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Transbound Emerg Dis . Co-circulation of coronavirus and avian influenza virus in wild birds in Shanghai, 2020-2021

tetano

Editor, Senior Moderator
Transbound Emerg Dis


. 2022 Sep 2.
doi: 10.1111/tbed.14694. Online ahead of print.
Co-circulation of coronavirus and avian influenza virus in wild birds in Shanghai, 2020-2021


Min Ma[SUP] 1 [/SUP], Lei Ji[SUP] 2 [/SUP], Le Ming[SUP] 1 [/SUP], Yuting Xu[SUP] 1 [/SUP], Chenyao Zhao[SUP] 2 [/SUP], Tianhou Wang[SUP] 1 [/SUP], Guimei He[SUP] 1 3 [/SUP]



Affiliations

Abstract

Co-infection of SARS-CoV-2 and influenza viruses has been reported worldwide in humans. Wild birds are natural reservoir hosts for coronaviruses (CoVs) and avian influenza viruses (AIVs). It is unknown whether co-infection with these two types of viruses occurs in wild birds. In this study, the prevalence of co-infection with CoV and AIV in wild birds in Shanghai, China during 2020-2021, was investigated by detecting these viruses in cloacal, tracheal, and fecal samples. Results showed that the overall rate of samples positive for both CoV and AIV was 3.3% (82/2510; 95% CI 2.6-4.0%), and that was mainly from Anseriformes. In CoV positive samples, 38.9% (82/211; 95% CI 32.5-45.6%) of them had both CoVs and AIVs, whereas only 26.9% (82/305; 95% CI 22.2-32.1%) of AIV positive samples had both CoVs and AIVs. These results suggest that CoV infection in wild birds renders them more susceptible to AIV infection. Phylogenetic analysis based on partial RNA-dependent RNA polymerase (RdRp) gene sequences of CoVs revealed that gamma-CoVs mainly cluster with duck CoVs and that delta-CoVs are more diversified and cluster with those of various wild birds. Continual surveillance is necessity to monitor the transmission and evolution of co-infection of these two types of viruses in their natural hosts. This article is protected by copyright. All rights reserved.

Keywords: co-infection; coronavirus, avian influenza virus; wild birds.
 
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