tetano
Editor, Senior Moderator
Org Lett. 2018 Oct 17. doi: 10.1021/acs.orglett.8b03073. [Epub ahead of print]
[h=1]Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus.[/h] Jana S[SUP]1[/SUP], Sarpe VA[SUP]1[/SUP], Kulkarni SS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Fungal glycolipids emmyguyacins A and B inhibit the pH-dependent conformational change of hemaglutinin A during replication of the Influenza virus. Herein, we report the first total synthesis and structure confirmation of emmyguyacins A and B. Our efficient route, which involves regioselective functionalization of trehalose, allows rapid access to adequate amounts of chemically pure emmyguyacin analogues including the desoxylate derivatives for SAR studies.
PMID: 30350678 DOI: 10.1021/acs.orglett.8b03073
[h=1]Total Synthesis of Emmyguyacins A and B, Potential Fusion Inhibitors of Influenza Virus.[/h] Jana S[SUP]1[/SUP], Sarpe VA[SUP]1[/SUP], Kulkarni SS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Fungal glycolipids emmyguyacins A and B inhibit the pH-dependent conformational change of hemaglutinin A during replication of the Influenza virus. Herein, we report the first total synthesis and structure confirmation of emmyguyacins A and B. Our efficient route, which involves regioselective functionalization of trehalose, allows rapid access to adequate amounts of chemically pure emmyguyacin analogues including the desoxylate derivatives for SAR studies.
PMID: 30350678 DOI: 10.1021/acs.orglett.8b03073