tetano
Editor, Senior Moderator
Transbound Emerg Dis
. 2021 Apr 19.
doi: 10.1111/tbed.14110. Online ahead of print.
Characterization of Four Novel H5N6 Avian Influenza Viruses with the Internal Genes from H5N1 and H9N2 Viruses and Experimental Challenge of Chickens Vaccinated with Current Commercially Available H5 Vaccines
Chen Peng[SUP] 1 2 [/SUP], Pengwei Zhao[SUP] 3 [/SUP], Chu Jun[SUP] 1 [/SUP], Junda Zhu[SUP] 1 [/SUP], Qiuchen Li[SUP] 1 [/SUP], Haiyuan Zhao[SUP] 4 [/SUP], Yujie Li[SUP] 5 [/SUP], Lingxiang Xin[SUP] 6 [/SUP], Xiaoyue Yang[SUP] 6 [/SUP], Shijie Xie[SUP] 1 [/SUP], Changdong Zhu[SUP] 4 [/SUP], Wenbao Qi[SUP] 7 [/SUP], Guanlong Xu[SUP] 6 [/SUP], Jinxiang Li[SUP] 8 [/SUP]
Affiliations
Abstract
Since 2014, highly pathogenic avian influenza H5N6 viruses have been responsible for outbreaks in poultry. In this study, four H5N6 virus strains were isolated from fecal samples of sick white ducks and dead chickens in Shandong in 2019. These H5N6 viruses were triple-reassortant viruses that have not been previously characterized. Their HA genes were derived from the H5 viruses and were closely related to the vaccine strain Re-11. Their NA genes all fell into the N6-like lineage and the internal gene were derived from H5N1 and H9N2 viruses. They all showed high pathogenicity in mice and caused lethal infection with high rates of transmission in chickens. Moreover, the SPF chickens inoculated with the current used H5 (Re-11 and Re-12 strains)/H7 (H7-Re-2 strain) trivalent inactivated vaccines in China were completely protected from these four H5N6 viruses. Our study indicated the necessity of continued surveillance for H5 Influenza A viruses and the importance of timely update of vaccine strains in poultry industry.
. 2021 Apr 19.
doi: 10.1111/tbed.14110. Online ahead of print.
Characterization of Four Novel H5N6 Avian Influenza Viruses with the Internal Genes from H5N1 and H9N2 Viruses and Experimental Challenge of Chickens Vaccinated with Current Commercially Available H5 Vaccines
Chen Peng[SUP] 1 2 [/SUP], Pengwei Zhao[SUP] 3 [/SUP], Chu Jun[SUP] 1 [/SUP], Junda Zhu[SUP] 1 [/SUP], Qiuchen Li[SUP] 1 [/SUP], Haiyuan Zhao[SUP] 4 [/SUP], Yujie Li[SUP] 5 [/SUP], Lingxiang Xin[SUP] 6 [/SUP], Xiaoyue Yang[SUP] 6 [/SUP], Shijie Xie[SUP] 1 [/SUP], Changdong Zhu[SUP] 4 [/SUP], Wenbao Qi[SUP] 7 [/SUP], Guanlong Xu[SUP] 6 [/SUP], Jinxiang Li[SUP] 8 [/SUP]
Affiliations
- PMID: 33872465
- DOI: 10.1111/tbed.14110
Abstract
Since 2014, highly pathogenic avian influenza H5N6 viruses have been responsible for outbreaks in poultry. In this study, four H5N6 virus strains were isolated from fecal samples of sick white ducks and dead chickens in Shandong in 2019. These H5N6 viruses were triple-reassortant viruses that have not been previously characterized. Their HA genes were derived from the H5 viruses and were closely related to the vaccine strain Re-11. Their NA genes all fell into the N6-like lineage and the internal gene were derived from H5N1 and H9N2 viruses. They all showed high pathogenicity in mice and caused lethal infection with high rates of transmission in chickens. Moreover, the SPF chickens inoculated with the current used H5 (Re-11 and Re-12 strains)/H7 (H7-Re-2 strain) trivalent inactivated vaccines in China were completely protected from these four H5N6 viruses. Our study indicated the necessity of continued surveillance for H5 Influenza A viruses and the importance of timely update of vaccine strains in poultry industry.