tetano
Editor, Senior Moderator
Neurol Res. 2017 Nov 24:1-8. doi: 10.1080/01616412.2017.1407021. [Epub ahead of print]
[h=1]Time-series analysis: variation of anti-acetylcholine receptor antibody titer in myasthenia gravis is related to incidence of Mycoplasma pneumoniae and influenza virus infections.[/h] Iwasa K[SUP]1[/SUP], Yoshikawa H[SUP]2[/SUP], Hamaguchi T[SUP]1[/SUP], Sakai K[SUP]1[/SUP], Shinohara-Noguchi M[SUP]1[/SUP], Samuraki M[SUP]1[/SUP], Takahashi K[SUP]1,[/SUP][SUP]3[/SUP], Yanase D[SUP]1,[/SUP][SUP]4[/SUP], Ono K[SUP]1,[/SUP][SUP]5[/SUP], Ishida C[SUP]1,[/SUP][SUP]3[/SUP], Yoshita M[SUP]1,[/SUP][SUP]6[/SUP], Nakamura H[SUP]7[/SUP], Yamada M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Objectives The exacerbating factors of myasthenia gravis (MG) are unknown. However, it has been speculated that infections may play a role in disease progression. Methods We calculated the adjusted anti-acetylcholine receptor antibody (Adj-AChR-Ab) titers (range, 0-1) in 58 MG patients between 2006 and 2012. We determined the relationship between Adj-AChR-Ab titer and infection incidence. Results A cross-correlation function (CCF) analysis of Adj-AChR-Ab titer and incidence of Mycoplasma pneumoniae (M. pneumoniae) (r = 0.449, P < 0.0001) and influenza virus (r = 0.411, P < 0.001) infections indicated significant correlations. MG with thymoma was highly correlated with M. pneumoniae infection (r = 0.798, P < 0.0001). The relative risk for Adj-AChR-Ab titer was 1.407 for M. pneumoniae (95% CI, 1.193-1.661 for an increase in one infected patient per monitoring point) and 1.158 for influenza (95% CI, 1.071-1.253 for 100 infected patients). Conclusion Variation of Adj-AChR-Ab titer is significantly influenced by the presence of M. pneumoniae and influenza virus infections.
[h=4]KEYWORDS:[/h] Myasthenia gravis; Mycoplasma pneumoniae; anti-acetylcholine receptor antibody; immune response; influenza virus
PMID: 29173125 DOI: 10.1080/01616412.2017.1407021
[h=1]Time-series analysis: variation of anti-acetylcholine receptor antibody titer in myasthenia gravis is related to incidence of Mycoplasma pneumoniae and influenza virus infections.[/h] Iwasa K[SUP]1[/SUP], Yoshikawa H[SUP]2[/SUP], Hamaguchi T[SUP]1[/SUP], Sakai K[SUP]1[/SUP], Shinohara-Noguchi M[SUP]1[/SUP], Samuraki M[SUP]1[/SUP], Takahashi K[SUP]1,[/SUP][SUP]3[/SUP], Yanase D[SUP]1,[/SUP][SUP]4[/SUP], Ono K[SUP]1,[/SUP][SUP]5[/SUP], Ishida C[SUP]1,[/SUP][SUP]3[/SUP], Yoshita M[SUP]1,[/SUP][SUP]6[/SUP], Nakamura H[SUP]7[/SUP], Yamada M[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Objectives The exacerbating factors of myasthenia gravis (MG) are unknown. However, it has been speculated that infections may play a role in disease progression. Methods We calculated the adjusted anti-acetylcholine receptor antibody (Adj-AChR-Ab) titers (range, 0-1) in 58 MG patients between 2006 and 2012. We determined the relationship between Adj-AChR-Ab titer and infection incidence. Results A cross-correlation function (CCF) analysis of Adj-AChR-Ab titer and incidence of Mycoplasma pneumoniae (M. pneumoniae) (r = 0.449, P < 0.0001) and influenza virus (r = 0.411, P < 0.001) infections indicated significant correlations. MG with thymoma was highly correlated with M. pneumoniae infection (r = 0.798, P < 0.0001). The relative risk for Adj-AChR-Ab titer was 1.407 for M. pneumoniae (95% CI, 1.193-1.661 for an increase in one infected patient per monitoring point) and 1.158 for influenza (95% CI, 1.071-1.253 for 100 infected patients). Conclusion Variation of Adj-AChR-Ab titer is significantly influenced by the presence of M. pneumoniae and influenza virus infections.
[h=4]KEYWORDS:[/h] Myasthenia gravis; Mycoplasma pneumoniae; anti-acetylcholine receptor antibody; immune response; influenza virus
PMID: 29173125 DOI: 10.1080/01616412.2017.1407021