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Tracking World Wide Tamiflu Resistant Novel H1N1 Cases - Links - Updated December 18, 2009

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L

Laidback Al

Well-known member
H1N1 Tamiflu Resistant Cases -- url Links
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WHO October 16, 2009
Systematic surveillance conducted by the Global Influenza Surveillance Network (GISN) including WHO Collaborating Centres (WHOCCs) for reference and research on influenza, continues to detect sporadic incidents of H1N1 pandemic viruses that show resistance to the antiviral oseltamivir. To date, 35 resistant pandemic H1N1 influenza viruses have been detected and characterized worldwide. All of these viruses show the same H275Y mutation that confers resistance to the antiviral oseltamivir, but not to the antiviral zanamivir. Worldwide, more than 10,000 clinical specimens (samples and isolates) of the pandemic H1N1 virus have been tested and found to be sensitive to oseltamivir.
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WHO October 22, 2009 http://www.who.int/wer/2009/wer8444/en/index.html
. . .
Description of cases of oseltamivir resistance

WHO received the first report of an oseltamivir-resistant pandemic (H1N1) 2009 virus in July 2009. As of 22 October 2009, a total of 39 cases had been described, 7 of which are still under investigation. . . .
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WHO November 13, 2009

To date, 52 oseltamivir resistant pandemic H1N1 influenza viruses have been detected and characterized worldwide. All of these viruses show the same H275Y mutation. All these viruses remain sensitive to zanamivir.
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WHO December 18, 2009

Systematic surveillance conducted by the GISN including WHOCCs for Reference and Research on Influenza, continues to identify sporadic incidents of H1N1 pandemic viruses that show resistance to the antiviral oseltamivir. Antiviral susceptibility testing was carried out by WHO CCs and GISN labs on specimens and isolates of pandemic H1N1 viruses from at least 31 countries. 136 cases of oseltamivir resistant pandemic H1N1 have been reported by GISN so far.
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Here is a preliminary list of H1N1 cases reported from around the world as resistant to Tamiflu roughly sorted by date. First reported url link is generally provided. The number in parentheses following the location is the number of resistant cases. Sequence numbers are provided for some of the early cases. This list is incomplete.

<st1:country-region w:st="on">Japan</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Osaka</st1:place></st1:city> (1) (May, 2009) (A/Osaka/180/2009?)
http://www.flutrackers.com/forum/showthread.php?t=121517
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:state w:st="on">Hawaii</st1:state> (1) (May 26, 2009) (<st1:country-region w:st="on"><st1:place w:st="on">Singapore</st1:place></st1:country-region>) (A/Singapore/57/2009?)
http://www.recombinomics.com/News/08090903/H274Y_Singapore_Hawaii.html

Denmark, (1) (June 9,<sup> </sup>2009) (A/Denmark/528/2009)
http://www.flutrackers.com/forum/showpost.php?p=257317&postcount=7

<o:p> </o:p><st1:place w:st="on">Hong Kong</st1:place> (1) (June 11, 2009)
http://www.flutrackers.com/forum/showpost.php?p=260569&postcount=1
http://www.flutrackers.com/forum/showpost.php?p=314651&postcount=249

<st1:country-region w:st="on">Canada</st1:country-region>, <st1:state w:st="on"><st1:place w:st="on">Quebec</st1:place></st1:state> (1) (June 26, 2009)
http://www.flutrackers.com/forum/showpost.php?p=270251&postcount=18
http://www.flutrackers.com/forum/showpost.php?p=325581&postcount=280
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:city w:st="on">San Francisco</st1:city>, <st1:state w:st="on">California</st1:state></st1:place> (1) (July 3, 2009) (Hong Kong)
http://www.flutrackers.com/forum/showpost.php?p=259678&postcount=1
<o:p> </o:p>
<st1:place w:st="on"></st1:place><st1:country-region w:st="on">Viet Nam</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Hanoi</st1:place></st1:city> (2) (July 9, 2009)
http://www.flutrackers.com/forum/showpost.php?p=263660&postcount=6
<o:p> </o:p>
<st1:country-region w:st="on"><st1:place w:st="on">Japan</st1:place></st1:country-region>, Yamaguchi (1) (July, 2009?) (A/Yamaguchi/22/2009)
http://www.flutrackers.com/forum/showpost.php?p=270251&postcount=18
<o:p> </o:p>
<st1:place w:st="on">Hong Kong</st1:place>, Eastern District (1) (July 15, 2009)
http://www.flutrackers.com/forum/showpost.php?p=281081&postcount=1
<o:p> </o:p>
<st1:country-region w:st="on"></st1:country-region><st1:country-region w:st="on">Japan</st1:country-region>, <st1:city w:st="on"><st1:place w:st="on">Tokushima</st1:place></st1:city> (1) (July 26, 2009)
http://www.flutrackers.com/forum/showthread.php?t=118137

