tetano
Editor, Senior Moderator
Thromb Res. 2020 May 6;192:3-8. doi: 10.1016/j.thromres.2020.05.006. [Epub ahead of print]
The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.
Fu J[SUP]1[/SUP], Kong J[SUP]2[/SUP], Wang W[SUP]3[/SUP], Wu M[SUP]4[/SUP], Yao L[SUP]4[/SUP], Wang Z[SUP]5[/SUP], Jin J[SUP]2[/SUP], Wu D[SUP]6[/SUP], Yu X[SUP]7[/SUP].
Author information
Abstract
OBJECTIVE:
To investigate the clinical features of COVID-19 cases in Suzhou China. Biomarkers were screened out of hematological parameters for risk stratification.
METHOD:
Confirmed COVID-19 adult patients in Suzhou were included. The patient data was collected, and the results of laboratory examinations were compared between the mild/moderate and severe COVID-19 groups. A ROC was calculated to compare the diagnostic performance of candidate indexes, and dynamic levels of hematological indexes were compared between the two groups.
RESULT:
75 patients were enrolled, with a mean age of 46.6 ? 14 years, and 45 patients were male. All patients were classified into two groups: the mild/moderate group and the severe group. WBC, neutrophil to lymphocyte ratio (NLR), D-dimer, and fibrinogen levels of the severe group were significantly higher (P < 0.05) than the mild/moderate, and the lymphocyte was lower. The ROC test showed that the hematological parameters had a larger AUC than that of inflammatory factors. There was a significant difference in lymphocyte and fibrinogen levels between the two groups on day 1 (P < 0.05). However, NLR of the severe group was higher than the mild/moderate on days 1, 4 and 14 (P < 0.01), and so was D-dimer on days 1, 7 and 14 (P < 0.05).
CONCLUSION:
The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leukopenia, which were significantly different between the mild/moderate and severe COVID-19 groups. Furthermore, the dynamic change of NLR and D-dimer level can distinguish severe COVID-19 cases from the mild/moderate.
Copyright ? 2020. Published by Elsevier Ltd.
KEYWORDS:
Coronavirus disease 2019; D-dimer; Neutrophil to lymphocyte ratio
PMID:32407937DOI:10.1016/j.thromres.2020.05.006
The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China.
Fu J[SUP]1[/SUP], Kong J[SUP]2[/SUP], Wang W[SUP]3[/SUP], Wu M[SUP]4[/SUP], Yao L[SUP]4[/SUP], Wang Z[SUP]5[/SUP], Jin J[SUP]2[/SUP], Wu D[SUP]6[/SUP], Yu X[SUP]7[/SUP].
Author information
Abstract
OBJECTIVE:
To investigate the clinical features of COVID-19 cases in Suzhou China. Biomarkers were screened out of hematological parameters for risk stratification.
METHOD:
Confirmed COVID-19 adult patients in Suzhou were included. The patient data was collected, and the results of laboratory examinations were compared between the mild/moderate and severe COVID-19 groups. A ROC was calculated to compare the diagnostic performance of candidate indexes, and dynamic levels of hematological indexes were compared between the two groups.
RESULT:
75 patients were enrolled, with a mean age of 46.6 ? 14 years, and 45 patients were male. All patients were classified into two groups: the mild/moderate group and the severe group. WBC, neutrophil to lymphocyte ratio (NLR), D-dimer, and fibrinogen levels of the severe group were significantly higher (P < 0.05) than the mild/moderate, and the lymphocyte was lower. The ROC test showed that the hematological parameters had a larger AUC than that of inflammatory factors. There was a significant difference in lymphocyte and fibrinogen levels between the two groups on day 1 (P < 0.05). However, NLR of the severe group was higher than the mild/moderate on days 1, 4 and 14 (P < 0.01), and so was D-dimer on days 1, 7 and 14 (P < 0.05).
CONCLUSION:
The common COVID-19 abnormal hematological indexes on admission included hyperfibrinogenemia, lymphopenia, the elevation of D-dimer, and leukopenia, which were significantly different between the mild/moderate and severe COVID-19 groups. Furthermore, the dynamic change of NLR and D-dimer level can distinguish severe COVID-19 cases from the mild/moderate.
Copyright ? 2020. Published by Elsevier Ltd.
KEYWORDS:
Coronavirus disease 2019; D-dimer; Neutrophil to lymphocyte ratio
PMID:32407937DOI:10.1016/j.thromres.2020.05.006