transmission of the viruses to mammals. These findings underscore the importance of continued genomic surveillance to monitor the evolution of H9N2 viruses and assessment of zoonotic potential.
. 2025 Aug 13:2025:8009335.
doi: 10.1155/tbed/8009335. eCollection 2025. Evolution and Spread of Y280-Lineage H9N2 Low Pathogenicity Avian Influenza Viruses in Korea, 2020-2023
Andrew Y Cho[SUP] 1 [/SUP], Tae-Hyeon Kim[SUP] 1 [/SUP], Heesu Lee[SUP] 1 [/SUP], Sun-Hak Lee[SUP] 1 [/SUP], Yeram Seo[SUP] 1 [/SUP], Bitgoeul Kim[SUP] 2 [/SUP], Chung-Young Lee[SUP] 2 [/SUP], Sungsu Youk[SUP] 3 [/SUP], Jung-Hoon Kwon[SUP] 4 [/SUP], Chang-Seon Song[SUP] 1 [/SUP], Dong-Hun Lee[SUP] 5 [/SUP]
Affiliations
- PMID: 40843278
- PMCID: PMC12367370
- DOI: 10.1155/tbed/8009335
In 2020, Y280-lineage H9N2 low pathogenic avian influenza was detected in South Korea for the first time. Active surveillance from live bird markets (LBMs) and farms revealed the continuous circulation of Y280-lineage H9N2 viruses, replacing the previously indigenous Y439-lineage and becoming dominant in South Korea. Antigenic mapping showed a substantial antigenic difference between the Y280 and Y439-lineage viruses. Bayesian phylodynamic approach suggests the introduction of Y280-lineage viruses from China and revealed the frequent exchange of viruses between LBM and farms. The presence of mammalian adaptation markers and high binding affinity to human-type sialic acid receptor raise a concern on interspecies transmission of the viruses to mammals. These findings underscore the importance of continued genomic surveillance to monitor the evolution of H9N2 viruses and assessment of zoonotic potential.