tetano
Editor, Senior Moderator
Trans R Soc Trop Med Hyg
. 2021 Aug 2;trab109.
doi: 10.1093/trstmh/trab109. Online ahead of print.
The seroprevalence of severe acute respiratory syndrome coronavirus 2 in Delhi, India: a repeated population-based seroepidemiological study
Nandini Sharma[SUP] 1 [/SUP], Pragya Sharma[SUP] 1 [/SUP], Saurav Basu[SUP] 1 [/SUP], Sonal Saxena[SUP] 2 [/SUP], Rohit Chawla[SUP] 2 [/SUP], Kumar Dushyant[SUP] 1 [/SUP], Nutan Mundeja[SUP] 3 [/SUP], Zeasaly Marak[SUP] 4 [/SUP], Sanjay Singh[SUP] 5 [/SUP], Gautam Singh[SUP] 6 [/SUP], Ruchir Rustagi[SUP] 5 [/SUP]
Affiliations
Abstract
Background: Three rounds of a repeated cross-sectional serosurvey to estimate the change in seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were conducted from August to October 2020 in the state of Delhi, India, in the general population ≥5 y of age.
Methods: The selection of participants was through a multistage sampling design from all 11 districts and 280 wards of the city-state, with multistage allocation proportional to population size. The blood samples were screened using immunoglobulin G (IgG) enzyme-linked immunosorbent assay kits.
Results: We observed a total of 4267 (N=150 46), 4311 (N=17 409) and 3829 (N=15 015) positive tests indicative of the presence of IgG antibody to SARS-CoV-2 during the August, September and October 2020 serosurvey rounds, respectively. The adjusted seroprevalence declined from 28.39% (95% confidence interval [CI] 27.65 to 29.14) in August to 24.08% (95% CI 23.43 to 24.74) in September and 24.71% (95% CI 24.01 to 25.42) in October. On adjusted analysis, participants with lower per capita income, living in slums or overcrowded households and those with diabetes comorbidity had significantly higher statistical odds of having antibody positivity (p<0.01).
Conclusions: Nearly one in four residents in Delhi, India ≥5 y of age had the SARS-CoV-2 infection during August-October 2020.
Keywords: COVID-19; SARS-CoV-2; serosurvey.
. 2021 Aug 2;trab109.
doi: 10.1093/trstmh/trab109. Online ahead of print.
The seroprevalence of severe acute respiratory syndrome coronavirus 2 in Delhi, India: a repeated population-based seroepidemiological study
Nandini Sharma[SUP] 1 [/SUP], Pragya Sharma[SUP] 1 [/SUP], Saurav Basu[SUP] 1 [/SUP], Sonal Saxena[SUP] 2 [/SUP], Rohit Chawla[SUP] 2 [/SUP], Kumar Dushyant[SUP] 1 [/SUP], Nutan Mundeja[SUP] 3 [/SUP], Zeasaly Marak[SUP] 4 [/SUP], Sanjay Singh[SUP] 5 [/SUP], Gautam Singh[SUP] 6 [/SUP], Ruchir Rustagi[SUP] 5 [/SUP]
Affiliations
- PMID: 34339514
- DOI: 10.1093/trstmh/trab109
Abstract
Background: Three rounds of a repeated cross-sectional serosurvey to estimate the change in seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were conducted from August to October 2020 in the state of Delhi, India, in the general population ≥5 y of age.
Methods: The selection of participants was through a multistage sampling design from all 11 districts and 280 wards of the city-state, with multistage allocation proportional to population size. The blood samples were screened using immunoglobulin G (IgG) enzyme-linked immunosorbent assay kits.
Results: We observed a total of 4267 (N=150 46), 4311 (N=17 409) and 3829 (N=15 015) positive tests indicative of the presence of IgG antibody to SARS-CoV-2 during the August, September and October 2020 serosurvey rounds, respectively. The adjusted seroprevalence declined from 28.39% (95% confidence interval [CI] 27.65 to 29.14) in August to 24.08% (95% CI 23.43 to 24.74) in September and 24.71% (95% CI 24.01 to 25.42) in October. On adjusted analysis, participants with lower per capita income, living in slums or overcrowded households and those with diabetes comorbidity had significantly higher statistical odds of having antibody positivity (p<0.01).
Conclusions: Nearly one in four residents in Delhi, India ≥5 y of age had the SARS-CoV-2 infection during August-October 2020.
Keywords: COVID-19; SARS-CoV-2; serosurvey.