Hong Kong (1) (July 26, 2009)
http://www.flutrackers.com/forum/showthread.php?t=124881

<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:state w:st="on">North Carolina</st1:state></st1:place> (2) (July, 2009)
http://www.flutrackers.com/forum/showpost.php?p=284360&postcount=3

Viet Nam (7) (July, 2009)
http://www.flutrackers.com/forum/showthread.php?t=136237

Singapore (1) (July 2009)
http://www.ncbi.nlm.nih.gov/protein/ACY46782
<o:p> </o:p>
<st1:country-region w:st="on"><st1:place w:st="on">Thailand</st1:place></st1:country-region> (1?) (August 4, 2009)
http://www.flutrackers.com/forum/showthread.php?t=120147
<o:p> </o:p>
<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:city w:st="on">Seattle</st1:city>, <st1:state w:st="on">Washington</st1:state></st1:place> (2) (August 14, 2009)
http://www.flutrackers.com/forum/showpost.php?p=281311&postcount=1

Japan, Nagoya (2) (August 16, 2009)
http://www.flutrackers.com/forum/showpost.php?p=314655&postcount=252
<o:p> </o:p>
<st1:country-region w:st="on">China</st1:country-region>, <st1:place w:st="on"><st1:placename w:st="on">Pingtung</st1:placename> <st1:placetype w:st="on">County</st1:placetype></st1:place> (1) (August 17, 2009)
http://www.flutrackers.com/forum/showpost.php?p=288381&postcount=237

Japan, Sapporo (1) (August 22, 2009)
http://www.flutrackers.com/forum/showpost.php?p=302451&postcount=4

<st1:country-region w:st="on">USA</st1:country-region>, <st1:place w:st="on"><st1:state w:st="on">California</st1:state></st1:place>, northern (1) (August 28, 2009)

Canada, Alberta (1) August ??, 2009)
http://www.flutrackers.com/forum/showpost.php?p=294642&postcount=1

<st1:country-region w:st="on">USA</st1:country-region> , <st1:state w:st="on"><st1:place w:st="on">Texas</st1:place></st1:state> (2) (August, 2009)
http://www.dshs.state.tx.us/idcu/disease/influenza/surveillance/2009/CurrentFlu.pdf
<o:p> </o:p>
<st1:place w:st="on"><st1:country-region w:st="on">Japan</st1:country-region></st1:place>, Shiga (1) (August 31, 2009)
http://www.flutrackers.com/forum/showpost.php?p=288401&postcount=261
http://www.flutrackers.com/forum/showpost.php?p=288403&postcount=264

Sweden (2) (July August 2009)
http://www.flutrackers.com/forum/showpost.php?p=322440&postcount=58

Taiwan, (1) (September 1, 2009)
<link rel="File-List" href="file:///C:%5CDOCUME%7E1%5CARS%5CLOCALS%7E1%5CTemp%5Cmsohtml1%5C01%5Cclip_filelist.xml"><!--[if gte mso 9]><xml> <w:WordDocument> <w:View>Normal</w:View> <w:Zoom>0</w:Zoom> <w:PunctuationKerning/> <w:ValidateAgainstSchemas/> <w:SaveIfXMLInvalid>false</w:SaveIfXMLInvalid> <w:IgnoreMixedContent>false</w:IgnoreMixedContent> <w:AlwaysShowPlaceholderText>false</w:AlwaysShowPlaceholderText> <w:Compatibility> <w:BreakWrappedTables/> <w:SnapToGridInCell/> <w:WrapTextWithPunct/> <w:UseAsianBreakRules/> <w:DontGrowAutofit/> </w:Compatibility> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--><!--[if gte mso 9]><xml> <w:LatentStyles DefLockedState="false" LatentStyleCount="156"> </w:LatentStyles> </xml><![endif]--><style> <!-- /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-parent:""; margin:0in; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:12.0pt; font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";} a:link, span.MsoHyperlink {color:blue; text-decoration:underline; text-underline:single;} a:visited, span.MsoHyperlinkFollowed {color:purple; text-decoration:underline; text-underline:single;} @page Section1 {size:8.5in 11.0in; margin:1.0in 1.25in 1.0in 1.25in; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} --> </style><!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} </style> <![endif]-->http://www.flutrackers.com/forum/showthread.php?t=129135
http://www.flutrackers.com/forum/showpost.php?p=314650&postcount=248

Viet Nam (3) (August, September 2009)
http://www.flutrackers.com/forum/showpost.php?p=304052&postcount=2
http://www.flutrackers.com/forum/showpost.php?p=314646&postcount=244

Australia (1) (September 11, 2009)
http://www.flutrackers.com/forum/showthread.php?p=293269#post293269

United Kingdom (2) (September ??, 2009)
http://www.flutrackers.com/forum/showpost.php?p=295469&postcount=1

