tetano
Editor, Senior Moderator
Tohoku J Exp Med
. 2022;256(3):209-214.
doi: 10.1620/tjem.256.209.
Chronic Obstructive Pulmonary Disease is Associated with a More Symptomatic Burden and Severe Presentation of COVID-19: A Korean National COVID-19 Cohort Study
Youlim Kim[SUP] 1 [/SUP], Hyun Lee[SUP] 2 [/SUP], Sun-Kyung Lee[SUP] 2 3 [/SUP], Bumhee Yang[SUP] 4 [/SUP], Hayoung Choi[SUP] 5 [/SUP], Dong Won Park[SUP] 2 [/SUP], Tai Sun Park[SUP] 2 [/SUP], Ji-Yong Moon[SUP] 2 [/SUP], Tae-Hyung Kim[SUP] 2 [/SUP], Jang Won Sohn[SUP] 2 [/SUP], Ho Joo Yoon[SUP] 2 [/SUP], Sang-Heon Kim[SUP] 2 [/SUP]
Affiliations
Abstract
Insufficient data are available on comprehensive evaluation of demographics, symptoms or signs, laboratory findings, and disease course in patients with coronavirus disease 2019 (COVID-19) and chronic obstructive pulmonary disease (COPD). We aimed to evaluate whether COPD patients are more prone to severe COVID-19 compared with those without COPD. We also investigate the clinical characteristics and disease course of COVID-19 in patients with COPD versus those without COPD. Patients were selected from a Korean nationwide cohort of 5,628 patients with confirmed COVID-19 and who had completed treatment or quarantine by April 30, 2020; 3,673 patients aged 40 years or older were included in this study. COPD was diagnosed using patient reports of physician-diagnosed COPD. During the study period, all patients with COVID-19 in Korea were hospitalized following the national health policy. Of the study participants, 38 (1.0%) had COPD. Regarding initial symptoms, COPD patients with COVID-19 showed greater sputum production (50.0% vs. 29.8%, p < 0.01) and dyspnea (36.8% vs. 14.9%, p < 0.01) than those without COPD. In addition, patients with COPD were more likely to receive oxygen therapy or non-invasive ventilation (29.0% vs. 13.7%, p = 0.01) and had a higher mortality (21.1% vs. 6.4%, p < 0.01) than those without COPD. After adjusting for age, sex, body mass index, and comorbidities, COPD patients showed increased risk of severe COVID-19 compared with those without COPD. Our nationwide study showed that COVID-19 patients with COPD have higher symptomatic burden and more severe disease course than those without COPD.
Keywords: COPD; COVID-19 infection; disease severity; mortality; symptom burden.
. 2022;256(3):209-214.
doi: 10.1620/tjem.256.209.
Chronic Obstructive Pulmonary Disease is Associated with a More Symptomatic Burden and Severe Presentation of COVID-19: A Korean National COVID-19 Cohort Study
Youlim Kim[SUP] 1 [/SUP], Hyun Lee[SUP] 2 [/SUP], Sun-Kyung Lee[SUP] 2 3 [/SUP], Bumhee Yang[SUP] 4 [/SUP], Hayoung Choi[SUP] 5 [/SUP], Dong Won Park[SUP] 2 [/SUP], Tai Sun Park[SUP] 2 [/SUP], Ji-Yong Moon[SUP] 2 [/SUP], Tae-Hyung Kim[SUP] 2 [/SUP], Jang Won Sohn[SUP] 2 [/SUP], Ho Joo Yoon[SUP] 2 [/SUP], Sang-Heon Kim[SUP] 2 [/SUP]
Affiliations
- PMID: 35314528
- DOI: 10.1620/tjem.256.209
Abstract
Insufficient data are available on comprehensive evaluation of demographics, symptoms or signs, laboratory findings, and disease course in patients with coronavirus disease 2019 (COVID-19) and chronic obstructive pulmonary disease (COPD). We aimed to evaluate whether COPD patients are more prone to severe COVID-19 compared with those without COPD. We also investigate the clinical characteristics and disease course of COVID-19 in patients with COPD versus those without COPD. Patients were selected from a Korean nationwide cohort of 5,628 patients with confirmed COVID-19 and who had completed treatment or quarantine by April 30, 2020; 3,673 patients aged 40 years or older were included in this study. COPD was diagnosed using patient reports of physician-diagnosed COPD. During the study period, all patients with COVID-19 in Korea were hospitalized following the national health policy. Of the study participants, 38 (1.0%) had COPD. Regarding initial symptoms, COPD patients with COVID-19 showed greater sputum production (50.0% vs. 29.8%, p < 0.01) and dyspnea (36.8% vs. 14.9%, p < 0.01) than those without COPD. In addition, patients with COPD were more likely to receive oxygen therapy or non-invasive ventilation (29.0% vs. 13.7%, p = 0.01) and had a higher mortality (21.1% vs. 6.4%, p < 0.01) than those without COPD. After adjusting for age, sex, body mass index, and comorbidities, COPD patients showed increased risk of severe COVID-19 compared with those without COPD. Our nationwide study showed that COVID-19 patients with COPD have higher symptomatic burden and more severe disease course than those without COPD.
Keywords: COPD; COVID-19 infection; disease severity; mortality; symptom burden.