Hong Kong (1) (September 14, 2009)
http://www.flutrackers.com/forum/showpost.php?p=314652&postcount=250

Finland? (1) (September ? 2009)
http://www.flutrackers.com/forum/showpost.php?p=322440&postcount=58

Canada, Ontario (1) (October, 2009)
http://www.flutrackers.com/forum/showpost.php?p=314647&postcount=245

Netherlands, Groningen (1) (October, 2009)
http://www.flutrackers.com/forum/showpost.php?p=314663&postcount=259

Hong Kong (1) (October 7, 2009) (Cumulative Hong Kong total 5)
http://www.flutrackers.com/forum/showpost.php?p=315235&postcount=262
http://www.flutrackers.com/forum/showpost.php?p=319416&postcount=269

Japan, Yokahama (1) (October, 2009) (Cumulative Japan total 12)
http://www.flutrackers.com/forum/showpost.php?p=314658&postcount=255

Japan, Shiga (1) (October 14, 2009) (Cumulative Japan total 13)
http://www.flutrackers.com/forum/showpost.php?p=315257&postcount=264

USA, Durham North Carolina (4) (mid October, 2009?)
http://www.flutrackers.com/forum/showpost.php?p=321167&postcount=1

USA, Utah (1) (Fall 2009)
http://www.flutrackers.com/forum/showthread.php?t=123546&page=10

United Kingdom, Wales (5) (early November, 2009?)
http://www.flutrackers.com/forum/showthread.php?p=321283

Italy, Pavia (1) (November 13, 2009)
http://www.ncbi.nlm.nih.gov/genomes/FLU/SwineFlu.html
http://www.flutrackers.com/forum/showthread.php?t=134052

Scotland (2) (November 16, 2009)
http://www.flutrackers.com/forum/showpost.php?p=319059&postcount=267
http://www.flutrackers.com/forum/showthread.php?t=133368

South Korea (1) (November 2009)
http://www.flutrackers.com/forum/showthread.php?t=135242

South Korea (1) (November 16, 2009)
http://www.flutrackers.com/forum/showpost.php?p=329667&postcount=293
http://www.flutrackers.com/forum/showthread.php?t=136902


USA, Tennessee (1) (November 2009)
http://www.flutrackers.com/forum/showpost.php?p=325013&postcount=278

USA, Delaware, Kent County (1) (November 2009)
http://www.flutrackers.com/forum/showpost.php?p=327608&postcount=292

USA, Virginia (1) (November ? 2009)
http://www.flutrackers.com/forum/showpost.php?p=325500&postcount=279

USA, Maryland (1) (November ? 2009)
http://www.flutrackers.com/forum/showpost.php?p=325500&postcount=279

Spain (2?) (November ? 2009)
http://www.flutrackers.com/forum/showpost.php?p=325942&postcount=2

USA, Pennsylvania (2) ( November ? 2009)
http://www.flutrackers.com/forum/showpost.php?p=326251&postcount=289

France (2) (November? 2009)
http://www.flutrackers.com/forum/showpost.php?p=323523&postcount=79

Spain, Cataluña (1) (December ? 2009) (Cumulative Spain total 3)
http://www.flutrackers.com/forum/showpost.php?p=325581&postcount=280

Netherlands, Groningen (1) (December 2009) (Cumulative Netherlands total 3)
http://www.flutrackers.com/forum/showpost.php?p=325943&postcount=282

Netherlands (3) (December 2009) (Cumulative Netherlands total 6)
http://www.flutrackers.com/forum/showpost.php?p=325944&postcount=287

Japan, Mie Prefecture Yokkaichi City (1) (December 15, 2009)
http://www.flutrackers.com/forum/showpost.php?p=329099&postcount=292

Germany (2) (December 2009)
http://www.flutrackers.com/forum/showpost.php?p=330189&postcount=1

Netherlands (5) (December 18, 2009) (Cumulative Netherlands total 11)
http://www.flutrackers.com/forum/showpost.php?p=330173&postcount=298

Japan, Aichi Prefecture, Nagoya (1) (December 18, 2009)
http://www.flutrackers.com/forum/showpost.php?p=330250&postcount=300

Brazil?

Argentina?


Corrections and additions welcome.
 
Last edited:
Re: Tracking World Wide Tamiflu Resistant Novel H1N1 Cases - Links - Updated December 10, 2009

Re: Tracking World Wide Tamiflu Resistant Novel H1N1 Cases - Links - Updated December 10, 2009

Updated with a cluster of seven cases from Viet Nam in July. Bump this.
 
Re: Tracking World Wide Tamiflu Resistant Novel H1N1 Cases - Links - Updated December 18, 2009

Links in post number 1 will no longer be added or updated and this thread will be closed. Tamiflu resistance has now been reported from more than 100 individuals from all around the world. Genetic analysis coupled with clinical data will be the next step to deciphering this aspect of novel H1N1.
 
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